Central role: - Regulating the immune system - Influencing metabolic and endocrine functions
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1 Spleen
2 Central role: - Regulating the immune system - Influencing metabolic and endocrine functions
3 Anatomy: An encapsulated mass of vascular and lymphatic tissue The largest RES organ 9-11 th ribs 4 impressions ligamentous attachments Related to pancreatic tail Blood supply
4 Embryonic anomaly: Accessary spleen Functions: Removal of RBCs,WBCs and Platelets Extramedullary hemopoeisis Recycling Iron Immunological (T and B cell lymphocytes )
5 Splenomegaly: Weight 500 gms Average 15 cm Massive, > 1 Kgm > 15 cm
6 Imaging studies: - USS - CT.Trauma scoring - MRI - Angiography (embolization)
7 Indications for splenectomy: The commonest is trauma For elective,the commonest is ITP 1. Benign disorders: Hereditary spherocytosis G6PD deficiency Auto immune hemolytic disease Sickle cell disease Thalassemia
8 Indications foe splenectomy..continued 2. Malignant diseases: WBCs disorders Hodgkins disease Non Hodgkins lymphoma Chronic lymphocytic lukemia Myeloproliferative disorders Acute myeloid lukemia Essential thrombocytopenia Polycythemia
9 Indications for splenectomy..continued 3. Others: 3a. Infections: Infectious mononucleosis EB virus CMV ( spontaneous rupture ) 3b. Abscess 3c. Cysts: Parasitic Traumatic Dermoid 3d. Tumors: Primary (Sarcoma) Metastatic
10
11
12 Indications for splenectomy..continued 3e. Storage diseases: Gauchers disease Niemann-Pick disease 3f. Splenic artery aneurysm 3g. Portal H.T 3h. Feltys syndrome 3i. Wandering spleen
13 Preoperative considerations: Patient Education Overwhelming sepsis Splenic vein thrombosis Vaccinations: Encapsulated pathogens More with hematological and malignant disorders More in children Greatest risk, 1 st 2 years Timing
14 The largest organ (1500 Gm) Two lobes 8 segments Protected by rib cage Fibrous capsule (Glissons ) 8 ligaments Foramen of Winslow Dual supply Hepatic artery 25% Portal vein 75% Portosystemic anastomosis The Liver
15 Physiology: Storage Production Secretion Proteins ( AA) Glucose (Glycogen) Fat (Cholesterol) All plasma proteins All coagulation factors Detoxification
16 Bile: I litre per day Bilirubin metabolism Composition: water Organic molecules: Bile pigments Bile salts Phospholipids (Lecithin) Cholesterol Enterohepatic circulation
17 Jaundice: Bilirubin more than mgs/dl Causes: Prehepatic Intrahepatic, Gilberts syndrome Crigler-Najjar syndrome Dubin-Johnson syndrome Posthepatic..extrinsic or intrinsic obstruction of the biliary tree
18 Imaging: - USS - CT - MRI - PET - Angiography
19 Liver cirrhosis: The final sequela of chronic hepatic insult Morphology Micronodular Macronodular
20 Liver Cirrhosis..continued Etiology: Viral hepatitis Autoimmune hepatitis Drug induced Cholestasis Metabolic Hemochromatosis Wilsons disease Hepatic vein outflow obstruction Budd chiari syndrome Congestive cardiac failure Constrictive pericarditis
21 Portal Hypertension: Portal venous system contributes 75% of the blood supply 72% of the Oxygen Normal pressure 5-10 mmhg
22 Portal HT continued Etiology: 1. Presinusoidal Extrahepatic Splenic vein thrombosis Splenomegaly Splenic A-V fistula Intrahepatic Schistosomiasis Congenital hepatic fibrosis Idiopathic portal fibrosis Myeloproliferative disorders Sarcoid
23 Portal HT etiology continued 2. Sinusoidal Intrahepatic cirrhosis 3. Post sinusoidal Intrahepatic Vascular occlusive disease Posthepatic Budd Chiari CCF IVC web Constrictive pericarditis
24 Varices: 30% of patients with compensated cirrhosis 60% of patients with decompensated cirrhosis 1/3 of all patients with varices will experience variceal bleeding Each episode 20-30% mortality if untreated 70% of patients who survive the initial episode will experience recurrent haemorrhage within 2 years
25 Prevention of variceal bleeding: Non selective Beta blockers Prophylactic endoscopic suveillance and band ligation
26 Acute Vareceal Bleeding: Admission to ICU Careful blood replacement FFP Platelets Antibiotics Vasopressin Luminal tamponade Blackmore-Sengstaken tube TIPS Surgery: Shunting Portocaval Mesocaval Distal lienorenal (Warren) Non shunting Sigiura Liver transplant
27 Budd Chiari syndrome: Congestive Hepatopathy Primary Thrombosis Secondary Compresion
28 Liver Abscess: Pyogenic Amebic
29 Hydatid Disease: 70% in the liver May be silent May become infected or may rupture Diagnosis: ELISA 80% Positive (Weinburg) Casoni Eosinophilia 30% Imaging
30 Hydatid disease continued Treatment: Albendazole Mebendazole Surgery E.multilocularis (in the west )
31 Ascariases: Retrograde locomotion into the bile ducts Treatment: Piperazine citrate Albendazole Mebendazole ERCP
32 Schistosomiasis: Perisinosoidal portal HT Education Hygiene Praziquantel Single dose mg/kilo wt.
33 Liver Cysts: Congenital Benign cystadenoma Polycystic liver disease Caroli s disease Biliary lithiasis 33% Cholangitis Biliary abscesses Cholangiocarcinoma 7%
34 Benign Liver Lesions: 1. Cysts Primary ( congenital) Secondary (traumatic) Seromas Bilomas 2. Hemangiomas 3. Adenoma Females OCP Significant risk of rupture Risk of malignant transformation to HCC
35 Benign Liver Lesions.continued 4. Focal nodular hyperplasia
36 Malignant Liver tumors: 1. Primary 1a. From liver cells (HCC) Hepatocellular carcinoma 1b. From bile ducts (CC) Cholangiocarcinoma
37 Malignant Liver Tumors continued HCC: The 5 th common malignancy High fatality Risk factors Viral hepatitis Alcoholic cirrhosis Hemochromatosis Aflatoxin
38 Malignant liver Lesions.continued Cholangiocarcinoma An adenocarcinoma of the biliary tree Peripheral ( intrahepatic) Central(extrahepatic) Distal Proximal(hilar) Klatskin tumor
39 Questions?
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