Will Research Completed on Health Effects of Palm Phytonutrients buoy the

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1 Will Research Completed on Health Effects of Palm Phytonutrients buoy the Palm Oil Market? GOFF 7, Sept 29-30, 2011 USA U. R. Unnithan 1

2 What Does the Market Demand from a Vegetable Oil? As close to Natural as possible. No Trans Fatty Acids the new slogan. No Chemical Refining. Natural Anti-Oxidants and Natural Colorants in Vogue. More than merely an Oil or Fat The Functional Food Perspective. The New Value Proposition Value for Money & Health. 2

3 Constituents of Crude Palm Oil (CPO) CRUDE PALM OIL 1% Minor Trace 3-5% Fatty Acids 94%Glycerides Components Carotenoids( ppm) Tocotrienols& Tocopherols( ppm) Phytosterols Co-Q10 Squalene Others 3

4 Comparison of Carotenes & Vitamin E Vegetable Oil Carotenes (ppm) in Vegetable Oils Tocotrienols (ppm) Tocopherols (ppm) T + T3 (ppm) Red Palm RBD Palm Soybean Corn Sunflower Rice Bran Olive

5 Benefits of Red Palm Fruit Oil Gives natural golden yellow color to the food products. Boosts the nutritional content with natural carotenes, tocopherols and tocotrienols. Free from GMO. No TFA. Non-Allergic. No Cholesterol. Nutritional Claims. 5

6 Nutritional & Medical Benefits Nutritional & Medical benefits of Red Palm Fruit Oil scientifically evaluated and documented. Red Palm Fruit Oil has a huge potential to combat Vitamin A deficiency in the world as well as offer potential health benefits in the area of CHD/Cancer. 6

7 Palm Phytonutrient Mix & Carotenes Applications Natural Palm Phytonutrient Mix Colorant Substrate for food supplements Animal feed ingredient Feed material for higher concentration of carotenes and tocotrienols Natural Palm Carotenes Food colorant margarine, snack foods, sauces, soups Skin care & cosmetics suntan lotion, moisturizer, face creams Dietary nutritional supplements soft gelatin capsules Functional ingredients margarine, snack foods, seasoning 7

8 Natural Palm Carotenes Key Research Findings Inhibits certain types of cancer cells Kalanithi Nesaretnam, Eu Jin Lim, Karin Reimann, Leslie C. Lai : Effect of a carotene concentrate on the growth of human breast cancer cells and ps2 gene expression. Toxicology, Vol. 151 (1-3); pp: , 2000 Nishino H, Takayasu J, Iwashima A, Murakoshi M, Imanishi J : Anticarcinogenesis activity of natural carotenes, C R Seances Soc Biol Fil 1989; 183(1):85-9 Strong anti-oxidant properties Elena Serbinovaa; May Choo; Lester Packer : Distribution and antioxidant activity of a palm oil carotene fraction in rats. Biochem Intl, 28, ,

9 Natural Palm Carotenes Key Research Findings Precursors of Vitamin A L M Canfield, R G Kaminsky, D L Taren, E Shaw, and J K Sander : Red Palm Oil in the maternal diet increases provitamin A carotenoids in breastmilk and serum of the mother-infant dyad. Eur J Nutr, 40(1):30-8, 2001 Essential for good vision Parisi V. Tedeschi M, Galinaro G, Varano G, Varano M, Saviano S, Piermarocchi S : Carotenoids and Antioxidants in Age-Related Maculopathy Italian Study : Multifocal Electroretinogram Modifications after 1 Year. Ophtalmology, 115, ,

10 Natural Palm Carotenes Key Research Findings Important for healthy skin & hair, strong teeth & bones Keita Someya, Yuka Totsuka, Michiaki Murakoshi, Hirokazu Kitano, Teruo Miyazawa : The Antioxidant Effect of Palm Fruit Carotene on Skin Lipid Peroxidation in Guinea Pigs as Estimated by Chemilimunescence-HPLC Method. J Nutr Sci Vitaminol 40 : , 1994 Crucial for functioning immune system, cell development & reproductive system Parisi V. Tedeschi M, Galinaro G, Varano G, Varano M, Saviano S, Piermarocchi S : Carotenoids and Antioxidants in Age-Related Maculopathy Italian Study : Multifocal Electroretinogram Modifications after 1 Year. Ophtalmology, 115, ,

