Islam Gamaleddin, M.D., M.Sc., Ph.D., CISAM. 1Abdel Hakim El Rifae St. Nasr City, Cairo

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1 Islam Gamaleddin, M.D., M.Sc., Ph.D., CISAM. 1Abdel Hakim El Rifae St. Nasr City, Cairo CURRENT POSITION: Cell: Lecturer of Pharmacology and Toxicology, Department of Medical Sciences, Institute of Environmental Research and Studies, Ain Shams University. EDUCATION: PhD: Pharmacology and Toxicology, Collaborative Program in Addiction Studies, Faculty of Medicine, University of Toronto, Master s: Clinical Toxicology, Faculty of Medicine, Ain Shams University, 08/ /2001. Bachelor: Medicine and Surgery, Faculty of Medicine, Ain Shams University, 09/ /1996. British General Certificate of Education: June TEACHING: Lecturer, teaching the following courses: Scientific Writing & Methodology, Environmental Toxicology. Lecturer, Behavioral Pharmacology course (JPM1005Y), Department of Pharmacology and Toxicology, University of Toronto, Received outstanding evaluations from Master s and Ph.D. students. Teaching assistant, Laboratory Pharmacology Course (PCL 471 Y), Department of Pharmacology and Toxicology, University of Toronto, 2008 & Certified trainer at the Translational Addiction Research Laboratory - CAMH Providing mentoring and technical training on the nicotine self- administration paradigm for new post-doctoral fellows, students and trainees Assistant lecturer, Institute of Environmental Research and Studies, Ain Shams, University, 11/ /2006. Duties included, teaching courses to Diploma and Master`s students and assisting senior staff in conducting their research and collecting and analyzing scientific material. Lectured and Trained physicians working at the Egyptian Ministry of Health on the Management and of cases of acute poisoning TEACHING & CLINICAL CERTIFICATIONS: Effective Use of Communication Skills in Teaching Effective Evaluation Techniques Setting and Creating Teaching Curriculums Use of Media in Teaching Effective Grant Writing Certification of the International Society of Addiction Medicine (CISAM) Structured Clinical Interview for DSM Disorders CAMH

2 Motivational Interviewing in Primary Care Setting - CAMH. Drug Dependence Treatment Approaches- CAMH. Methadone Maintenance Treatment Guidelines course - CAMH.. CPR Training for Health Care Providers - CAMH. Good Clinical Practice course Tri council Policy Statement 2 course Writing, Modifying and Revising Informed Consent Form SOP CAMH Obtaining and Documenting Informed Consent SOP CAMH AWARDS AND ACHIEVEMENTS: Ontario Post-doctoral Fellowship Award, from Canadian Ministry of Research and Innovation, University of Toronto Fellowship for outstanding academic performance, Student Grant Award from Canadian Tobacco Control Research Initiative to conduct research on the role of CB2 receptors in nicotine reward, Travel award from CTCRI to attend College on Problems of Drug dependence meeting in San Juan Puerto Rico, June Manuscript selected by Faculty 1000 to be in the top 2% of published articles in the field of Medicine and Biology, April (Please refer to publications section). Post Graduate scholarship from Egyptian Ministry of Higher Education. CLINICAL RESEARCH: Post-Doctoral Clinical Research Fellow, Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, Toronto, Canada, July June Projects: o Effects of fixed and self-titrated dosages of Sativex on cannabis users. o Acute and Residual Effects of Smoked Cannabis on Young Drivers Performance. o Imaging IV Alcohol induced dopamine release in the human brain: a PHNO, PET study. PRECLINICAL RESEARCH: Expert in surgical external jugular venous catheterization, handling, training, intra-peritoneal and subcutaneous injection of rats and mice involved in intravenous self-administration behaviour paradigms. Expert in subcutaneous implantation of drug infusion pumps. Expert in the construction, sterilization, quality assurance of intravenous catheters used for intravenous self-administration procedures. Comfortable with conducting experiments involving conditioned place preference and aversion paradigms.

