Monographs on Endocrinology
|
|
- Rodger Neal
- 5 years ago
- Views:
Transcription
1 Monographs on Endocrinology Volume 18 Edited by F. Gross, Heidelberg M. M. Grumbach, San Francisco A. Labhart, Zurich M. B. Lipsett, Bethesda T. Mann, Cambridge L. T. Samuels ("I), Salt Lake City 1. Zander, Mlinchen
2 Inder J. Chopra Triiodothyronines in Health and Disease With a Contribution by V. Cody With 76 Figures and 18 Tables Springer-Verlag Berlin Heidelberg New York 1981
3 Inder J. Chopra, M.D. Professor of Medicine, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90024, U.S.A. Vivian Cody, Ph.D. Associate Research Scientist, Medical Foundation of Buffalo, Inc., Research Laboratories, Buffalo, NY 14203, U.S.A. ISBN-13: e-isbn-13: DOl: 1O.1007! Library of Congress Catalogmg in Publication Data. Chopra, hider J TriiOdothyronincs in health and disease. (Monographs on endocrinology; v. 18) Bibliography; p. Includes mdex. 1. Triiodothyronine. 2. Thyroid hormones. l. Title. [DNLM I Irllodothyronmc. WI M057 v. 18jWK 202 C 549 tj QP572.T5C47 612' This work is sub]t!ct to copyright. All rights are reserved. whether the whole or part of the material IS concerned, specifically those of translation, reprmting. fe-use of illustrations, hroa.. -::asting, reproductlon by photocopying mach me or similar means, and storage lfi data banks. Under S 54 of the German Copynght Law Voihere COpIes are made for other than private usc, a fcc is payable to 'Verwertungsgesellschaft \Vort" Mumch. (0 Springer-Verlag Berlin, HeIdelberg 1981 Softcover reprint of the hardcover 1 st edition 1981 The use of registered names, trademarks, etc. in this publication docs not Imply, even in the absence of a specific statement, that such names are exempt from the relevant proleclive laws and regulations and therefore free for general use. Typesetting: Oscar Brandstetter Druckerel KG, Wiesbaden 2125/
4 Preface The physiology and metabolism of thyroid hormones were areas of intense research investigation during the 1970s. Radioimmunoassays were applied to study the concentration of iodothyronines in biologic fluids. These techniques proved to be highly sensitive, specific, and reproducible as well as rapid. The availability of specific radioimmunoassays led to the detection of several iodothyronines in human biologic fluids, e. g., reverse triiodothyronine (rt 3), diiodothyronines, monoiodothyronines, and acetic acid derivatives of thyroxine (T 4) and T 3, which were previously either unknown or briefly considered but forgotten in the 1950s. This monograph is intended for readers who desire an overview of thyroid hormone physiology as it was understood in It should be especially useful to trainees in endocrinology and individuals interested in potential research projects. The main focus has been on the studies conducted between 1969 and 1978, alt~lough other information has been reviewed to provide an overall working knowledge of the field. A list of over 500 references, although probably still incomplete, should lead a reader to at least a few important articles in each area relevant to thyroid hormone physiology. The knowledge of several deiodinated derivatives as well as the production rates of thyroid hormones (T 4 and T 3) has raised several questions concerning the routes of metabolism of thyroid hormones along with the physiologic controls involved. In writing this book, 1 have examined the available information on various physiologic aspects of T 3 in health and their alteration in disease. In addition, key questions concerned with the understanding of thyroid hormone physiology have been reviewed; these include the following: (l) Is T 4 merely a prohormone for T 3 or is it also a hormone? (2) Is rt 3 merely a metabolic waste oft 4 or is it capable of biologic effects? (3) What is the nature of the processes of monodeiodination of T 4 to T 3 and to rt 3 and what are the factors that control these processes? (4) Why is serum T 310w and rt 3 high in the fetus, in starvation, in systemic illness, and after the administration of some drugs? (5) Can the measurement of rt 3 in amniotic fluid serve as a prenatal index of thyroid function in man? (6) What are the routes of metabolism of T 3S, and are these routes altered in a characteristic fashion in some situations? (7) What is the relativc potency ofvm ious circulating iodothyronines in the suppression of TSH? The information covered in cach chapter of the volume is as follows: Chapter 1 deals with the nomenclature, structure, and a history of the discovery of the triiodothyronines (T 3 and rt 3). Chapter 2 reviews serum binding of T 3S (T 3 and rt 3). Chapter 3, by Dr. Vivian Cody, reviews the molecular structure oft 3 and T 4, as determined by crystallographic studies. Dr. Cody analyzes the structure-activity relationship of thyroid hormones as it applies to serum binding as well as hormonal
