SFRBM Annual Meeting, Pre-meeting Workshop II Flavanols in Health and Disease
|
|
|
- Karen Bishop
- 5 years ago
- Views:
Transcription
1 FLAVILA Targeted delivery of dietary flavanols for optimal human cell function: Effects on cardiovascular health SFRBM Annual Meeting, Pre-meeting Workshop II Flavanols in Health and Disease Flavanols and Procyanidins: Absorption, Distribution, Metabolism, and Excretion Jeremy P E Spencer, University of Reading San Diego, 14 November 2012
2 !! Flavanols and procyanidins present in cocoa LU$$$$$ Epicatechin (DP1) Dimer B2 (DP2) $$ 400$ $$ DP1$ DP2$ H H H 200$ $$ DP3$ DP4$ DP5$ DP6$ DP7$ DP8$ DP9$ DP10$ Hammerstone et al., J. Agr. Food Chem., 47, FLAVILA session at the annual SFRBM meeting 14 November 2012
3 Are procyanidins absorbed and do they contribute to the pool of circulating flavanols in humans? FLAVILA session at the annual SFRBM meeting 14 November 2012
4 Procyanidins higher than DP2 are not absorbed following cocoa flavanol intake Flavanols and procyanidins ingested with each test drink (mg/kg BW) Flavanols(+(Procyanidins( ( DP(1210( DP22DP10( DP1( Flavanols((1(unit)( 2.10( 0.16( 1.8( ((((((4)4epicatechin( 1.80( 0.14( 1.8( ((((((+)4catechin( 0.28( 0.02( 0( There was no evidence for the absorption of procyanidins higher than DP 2 Procyanidins(( 9.91( 9.91( 0( (((((Dimers( 1.8( 1.8( 0( (((((Trimers( 1.6( 1.6( 0( (((((Tetramers(to(decamers( 6.5( 6.5( 0( "aviani et al. AJCN(2012) 95(4):851-8 FLAVILA session at the annual SFRBM meeting 14 November 2012
5 Procyanidin intake does not contribute to the pool of circulating flavanols in humans "aviani et al. AJCN(2012) 95(4):851-8 FLAVILA session at the annual SFRBM meeting 14 November 2012
6 Consumption of flavanol monomer (DP1) and procyanidins (DP 2-10) give rise to γ-valerolactone metabolites "aviani et al. AJCN(2012) 95(4):851-8 FLAVILA session at the annual SFRBM meeting 14 November 2012
7 What about the monomeric flavanols? FLAVILA session at the annual SFRBM meeting 14 November 2012
8 Chemical structure of flavanol stereoisomers ( )epicatechin, (+)epicatechin, ( )catechin, and (+)catechin H H (-)-Epicatechin (-)-Catechin H H (+)-Epicatechin (+)-Catechin FLAVILA session at the annual SFRBM meeting 14 November 2012
9 Plasma levels of flavanols after consumption of ( )epicatechin, (+)epicatechin, ( )catechin, or (+)catechin (1.5 mg/kg BW) Profile of flavanol metabolites in plasma 2 h post-consumption 800 ( )-epicatechin (+)-epicatechin ( )-catechin (+)-catechin Plasma flavanol metabolites 2 h post-consumption (nm) p<0.05 non-methylated metabolites 3'--methylated metabolites 4'--methylated metabolites ( )-epicatechin (+)-epicatechin ( )-catechin (+)-catechin n.d. n.d. "aviani et al. FRBM (2011) 50, FLAVILA session at the annual SFRBM meeting 14 November 2012
10 Standard food manufacture processes decrease flavanol contents Heat xidation ph Isomerisation (change in chemical structure) ( )$epicatechin- ( )$epicatechin- ( )$catechin- Based-on-these-findings,-we-created-technologies-that-preserve-the-flavanols-naturally-presentin-cocoa-during-food-manufacture,-making-flavanols-available-in-the-final-food-product.- FLAVILA session at the annual SFRBM meeting 14 November 2012
11 What are the major circulating flavanol metabolites in humans? FLAVILA session at the annual SFRBM meeting 14 November 2012
12 HPLC chromatogram trace of de novo synthesized (-)-epicatechin metabolites epicatechin 3'- sulphate 3'- - methyl epicatechin- 5- sulfate 3'- - methyl epicatechin- 7- sulfate epicatechin 3'- β- D - glucuronide E5G E7G
13 Circulating levels of (-)-epicatechin glucuronides following intake of the Flaviola test drink Level of ( )-epictechin glucuronides in plasma (nm) A ( )-epicatechin-3'-β-d-glucuronide 4'--methyl( )-epicatechin-7-β-d-glucuronide FLD intensity (LU) B A B C D Authentic standards Plasma 0 h Plasma 2 h F G Time after consumption (h) Elution time (min)! "aviani et al. FRBM (2012) 52(8): FLAVILA session at the annual SFRBM meeting 14 November 2012
14 Circulating levels of (-)-epicatechin sulfates following intake of the Flaviola test drink Level of individual ( )-epictechin sulfates in plasma (nm) A ( )-epicatechin-5-sulfate B I Authentic standards ( )-epicatechin-7-sulfate Plasma 0 h ( )-epicatechin-3'-sulfate Plasma 2 h 150 E H J Time after consumption (h) ECD intensity (na) ECD 550 mv ECD 550 mv ECD 225 mv Elution time (min) i ii iii iv! "aviani et al. FRBM (2012) 52(8): FLAVILA session at the annual SFRBM meeting 14 November 2012
