volume 56 no.3 september 2007

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1 volume 56 no.3 september 2007 PUBLISHED BY THE AMERICAN PHYSIOLOGICAL SOCIETY ALSO PUBLISHED IN AJP (CONSOLIDATED), vol. 293, no. 3 ajpgi.org

2 PAGES G519 G644 AJP - GASTROINTESTINAL AND LIVER PHYSIOLOGY september 2007 no. 3 volume 56

Garvin Henry Ford Hospital Lisa M. Satlin Mount Sinai School of Medicine Kumar Sharma Thomas Jefferson Univ. Susan M. Wall Emory Univ.

3 A J o u r n a l o f T h e A m e r i c a n P h y s i o l o g i c a l S o c i e t y full text online at ajprenal.org Editor-in-Chief Thomas R. Kleyman University of Pittsburgh School of Medicine Associate Editors Gerard Apodaca Univ. of Pittsburgh School of Medicine P. Darwin Bell Medical Univ. of South Carolina Jeffrey L. Garvin Henry Ford Hospital Lisa M. Satlin Mount Sinai School of Medicine Kumar Sharma Thomas Jefferson Univ. Susan M. Wall Emory Univ. School of Medicine American Journal of Physiology- Renal Physiology Scope of Journal The American Journal of Physiology- Renal Physiology covers all areas of renal physiology, including: original, innovative research on the kidney, urinary tract, and their respective cells and vasculature thought-provoking investigations involving human and animal models, individual cell types, and isolated membrane systems cross-disciplinary papers on the pathophysiological basis of disease processes in the kidney, the urinary tract, and in the regulation of body fluids timely editorial reviews Authors are required to submit papers online at A Few HOT Articles Vitamin D Adriana S. Dusso, Alex J. Brown, Eduardo Slatopolsky Am. J. Physiol. Renal Physiol. Jul 01, 2005; 289: 8-28 Advanced glycation end products and the kidney Jürgen M. Bohlender, Sybille Franke, Günter Stein, Gunter Wolf Am. J. Physiol. Renal Physiol. Oct 01, 2005; 289: Structure and function of aquaporin water channels A. S. Verkman, Alok K. Mitra Am. J. Physiol. Renal Physiol. Jan 01, 2000; 278: Tight junction biology and kidney dysfunction David B. N. Lee, Edmund Huang, Harry J. Ward Am. J. Physiol. Renal Physiol. Jan 01, 2006; 290: New insights into the regulation of V-ATPase-dependent proton secretion Sylvie Breton, Dennis Brown Am. J. Physiol. Renal Physiol. Jan 01, 2007; 292: 1-10 Hypoxia-inducible factors in the kidney Volker H. Haase Am. J. Physiol. Renal Physiol. Aug 01, 2006; 291: Reader & Author Benefits Fully searchable text, including PubMed Rich color and sharp resolution of figures Editor s Home Page at FREE access to the extensive collection of back issues available online 12 months after publication FREE notification of new content as it becomes available Manuscripts online within days of acceptance Perpetual/Electronic Archiving of the LOCKSS and CLOCKSS systems preserves the electronic content of all APS journals. Authors can choose to pay $2,000 on top of regular author fees and have their article made free immediately. To Start your Subscription or Submit your Manuscript subscriptions@the-aps.org, Call , Fax , or mail to The American Physiological Society, 9650 Rockville Pike, Bethesda, MD (USA) /9:35

Director of Publications/Executive Editor, Margaret Reich (301) 634-7070 Editorial Manager, Mark Goodwin (301) 634-7072 Submitted and Accepted Manuscripts: Mona Trang (301) 634-7188 Copyediting and

4 Director of Publications/Executive Editor, Margaret Reich (301) Editorial Manager, Mark Goodwin (301) Submitted and Accepted Manuscripts: Mona Trang (301) Copyediting and Production: Journal Supervisor, Stephanie Demma (301) Editorial Art Manager, Eric Pesanelli (301) Permissions: Penny Ripka (301) Reprints: Carolyn Villemez (301) Publication FAX: (301) American Journal of Physiology-Renal Physiology Executive Director, Martin Frank, PhD (301) Education Officer, Marsha Matyas, PhD (301) Director of Finance: Robert T. Price (301) Subscriptions: Lucia Tayiel (301) Public Affairs: Alice Ra anan (301) Marketing: Sue Sabur (301) Meetings/Confs: Linda Allen (301) Membership: Georgia Stine (301) Communications (media inquiries): Donna Krupa (301) Administration FAX: (301) APS Home Page: http: // For instructions on how to prepare your manuscript to conform to APS style, please see For a guide to submitting to see Manuscripts to AJP-Renal Physiology are submitted online through Mandatory Submission Forms and Fee Forms customized to your manuscript become available on completion of the submission process. For extra copies of blank forms, see If you use a blank form, please write the manuscript number, title, and author s name CLEARLY on the form. FEDERATION of AMERICAN SOCIETIES for EXPERIMENTAL BIOLOGY Benefits for FASEB Society Scientists The Federation of American Societies for Experimental Biology is an organization of multiple member societies representing tens of thousands of life scientists. Working closely with member societies, FASEB staff provide strategic intelligence on policy developments, conduct policy research, and engage government and media relations. HOW FASEB HELPS YOU In addition to the benefits you receive from being a member in your own professional society, you also receive a variety of important benefits through your society s membership in FASEB including: Access to FASEB s Legislative Action Center FASEB s Washington Update Subscription discounts for The FASEB Journal Members only online access to the FASEB Directory of Members CME at FASEB Summer Research Conferences and society meetings Career development resources Personal insurance programs Credit card and line of credit programs To learn more about FASEB, visit and go to Information for Scientists to download a brochure. Call toll-free FASEB or memberbenefits@faseb.org.