5 VI Preface effects. Radioimmunoassay methodology for measurement of T 3S and the data on their concentration in biologic fluids during various clinical states is reviewed in Chap. 4. Chapter 5 discusses the data on metabolic clearance and production rates of T 3S, while information on the sources of T 3S is reviewed in Chap. 6. Chapters 7 and 8 discuss the metabolism oft 4 and T 3S in extrathyroidal tissues, and Chap. 9 is a brief overview of the biologic effects of iodothyronines. Much of the data on the serum concentrations ofiodothyronines is derived from the author's laboratory. The sections discussing the routes of iodothyronine metabolism, as reviewed here, should be considered gross estimates based on the available information. Sophisticated readers will no doubt appreciate the uncertainties and limitations of the analytic methods on which these estimates have been based. Although emphasis has been placed on data from my research, I have reviewed studies from various other laboratories, especially in controversial situations. I believe these reviews to be fair. However, I beg understanding and kind consideration from those who may feel that an insufficient or misplaced emphasis has been associated with their contributions. If this has occurred, it reflects naivety and/or other limitations in the ability of the author. Over the last 10 years, I have been extremely fortunate in my research to have benefited from the help and guidance of Dr. David H. Solomon, Professor and Chairman of the University of California, Los Angeles, Department of Medicine. He has been my mentor as well as a highly valued collaborator and colleague, and I am sorry that he was unable to join me in writing this monograph. Collaborative studies with Dr. Delbert Fisher of the Department of Pediatrics, University of California, Los Angeles, have also contributed invaluably to my work. I am grateful to Dr. Vivian Cody for contributing an excellent chapter on the molecular structure of thyroid hormones, which clearly enhances the scope of this monograph. I am grateful to Ms. Guadalupe N. Chua Teco and Ms. Aimee Nguyen, as well as the other research associates and many fellows who have contributed so significantly to this study and to the overall knowledge of thyroid hormone physiology. I also thank Ms. Kim Harrell, Ms. Teresa Aguilar, and Ms. Kate Kavanaugh for their cooperation and excellent secretatial assistance. I am very appreciative of the skillful editorial assistance of Ms. Linda 011. The research of the author cited in this monograph was supported in part by USPHS grants AM16155 and AMl7251 and the Research Career Development Award (K04 AM 70, 225) from the National Institutes of Health. Los Angeles, December 1980 Inder J. Chopra
6 Contents Chapter 1. Description, History, and Calorigenic Activity of Iodothyronines. 1 Chapter 2. Transport of Iodothyronines. 8 A. Thyroxine-Binding Globulin. 10 B. Thyroxine-Binding Prealbumin 12 C. Free Thyroid Hormones Chapter 3. Triiodothyronine: Molecular Structure and Biologic Function (V. Cody) A. Introduction B. Stereochemistry and Molecular Conformation 16 C. Conformational Analysis I. Diphenyl Ring Conformation II. 3' -Substituent Orientation - Distal or Proximal. 28 III. Side Chain Orientation IV. Intermolecular Interactions D. Role of Iodine in Conformation and Activity. 41 I. Conformational Constraints 42 II. Electronic Effects. 42 III. Iodine Interactions IV. Acidity 4'-OH E. Protein Binding and Biologic Activity. 46 I. Nuclear Binding Proteins II. Binding and Potency of TBG.. 50 III. Thyroxine-Binding Prealbumin Interactions 53 F. Summary Chapter 4. Concentration of Triiodothyronines (T 3 and Reverse T 3) in Serum and Other Body Fluids A. Methods of Measurements. 58 I. T 3 (3, 5, 3'-T 3)
7 VIII Contents 1. T 3 Radioimmunoassay a) Reagents..... b) Procedure..... II. Reverse T 3 (3, 3', 5'-T 3, rt 3) 1. Reverse T 3 Radioimmunoassay a) Reagents b) Procedure B. Serum T 3 Concentration in Health and Disease I. Age-Related Changes Fetal and Neonatal Life Childhood (1-15 Years of Age). 3. Adult Life II. Effect of Sex III. Effect of Thyroid Disease 1. Hyperthyroidism.. 2. Hypothyroidism.. 3. Chronic Thyroiditis. 4. Endemic Goiter.. IV. Effect of Nonthyroidal Illnesses. V. Effect of Diet on Serum Concentration of T 3S 86 VI. Effect of Drugs Drugs Influencing Extrathyroidal Metabolism of Iodothyronines Serum Levels oft 3S During Treatment with Thyroid Preparations Effect of Administration of TSH and TRH 92 C. Urinary Excretion of T 3S " Chapter 5. Kinetics of Peripheral Metabolism and Production Rates of T3S 95 A. Methods of Measurement and Normal Values 95 B. Alterations in Thyroid Diseases C. Alterations in Nonthyroid Diseases and Low-T 3 Syndrome 99 Chapter 6. Sources of T3S: Thyroidal Secretion Versus Extrathyroidal Metabolism of T Chapter 7. Nature of the Processes of and Factors Influencing Production of T3S from T A. Outer-Ring Monodeiodination of T 4 to T 3' B. Inner-Ring Monodeiodination of T 4 to Reverse T Chapter 8. Routes of T3S Metabolism. 114 A. In Vivo Studies. 114 B. In Vitro Studies. 116
8 Contents Chapter 9. Biologic Effects of Iodothyronines A. Mechanism of Action B. Some Other Interesting Effects of Thyroid Hormones. I. Erythropoiesis II. Cyclic (3', 5'-)Adenosine Monophosphate III. Self Degradation C. Relative Potency in Various Effects References.. IX Subject Index 143
Positive Family Therapy
N. Peseschkian Positive Family Therapy The Family as Therapist Springer-Verlag Berlin Heidelberg N ew York Tokyo Dr. med. Nossrat Peseschkian Facharzt flir Neuroiogie und Psychiatrie Psychotherapie An
More informationOrthopaedic Diagnosis
Hubert A. Sis sons. Ronald O. Murray H.B.S. Kemp Orthopaedic Diagnosis Clinical, Radiological and Pathological Coordinates With 534 Figures, Many in Colour Springer-Verlag Berlin Heidelberg New York Tokyo
More informationVol. 1. Progress in Orthopaedic Surgery
Progress in Orthopaedic Surgery Vol. 1 Editorial Board N. Gschwend, Zurich D. Hohmann, Erlangen. J. L. Hughes, Jackson' D. S. Hungerford, Baltimore' G. D. MacEwen, Wilmington. E. Morscher, Basel. J. Schatzker,
More informationNeuroethology. Jorg-Peter Ewert. An Introduction to the Neurophysiological Fundamentals of Behavior. Translation: Transemantics, Inc.
