Key Words: Parkinson's disease, Magnetic resonance spectroscopy (MRS) 대한신경과학회지 21 권 6 호

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1 Jong-Ki Kim,.D., Byeong-Chae Kim,.D., Kee-Ra Lee,.D., in-kyung Song,.D., an-seok Park,.D., yeong-kyu Kim,.D., Ki-Hyun Cho,.D., Jeong-Jin Seo,.D. Background: Parkinson's disease is a progressive, common neuro-degenerative disorder of the extrapyramidal system leading to specific motor symptoms, but there is no specific early diagnostic tool. This study was aimed to investigate the change of cerebral metabolites in patients with parkinson's disease by H magnetic resonance spectroscopy (RS). ethods: Eighteen patients with idiopathic unilateral symptomatic parkinson's disease underwent RS study to compare metabolites of basal ganglia and thalamus, in ipsilateral and contralateral to the clinically affected side. Results: In patients with unilateral symptomatic parkinson's disease, N-acetyl aspartate (NAA)/Creatine (Cr) ratio was significantly lower in contralateral side to the clinically affected side than in ipsilateral side (p=0.02). Other cerebral metabolites (Cho, mi, - Glx, -Glx, lactate, lipid) were showed no significant difference in patients with parkinson's disease. Conclusions: The comparison and quantification of cerebral metabolites by using RS may be helpful to diagnosis and investigation of parkinson's disease. J Korean Neurol Assoc 2(6): , 200 Key Words: Parkinson's disease, agnetic resonance spectroscopy (RS) 서론 대한신경과학회지 2 권 6 호

2 대상과방법 igure.. Region of interest (ROI) in T weighted image. ROIs are 8 cm sized areas including thalamus, genu and posterior limb of internal capsule, and small part of putamen in both hemispheres. 결과 2 권 6 호대한신경과학회지

3 igure 2. agnetic resonance spectrum (RS). By using RS, we obtains cerebral metabolites from the left cerebral hemisphere (A) and from the right hemisphere (B) in patient with left symptomatic Parkinson's disease. NAA; N-acetyl aspartate, Cr; creatine, Cho; choline, mi; myo-inositol, a-glx; a-glutamate & glutamine, b-glx; b and r-glutamate & glutamine. Table. The clinical characteristics of patients with Parkinson's disease Case No Sex Age (yr) Duration of disease (yr) ean±sd 65.± ±.4 No; numbers, yr; year Affected Side igure. Comparison of NAA/Cr ratio. In patients with unilateral symptomatic Parkinson's disease, NAA/Cr ratio is significantly lower in contralateral to the clinically affected side than in ipsilateral side. 고찰 대한신경과학회지 2 권 6 호

4 Table 2. Results from magnetic resonance spectroscopy of patients with unilateral symptomatic Parkinson's disease in contralateral and ipsilateral to the clinically affected side, and p-value comparing between two sides. Case No. NAA/Cr Cho/Cr ml/cr α-glx/cr β-glx/cr Lac/Cr Lip/Cr C Ip C Ip C Ip C Ip C Ip C Ip C Ip ean SD C Ip p Value NAA; N-acetyl aspartate, Cr; Creatine, Cho; Choline, mi; myo-inositol, α-glx; α-glutamate & glutamine, β-glx; b-and r-glutamine, Lac; Lactate, Lip; Lipid, C; Contralateral, Ip; Ipsilateral, SD; Standard deviation 권 6 호대한신경과학회지

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