CLINICAL EPIDEMIOLOGY

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1 POSTGRADUATE COURSE CLINICAL EPIDEMIOLOGY 26 th -30 th January, 2015 Faculty of Medicine, University of Belgrade Belgrade, Serbia FIRST ANNOUNCEMENT

2 Dear participants, It is our great pleasure to announce that the Erasmus Medical Center, Rotterdam and Faculty of Medicine University of Belgrade, within the ERAWEB II project, will organize one week Postgraduate course Clinical Epidemiology, that will take place at the Head Building of the Faculty of Medicine, University of Belgrade from January 26 to January 30, Course is dedicated to clinical epidemiologists and clinical researchers, as well as postgraduate students from the ERAWEB partner universities. Looking forward to welcome you in Belgrade, Prof. Nebojša M. Lalić Dean, Faculty of Medicine, University of Belgrade Prof. Albert Hofman Project Coordinator Scientific Committee Prof. Albert Hofman, Erasmus Medical Center, Rotterdam Prof. Nebojša Lalić, Dean, Faculty of Medicine, University of Belgrade Prof. Henning Tiemeier, Erasmus Medical Center, Rotterdam Local Organizing Committee Prof. Nebojša Lalić, Dean, Faculty of Medicine, University of Belgrade, President Jelena Šantrić, PhD, Faculty of Medicine, University of Belgrade Nataša Ognjanović, MSc, Faculty of Medicine, University of Belgrade Ivana Katić, MSc, Faculty of Medicine, University of Belgrade

3 SCIENTIFIC PROGRAM Lecturers: Prof. Albert Hofman Prof. Henning Tiemeier Erasmus Medical Center, Rotterdam, the Netherlands Monday, January 26, 2015 RISK Exercise 1 Introduction, determinants of disease, disease risk, risk from life table Incidence and risk Risk function Rose G. Sick individuals and sick populations. Int J Epidemiol 1985;14:32-8. Rothman KJ, Greenland S, Lash TL. Measures of occurrence. In: Modern Epidemiology, Edition 3, chapter 3, Lippincott, 2008: PROGNOSIS Exercise Prognosis, life table, censoring Population risk Introduction randomised clinical trial Design Study design 1 1. NSAIDs and Alzheimer s disease 2. LpPLA2 and coronary heart disease 3. Vaccination for the prevention of HIV infection 4. Homocysteine and fractures Tugwell PX. How to read clinical journals III. To learn the clinical course and prognosis of disease. Can Med Ass J 1981;124: Kurtzke JF. On estimating survival; a tale of two censors. J Clin Epidemiol 1989;

4 Tuesday, January 27, 2015 THERAPY: EFFICACY Design options randomised trial Design Study design 2 Analysis randomised trial Peto R, Pike MC, Armitage P, Breslow E, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG. Design and analysis of randomised clinical trials requiring prolonged observation of each patient (part I and II). Br J Cancer 1976;34: , and Br J Cancer 197;7:1-39. Cornfield J. Recent methodological contributions to clinical trials. Am J Epid 1976;104: Wedneday, January 28, 2015 THERAPY: SIDE EFFECTS Intended and unintended effects, confounding by indication, meta-analysis Design Study design 3 Exercise Meta-analysis Anticoagulation after myocardial infarction Miettinen OS. The need for randomisation in the study of intended effects. Stat Med 1983;2: Miettinen OS, Caro JJ. Principles of non-experimental assessment of excess risk, with special reference to adverse drug reactions. J Clin Epid 1989;42: Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple graphical test. BMJ 1997;315: Lau J, Antman EM, Jimenez-Siwa J, Kupelnick B, Mosteller M, Chalmers TC. Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med 1992;327:

5 Thursday, January 29, 2015 DIAGNOSIS Lecture Exercise Diagnostic tests, sensitivity, specificity, predictive value, Bayes theorem. Bates DW, Cook F, Goldman L, Lee Th. Predicting bacteremia in hospitalised patients a prospectively validated study. Ann Int Med 1990;113: Sox HC. Probability theory in the use of diagnostic tests. Ann Intern Med 1986;104:60-6. Friday, January 30, 2015 META-ANALYSIS PRESENTATION OF STUDY DESIGNS Evaluation Closure

6 REGISTRATION You can register on the following s: and The Deadline for registration is January 16, TRAVEL AND ACCOMMODATION It is possible to use the organisational budget of the ERAWEB partner university to cover travel and accomodation costs for coordinating staff or other members of the partner universities. This is the responsibility of the partner universities. There is no additional budget available. For current ERAWEB students who would like to participate in the course, it is possible to use the participation fee that the host university receives for the student. This is the responsibility of the host university. Belgrade is easily accessed by plain (direct flights from major European cities), as well as by other means of transportation. The entrance visa is not needed for EU countries and for a significant number of other countries (please verify at the Embassy of Serbia). Hotel accommodation offers wide variety of possibilities at different prices. Most of the hotels are easily reachable from the airport (15-20 minutes by car). The following hotels are at the vicinity of Course venue: (5) Crystal Hotel (6) Park Hotel CONTACT: Center for International Collaboration Faculty of Medicine, University of Belgrade Dr Subotica 8, Belgrade, Serbia Phone/Fax: , Natasa Ognjanovic natasa_cms@med.bg.ac.rs Ivana Katic ivana.katic@mfub.bg.ac.rs