Jorg-Peter Ewert Neuroethology An Introduction to the Neurophysiological Fundamentals of Behavior Translation: Transemantics, Inc. With 171 Figures, Most in Color Springer-Verlag Berlin Heidelberg New
More informationCross-Sectional Anatomy for Computed Tomography
Cross-Sectional Anatomy for Computed Tomography Michael L. Farkas Cross-Sectional Anatomy for Computed Tomography A Self-Study Guide with Selected Sections from Head, Neck, Thorax, Abdomen, and Pelvis
More informationManagement of Headache and Headache Medications
Management of Headache and Headache Medications Lawrence D. Robbins, M.D. Management of Headache and Headache Medications Foreword by Jerome Goldstein, M.D. Springer-Verlag New York Berlin Heidelberg London
More informationThe. Vertebral Artery. Pathology and Surgery. Bernard George. Claude Laurian. Springer-Verlag Wi en New York
The Vertebral Artery Pathology and Surgery Bernard George Claude Laurian Springer-Verlag Wi en New York Bernard George, M.D. Department of Neurosurgery, H6pital Lariboisiere, Paris, France Claude Laurian,
More informationRadiology Illustrated
Radiology Illustrated For further volumes: http://www.springer.com/series/11755 In-One Kim Editor Radiology Illustrated: Pediatric Radiology Editor In-One Kim, M.D. Department of Radiology Seoul National
More informationThe Pharmacology of Alcohol and Drugs of Abuse and Addiction
The Pharmacology of Alcohol and Drugs of Abuse and Addiction Norman S. Miller The Pharmacology of Alcohol and Drugs of Abuse and Addiction Springer-Verlag New York Berlin Heidelberg London Paris Tokyo
More informationAnaesthesiology and Resuscitation Anaesthesiologie und Wiederbelebung Anesthesiologie et Reanimation
Anaesthesiology and Resuscitation Anaesthesiologie und Wiederbelebung Anesthesiologie et Reanimation 75 Editors Prof. Dr. R. Frey, Mainz' Dr. F. Kern, St. Gallen Prof. Dr. O. Mayrhofer, Wien Managing Editor:
More informationChapman and Hall Animal Behaviour Series
ANIMAL MOTIVATION Chapman and Hall Animal Behaviour Series SERIES EDITORS D.M.Broom Colleen Macleod Professor of Animal Welfare, University of Cambridge, UK P.W. Colgan Professor of Biology and Psychology,
More informationUltrasonography of Muscles and Tendons
Ultrasonography of Muscles and Tendons Bruno D. Fomage Ultrasonography of Muscles and Tendons Examination Technique and Atlas of Normal Anatomy of the Extremities With 612 Illustrations Springer-Verlag
More informationIntraoperative Ultrasound Imaging in Neurosurgery
Ludwig M.Auer Vera Van Velthoven Intraoperative Ultrasound Imaging in Neurosurgery Comparison with CT and MRI With 466 Figures in 547 Separate Illustrations Springer-Verlag Berlin Heidelberg New York London
More informationTemperature Regulation in Humans and Other Mammals
Temperature Regulation in Humans and Other Mammals Springer Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Singapore Tokyo Claus Jessen Temperature Regulation in Humans and Other Mammals
More informationPercutaneous Surgery of Kidney Stones
KnutKorth Percutaneous Surgery of Kidney Stones Techniques and Tactics Foreword by W. Mauermayer With 65 Figures and 3 Color Plates Springer-Verlag Berlin Heidelberg New York Tokyo 1984 Dr. med. Knut Korth
More informationLumbar Spine Syndromes
Gunnar B. J. Andersson and Thomas W. McNeill Lumbar Spine Syndromes Evaluation and Treatment Springer-Verlag Wien New York Gunnar B. J. Andersson, M.D., Ph.D. Thomas W. McNeill, M.D. Department of Orthopedic
More informationReal-time Ultrasound Imaging in the Abdomen
Real-time Ultrasound Imaging in the Abdomen Real-time Ultrasound Imaging in the Abdotnen M. Leon Skolnick, M. D. Associate Professor of Radiology University of Pittsburgh School of Medicine Director of
More informationPostgastrectomy and Postvagotomy Syndromes
H. D. Becker W.F. Caspary Postgastrectomy and Postvagotomy Syndromes With 84 Figures (Mainly in Two Colors) Springer-Verlag Berlin Heidelberg New York 1980 Professor Dr. med. H. D. Becker KlInik und PolIklImk
More informationPerspectives on Methodology in Consumer Research