5 Special Call for Papers American Journal of Physiology-Renal Physiology Aldosterone and Epithelial Na Channels The American Journal of Physiology-Renal Physiology is seeking manuscripts to be submitted specifically related to the biology of epithelial Na channels (ENaC) and the actions of the hormone aldosterone. This call for papers is in conjunction with the 6th International Symposium on Aldosterone and ENaC, which will be held on October 3 7, Submitted papers should address the central themes of ENaC, mineralocorticoid receptors and aldosterone signaling. Papers may focus on structure, regulation, involvement in normal and pathophysiological states, or therapeutic interventions. All papers will receive expedited review. Authors should indicate in their letter to the editor and on the online submission form under Manuscript Type that the submitted manuscript is in response to a Special Call for Papers. Accepted manuscripts will be publisehd under a distinct heading and will receive special attention and handling. Only those papers not requiring extensive revision will be published under this call. The submission deadline is January 1, If you have any questions or currently have a manuscript on this topic that has already been submitted and would like to be included in the Special Call, please contact Dr. Thomas Kleyman, Editor-in-Chief, via at ajprenal@emory.edu. Special Call for Papers American Journal of Physiology-Renal Physiology Renal Hemodynamics: Biomolecular Control Mechanisms and Integration of Vascular and Tubular Function The American Journal of Physiology-Renal Physiology is seeking manuscripts to be submitted specifically related to biomolecular control of renal hemodynamics and the integration of vascular and tubular function. This call for papers is in conjunction with the 2007 FASEB Summer Research Conference on Renal Hemodynamics held July 7 12, 2007, in Saxtons River, VT. Submitted papers should address the central themes of hormonal, neural or molecular control of renal hemodynamics, pathophysiology of renal hemodynamics, or integration of vascular and tubular function. All papers will receive expedited review. Authors should indicate in their letter to the editor and in the online submission form under Manuscript Type that the submitted manuscript is in response to a Special Call for Papers. Accepted manuscripts will be published under a distinct heading and will receive special attention and handling. Only those papers not requiring extensive revision will be published under this call. The deadline for submission is October 1, If you have any questions or currently have a manuscript on this topic that has already been submitted and would like it to be included in this Special Call, please contact Dr. Thomas Kleyman, Editor-in-Chief via at ajprenal@emory.edu.

T H E A M E R I C A N P H Y S I O L O G I C A L S O C I E T Y 1898 ARTICLES 1921 Commemorating the APS Legacy Project more than 100 years of the APS Journals content The American Physiological

This content goes back to the very first issues of the American Journal of Physiology in 1898.

A Few Samples of the Classic Articles, listed below, have been singled out for essays written by eminent scientists with first-hand or personal experience in the field.

6 T H E A M E R I C A N P H Y S I O L O G I C A L S O C I E T Y 1898 ARTICLES 1921 Commemorating the APS Legacy Project more than 100 years of the APS Journals content The American Physiological Society provides the full historical content of 13 research journals as one online package called the APS Journal Legacy Content. This content goes back to the very first issues of the American Journal of Physiology in To commemorate this event, APS asked a group of expert authors to write essays on some of the most significant articles from the body of APS literature. A Few Samples of the Classic Articles, listed below, have been singled out for essays written by eminent scientists with first-hand or personal experience in the field. All the essays and Classic Articles are free for viewing by all users at this web site: Cannon WB. The emergency function of the adrenal medulla in pain and the major emotions. Am J Physiol 33: , Fenn WO, Rahn H, and Otis AB. A theoretical study of the composition of the alveolar air at altitude. Am J Physiol 146: , Guyton AC, Lindsey AW, and Kaufmann BN. Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180: , Kuffler SW. Discharge patterns and functional organization of mammalian retina. J Neurophysiol 16: 37-68, Landis EM. The capillary pressure in frog mesentery as determined by micro-injection methods. Am J Physiol 75: , Pitts RF and Lotspeich WD. Bicarbonate and the renal regulation of acid base balance. Am J Physiol 147: , Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, Riley RL and Cournand A. Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of lungs: theory. J Appl Physiol 4: , You can order the full online set of Legacy Content for a one-time low price of $2,000 for perpetual use (FREE to APS Members). For more information, go online at: The American Physiological Society 9650 Rockville Pike, Bethesda, MD Phone: Fax:

5/8/2013. Recognize, Respond to and Prevent the Publication of Research Misconduct. Overview

5/8/2013. Recognize, Respond to and Prevent the Publication of Research Misconduct. Overview The American Physiological Society Recognize, Respond to and Prevent the Publication of Research Misconduct Christina N. Bennett, PhD Publications Ethics Manager American Physiological Society Bethesda,