Flavonoid structures. Other dietary polyphenols with biological activity
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1 Flavonoid structures Polyphenol Bioactivity: Antioxidants? Prof Kevin D Croft University of Western Australia Riemersma RA et al QJM 1; 9:77-8 ther dietary polyphenols with biological activity Phenolic acids, eg caffeic acid (fruits, coffee etc) Lignans, eg. Sesamin (sesame seed), isolariciresinol etc (flax seed, bran) Stilbenes, eg. resveratrol (grapes) Phenylpropanoids, eg Curcumin (turmeric), zingerone (ginger) Terpenoids, eg. leuropein (olive oil) Dietary polyphenols and cardiovascular disease: more than antioxidants low concentrations in vasculature metabolic transformation specific targets, key enzymes
2 Flavonoid Metabolism 1 H CH 3 H glucuronidation H H H C LTB Inhibition (%) [Polyphenol] ( M) Q MQ QS QG MQG H S Human neutrophils stimulated with Ca ionophore Loke et.al.biochem Pharmacol 8 F -isoprostanes (ng/ ml) Antioxidant activity LDL Q MQ QS QG MQG L K T Atherosclerosis (animal models) Apo E deficient mouse Faulty uptake of lipoproteins in the liver Very high circulating cholesterol AAPH induced oxidation of LDL, all compounds 1 um. F -isoprostanes measured at 1 min Loke et.al.biochem Pharmacol 8
3 Effect of pure polyphenols incorporated into the diet, apoe-/-, ~1 mg/day, weeks Table 1. Effects of specific polyphenols on tested pathways at week 6 (expressed as % change compared to the ApoE -/- mice fed on control diet). Quercetin Epicatechin Theaflavin Sesamin Chlorogenic acid (A) Aortic sinus lesion formation Aortic sinus lesion area (% of total aortic cross-sectional area) 3 1 C57BL/ control ApoE/ control ApoE/ Quercetin ApoE/ (-)-epicatechin ApoE/ theaflavin ApoE/ sesamin ApoE/ chlorogenic acid Thoracic aorta lesion formation Plasma cholesterol Aortic F -isoprostanes H-1 protein ND ND ND Aortic superoxide Aortic LTB Plasma soluble P-selectin Urinary nitrate Vascular ens activity Loke et.al. Arterioscl Throm Vascl Biol. 1 Urinary ET p<.5 vs ApoE -/- control mice. ND = not determined Loke et.al. Arterioscl Throm Vascl Biol 1 sum pixels of H-1 stain / lesion area C57Bl/ control All data; lesion absence assigned value ApoE/ control ApoE/ Quercetin ApoE/ Epicatechin Evidence for effects of dietary flavonoids on major CVD risk factors in humans Endothelial Function Blood Pressure Heme oxygenase-1 is the inducible form of the enzyme involved in heme degradation and the release of iron, carbon monoxide and the bile pigment biliverdin that is then converted to bilirubin. H-1 exerts an anti-inflammatory and antioxidant action within the vasculature and can protect against oxidative damage. Loke et.al. Arterioscl Throm Vascl Biol 1
4 Endothelium-dependent FMD Endothelial cells forearm ischaemia Increased blood flow Shear stress Vasodilatory mediators - N (8%) / EDHF / PG Comparison of quercetin, epicatechin, epigallocatechin gallate on plasma N Cross-over study, 1 healthy subjects mg of each flavonoid or water control Blood collected at baseline and after hours, urine at baseline and 5 hours. Plasma nitrosothiols measured by gas phase chemiluminescence. Nitrate/nitrite measured by GCMS Plasma and urinary flavonoids measured by GCMS Loke et.al. Am J Clin Nutr 8 Plasma [SN] (nm equiv. of N) Plasma and urinary nitrate and nitrite support results 5 Total plasma N Q EC EGCG W P<.1, P<.5 Urinary [ET-1] (pg/ mmol creatinine) Q EC EGCG W Endothelin -1 was decreased by quercetin treatment No effects on oxidative stress (plasma or urinary F-isoprostanes) Loke et.al. Am J Clin Nutr 8
5 Bioavailability of flavonoids -plasma quercetin epicatechin How do flavonoids effect N? (A) Plasma [Flavonoids] ( M) 3 1,, Q 3'-MQ Total Q (B) Plasma [Flavonoids] ( M) 3 1, EC 3'-MEC Total EC Increase ens enzyme activity, produce more N Prevent the breakdown of N Recent in vitro evidence that methylated metabolites of epicatechin can inhibit NADPH oxidase (Steffan, Sies, FRBM 7) Reduction of N 3 - to N - and N Cathy Bondonno 3 healthy men and women (18 to 65 years of age) recruited from the general population visits in random order 1 week washout between testing days Same dinner night before each visit Same low flavonoid / low nitrate breakfast on morning of each visit Bondonno et.al. Free Rad Biol Med. 1
6 Nx BY TREATMENT: P<.1 Visit Pre and during visit: During visit: A FLAVNID CNTRL NITRATE CNTRL <5 mg quercetin & epicatechin 5 P<. P<.1 B FLAVNID ACTIVE NITRATE CNTRL C FLAVNID CNTRL NITRATE ACTIVE D FLAVNID ACTIVE NITRATE ACTIVE 15 mg quercetin & epicatechin Nx nmol/l Breakfast and flavonoid treatment hr Lunch and flavonoid / nitrate treatment hr FMD Blood sample Flavonoid control/ Nitrate control Flavonoid active/ Nitrate control Flavonoid control/ Nitrate active Flavonoid active/ Nitrate active % FMD BY TIME AFTER CUFF INFLATIN (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans H Schroeter et.al PNAS P<.5 vs. control Flavonoid control / Nitrate control Flavonoid active / Nitrate control Flavonoid control / Nitrate active Flavonoid active / Nitrate Active High flav cocoa; 917 mg flavanols 5 % FMD 3 Pure epicatechin, 1 or mg/kg n= Time (seconds) Bondonno et.al. Free Rad Biol Med. 1
7 Mechanisms of action Activation of key signalling pathways or enzymes AMPK activation, enzymes involved in lipid and glucose metabolism, ens. Resveratrol, quercetin etc Estrogenic effects, isoflavones, some lignans Redox sensitive transcription factors NF-kB inflammation Nrf binds antioxidant response elements of genes encoding for antioxidant enzymes eg H-1 Cardiovascular health effects vascular function, BP Thrombosis Lipids Inflammation Glucose metabolism Bioactivity overview Polyphenols are a diverse range of compounds. Global measures such as Total Antioxidant Capacity (TAC) may be of little value. Bioactive polyphenols may be beneficial either as food components or isolated compounds. Food matrix effects on bioavailability may influence absorption and metabolism. Different polyphenols may have very different and specific activity, eg grapefruit flavonoids and drug metabolising enzymes. Acknowledgements National Health & Medical Research Council, National Heart Foundation of Australia Australian Research Council Collaborators UWA Jonathan Hodgson Natalie Ward Trevor Mori Anne Barden Ian Puddey Julie Proudfoot Adeline Indrawan PhD students: Jason Wu Wai Mun Loke Cathy Bondonno Helen Yu Shen Aidilla Mubarak University of Sydney Roland Stocker Inst of Food Research, UK Paul Kroon
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