15 (-)-epicatechin metabolism in humans H UGT ( )-epicatechin CMT + SULT H H SULT - C ( )-epicatechin-3 -β-dglucuronide ( )-epicatechin-3 - sulfate S - H - 3 S 3 --methyl( )-epicatechin- 5/7-sulfate CH 3 FLAVILA session at the annual SFRBM meeting 14 November 2012
16 Relative amounts of individual ( )-epicatechin metabolites in the circulation ( )-epicatechin-3 - β-d-glucuronide ( )-epicatechin- 3 -sulfate ( )-epicatechin- 5-sulfate "aviani et al. FRBM (2012) 52(8): ( )-epicatechin- 7-sulfate 4 --methyl( )- epicatechin-5/7-sulfates* 3 --methyl( )- epicatechin-5/7-sulfates* FLAVILA session at the annual SFRBM meeting 14 November 2012
17 Factors affecting flavanol absorption, distribution, metabolism and excretion FLAVILA session at the annual SFRBM meeting 14 November 2012
18 Intra-individual absorption and metabolism (n=9; 2 visits; 1 week washout) 2500 IntraAindividual,variability,(n=7) CV#%# C max %% T max %% AUC (0+6h)% Sum,of,flavanols,metabolites,,(,nM) CV 36% CV 19% CV 19% CV 22% CV 15% CV 21% CV 42% CV 49% E3'G% 30.1% 21.7% 26.0% E3'S% 25.3% 33.4% 32.8% 3ME5S% 18.9% 11.5% 24.4% 3ME7S% 25.7% 24.2% 32.0% Total% flavanols% 16.6# 13.9# 15.8# Time,after,flavanol,consumption,(h) According to FDA, drugs exhibi@ng intra- subject variability greater than 30% in AUC or Cmax are considered highly variable drugs FLAVILA session at the annual SFRBM meeting 14 November 2012
19 Inter-individual absorption and metabolism 2500 InterAindividual,variability,(n=20) CV#%# C max %% T max %% AUC (0+6h) % Sum,of,flavanols,metabolites,(nM) CV 49% CV 47% CV 42% CV 43% CV 44% CV 40% CV 50% CV 58% E3'G% 54.2% 23.7% 50.0% E3'S% 36.4% 34.4% 43.5% 3ME5S% 34.9% 46.2% 39.0% 3ME7S% 50.6% 38.2% 46.4% Total%flavanols% 38.6% 26.0% 38.1% Time,after,flavanol,consumption,(h) CV#%# C max %% T max %% %AUC (0+6h)% % Acetaminophen% glucuronide% Acetaminophen% sulfate% 48.8% 33.0% 55.4% 54.4% 34.4% 56.1% Acetaminophen% 27.1% 47.1% 25.2% Total% acetaminophen% 40.9% 41.4% 39.0% FLAVILA session at the annual SFRBM meeting 14 November 2012
20 Influence of age on the absorption and metabolism of flavanols CharacterisMcs Elderly (n=20) Young (n=20) Age (years) 70 ± 4 a 26 ± 6 b Weight (kg) 81 ± ± 9 BMI (kg/m 2 ) 27 ± 3 24 ± 2 GFR (ml/min/1.73m 2 ) 72 ± ± 22 Cholesterol (mm) 4.6 ± ± 1.2 Triglycerids (mm) 1.0 ± ± 0.4 Glucose (mm) 5.1 ± ± 0.4 CreaMnine (µm) 96.2 ± ± 14.4 Bilirubin (µm) 17.0 ± ± 5.5 Uric acid (µm) ± ± 74.1 ALT (U/L) 21.7 ± ± 6.3 GGT- L (U/L) 25.0 ± ± 8.0 ALP (U/L) 61.7 ± ± 15.4 n medicamon 7 - FLAVILA session at the annual SFRBM meeting 14 November 2012
21 Age does not influence total levels (AUC: 0-6h) of circulating flavanol metabolites Total Plasma AUC 5000 * * Young Elderly AUC 0-6h (nm*h) mg CF 800 mg CF FLAVILA session at the annual SFRBM meeting 14 November 2012
22 Plasma levels (AUC: 0-6h) of (-)-epicatechin metabolites in young and old AUC (-)-epicatechin-3'-glucuronide AUC 3'methyl-(-)-epicatechin-5-sulfate AUC 0-6h (nm*h) * * * Young Elderly AUC 0-6h (nm*h) * * * Young Elderly mg CF 800 mg CF mg CF 800 mg CF FLAVILA session at the annual SFRBM meeting 14 November 2012
23 Influence of age on (-)-epicatechin metabolism AUC%(036h)%in%Young%individuals% AUC(036h)%in%Elderly%individuals% EC% 1%% E3'G% 45%% E7S% 1%% E3'S% 20%% 3ME7S% 16%% E5S% 2%% 3ME5S% 15%% E3'G% 56%% E3'S% 18%% EC% 1%% 3ME5S% 11%% 3ME7S% 10%% E7S% 1%% E5S% 3%% FLAVILA session at the annual SFRBM meeting 14 November 2012
24 Urinary excretion of γ-valerolactones in young and old individuals Urinary -(3,4 dihydroxyphenyl)- gamma-valerolactone (µmol) * * * 400 mg CF 800 mg CF Young Elderly FLAVILA session at the annual SFRBM meeting 14 November 2012
![[microbes in the gut]](/docs-images/89/97557789/images/25-3.jpg "Diges@ve Tract [gut] ( )-")
![circulamon [blood] H H](/docs-images/89/97557789/images/25-13.jpg "AbsorpMon and chemical")