Perspectives on Methodology in Consumer Research Perspectives on Methodology in Consumer Research Edited by David Brinberg and Richard 1. Lutz With 32 Figures Springer-Verlag New York Berlin Heidelberg
More informationMonographs. Series Editor: U. Veronesi
Monographs Series Editor: U. Veronesi The European School of Oncology gratefully acknowledges financial support for the production of this monograph received from Farmacia (Hellas) SA, Schering-Plough
More informationSpringer London Berlin Heidelberg New York Barcelona Budapest Hong Kong Milan Paris Santa Clara Singapore Tokyo
Focus on Cancer Springer London Berlin Heidelberg New York Barcelona Budapest Hong Kong Milan Paris Santa Clara Singapore Tokyo Robert Dunlop Cancer: Palliative Care, Springer Robert Dunlop St Christopher's
More informationThe Neurobiology of Motivation and Reward
The Neurobiology of Motivation and Reward James R. Stellar Eliot Stellar The Neurobiology of Motivation and Reward With 66 Figures Springer-Verlag New York Berlin Heidelberg Tokyo James R. Stellar Department
More informationGuide to the Ultrasound Examination of the Abdomen
Guide to the Ultrasound Examination of the Abdomen Guide to the Ultrasound Examination of the Abdomen M. Leon Skolnick, M.D. Professor of Radiology University of Pittsburgh School of Medicine Director,
More informationMRIofthe Central Nervous System
K. Mori (Ed.) MRIofthe Central Nervous System A Pathology Atlas With the Collaboration of M. Kurisaka A. Moriki A. Sawada With 116 Case Studies and 372 Figures Springer-Verlag Tokyo Berlin Heidelberg New
More informationUltrasound Mammography
Ultrasound Mammography B.-J. Hacke16er V. Duda G. Lauth Ultrasound Mammography Methods, Results, Diagnostic Strategies With the Collaboration of Jack Jellins Foreword by Elizabeth Kelly-Fry With 186 Illustrations
More informationSocial Psychology of Self-Referent Behavior
Social Psychology of Self-Referent Behavior Social Psychology of Self-Referent Behavior Howard B. Kaplan Baylor College of Medicine Houston, Teras Springer Science + Business Media, LLC Library of Congress
More informationAIDS Testing Methodology and Management Issues
AIDS Testing Gerald Schochetman J. Richard George Editors AIDS Testing Methodology and Management Issues Foreword by Walter R. Dowdle With 38 Illustrations Springer-Verlag New York Berlin Heidelberg London
More informationThe Polyol Paradigm and Complications of Diabetes
The Polyol Paradigm and Complications of Diabetes Margo Panush Cohen The Polyol Paradigm and Complications of Diabetes With a Foreword by Harold Rifkin With 25 Figures Springer-Verlag New York Berlin Heidelberg
More informationDonald E. Wesson. Editor. Metabolic Acidosis. A Guide to Clinical Assessment and Management
Metabolic Acidosis Donald E. Wesson Editor Metabolic Acidosis A Guide to Clinical Assessment and Management Editor Donald E. Wesson, MD, MBA Baylor Scott and White Health Department of Internal Medicine
More informationIndirect Questioning in Sample Surveys
Indirect Questioning in Sample Surveys Arijit Chaudhuri Tasos C. Christofides Indirect Questioning in Sample Surveys 123 Arijit Chaudhuri Applied Statistics Unit Indian Statistical Institute Kolkata,
More informationClinical and Radiological Aspects of Myopathies
J.A.L.Bulcke A.L.Baert Clinical and Radiological Aspects of Myopathies CT Scanning EMG Radioisotopes With 151 Figures and 30 Tables Springer-Verlag Berlin Heidelberg GmbH Dr. JAN A. L BULCKE K. U. Leuven,
More informationSeries in Psychopathology. Series Editor Lauren B. Alloy
Series in Psychopathology Series Editor Lauren B. Alloy Michael W. O'Hara Postpartum Depression Causes and Consequences With a Foreword by Lee S. Cohen, M.D. With 22 Illustrations Springer-Verlag New York
More informationNeuroblastoma. mibg in its Diagnosis and Management. Judy Moyes' V. Ralph McCready Ann Fullbrook
Judy Moyes' V. Ralph McCready Ann Fullbrook Neuroblastoma mibg in its Diagnosis and Management With 241 Figures Springer-Verlag London Berlin Heidelberg New York Paris Tokyo Judy S.E. Moyes. MA (Cantab).
