Material Safety Data Sheet

Transcription

1 Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 2 0 Health Hazard Fire Hazard 2 0 See Section 5. Section. Chemical Product and Company Identification Page Number: Common Name/ Trade Name Dextromethorphan HBr monohydrate Catalog Number(s). YY949, DE39 CAS# Manufacturer SPECTRUM LABORATORY PRODUCTS INC S. SAN PEDRO STREET GARDENA, CA RTECS TSCA QD (anhydrous) TSCA 8(b) inventory: No products were found. Commercial Name(s) Synonym Chemical Name Chemical Family Chemical Formula Supplier 3-Methoxy-7-methyl-9-alpha.3-alpha,4-alpha-morphinan hydrobromide; D-Methorphan hydrobromide monohydrate Morphinan,3-methoxy-7-methyl-,(9alpha,3alpha,4alpha)-, hydrobromide, monohydrate A Morphinan derivative C8H27NO2.HBr.H2O SPECTRUM LABORATORY PRODUCTS INC S. SAN PEDRO STREET GARDENA, CA CI# CALL (30) IN CASE OF EMERGENCY CHEMTREC (24hr) Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Dextromethorphan HBr Toxicological Data on Ingredients Dextromethorphan HBr (anhydrous): ORAL (LD50): Acute: 350 mg/kg [Rat]. 65 mg/kg [Mouse]. Section 3. Hazards Identification Potential Acute Health Effects Potential Chronic Health Effects Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant). Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY:

2 Dextromethorphan HBr monohydrate Page Number: 2 Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 5 minutes. Cold water may be used. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Inhalation Serious Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances Explosion Hazards in Presence of Various Substances Fire Fighting Media and Instructions May be combustible at high temperature. These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks. Risks of explosion of the product in presence of mechanical impact: Slightly explosive in presence of open flames and sparks. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Fire Hazards Explosion Hazards Section 6. Accidental Release Measures When heated to decomposition it emits toxic fumes of NOx and HBr. As with most organic solids, fire is possible at elevated temperatures Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust explosion hazard. Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Precautions Storage Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, alkalis. Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in light-resistant containers.

3 Dextromethorphan HBr monohydrate Page Number: 3 Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Personal Protection in Case of a Large Spill Exposure Limits Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystalline powder.) Odor Slight. Molecular Weight ph (% soln/water) g/mole Taste Color White. Off-white. Boiling Point Melting Point Decomposition temperature: 22 C (25.6 F) Critical Temperature Specific Gravity Vapor Pressure Not applicable. Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties See solubility in water, methanol. Solubility Soluble in methanol. Partially soluble in cold water. Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Excess heat, dust generation, incompatible materials Reactive with oxidizing agents, alkalis. Non-corrosive in presence of glass. Corrosivity Polymerization Sensitive to light. Will not occur.

4 Dextromethorphan HBr monohydrate Page Number: 4 Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Inhalation. Ingestion. Acute oral toxicity (LD50): 65 mg/kg [Mouse]. (for the anhydrous form) Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant). Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause gastrointestinal tract irritation with stomach pain, severe nausea or vomiting, difficulty in urination. May affect behavior/central nervous system(headache, drowsiness or dizziness, unusual excitement, confusion, nervousness or irritability, shakiness and unsteady walk, coma, toxic psychosis (hyperactivity, vusual and auditory hallucinations), muscle contraction or spasticity, rigidity, somnolence, convulsions, ataxia), respiration (respiratory depression, dyspnea), eyes/vision (blurred vision, pupilliary dilation). Chronic Potential Health Effects: Prolonged or repeated skin contact, inhalation or ingestion can cause allergic reaction. Conditions aggravated by exposure may include hypersensitivity to material, asthma, bronchitis, emphysema, productive cough, and concurrent therapy with MAO inhibitors. Section 2. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Toxicity of the Products of Biodegradation the Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are as toxic as the product itself. Section 3. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 4. Transport Information DOT Classification Identification Not a DOT controlled material (United States). Not applicable. Special Provisions for Transport Not applicable. DOT

5 Dextromethorphan HBr monohydrate Page Number: 5 Section 5. Other Regulatory Information and Pictograms Federal and State Regulations California Proposition 65 Warnings Other Regulations No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR ). Other Classifications WHMIS (Canada) CLASS D-B: Material causing immediate and serious toxic effects (TOXIC). DSCL (EEC) R22- Harmful if swallowed. S46- If swallowed, seek medical advice immediately and show this container or label. HMIS (U.S.A.) Health Hazard Fire Hazard Personal Protection 2 0 E National Fire Protection Association (U.S.A.) Health 2 0 Flammability Specific hazard WHMIS (Canada) DSCL (Europe) TDG (Canada) ADR (Europe) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses.

6 Dextromethorphan HBr monohydrate Page Number: 6 Section 6. Other Information MSDS Code References Other Special Considerations D300 Major Use: Medication - antitussive Validated by Sonia Owen on 9/25/2009. Verified by Sonia Owen. Printed 9/30/2009. CALL (30) Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.