Energy Balance" Outline" Comfort and health" Comfort and health: conflicting?" To comfort or not to comfort! Comfort" Health"
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1 To comfort or not to comfort Wouter van Marken Lichtenbelt Dept. Human Biology Healthy Buildings Eindhoven May 18-20, 2015 Energy Balance Outline Current models Living outside thermoneutral zone Temperature and health: acclimatization Cold acclimation, energy expenditure, insulin sensitivity, comfort Heat acclimation, energy expenditure, comfort Interaction with other senses Light Implications for modeling 3 4 Comfort and health: conflicting? Comfort and health Comfort Comfortable conditions satisfy optimal human condition in natural environment (e.g. energy savings) Drives human (thermal) behavior Health Slight discomfort Food Physical activity (Thermal) environment Increase resilience to uncomfortable conditions Increase energy metabolism 5 6
2 Built environment conventional model (Fanger) Adaptive comfort model Based on the physics of heat transfer. Limited inclusion of human physiology. Limited validity on individual level. Valid in steady state situations. Has led to tightly controlled indoor temperatures with minor seasonal and daily fluctuations. Indoor temperature ( C) Adaptive model Conventional model Outdoor temperature ( C) Fanger, Danish Techn Press 1970 Humphreys et al., Energy and Buildings 2007; De Dear et al., Energy and Buildings 2001 Include health Suggested model improvements Thermoregulation Heat loss Energy metabolism Glucose and lipid metabolism Cardiovascular Resilience to cold and heat (winter/summer mortality) Include thermal physiology Include individual variation (body composition; acclimatization) Include specific groups Obese; elderly; females 9 Thermoneutral zone Thermoneutral zone in humans heat production Comfort zone C ambient temperature mild cold van Marken Lichtenbelt and Kingma 2013
3 Metabolic Research Unit Maastricht (MRUM) Energy expenditure/thermoregulation: Indirect calorimetry Wireless thermometry Skin blood flow Maastricht Respiration Chambers Mild cold: nonshivering thermogenesis Non-shivering Brown fat shivering Skeletal muscle Short term (3 hour) mild cold (15 C) exposure EE (kj/min) 5.4 Thermo- 5.3 neutral Mild cold NST up to 30 % of RMR Large individual variation time (h) NST (%) Van Ooijen et al. Br J Nutr 2005 Van Ooijen et al. Physiol & Behav 2004 Brown fat White fat
4 Combining metabolic studies and PET/CT scans Brown fat activity Thermoneutral versus cold 24 male subjects (age:18-32 y; BMI kg/m 2 ) Thermoneutral 1h (22 C); mild cold 2h (16 C) Thermoneutral Mild cold 19 Van Marken Lichtenbelt et al., NEJM Brown Fat activity inversely related to body fat Summary Brown adipose (BAT) tissue in adults BAT activity is related to thermogenesis BAT is blunted or absent compared to lean young adults (in line with results on thermogenesis) in: obese elderly type2 diabetes Van Marken Lichtenbelt et al., NEJM 2009 Vijgen et al. PlosONE (mild) cold acclimation Cold acclimation experiment in lean young adults 9 females; 8 males 10 day cold exposure 6 h/d C 23 Van der Lans,JCI 2013
5 Cold acclimatization Cold acclimatization Increase in energy expenditure (NST) Increase brown fat No gender differences * * before after Van der Lans, Van der Lans et al. JCI 2013 Cold acclimation experiment in diabetes type 2 8 male patients T2D (age 59.3±5.8 y, BMI 29.8±3.2 kg/m 2 ) 10 day cold exposure 6 h/d C hyperinsulinemic-euglycemic clamp Thermal comfort increase after cold acclimation (10 day, 6 h/d, 15 C) before after comfortable just comfortable just uncomfortable uncomfortable Van der Lans et al. JCI 2013 Hanssen et al., Nature Med accepted Hanssen et al. Nature Med 28 Summary cold acclimation Heat acclimation Increase brown adipose tissue and energy expenditure in healthy lean young subjects Significant increases insulin sensitivity in type2 diabetes Increase thermal comfort To study thermoregulatory behavior and thermo-physiology before and after mild heat acclimation - 22 lean subjects - 7 day heat acclimation (.5 h/d; 33 C) - behavior assessment and thermoneutral zone 29 Pallubinsky et al. 30
6 Thermoneutral zone in humans Example effect heat acclimation Increase thermal comfort Relative energy expenditure before heat Aacclimation very comfortable comfortable just comfortable just uncomfortable uncomfortable 0.5 very uncomfortable after Temperature heat Bacclimation in C TNZcool TNZwarm 2.0 very comfortable thermal comfort TNZcold thermal comfort TNZwarm T = 10 C/h Relative energy expenditure comfortable just comfortable just uncomfortable uncomfortable Schellen et al. in prep. 0.5 very uncomfortable Temperature in C TNZcold TNZwarm thermal comfort TNZcold thermal comfort TNZwarm Comfort zone before and after (mild) cold/heat acclimation Light, thermal physiology and comfort heat production Comfort zone unacclimated Cold acclimation Heat acclimation C ambient temperature Poster: Marije te Kulve: poster 444 session 4 13:30h 34 Light, thermal physiology and comfort Body composition and heat balance Poster: Marije te Kulve: poster 444 session 4 13:30h 35 Savastano et al., AJCN 2009
7 Modeling the thermoneutral zone Modeling the thermoneutral zone and comfort Comfort zone Boris Kingma: oral 512 tomorrow 9:30 h Boris Kingma: oral 512 tomorrow 9:30 h future thermal comfort models Healthy thermal environment Include physiology (body composition) Take individual differences into account Include dynamic indoor environment Optimal comfort NOT maximal comfort Include health Include other environmental factors light/noise Need to exercise our thermoregulatory system as part of a healthy lifestyle (use it or lose it ) By regular exposure outside the thermoneutral zone: Increase energy expenditure and brown adipose tissue Increase insulin sensitivity Increase resilience to more extreme weather conditions (important for healthy aging) 40 Temperature training Allowing indoor temperatures to drift may be healthy and contribute to a sustainable built environment: less (fossil) energy consumption Lifestyle programs: diet, physical activity in a healthy environment taking into account individual differences Thanks to: Peter Op t Veld Luc Schlangen Boudewijn Brans Patrick Schrauwen Boris Kingma Lisje Schellen Hannah Pallubinsky Marije te Kulve Maarten Vosselman Anouk van der Lans Evie Broeders Mark Hanssen Nicole Bouvy Roel Wierts Jaap Teule Funded by NOW ZonMW TOP RVO: INTEWON EOS LT10033 DIABAT - HEALTH-F RVO: TKI Energo STW-Philips partnership Department
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