More informationPsychopharmacology Series 8
Psychopharmacology Series 8 Methodology of the Evaluation of Psychotropic Drugs Edited by O. Benkert, W. Maier, and K. Rickels With 19 Figures Springer-Verlag Berlin Heidelberg New York London Paris Tokyo
More informationCongenital Hip Disease in Adults
Congenital Hip Disease in Adults George Hartofilakidis George C. Babis Kalliopi Lampropoulou-Adamidou Congenital Hip Disease in Adults George Hartofilakidis, MD, FACS Orthopaedic Department Medical School
More informationWilliam A. Yost and George Gourevitch Editors. Directional Hearing. With 133 Figures. Springer-Verlag New York Berlin Heidelberg London Paris Tokyo
Directional Hearing William A. Yost and George Gourevitch Editors Directional Hearing With 133 Figures Springer-Verlag New York Berlin Heidelberg London Paris Tokyo William A. Yost Director Parmly Hearing
More informationCurrent Topics in Pathology
Current Topics in Pathology Continuation of Ergebnisse der Pathologie 71 Editors c. L. Berry E. Grundmann W. H. Kirsten Advisory Board H.-W. Altmann, K. Benirschke, A. Bohle, H. Cottier M. Eder, P. Gedigk,
More informationDiagnostic Imaging of the Liver
S. Sakuma T. Ishigaki T. Takeuchi Diagnostic Imaging of the Liver Biliary Tract and Pancreas Data Analysis and Diagnostic Procedures With 312 Figures in 932 Separate Illustrations Springer-Verlag Berlin
More informationA Practical Guide to Real-Time Office Sonography in Obstetrics and Gynecology
A Practical Guide to Real-Time Office Sonography in Obstetrics and Gynecology A Practical Guide to Real-Time Office Sonography in Obstetrics and Gynecology Robert V. Giglia, R. T., R.D.M.S. Kara L. Mayden,
More informationDifferential Diagnosis of Movement Disorders in Clinical Practice
Differential Diagnosis of Movement Disorders in Clinical Practice Abdul Qayyum Rana Peter Hedera Differential Diagnosis of Movement Disorders in Clinical Practice Abdul Qayyum Rana Parkinson's Clinic
More informationContributions to Lexical Semantics
Right Hemisphere Contributions to Lexical Semantics Edited by Christine Chiarello With 25 Figures Springer-Verlag Berlin Heidelberg New York London Paris Tokyo CHRISTINE CHIARELLO, Ph. D. Syracuse University
More informationMR Mammography (MRM) Werner A. Kaiser. Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Werner A. Kaiser MR Mammography (MRM) With 648 Figures and 25 Tables Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Priv.-Doz., Dr. med., Dipl.-Chem. Werner
More informationGeorge R. Honig Junius G. Adams III. Human Hemoglobin. Genetics. Springer-Verlag Wien New York
George R. Honig Junius G. Adams III Human Hemoglobin Genetics Springer-Verlag Wien New York George R. Honig, M.D., Ph.D. Professor and Head Department of Pediatrics, College of Medicine University of Illinois
More informationAtlas of Bone Scintigraphy in the Developing Paediatric Skeleton
Klaus Hahn Sibylle Fischer Isky Gordon Atlas of Bone Scintigraphy in the Developing Paediatric Skeleton The Normal Skeleton, Variants and Pitfalls In Collaboration with J. Guillet, A. Piepsz, I. Roca and
More informationWerner Glinz. Chest Trauma. Diagnosis and Management. With 133 Figures
Werner Glinz Chest Trauma Diagnosis and Management With 133 Figures Springer-Verlag Berlin Heidelberg New York 1981 Priv.-Doz. Dr. WERNER GLINZ Universitatsspital ZUrich Chirurgische Klinik B RamistraBe
More informationDeath Threats and Violence
Death Threats and Violence Stephen J. Morewitz Death Threats and Violence New Research and Clinical Perspectives Stephen J. Morewitz San Francisco, California Tarzana, California Buffalo Grove, Illinois
More informationSPRINGER BRIEFS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. Gerhard Bauer Joseph S. Anderson. Gene Therapy for HIV From Inception to a Possible Cure
SPRINGER BRIEFS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY Gerhard Bauer Joseph S. Anderson Gene Therapy for HIV From Inception to a Possible Cure 123 SpringerBriefs in Biochemistry and Molecular Biology For
More informationProgress in Social Psychiatry in Japan
Progress in Social Psychiatry in Japan Yoshibumi Nakane Progress in Social Psychiatry in Japan An Approach to Psychiatric Epidemiology Yoshibumi Nakane Department of Neuropsychiatry Nagasaki University
More informationExercises in Radiological Diagnosis
Exercises in Radiological Diagnosis Michel Runge Bones and Joints 170 Radiological Exercises for Students and Practitioners With 407 Illustrations Springer-Verlag Berlin Heidelberg New York London Paris
More informationHormonal Regulation of Fluid and Electrolytes. Environmental Effects
Hormonal Regulation of Fluid and Electrolytes Environmental Effects Hormonal Regulation of Fluid and Electrolytes Environmental Effects Edited by John R. Claybaugh TripIer Army Medical Center, Hawaii and