3 Familiar with stereotaxic brain cannulation. CLINICAL EXPERIENCE: Clinical Fellow: Addiction Program, Department of Family & Community Medicine, CAMH, University of Toronto, 08/ /2013 Rotations: Nicotine Dependence Treatment Clinic: Supervisor, Dr. Peter Selby. Duties included Assessment, case planning, providing counseling and prescribing medications for patients presenting with nicotine dependence. Alcohol Research and Treatment Clinic: Supervisor, Dr. Bernard Le Foll. Addiction Medicine Clinic: Supervisor, Dr. Bernard Le Foll. Medical Withdrawal Services: Supervisor Dr. Keyghobad Araki Specialist: Clinical Toxicology Staff, Poison Control Centre, Ain Shams University Hospital, 05/ /2006. Duties including managing cases admitted to PCC Intensive Care Unit, Inpatient unit and Emergency Department, leading rounds, mentoring and training junior residents, interns and trainees. Hospitalist: Staff Physician, Departments of Emergency Medicine and Intensive Care Unit, Nasr City Insurance Hospital, (Tertiary Hospital), 07/ /2005. Duties included providing clinical service and managing cases at the Emergency Department & the Intensive Care Unit. Resident: Clinical Toxicology, Poison Control Centre, Ain Shams University Hospital, 05/ / Intern: Ain Shams University Hospitals, 03/ /1998. Rotations: General surgery, Internal Medicine, Pediatrics, Obstetrics & Gynecology, Emergency medicine, Anesthesiology & Respirology PUBLICATIONS (Peer Reviewed): 1. Gamaleddin I, Guranda M, Scherma M, Fratta W, Makriyannis A, Vaidivel S, Goldberg SR, Le Foll B(2013). AM404 attenuates reinstatement of nicotine seeking induced by nicotineassociated cues and nicotine priming, but does not affect nicotine- and food-taking. J of Psychopharmacology. 27(6): Gamaleddin I, Zvonok A, Makriyannis A, Goldberg SR, Le Foll B (2012).The Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking behaviour. PLOS One, 7(1): e (Selected by Faculty 1000 as one of the top 2% of publications in the field of Medicine and Biology, April, 2012). 3. Gamaleddin I, Wertheim C, Zhu AZ, Coen KM, Vemuri K, Makriyannis A, Goldberg SR, Le Foll B(2012). Cannabinoid receptor stimulation increases motivation for nicotine and nicotine seeking. Addict Biol. 17 (1): Gamaleddin I, Guranda M, Goldberg SR, Le Foll B (2011). The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking induced by nicotine associated cues and nicotine priming, but does not affect nicotine-intake. Br J Pharmacol.164 (6): Samokhvalov AV, Gamaleddin I, Sproule B, Rehm J. Naltrexone may block euphoria-like placebo effect. BMJ Case Rep Aug 7;2013.

4 6. Le Foll B, Chakraborty-Chatterjee M, Lev-Ran S, Barnes C, Pushparaj A, Gamaleddin I, Yan Y, Khaled M, Goldberg SR (2011).Varenicline decreases nicotine selfadministration and cue-induced reinstatement of nicotine-seeking behaviour in rats when a long pretreatment time is used. Int J Neuropsychopharmacol. 23: Yan Y, Pushparaj A, Le Strat Y, Gamaleddin I, Barnes C, Justinova Z, Goldberg SR, Le Foll B(2012) Blockade of dopamine D4 receptors attenuates reinstatement of extinguished nicotineseeking behavior in rats. Neuropsychopharmacology, 37(3): Scherma M, Justinová Z, Zanettini C, Panlilio LV, Mascia P, Fadda P, Fratta W, Makriyannis A, Vadivel SK, Gamaleddin I, Le Foll B, Goldberg SR.(2012). The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. Br J Phar. 9. Scherma M, Panlilio LV, Fadda P, Fattore L, Gamaleddin I, Le Foll B, Justinová Z, Mikics E, Haller J, Medalie J, Stroik J, Barnes C, Yasar S, Tanda G, Piomelli D, Fratta W, Goldberg SR (2008). Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. J Pharmacol Exp Ther Nov; 327 (2): Yan Y, Pushparaj A, Gamaleddin I, Steiner R, Picciotto M, Roderand J, Le Foll B(2012). Nicotine-taking and nicotine-seeking in C57Bl/6J Mice with no prior training Behavioural Brain Research, 230(1): PRESENTATIONS: Gamlaeddin I, Golberg SR. & Le Foll B. The endocannabinoid system: Useful target of anti addiction treatment, International Society of Addiction Medicine 14th annual meeting, Geneva, Switzerland (October, 2012) Gamaleddin I. Cannabinoids: role in mental health and addictions, Clinical Fellowship Rounds, CAMH, Toronto, Canada (January, 2012) Gamaleddin I & Le Foll B. Targeting the Cannabinoid System for Nicotine Addiction and Obesity Treatment, Addiction Rounds, CAMH, Toronto, Canada (September, 2011). Gamaleddin I. Targetting the endocannabinoid system for the treatment of nicotine addiction : Novel insights. The Translational Nicotine Meeting, Dusseldorf, Germany (September, 2009). Gamaleddin I & Le Foll B, Lack of Evidence Supporting a Functional Role of CB2 Receptors in Nicotine Reward. 17th Annual Meeting of Society for Research on Nicotine and Tobacco, Toronto, Canada (2011). Yan Y, Pushparaj A, Gamaleddin I & Le Foll B, Chronic intravenous nicotine selfadministration in C57B1/6J mice with no prior training, 17th Annual Meeting of Society for Research on Nicotine and Tobacco, Toronto, Canada (2011). Le Foll B, Chatterjee M, Lev-Ran S, Barnes C, Gamaleddin I, Pushparaj I, Yan Y, Khaled M, & Goldberg SR. The nicotine partial agonist varenicline blocks motivation for nicotine and significantly reduces cue-induced reinstatement of nicotine-seeking in rats. 17th Annual Meeting of Society for Research on Nicotine and Tobacco, Toronto, Canada (2011). Gamaleddin I & Le Foll B. Role of CB receptors in reinstatement of nicotine seeking behaviour in rats.70th Annual Meeting of College on Problems of Drug Dependence, San Juan, Puerto Rico (2008).

5 VOLUNTEERING AND LEADERSHIP: Judge at the Toronto Science fair March 30 & 31st Co-founder and former elected vice president and later president of Egyptian Students Association (ESA) at U of T (2007 & 2008). Head of registration team at the 20th, 21st and 22nd Annual International Ain Shams Medical Congress. ( ). Member of the organizing committee of the 22nd Annual Conference of the Egyptian Society of Cardiology (March 1996). LANGUAGES: Excellent command of English written and spoken. Arabic mother language.