25 Summary of the metabolism of flavanols following consumption H H Flavanol- and procyanidin- containing foods enter into the H H Chemical breakdown by gut microbiome [microbes in the gut] Diges@ve Tract [gut] ( )- epicatechin No absorpmon Flavanol oligomers (Procyanidins) 5- (3,4- dihydroxyphenyl) - γ- valerolactone Further reading: Saviani et al. FRBM (2012) Gastro- intesmnal barrier [gut cells] Systemic circulamon [blood] H H AbsorpMon and chemical modificamons - C S 3 - H ( )- epicatechin- 3ʹ - sulfate ( )- epicatechin- 3ʹ - β- D- glucuronide AbsorpMon and chemical modificamons S 3 - CH 3 3ʹ - - methyl( )- epicatechin- 5- sulfate S 3-5- (3,4- dihydroxyphenyl)- γ- valerolactone metabolites
26 Relevance for mechanistic assessment of flavanol function Flavanols in plants and foods Flavanols in humans H H H Flavanol oligomers (Procyanidins) H Flavanol ( )- epicatechin H H - C S 3 - H Flavanol metabolites S 3 - CH 3 - S 3 These findings are important, as they inform us about the chemical structure of the flavanols present in the human body, which enables research aimed at understanding the mechanisms by which flavanol- rich diets mediate cardiovascular health benefits.
SFRBM Annual Meeting, Pre-meeting Workshop II Flavanols in Health and Disease
FLAVIOLA Targeted delivery of dietary flavanols for optimal human cell function: Effects on cardiovascular health SFRBM Annual Meeting, Pre-meeting Workshop II Flavanols in Health and Disease Flavanol
PURSUING ADVANCES IN CARDIOVASC UL AR HEALTH. FLAVIOLA Final Publishable Summary
PURSUING ADVANCES IN CARDIOVASC UL AR HEALTH Phytochemical constituents of certain foods and beverages, in particular a class of compounds called flavanols, have been avidly investigated in recent years.
Fruits and Vegetables Why More Matters
Fruits and Vegetables Why More Matters Francene Steinberg, PhD, RD Professor and Chair Department of Nutrition University of California, Davis September 22, 2012 Obesity & Nutrition in a Changing World
The Bioavailability of Dietary Flavonoids & Related Phenolic Compounds. Dietary phenolics. Feeding Studies. Stomach. Tissues. bile.
The Bioavailability of Dietary Flavonoids & Related Phenolic Compounds Dietary phenolics Stomach Tissues Possible Routes for Consumed Dietary Phenolics in Humans bile General circulation Small intestine
Supporting information to research article:
Supporting information to research article: Dietary epicatechin is available to breastfed infants through human breast milk in the form of host and microbial metabolites. Olha Khymenets 1*, Montserrat
Bioavailability of dietary (poly)phenols following acute. ingestion of an enriched drink by ileostomists
SUPPLEMENTARY MATERIAL Bioavailability of dietary (poly)phenols following acute ingestion of an enriched drink by ileostomists Gina Borges a, Michael E.J. Lean b, Susan A. Roberts c, and Alan Crozier *a
Dietary Flavonoids: Modulators of Brain Ageing?
MLECULAR NUTRITIN GRUP Established 2004 Dietary Flavonoids: Modulators of Brain Ageing? Jeremy P E Spencer School of Food Biosciences University of Reading, UK The Sensitivity of the Brain to xidative
Bioavailability of Phyto(nutrients) in Orange Juice
Sao Paulo State University - UNESP Faculty of Pharmaceutical Sciences of Araraquara Food and Nutrition Department Bioavailability of Phyto(nutrients) in Orange Juice Thais Cesar, Prof. tcesar@fcfar.unesp.br
Reporting Requirements for Flavonoid Research: A critical component in enhancing our understanding
Reporting Requirements for Flavonoid Research: A critical component in enhancing our understanding Ferruzzi MG 1, Balentine DA 2, Dwyer JT 3, Erdman JW 4, Gaine PC 5, Harnly JM 6, Kwik-Uribe CL 7 1 Purdue
apparent that a substantial contribution to this cognitive impairment during aging comes from
Modulation of Cerebral Blood Perfusion by Cocoa Flavanols in Aged Mice Amanda Snyder, C Rendeiro, C Konopka, H Pinardo, P Thaman, W Dobrucki, JS Rhodes Beckman Institute for Advanced Science and Technology,
SUMMARY AND CONCLUSION
CHAPTER VI SUMMARY AND CONCLUSION CHAPTER 6. SUMMARY AND CONCLUSION "The doctor of the future will no longer treat the human frame with drugs, but rather will cure and prevent disease with nutrition."
Cocoa beans as the starting ingredients in manufacturing dark chocolate
Cocoa beans as the starting ingredients in manufacturing dark chocolate Raw cocoa beans contain large amounts of flavanols Polyphenols Flavonoids Flavonols Flavones Isoflavones Flavanones Anthocyanidins
Numerous epidemiology studies support the concept that diets rich in plant foods are associated with a reduced risk for vascular disease.
