Neuroimaging Findings in Young Drinkers: Does Teenage Drinking Harm the Brain? Susan F. Tapert, Ph.D. University of California, San Diego
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1 Neuroimaging Findings in Young Drinkers: Does Teenage Drinking Harm the Brain? Susan F. Tapert, Ph.D. University of California, San Diego
2 2 Overview What is normal adolescence? How do binge drinkers differ? Does the media have a role? Prevention implications
3 Past Month Use of Substances Monitoring the Future, 2013, ESPAD
4 % Meeting Alcohol Use Disorder Criteria by Adulthood Age of First Drink or Younger or Older Age at First Drink National Household Drug Use & Health,
5 Quick Brain Review! 5
6 6 Gray & White Matter Top view Side view
7 Tapert & Schweinsburg, Adolescent Brain Development Volume Metabolism Myelination Blood Flow Receptors Synaptic Refinement Adolescence RATE OF CHANGE Prenatal Post-birth - Age
8 Volume (Cubic cm) Prefrontal Gray Matter Boys Peak Girls Peak Age Giedd et al., 1999, 2006; Lenroot & Giedd,
9 Bava, Thayer, Jacobus, Ward, Jernigan, & Tapert, 2010, Brain Research 9 White Matter Change Right Frontal- Parietal +11% Frontal +8% Left Frontal- Parietal +5% R thalamic fibers +10% R posterior limb of internal capsule +5% Significant fiber improvement, age 17.5 to 19
10 Casey et al., 2008; Eaton et al., 2006; Galvan et al., Adolescent Brain Development 2-4x higher rate of death, crime, substance use Overactive limbic/subcortical + underdeveloped frontal lobe
11 11 Adolescent Binge Drinking What is normal adolescence? How do binge drinkers differ? Does the media have a role? Prevention implications
12 Retention Rate Brown, Tapert, Granholm, & Delis, 2000, ACER 12 Memory 100% 95% 90% Light Drinkers (n=24) Heavy Drinkers (n=33) 85% 80% 75% Verbal Info Nonverbal Info
13 T-score Tapert & Brown, 2000, Addictions 13 Attention Light Drinkers (n=50) Heavy Drinkers (n=101) Attention Speeded Info Processing
14 Longitudinal Study of Initiation Recruited from middle schools Followed annually: cognitive test, brain imaging, interviews Age Age Testing & Scans Non-Users N=296 R01 AA13419 (PI: Tapert) Follow up Testing &Scans Non-Users ~40% Heavy Users ~30% 14
15 Complex Figure Memory 15
16 Z-Score Change <-- Worse Better --> Initiation of Drinking: Females More drinks worse picture memory Drinks Per Month Squeglia et al., 2009, Psychol Add Beh 16
17 Digit Vigilance 17
18 Squeglia et al., 2009, Psychol Add Beh Z-Score Change <-- Worse Better --> 18 Initiation of Drinking: Males More hangovers worse attention 3 2,5 2 1,5 1 0,5 0-0,5-1 -1, Hangover Symptoms Scale
19 Winward et al., in press, JINS 19 Recovery with Abstinence p=.009
20 20 Summary Adolescent heavy drinkers show: 10% less information retrieved Reduce spatial skills for girls Can recover with abstinence Do problems relate to brain?
21 21 MRI Safe Non-invasive No radioactivity Issues Motion Artifact
22 Medina, Nagel et al., 2007, NTT 22 Hippocampal Volume Critical for memory Ages days abstinence Left hippocampus smaller in drinkers Right / Left
23 Medina, Tapert et al., Prefrontal Cortex Volume Key for planning and reasoning Ages days abstinence Smaller in drinkers Especially girls Anterior Ventral
24 Lisdahl et al., 2013, Psychiatry Research 24 Cerebellar Volume Important for balance and attention Higher peak drinks predicted smaller: Left cerebellar gray matter Left cerebellar white matter Right cerebellar gray matter Improves with abstinence
25 Volume Changes After Drinking Smaller volumes in future drinkers: Areas key to inhibition Reductions after drinking: Temporal gyrus Thalamus Caudate Brain stem Squeglia et al., in press, Developmental Cog Nsci 25
26 McQueeny, Schweinsburg, Jacobus, Bava, Frank, & Tapert, 2009, ACER 26 White Matter in Binge Drinkers Bingers poorer than Controls
27 Higher BAL Worse White Matter McQueeny, Schweinsburg, Jacobus, Bava, Frank, & Tapert, 2009, ACER 27
28 Mean Diffusivity <-- better -- worse --> Bava et al., 2013, ACER 28 Increased Drinking Worse White Matter Right Superior Longitudinal Fasciculus Integrity, Time 2 0,65 Users 0,6 showed poorer white matter integrity than Controls in 7 tracts (p<.01) 0,55 0, Drinking Days Between Scans
29 29 Functional MRI MRI Task Changes in blood oxygenation Identify areas involved in task
30 Brain Activation Brain Activation and Early Drinking Early drinking (1-2 yrs) Pre-initiation Substance Use Continued use Tapert et al., 2001, ACER; Tapert et al., 2004, ACER; Squeglia et al., 2012, JSAD 30
31 Squeglia, Pulido, Wetherill, Jacobus, Brown, & Tapert, 2012, JSAD 31 Activation Differences over Time N=40 age binging by age matched non-drinkers Before drinking: Future drinkers: activation After drinking: activation
32 Summary of Findings Alcohol Marijuana Cognition Brain volume White matter Activation Retrieval Spatial Attention Hippocampus Prefrontal Cerebellum Quality Spatial Learning Inhibition Jacobus & Tapert (2013). Annual Review of Clinical Psychology Learning Sequencing Errors = Quality Spatial Learning Inhibition 32
33 33 Adolescent Binge Drinking What is normal adolescence? How do binge drinkers differ? Does the media have a role? Prevention implications
34 34 Role of Media Food Violence Sex Tobacco Alcohol $3 billion/yr
35 Alcohol Ads & Underage Drinking Ad awareness More positive views on alcohol effects Greater plans to drink as adults Boys more aware than girls Ad liking More likely to drink Humor Story People with youth appeal Animals 35
36 Tapert et al., 2003, Arch Gen Psychiatry Alcohol Cue Task Alcohol Pictures Non-Alcohol Pictures
37 Youth Response to Alcohol Ads Alcohol pictures relative to non-alcohol pictures: LEFT HEMISPHERE Posterior Posterior cingulate cingulate Nucleus Accumbens Orbital/prefrontal Hypothalamus Temporal Prefrontal Heavy drinkers had more response to alcohol pictures than Light drinkers
38 Tapert et al., 2003, Arch Gen Psychiatry Signal Contrast Youth Response to Alcohol Ads side view Red: Heavy > Light Blue: Light > Heavy Light Drinker Heavy Drinker Drinks per Month
39 Heavy Drinking Adolescents Neurocognition Females: visuospatial fxn, Males: attention Brain size reductions White matter worsens Actively developing Worst for heaviest drinkers Use Brain Brain activation Increases: brain has to work harder 39
40 40 Adolescent Binge Drinking What is normal adolescence? How do binge drinkers differ? Does the media have a role? Prevention implications
41 41 Prevention Implications 1. Inform students of risks Don t get hungover! >12 drinks/mo may harm females cognition 2. Heavy use linked to impaired learning Can improve after >2 weeks of no using Before then, have info repeated 3. Delay the start of using alcohol
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