More informationThe Cleveland Clinic Manual of Dynamic Endocrine Testing
The Manual of Dynamic Endocrine Testing Ahmet Bahadir Ergin A. Laurence Kennedy Manjula K. Gupta Amir H. Hamrahian The Manual of Dynamic Endocrine Testing Ahmet Bahadir Ergin Department of Endocrinology,
More informationZayas, Functionality of Proteins in Food
Zayas, Functionality of Proteins in Food Springer-Verlag Berlin Heidelberg GmbH Joseph F. Zayas Functionality of Proteins in Food Wit h 86 Figures and 21 Tables Springer Prof. Dr. Joseph F. Zayas t Kansas
More informationWater-soluble Vitamin Assays in Human Nutrition
Water-soluble Vitamin Assays in Human Nutrition Water-soluble Vitamin Assays in Human Nutrition G.F.M. Ball SPRINGER-SCIENCE+BUSINESS MEDIA, B.V. First edition 1994 1994 Springer Science+Business Media
More informationTHE RELEVANCE OF SOCIAL SCIENCE FOR MEDICINE
THE RELEVANCE OF SOCIAL SCIENCE FOR MEDICINE CULTURE, ILLNESS, AND HEALING Studies in Comparative Cross-Cultural Research Editor-in-Chief: ARTHUR KLEINMAN University of Washington, Seattle, Washington,
More informationEvidence-Based Forensic Dentistry
Evidence-Based Forensic Dentistry Balwant Rai Jasdeep Kaur Evidence-Based Forensic Dentistry Authors Balwant Rai Earth and Life Sciences Vrije Universiteit Amsterdam and ILEWG Amsterdam The Netherlands
More informationPSYCHIATRIC CONSEQUENCES OF BRAIN DISEASE IN THE ELDERLY. A Focus on MANAGEMENT
PSYCHIATRIC CONSEQUENCES OF BRAIN DISEASE IN THE ELDERLY A Focus on MANAGEMENT PSYCHIATRIC CONSEQUENCES OF BRAIN DISEASE IN THE ELDERLY A Focus on MANAGEMENT Edited by David K. Conn Bayerest Centre for
More informationNeurobiological Bases of Abnormal Aggression and Violent Behaviour
Neurobiological Bases of Abnormal Aggression and Violent Behaviour . József Haller Neurobiological Bases of Abnormal Aggression and Violent Behaviour József Haller Department of Behavioral Neurobiology
More informationErin Lawson Mark S. Wallace Editors. Fibromyalgia. Clinical Guidelines and Treatments
Fibromyalgia Erin Lawson Mark S. Wallace Editors Fibromyalgia Clinical Guidelines and Treatments Editors Erin Lawson, MD Voluntary Faculty Department of Anesthesiology Center for Pain Medicine University
More informationEsthetic and Functional Management of Diastema
Esthetic and Functional Management of Diastema Ugur Erdemir Esra Yildiz Editors Esthetic and Functional Management of Diastema A Multidisciplinary Approach Editors Ugur Erdemir Faculty of Dentistry University
More informationTransesophageal Echocardiography
N. Kolev, G. Huemer, M. Zimpfer Transesophageal Echocardiography A New Monitoring Technique Springer-Verlag Wien New York Nikolai Kolev, MD, FACC Research Cardiologist Associate in Anesthesia and Consultant
More informationThe Psychology of Physical Symptoms
The Psychology of Physical Symptoms James W. Pennebaker The Psychology of Physical Symptoms Springer-Verlag New York Heidelberg Berlin James W. Pennebaker Department of Psychology Gilmer Hall University
More informationIn Clinical Practice
In Clinical Practice Taking a practical approach to clinical medicine, this series of smaller reference books is designed for the trainee physician, primary care physician, nurse practitioner and other
More informationAbnormal Female Puberty
Abnormal Female Puberty Heather L. Appelbaum Editor Abnormal Female Puberty A Clinical Casebook Editor Heather L. Appelbaum, MD Department of Obstetrics and Gynecology Hofstra Northwell School of Medicine
More informationEfim Benenson. Rheumatology. Clinical Scenarios. Syndrome or disease?
Rheumatology Efim Benenson Rheumatology Clinical Scenarios Syndrome or disease? Author Efim Benenson, MD Professor of Medicine Department of Internal Medicine University of Cologne Cologne Germany The
More informationNeurosonography of the Pre-Term Neonate
Neurosonography of the Pre-Term Neonate Neurosonography of the Pre-Term Neonate Edited by Edward G. Grant With Contributions by James D. Richardson, Dieter Schellinger, Yolande F. Smith, K.N. Siva Subramanian,
More informationClinical In Vitro Fertilization
Clinical In Vitro Fertilization Edited by Carl Wood and Alan Trounson With 23 Figures Springer-Verlag Berlin Heidelberg New York Tokyo 1984 Carl Wood, CBE, FRCS, FRCOG, FRACOG Chairman Department of Obstetrics
More informationRecent Research in Psychology
Recent Research in Psychology 1.0. Fisher R.C. Silver 1.M. Chinsky B. Goff Y. Klar Evaluating a Large Group Awareness Training A Longitudinal Study of Psychosocial Effects Springer-Verlag New York Berlin
More informationEditors: A. Brodal, Oslo W. Hild, Galveston. 1. van Limborgh, Amsterdam R. Ortmann, Koln T.H. Schiebler, Wurzburg G. Tondury, Zurich E.