13 Numerous epidemiology studies support the concept that diets rich in plant foods are associated with a reduced risk for vascular disease. Fruits/Vegetables - Multivariate adjusted RR for >=3 times/day
Safety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trial 1,2
Safety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trial 1,2 Javier I Ottaviani, 3 * Marion Balz, 3 Jennifer Kimball, 4 Jodi L Ensunsa, 4 Reedmond Fong,
Gemma Cooper University of Nottingham
Gemma Cooper University of Nottingham mbxgc@nottingham.ac.uk Outline Introduction to flavanols What are flavanols? What do flavanols do? Flavanols In the diet In apples and apple juice My work Current
JoAnn E. Manson, MD, DrPH Howard D. Sesso, ScD, MPH Brigham and Women's Hospital Harvard Medical School
The COcoa Supplement and Multivitamin Outcomes Study (COSMOS): A Randomized Trial of Cocoa Flavanols and Multivitamins in the Prevention of CVD and Cancer JoAnn E. Manson, MD, DrPH Howard D. Sesso, ScD,
Online-Only Supplement. double-blind, randomized, placebo-controlled trial. Gerd R. Hetzel, MD 2 ; Malte Kelm, MD 1,4
Online-Only Supplement Vasculoprotective effects of dietary cocoa flavanols in hemodialysis patients: a double-blind, randomized, placebo-controlled trial 7 8 Tienush Rassaf, MD 1 *; Christos Rammos, MD
Flavonoids and their contribution to health: a look at the scientific support
Flavonoids and their contribution to health: a look at the scientific support Frank Hu, MD, PhD Professor of Nutrition and Epidemiology Harvard School of Public Health Professor of Medicine Harvard Medical
1. BACKGROUND. Lovastatin β-hydroxyacid No effect on methane production Inhibits cholesterol synthesis
1. BACKGRUND Methane production by the archeon Methanobrevibacter smithii (M. smithii) is a ubiquitous process in the intestine, disposing of hydrogen and other by-products formed during carbohydrate digestion
What is the evidence that dietary components can act on the microbiome and influence health?
What is the evidence that dietary components can act on the microbiome and influence health? Kristin Verbeke Translational Research in Gastrointestinal Disorders KU Leuven, Leuven, Belgium Diet? health
Flavonoid structures. Other dietary polyphenols with biological activity
Flavonoid structures Polyphenol Bioactivity: Antioxidants? Prof Kevin D Croft University of Western Australia Riemersma RA et al QJM 1; 9:77-8 ther dietary polyphenols with biological activity Phenolic
Influence of sugar type on the bioavailability of cocoa flavanols.
Influence of sugar type on the bioavailability of cocoa flavanols. Article Published Version Rodriguez Mateos, A., Oruna Concha, M. J., Kwik Uribe, C., Vidal, A. and Spencer, J. P.E. (2012) Influence of
ICPH 2013 Buenos Aires, Argentina October 19 th, 2013
Flavonoids and Cardiovascular Health What Progress Has Been Made Towards Public Health Recommendations for Flavonoids? Carl L. Keen Department of Nutrition University of California, Davis clkeen@ucdavis.edu
Health Benefits of Prebiotic Dietary Fiber
Health Benefits of Prebiotic Dietary Fiber JENNIFER ERICKSON, PhD, RD Objectives Provide some background on dietary fiber To define the term "prebiotic dietary fiber" To discuss potential health effects
Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites
/ Journal Homepage / Table of Contents for this issue REVIEW www.rsc.org/foodfunction Food & Function Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity
Metabolism. Objectives. Metabolism. 26 July Chapter 28 1
Metabolism bjectives Describe various processes by which drugs are metabolized Describe induction and inhibition of metabolism Use the venous equilibration model to describe hepatic clearance and the effect
EXAMINING THE EFFECTS OF FLAVONOIDS ON COGNITION
School of Psychology & Clinical Language Sciences EXAMINING THE EFFECTS OF FLAVONOIDS ON COGNITION ALifespan Prospective Dr Daniel Lamport 1 Copyright University of Reading LIMITLESS POTENTIAL LIMITLESS
Food Forum & the ILSI North American Project Committee on Flavonoids Washington, D.C. June 8 th, 2010
Biomarkers for Food Components With Health Benefits: Progress and Issues Carl L. Keen Department of Nutrition University of California, Davis clkeen@ucdavis.edu Food Forum & the ILSI North American Project
Mao-Jung Lee, Pius Maliakal, Laishun Chen, 2 Xiaofeng Meng, Flordeliza Y. Bondoc, Saileta Prabhu, George Lambert, Sandra Mohr, and Chung S.