11 Palm Vitamin E (800 ppm) α-tocopherol 22% δ-tocotrienol 12% α-tocotrienol 20% γ-tocotrienol 46% 11

12 Natural Palm Tocotrienols Applications Natural Palm Tocotrienols Skin care and cosmetics suntan lotion, moisturizer, face creams Dietary nutritional supplements soft gelatin capsules, animal feed, pet food Functional ingredients margarine, snack foods, seasoning 12

13 Natural Palm Tocotrienols Key Research Findings times more anti-oxidant potency than Tocopherol Lester Packer, Stefan U. Weber and Gerald Rimbach: Molecular Aspects of α-tocotrienol Antioxidant Action and Cell Signalling. J Nutr 2001;131:369S 73S Tomeo AC, Geller M, Watkins TR, et al. Antioxidant effects of tocotrienols in patients with hyperlipidemia and carotid stenosis. Lipids 1995;30: Protects skin from oxidative damage by UV radiation Thiele, JJ, Traber, MG, Packer, L: Depletion of human stratum corneum vitamin E. An early and sensitive in vivo marker of UVinduced photooxidation. J Invest Dermatol, :

14 Natural Palm Tocotrienols Key Research Findings Helps maintain healthy cholesterol level Qureshi, N Qureshi, JO Hasler-Rapacz, FE Weber, V Chaudhary, TD Crenshaw, A Gapor, AS Ong, YH Chong, and D Peterson: Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias. Am J Clin Nutr : 1042S-1046S Helps reduce risk of stroke Chandan K. Sen, Savita Khanna, Sashwati Roy, and Lester Packer: Molecular Basis of Vitamin E Action: Tocotrienol Potently Inhibits Glutamate-induced Pp60c-src Kinase Activation And Death Of Ht4 Neuronal Cells J. Biol. Chem : Leslie L. Bronner, Dr.P.H., Daniel S. Kanter, M.D., and JoAnn E. Manson, M.D., Dr.P.H Primary Prevention of Stroke N Engl J Med 1995:333:

15 Natural Palm Tocotrienols Key Research Findings Helps reverse Carotid Stenosis N.G Stephens, A Parsons, M.J Brown, P.M Schofield, F Kelly, K Cheeseman, Mj Mitchinson: Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). The Lancet 1996; 347:781 6 Prevents Neuronal Cell Death Chandan K. Sen, Savita Khanna, Sashwati Roy, and Lester Packer: Molecular Basis of Vitamin E Action: Tocotrienol Potently Inhibits Glutamate-induced Pp60c-src Kinase Activation And Death Of Ht4 Neuronal Cells J. Biol. Chem : Leslie L. Bronner, Dr.P.H., Daniel S. Kanter, M.D., and JoAnn E. Manson, M.D., Dr.P.H Primary Prevention of Stroke N Engl J Med 1995:333:

16 Natural Palm Tocotrienols Key Research Findings Inhibits certain types of cancer cells especially Human Breast Cancer Cells Nesaretnam K, Dorasamy S, Darbre PD: Tocotrienols Inhibit Growth of ZR-75-1 Breast Cancer Cells. Int J Food Sci Nutr, 2000; 51:S95 S103 Yu W., Simmons-Menchaca M., Gapor A., Sanders B. G., Kline K.: Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr. Cancer 1999b;33:26-32 Yap SP, Yuen KH, Wong JW.: Pharmacokinetics and bioavailability of α-, γ- and δ-tocotrienols under different food status. J Pharm Pharmacol. 2001;53:67 71 Nesaretnam K, Stephen R, Dils R & Darbre P. Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 1998; 33 :

17 Summary Refined Red Palm Fruit Oil is an excellent starting material for palm based nutraceuticals. A wide range of both food and non-food applications have been developed for both Natural Palm Carotenes and Tocotrienols. Efficacy of health benefits of Natural Palm Carotenes and Tocotrienols established through several scientific studies. Health benefits of palm phytonutrients will surely boost the value and acceptance of palm oil products. 17

18 THANK YOU 18

Food Applications of Natural Carotene & Tocotrienol Rich Oils & Fats

Food Applications of Natural Carotene & Tocotrienol Rich Oils & Fats Introduction U.R.Unnithan & S.P. Foo Crude or Natural palm oil is a rich source of natural carotenes (500-700 ppm) [1] and vitamin E