Advances in Anatomy, Embryology and Cell Biology Ergebnisse der Anatomie und Entwicklungsgeschichte Revues d'anatomie et de morphologie experimentale Vol. 54. Fasc. 3 Editors: A. Brodal, Oslo W. Hild,
More informationUpdate in Heart Valve Replacement
Update in Heart Valve Replacement D. Horstkotte and F. Loogen (Eds.) Update in Heart Valve Replacement Proceedings of the Second European Symposium on the St. Jude Medical Heart Valve Springer-Verlag Berlin
More informationLatest Achievements of Diabetes Research Reviewed Contents of 1984's Major Diabetes Congresses
Latest Achievements of Diabetes Research Reviewed Contents of 1984's Major Diabetes Congresses Frontiers in Diabetes Vol. 7 Series Editor F. Belfiore, Catania karger s. Karger Basel Munchen Paris London
More informationFerrozzi. Garlaschi. Bova CT of Metastases
Ferrozzi. Garlaschi. Bova CT of Metastases Springer Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Singapore Tokyo F. Ferrozzi. G. Garlaschi. D. Bova CT of Metastases With a Foreword
More informationCerebral Blood Flow, Metabolism, and Head Trauma
Cerebral Blood Flow, Metabolism, and Head Trauma Christian W. Kreipke Editors Jose A. Rafols Cerebral Blood Flow, Metabolism, and Head Trauma The Pathotrajectory of Traumatic Brain Injury Editors Christian
More informationFrozen Section Library Series Editor Philip T. Cagle, MD Houston, Texas, USA
Frozen Section Library Series Editor Philip T. Cagle, MD Houston, Texas, USA For further volumes, go to http://www.springer.com/series/7869 Frozen Section Library: Central Nervous System Richard A. Prayson
More informationBioavailability and Analysis of Vitamins in Foods
Bioavailability and Analysis of Vitamins in Foods JOIN US ON THE INTERNET VIA WWW, GOPHER, FTP OR EMAIL: WWW: http://www.thomson.com GOPHER: gopher.thomson.com FTP: ftp.thomson.com EMAIL: findit@kiosk.thomson.com
More informationAbout the Authors. Advances in Psychotherapy Evidence-Based Practice
Heart Disease About the Authors Judith A. Skala, RN, PhD, is a Research Instructor in the Department of Psychiatry at Washington University School of Medicine in St. Louis, MO, and an Instructor in Health
More informationThe Linear Regression Model Under Test
Walter Kramer Harald Sonnberger The Linear Regression Model Under Test Physica-Verlag Heidelberg Wien Professor Dr. WALTER KRAMER, Fachbereich Wirtschaftswissenschaften, UniversWit Hannover, Wunstorfer
More informationECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION
ECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION ECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION by Fred Kusumoto, MD Electrophysiology and Pacing Service Division of Cardiovascular
More informationInteraction Between. Mental and Physical. Needed Areas of Research. Edited by R. Ohman H. L. Freeman A. Franck Holmkvist S.
Interaction Between Mental and Physical Illness Needed Areas of Research Edited by R. Ohman H. L. Freeman A. Franck Holmkvist S. Nielzen In Collaboration with Members of the EMRC Study Group on Mental
More informationQuality Assurance Program on Stereotactic Radiosurgery
Quality Assurance Program on Stereotactic Radiosurgery Springer Berlin Heidelberg New York Barcelona Budapest Hong Kong London Milan Paris Tokyo Gunther H. Hartmann Quality Assurance Program on Stereotactic
More informationUrolithiasis: Etiology Diagnosis. Hans-Joachim Schneider. M.Peacock W. G. Robertson H.-J. Schneider W. Vahlensieck
Urolithiasis: Etiology Diagnosis Edited by Hans-Joachim Schneider Contributions by M.Peacock W. G. Robertson H.-J. Schneider W. Vahlensieck With 168 Figures Springer-Verlag Berlin Heidelberg New York Tokyo
More informationSmall Supernumerary Marker Chromosomes (ssmc)
Small Supernumerary Marker Chromosomes (ssmc) . Thomas Liehr Small Supernumerary Marker Chromosomes (ssmc) A Guide for Human Geneticists and Clinicians With contributions by Unique (The Rare Chromosome
More informationSix Group Therapies SAMUEL LONG. Edited by. Springer Science+Business Media, LLC. Empire Slale Poll, Inc. New York, New York
Six Group Therapies Six Group Therapies Edited by SAMUEL LONG Empire Slale Poll, Inc. New York, New York Springer Science+Business Media, LLC Six group therapies. Library of Congress Cataloging in Publication
More informationDisorders of the Human Adrenal Cortex
Disorders of the Human Adrenal Cortex Endocrine Development Vol. 13 Series Editor P. Mullis Bern Disorders of the Human Adrenal Cortex Volume Editors Christa E. Flück Bern Walter L. Miller San Francisco,
More informationLang, Ophthalmology, 2nd. Ed All rights reserved. Usage subject to terms and conditions of license.