Vol. 11, 1025 1032, October 2002 Cancer Epidemiology, Biomarkers & Prevention 1025 Pharmacokinetics of Tea Catechins after Ingestion of Green Tea and ( )-Epigallocatechin-3-gallate by Humans: Formation
Basic Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics
Basic Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Learning Outcomes Define biopharmaceutics Describe 4 processes of pharmacokinetics Describe factors that affect medication absorption Describe
Bioavailability and Metabolism of Flavonoids: A Review
Int J Nutr Sci 2017;2(4):180-184 International Journal of Nutrition Sciences Journal Home Page: ijns.sums.ac.ir Review Article Bioavailability and Metabolism of Flavonoids: A Review Masoumeh Akhlaghi 1*,
A healthy blend of polyphenols from Canadian wild blueberries and french grapes COGNITIVE HEALTH
A healthy blend of polyphenols from Canadian wild blueberries and french grapes COGNITIVE HEALTH Cerebelle TM : promoter of your brain health What is Cerebelle TM? Cerebelle TM is a standardized mixture
5.36 THIOPHANATE-METHYL (077)
391 5.36 THIOPHANATE-METHYL (077) TOXICOLOGY is the International Organization for Standardization (ISO) approved common name for dimethyl 4,4 -(o-phenylene)bis(3-thioallophanate) (International Union
Influence of COMT Genotype Polymorphism on Plasma and Urine. Green Tea Catechin Levels in Postmenopausal Women
Influence of COMT Genotype Polymorphism on Plasma and Urine Green Tea Catechin Levels in Postmenopausal Women A THESIS SUBMITTED TO THE FACULTY OF THE UNIVERSITY OF MINNESOTA BY Alyssa Heather Perry IN
SCIENTIFIC OPINION. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) 2,3. European Food Safety Authority (EFSA), Parma, Italy
EFSA Journal 2014;12(5):3654 SCIENTIFIC OPINION Scientific Opinion on the modification of the authorisation of a health claim related to cocoa flavanols and maintenance of normal endotheliumdependent vasodilation
Development of Canagliflozin: Mechanistic Absorption Modeling During Late-Stage Formulation and Process Optimization
Development of Canagliflozin: Mechanistic Absorption Modeling During Late-Stage Formulation and Process Optimization Nico Holmstock Scientist, Janssen R&D M CERSI 2017, BALTIMORE (USA) Canagliflozin An
Functional Properties of Cocoa Products: Health Aspects. Puspo Edi Giriwono SEAFAST Center - IPB
Functional Properties of Cocoa Products: Health Aspects Puspo Edi Giriwono SEAFAST Center - IPB Theobroma cacao Nutrient content of various cocoa products Colombo et al., Chocolate and Health., 2012 Cocoa
DIABETES AND LABORATORY TESTS. Author: Josephine Davis
DIABETES AND LABORATORY TESTS Author: Josephine Davis LAB TESTS Think twice before you test. What is the reason for testing? Laboratory tests are generally requested in primary care for one of the following
Clinical Study Synopsis
Clinical Study Synopsis This Clinical Study Synopsis is provided for patients and healthcare professionals to increase the transparency of Bayer's clinical research. This document is not intended to replace
Diet, Microbiome and Health Cindy D. Davis
Diet, Microbiome and Health Cindy D. Davis davisci@mail.nih.gov OFFICE OF DIETARY SUPPLEMENTS 1 Outline 1.What is the microbiome? 2.How does it vary over the lifespan? 3.What is the evidence that diet
APPLEPHENON POLYPHENOLS
APPLEPHENON POLYPHENOLS APPLEPHENON POLYPHENOLS RESPIRATORY SUPPORT 3 Human clinical studies 6 Supporting Pre-Clinical Trials DENTAL CARE 2 Human clinical studies 3 Supporting Pre-Clinical Trials CARDIOVASCULAR
APPLEPHENON POLYPHENOLS
APPLEPHENON POLYPHENOLS APPLEPHENON POLYPHENOLS RESPIRATORY 6 Supporting Pre-Clinical Trials CARDIOVASCULAR LDL Cholesterol lowering and lipid metabolism improvement: 6 Supporting Pre-Clinical Trials GLUCOSE
Staying on Trend: The Powerful Flavonoid Consumers Need Navindra P. Seeram, Ph.D. Bioactive Botanical Research Laboratory
FLRIDA DEPARTMENT F CITRUS Staying on Trend: The Powerful Flavonoid Consumers Need Navindra P. Seeram, Ph.D. Bioactive Botanical Research Laboratory 1 utline 1. Introduction Florida Department of Citrus
PREBIOTICS, THE INTESTINAL MICROBIOME AND BONE HEALTH
PREBIOTICS, THE INTESTINAL MICROBIOME AND BONE HEALTH Corrie Whisner, PhD School of Nutrition and Health Promotion Arizona State University June 7, 2017 OVERVIEW 1. Osteoporosis 1. Prevalence 2. Prevention
Anti-Diabetic and Anti-Obesity Activities of Cocoa (Theobroma cacao) via Physiological Enzyme Inhibition. Caroline Mary Ryan
Anti-Diabetic and Anti-Obesity Activities of Cocoa (Theobroma cacao) via Physiological Enzyme Inhibition Caroline Mary Ryan Thesis submitted to the faculty of the Virginia Polytechnic Institute and State
1,2. Abstract. The American Journal of Clinical Nutrition 12/31/2015 1:48 PM. ajcn.nutrition.org
