Material Safety Data Sheet

Transcription

1 Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 0 Health Hazard Fire Hazard 0 See Section 5. Section. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Amoxicillin Trihydrate SPECTRUM LABORATORY PRODUCTS INC S. SAN PEDRO STREET GARDENA, CA Amoxicillin 4-Thi a--azabi cycl o(3.2.0)heptane-2-carboxyl i c aci d, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-,trihydrate; 4-Thi a--azabi cycl o(3.2.0)heptane-2-carboxyl i c aci d, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate, (2S-(2-alpha,5-alpha,6-beta(S*)))- Catalog Number(s). CAS# RTECS TSCA CI# YY54, A XH TSCA 8(b) i nventory: No products were found. Exempt from TSCA 8(b) listing since it is a drug IN CASE OF EMERGENCY CHEMTREC (24hr) Page Number: Chemical Name Chemical Family Chemical Formula Supplier Amoxicillin Trihydrate An Aninopenicillanic acid derivative (Drug.) C6-H9-3-O5-S.3H2O SPECTRUM LABORATORY PRODUCTS INC S. SAN PEDRO STREET GARDENA, CA CALL (30) Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Amoxicillin Trihydrate Toxicological Data on Ingredients Amoxicillin Trihydrate: ORAL (LD50): Acute: >5000 mg/kg [Rat]. >25000 mg/kg [Mouse].

2 Amoxicillin Trihydrate Page Number: 2 Section 3. Hazards Identification Potential Acute Health Effects Potential Chronic Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (sensitizer), of inhalation (lung sensitizer). CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: The substance may be toxic to kidneys. Repeated or prolonged exposure to the substance can produce target organs damage. Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 5 minutes. Cold water may be used. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Inhalation Serious Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion May be combustible at high temperature. These products are carbon oxides (CO, CO2), sulfur oxides (SO2, SO3...). Fire Hazards in Presence of Various Substances Explosion Hazards in Presence of Various Substances Fire Fighting Media and Instructions Fire Hazards Explosion Hazards Slightly flammable to flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks. Risks of explosion of the product in presence of mechanical impact: Risks of explosion of the product in presence of static discharge: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

3 Amoxicillin Trihydrate Page Number: 3 Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Precautions Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 30 C (86 F). Store at controlled room temperature (5 to 30 deg. C.) Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill Exposure Limits Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Molecular Weight ph (% soln/water) Solid. (crystalline powder.) g/mole Odor Taste Color Off-white. White. Boiling Point Melting Point Critical Temperature Specific Gravity Vapor Pressure Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties See solubility in water. Solubility Partially soluble in cold water, hot water.

4 Amoxicillin Trihydrate Page Number: 4 Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Excess heat, light, humidity, excess dust generation Corrosivity Polymerization Light Sensitive Will not occur. Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Inhalation. Ingestion. Acute oral toxicity (LD50): >5000 mg/kg [Rat]. May cause damage to the following organs: kidneys. Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. May cause adverse reproductive effects (fetotoxicity/post-implantation mortality)and birth defects. Acute Potential Health Effects: Skin: May cause skin irritation (rash) with itching, redness and scaling and swelling of the skin. Eyes: May cause eye irritation. Ingestion: May cause gastrointestinal tract irritation with sore mouth or tongue, nausea, vomiting, and diarrhea, white patches in the mouth or tongue. May affect behavior, urinary system, and brain. Inhalation: May cause respiratory tract irritation with sore throat, sneezing, itching, Chronic Potential Health Effects: Skin: Prolonged or repeated skin contact may cause allergic skin reaction and hydpersensitization. Inhalation: Prolonged or repeated inhalation may rarely cause allergic reaction and hypersensitization. Symptoms might include running nose, sneezing, itching, coughing, pulmonary obstruction, signs similar to asthma, wheezing, difficulty breathing. Ingestion: Possible allergic reaction. Symptoms may include swelling of face, and difficulty breathing Other adverse reactions from inhalation and ingestion may include swelling of the face, hives, itching, a sudden, severe drop in blood pressure, headache, vaginal itching or discharge, fever, shortness of breath, and joint pain. Individuals allergic to penicillin or cephalosporins, cephamycins, griseofulvin, or penicillamine may also be allergic to Amoxicillin. Other medical conditions aggravated by exposure to Amoxicillin may include hypersensitivity to this material, bleeding disorders, gastrointestinal disease, infectuous mononucleosis, and impaired kidney function. Section 2. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

5 Amoxicillin Trihydrate Page Number: 5 Toxicity of the Products of Biodegradation The product itself and its products of degradation are not toxic. the Products of Biodegradation Section 3. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 4. Transport Information DOT Classification Identification Not a DOT controlled material (United States). Special Provisions for Transport DOT Section 5. Other Regulatory Information and Pictograms Federal and State Regulations California Proposition 65 Warnings Other Regulations No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances. Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL). China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Listed on National Inventory (PICCS). Australia: Listed on AICS. Other Classifications WHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC) This product is not classified according to the EU regulations. HMIS (U.S.A.) Health Hazard Fire Hazard 0 National Fire Protection Association (U.S.A.) Health 0 Flammability Personal Protection E Specific hazard WHMIS (Canada)

6 Amoxicillin Trihydrate Page Number: 6 DSCL (Europe) TDG (Canada) ADR (Europe) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. Section 6. Other Information MSDS Code References Other Special Considerations A537 Validated by Sonia Owen on 2/6/2009. Verified by Sonia Owen. Printed 3/6/2009. CALL (30) Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.