I III Ophthalmology A Pocket Textbook Atlas Gerhard K. Lang, MD Professor and Chairman University Eye Hospital Ulm, Germany With contributions by Oskar Gareis, Gabriele E. Lang, Doris Recker, Peter Wagner
More informationMEDICAL RADIOLOGY Diagnostic Imaging
I MEDICAL RADIOLOGY Diagnostic Imaging Editors: A. L. Baert, Leuven K. Sartor, Heidelberg II Contents Springer Berlin Heidelberg New York Hong Kong London Milan Paris Tokyo III A. Adam R. F. Dondelinger
More informationEmpathy and Counseling
Empathy and Counseling Gerald A Gladstein and Associates Empathy and Counseling Explorations in Theory and Research With Contributions by John Brennan, JoAnn Feldstein, Gerald A Gladstein, Mary Anna Ham,
More informationClinical Anatomy. of the Eye SECOND EDITION
Clinical Anatomy of the Eye SECOND EDITION, ~ Clinical Anatomy of he Eye SECOND EDITION RichardS. Snell, M.D., Ph.D. Emeritus Professor of Anatomy, The George Washington School of Medicine and Health Sciences,
More informationDecoding Your Thyroid Tests and Results
Decoding Your Thyroid Tests and Results Wondering about your thyroid test results? Learn about each test and what low, optimal, and high results may mean so you can work with your doctor to choose appropriate
More informationThe Use and Misuse of. Sleeping Pills. -A Clinical Guide-
The Use and Misuse of Sleeping Pills -A Clinical Guide- Head of Hypnos (Photograph courtesy of the British Museum) The Use and Misuse of Sleeping Pills --A Clinical Guide-- Wallace B. Mendelson, M. D.
More informationCone Beam CT of the Head and Neck
Cone Beam CT of the Head and Neck Chung How Kau Kenneth Abramovitch Sherif Galal Kamel Marko Bozic Cone Beam CT of the Head and Neck An Anatomical Atlas Professor Chung How Kau University of Alabama Birmingham
More informationClinician s Manual on Restless Legs Syndrome
Clinician s Manual on Restless Legs Syndrome Mark J. Buchfuhrer Clinician s Manual on Restless Legs Syndrome Second Edition Mark J. Buchfuhrer PIH Health Hospital - Downey Downey, CA USA ISBN 978-3-319-31372-6
More informationNATHAN D. SCHULTZ, MD ALLAN V. GIANNINI, MD TERRANCE T. CHANG, MD AND DIANE C. WONG I THIRD EDITION I SPRINGER SCIENCE+BUSINESS MEDIA, LLC
The Best Guide to Allergy NATHAN D. SCHULTZ, MD ALLAN V. GIANNINI, MD TERRANCE T. CHANG, MD AND DIANE C. WONG I THIRD EDITION I * SPRINGER SCIENCE+BUSINESS MEDIA, LLC Dedication We dedicate this book to
More informationPrevention of Skin Cancer
Prevention of Skin Cancer Cancer Prevention Cancer Causes Volume 3 Prevention of Skin Cancer Edited by David Hill, Ph.D. Centre for Behavioural Research in Cancer, The Cancer Council Victoria, Melbourne,
More informationHeart Failure in Congenital Heart Disease
Heart Failure in Congenital Heart Disease Robert E. Shaddy (Editor) Heart Failure in Congenital Heart Disease From Fetus to Adult Editor Robert E. Shaddy The Children s Hospital of Philadelphia School
More informationChronic Pain. For other titles published in this series, go to
Chronic Pain For other titles published in this series, go to www.springer.com/series/7633 Dawn A. Marcus, M.D. Chronic Pain A Primary Care Guide to Practical Management Second Edition Dawn A. Marcus,
More informationTherapeutic Angiography
Therapeutic Angiography Edited by C. A. Athanasoulis H. L. Abrams E. Zeitler Contributors K. Amplatz. K.H. Barth J.J. Bookstein. D.e. Brewster V.P. Chuang A.M. Cohen R.F. Colapinto. A.B. Co simi. N.P.
More informationVasilis Vasiliou. Q. Max Guo. Alcohol and Cancer
Alcohol and Cancer Samir Zakhari Editors Vasilis Vasiliou Q. Max Guo Alcohol and Cancer Editors Samir Zakhari, Ph.D. Director Division of Metabolism and Health Effects National Institute on Alcohol Abuse
More informationNew Results. in Depression Research. Edited by H. Hippius. G. L. Klerman. N. Matussek With the Assistance of M. Schmauss
New Results in Depression Research Edited by H. Hippius. G. L. Klerman. N. Matussek With the Assistance of M. Schmauss With 68 Figures Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Professor
More informationSpringerBriefs in Cancer Research
SpringerBriefs in Cancer Research For further volumes: http://www.springer.com/series/10786 Natalia Aptsiauri Angel Miguel Garcia-Lora Teresa Cabrera MHC Class I Antigens In Malignant Cells Immune Escape
More information