of 19 12/31/2015 1:48 PM The American Journal of Clinical Nutrition ajcn.nutrition.org First published November 4, 2015, doi: 10.3945/ajcn.115.116178 Am J Clin Nutr December 2015 vol. 102 no. 6 1425-1435
LC-MS Analysis of Botanicals
Botanical workshop UAB, Sept 11, 26 LC-MS Analysis of Botanicals Jeevan K. Prasain, Ph.D. Department of Pharmacology & Toxicology, UAB Purdue-UAB Botanicals Center for Age-related Disease Applications
In Vivo Bioavailability, Absorption, Excretion, and Pharmacokinetics of [ 14 C]Procyanidin B2 in Male Rats
![In Vivo Bioavailability, Absorption, Excretion, and Pharmacokinetics of [ 14 C]Procyanidin B2 in Male Rats](/thumbs/83/88401076.jpg "In Vivo Bioavailability, Absorption, Excretion, and Pharmacokinetics of [ 14 C]Procyanidin B2 in Male Rats")
0090-9556/10/3802-287 291$20.00 DRUG METABLISM AND DISPSITIN Vol. 38, No. 2 Copyright 2010 by The American Society for Pharmacology and Experimental Therapeutics 30304/3552763 DMD 38:287 291, 2010 Printed
Package Insert. Elkar
Package Insert Elkar Product Summary 1. Name of the medicinal product Elkar 500 mg tablets 2. Qualitative and quantitative composition Each tablet contains levocarnitine 500 mg. 3. Pharmaceutical form
COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS
The European Agency for the Evaluation of Medicinal Products Veterinary Medicines and Information Technology Unit EMEA/MRL/050/95-FINAL February 1996 COMMITTEE FOR VETERINARY MEDICINAL PRODUCTS AMINOSIDINE
Chemistry Reference Ranges and Critical Values
Alanine Aminotransferase (ALT, SGPT) 3-9 years 9-18 years 1-9 years 9-18 years 10-25 U/L 10-35 U/L 10-30 U/L 10-25 U/L 10-30 U/L 10-35 U/L 10-25 U/L 10-35 U/L 10-25 U/L 10-20 U/L 10-35 U/L Albumin 0-6
Chemistry Reference Ranges and Critical Values
Alanine Aminotransferase (ALT, SGPT) 3-9 years 9-18 years 1-9 years 9-18 years 10-30 U/L 10-30 U/L 10-20 U/L Albumin 0-6 days 6 days - 37 months 37 months - 7 years 7-20 years 2.6-3.6 g/dl 3.4-4.2 g/dl
Metabolic Factors Frequency of Chocolate Consumption and Body Mass Index
School of Medicine, Health Sciences and Engineering Susquehanna Township High School Lecture Series Week 23, February 4 2014 Clinical Relevance of This Week s Topic Metabolic Factors Frequency of Chocolate
Burak DiK 1, Emre BAHCIVAN 1,2, Hatice ESER 1,3, Kamil UNEY 1
Burak DiK 1, Emre BAHCIVAN 1,2, Hatice ESER 1,3, Kamil UNEY 1 1 Selcuk University Faculty of Veterinary Medicine, Pharmacology and Toxicology Department, Konya, TURKEY 2 Kafkas University Faculty of Veterinary
Disclosure. This study was sponsored by Pfizer, Inc. All authors are employees of Pfizer, Inc. with ownership of stock in Pfizer, Inc.
Disclosure This study was sponsored by Pfizer, Inc. All authors are employees of Pfizer, Inc. with ownership of stock in Pfizer, Inc. Effects of 12 Weeks of Treatment with RN316 (PF-04950615), a Humanized
Molecules 2018, 23, 2472; doi: /molecules
Supplementary Materials: Polyphenol-Rich Extracts from Cotoneaster Leaves Inhibit Pro-Inflammatory Enzymes and Protect Human Plasma Components Against Oxidative Stress in vitro Agnieszka Kicel, Joanna
Review Bioavailability issues in studying the health effects of plant polyphenolic compounds
DOI 10.1002/mnfr.200700234 S139 Review Bioavailability issues in studying the health effects of plant polyphenolic compounds Chung S. Yang, Shengmin Sang, Joshua D. Lambert, and Mao-Jung Lee Department
MS/MS as an LC Detector for the Screening of Drugs and Their Metabolites in Race Horse Urine
Application Note: 346 MS/MS as an LC Detector for the Screening of Drugs and Their Metabolites in Race Horse Urine Gargi Choudhary and Diane Cho, Thermo Fisher Scientific, San Jose, CA Wayne Skinner and
V&E and FST Symposium: Vision for the future
Alyson Mitchell, PhD John Kinsella Chair in Food, Nutrition and Health Department of Food Science & Technology, UC Davis Food Safety and Measurement Facility, UC Davis V&E and FST Symposium: Vision for
Examining the relationship between beverage intake and cardiovascular health. Ian Macdonald University of Nottingham UK
Examining the relationship between beverage intake and cardiovascular health Ian Macdonald University of Nottingham UK Outline Assessment of evidence in relation to health risks of dietary components Cardiovascular
Nicolucci C. (1), Rossi S. (2), Catapane M. (1), Introduction:
Bisphenol A and Nicolucci C. (1), Rossi S. (2), Catapane M. (1), (1) Dept. Experimental Medicine, Second University of (2) Institute of Genetic and Biophysics, CNR, Naples (3) Dept. of Pediatrics 'F. Fede',
Patrick, An Introduction to Medicinal Chemistry 5e Chapter 11 Pharmacokinetics and related topics
Patrick, An Introduction to dicinal Chemistry 5e Answers to end-of-chapter questions 1) In contrast to benzene, toluene has an accessible methyl group which can be manipulated easily by metabolic enzymes.
Nancy L. Booth, Ph.D.
Nancy L. Booth, Ph.D. Principles of Safety Assessment THE PATH TO FUNCTIONAL FOOD INGREDIENT APPROVAL: DEVELOPMENTS IN THE SCIENTIFIC AND REGULATORY PROCESSES American College of Nutrition November 18,
Katheryn Marie Goodrich
Colonic metabolism of dietary grape seed extract: Analytical method development, effect on tight-junction proteins, tissue accumulation, and pan-colonic pharmacokinetics Katheryn Marie Goodrich Dissertation
A novel ph-neutral formulation of the monomeric insulin VIAject has a faster onset of action than insulin lispro
A novel ph-neutral formulation of the monomeric insulin VIAject has a faster onset of action than insulin lispro Leszek Nosek, Tim Heise, Frank Flacke 2, Alan Krasner 2, Philip Pichotta 2, Lutz Heinemann,
Structurally related ( ) epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards
Structurally related ( ) epicatechin metabolites in humans: assessment using de novo chemically synthesized authentic standards Article Accepted Version Structurally related ( ) epicatechin metabolites
INTRODUCTION MATERIALS AND METHODS. Alyson E. Mitchell 1, Yun-Jeong Hong 1, J. Cale May 1, Christine A. Wright 1 and Charles W.
A Comparison of Polyvinylpolypyrrolidone (PVPP), Silica Xerogel and a Polyvinylpyrrolidone (PVP) Silica Co-Product for Their Ability to Remove Polyphenols from Beer Alyson E. Mitchell 1, Yun-Jeong Hong
-Liver function tests -
-Liver function tests - Biochimestry teamwork Osamah Al-Jarallah Abdulaziz Al-Shamlan Abdullah Al-Mazyad Turki Al-Otaibi Khalid Al-Khamis Saud Al-awad KhaledAlmohaimede Meshal Al-Otaibi Al-Anood Asiri
D. Vitamin K -- Group of naphthoquinones having antihemorrhagic activity.
D. Vitamin K -- Group of naphthoquinones having antihemorrhagic activity. 1. Structures VITAMIN K1; Phytonadione; 2-Methyl-3-phytyl-1,4-naphthoquinone VITAMIN K2; Menaquinone-6 and 7; N=6,7 n 2. Function
PERFORMANCE. ENDURANCE. STRENGTH.
PERFORMANCE. ENDURANCE. STRENGTH. POWERED BY Exclusively available through TODAY S SPORTS NUTRITION CHALLENGE: Innovation in the Creatine Category HORN S SCIENCE-BASED SOLUTION: Greater Creatine Absorption
Pharmaceutical Drug Development Consulting
Dr. Julia Eva Diederichs Pharmaceutical Drug Development Consulting Preclinical investigations and animal studies: for comprehensive characterisation what is scientifically possible and meaningful A Case
Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans 1 3
Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans 1 3 William Mullen, Gina Borges, Jennifer L Donovan, Christine A Edwards, Mauro Serafini, Michael
Public Assessment Report. Scientific discussion. Ropinirol Actavis. Ropinirole hydrochloride DK/H/1212/ /DC
Public Assessment Report Scientific discussion Ropinirol Actavis Ropinirole hydrochloride DK/H/1212/001-007/DC This module reflects the scientific discussion for the approval of Ropinirole film-coated
Nutrition JMRSO 2017 FOOD SCIENCE
Nutrition JMRSO 2017 FOOD SCIENCE What is nutrition? Nutrition is the science that interprets the interaction of nutrients and other substances in food in relation to maintenance, growth, reproduction,
BIOCHEMICAL REPORT. Parameters Unit Finding Normal Value. Lipase U/L Amylase U/L
Lipase U/L 88.9 10-195 Amylase U/L 1181.1 371.3-1192.6 West Delhi :- 7/148, Opp. MCD Office, Major Pankaj Batra Marg, Near Ramesh Nagar, New Delhi-15, Ph. : 011-47562566,9999830187 Liver Function Test
Are seed proteins a problem or a boon?
Are seed proteins a problem or a boon?, Biochemist Department of AgriFood Molecular Sciences Faculty of Agriculture University of Milan, Italy Main sources Production Concluding remarks Seed proteins Protein
What is Dietary Fibre?
Fibre What is Dietary Fibre? Non digestible part of plant foods Consists of one or more of edible CHO polymers and synthetic CHO polymers Types of Dietary Fiber There are many different types of fiber,
Higher levels of hair EtG in patients with decreased kidney function.
MD Jan Toralf Fosen 1, PhD Gudrun Høiseth 1, Ph.D Luca Morini 2, Prof. Jørg Mørland 1. 1 Norwegian Institute of Public Health, Division of forensic medicine and drug abuse research, Oslo, Norway. 2 Department
1. Which nutrient is so vital to health that you wouldn't live more than a few days without it? A) vitamins B) water C) minerals D) protein
Nutrition & You, 4e (Blake) Chapter 1 What Is Nutrition? Legend: For sentences / statements that DO NOT HAVE answer choices, Answer A if TRUE Answer B IF False 1. Which nutrient is so vital to health that
DANIEL R. DOERGE U.S. Food and Drug Administration National Center for Toxicological Research Jefferson, AR
NCTR Research Plan for BPA: Integrating pharmacokinetics in rodent and primate species, rat toxicology studies, human biomonitoring, and PBPK modeling to assess potential human risks from dietary intake
APDW 2016 Poster No. a90312
APDW 2016 Poster No. a90312 SYN-010, a Proprietary Modified-Release Formulation of Lovastatin Lactone, Lowered Breath Methane and Improved Stool Frequency in Patients with IBS-C Results of a multi-center,
Targeted Health Regimen Every Targeted Health Regimen builds upon the Foundations of Optimal Health Regimen. Blood Glucose Maintenance Regimen
Targeted Health Regimen Every Targeted Health Regimen builds upon the Foundations of Optimal Health Regimen. Blood Glucose Maintenance Regimen Every year we are faced with weight gain and increasingly
Zero on the Glycemic Index - will not raise insulin levels
fàxä t Zero on the Glycemic Index - will not raise insulin levels Stevia Leaves are 30 mes sweeter than sugar without calories and without raising insulin level. Cocoa, cranberries, Matcha tea & blueberries
Kuvings Silent Juicer ANALYSIS REPORT
Kuvings Silent Juicer ANALYSIS REPORT ANALYSIS REPORT on the performance of a Silent Juicer vs a Centrifugal Juicer Analysis Organization Korea Advanced Food Research Institute(KAFR) - Tomato(Feb. 2012),
DIETARY RISK ASSESSMENT
lambda Cyhalothrin 91 The maximum dietary burden for poultry is 1.3 ppm. No residues above the LOQ of the analytical method used were observed in the feeding study for laying hens at the lowest dose level
GSC CODEX MESSAGE CCFA48/2016/25
FORM FOR THE SUBMISSION OF SUBSTANCES TO BE EVALUATED BY JECFA In completing this form, only brief information is required. The form may be retyped if more space is needed under any one heading provided
D- Xylose Absorption Test
D- Xylose Absorption Test - Objectives To learn the technique of D-xylose absorption test and its relation to the function of the upper small intestine. To find out whether the malabsorption state of some
Molecular Aspects of Medicine
Molecular Aspects of Medicine 31 (2010) 446 467 Contents lists available at ScienceDirect Molecular Aspects of Medicine journal homepage: www.elsevier.com/locate/mam Review Bioavailability of dietary flavonoids
Bioavailability of Intact Proanthocyanidins in the Rat Colon after Ingestion of Grape Seed Extract
pubs.acs.org/jafc Bioavailability of Intact Proanthocyanidins in the Rat Colon after Ingestion of Grape Seed Extract Ying Yng Choy, Grayson K. Jaggers, Patricia I. Oteiza, and Andrew L. Waterhouse*, Department
Adams Memorial Hospital Decatur, Indiana EXPLANATION OF LABORATORY TESTS
Adams Memorial Hospital Decatur, Indiana EXPLANATION OF LABORATORY TESTS Your health is important to us! The test descriptions listed below are for educational purposes only. Laboratory test interpretation
General Chemistry Scheme Guide
General Chemistry Scheme Guide Copyright WEQAS. All rights reserved. No part of this document may be reproduced or utilised in any form without permission from WEQAS Contents. Scheme details and repertoire.....
1.2 Synonyms There are several synonyms e.g. diaminomethanal, but in a medical context, this substance is always referred to as urea.
Urea (serum, plasma) 1 Name and description of analyte 1.1 Name of analyte Urea 1.2 Synonyms There are several synonyms e.g. diaminomethanal, but in a medical context, this substance is always referred
Kristin Hales, PhD, PAS U.S. Meat Animal Research Center
Effects of shade and feeding zilpaterol hydrochloride to finishing steers on growth performance, carcass quality, heat stress, mobility, and body temperature Kristin Hales, PhD, PAS U.S. Meat Animal Research
Biochemical Investigations in Liver Disease. Dr Roshitha de Silva Department of Pathology Faculty of Medicine University of Kelaniya
Biochemical Investigations in Liver Disease Dr Roshitha de Silva Department of Pathology Faculty of Medicine University of Kelaniya Biochemical markers Albumin ALP ALT, AST Gamma-glutamyl transpeptidase
SULFOXAFLOR. First draft prepared by Rudolf Pfei1 1, David Schumacher 1 and Alan Boobis 2
SULFOXAFLOR First draft prepared by Rudolf Pfei1 1, David Schumacher 1 and Alan Boobis 2 1 Toxicology of Pesticides and Biocides, Federal Institute for Risk Assessment, Berlin, Germany 2 Faculty of Medicine,
Evaluation of a glomerular filtration term in the DISST model to capture the glucose pharmacodynamics of an insulin resistant cohort
Evaluation of a glomerular filtration term in the DISST model to capture the glucose pharmacodynamics of an insulin resistant cohort Paul D Docherty J Geoffrey Chase Thomas F Lotz Jeremy D Krebs Study
A Proposed Randomized Trial of Cocoa Flavanols and Multivitamins in the Prevention of Cardiovascular Disease and Cancer
A Proposed Randomized Trial of Cocoa Flavanols and Multivitamins in the Prevention of Cardiovascular Disease and Cancer JoAnn E. Manson, MD, DrPH Howard D. Sesso, ScD, MPH Brigham and Women's Hospital
Study Centers: This study was conducted in 2 centers in Italy.
Title of Trial: A randomised, double-blind, placebo-controlled, two-period, two-sequence-crossover interaction study to assess the effect of safinamide on levodopa pharmacokinetics in subjects with Parkinson
European public MRL assessment report (EPMAR)
15 November 2016 EMA/CVMP/351687/2016 Committee for Medicinal Products for Veterinary Use European public MRL assessment report (EPMAR) (bovine species) On 17 October 2016 the European Commission adopted