LoGiCal and Cerilliant

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1 LoGiCal and Two independent sources Reference materials 2017 Quality ISO 9001 ISO/IEC ISO Guide 34 GMP/GLP ISO ISO/IEC 17043

2 Science for a safer world Reference standards from two independent ISO Guide 34 reference material producers: LoGiCal and reference materials. a global leader in measurement standards, reference materials, laboratory services and proficiency testing. With 2,600 professionals working in 21 countries, our analytical measurement and quality control services are second-to-none. As the global leader, we provide the widest range of reference materials available from any single supplier. When you make a decision using our resources, you can be sure it s based on precise, robust data. And that together, we re creating fairer, safer, more confident societies worldwide. lgcstandards.com Making it easy for you. has brought together this listing to make it simple to order two independent sources of reference materials from one supplier, simplifying ordering and satisfying your accreditation needs. We can provide you with reference standards from two independent ISO Guide 34 reference material producers; our own manufactured the LoGiCal range of drug and metabolite standards and portfolio of reference materials. Ordering both brands from a single source will save you time and reduce your paperwork as you will need only one import license or documentation set. Our LoGiCal range, produced in s laboratories in Germany, offers you a wide selection of drugs of abuse, prescription drugs, metabolites, and stable isotope labelled reference materials. The products are ISO Guide 34 certified solutions and DEA exempt where appropriate. Each product is accompanied by a comprehensive certificate of analysis (CoA). s quality credentials also include accreditations to ISO Guide 34, ISO/IEC and certification to ISO For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 3

3 Certificate of analysis explained All LoGiCal reference materials are accompanied by comprehensive certificates of analysis. These provide a full description of the material to which they relate, and summarise the analyses undertaken during the characterisation process. Our certificates of analysis are prepared in accordance with ISO Guide 31, which specifies the requirements for the description of reference materials and the contents of certificates and labels. Current examples of our certificates of analysis for all products in the LoGiCal range are openly available via the lgcstandards.com website on the relevant product pages. 1 Certificate of Analysis Reference Material - Primary Standard Product Name: Amitriptyline Hydrochloride 1.0 mg/ml in Methanol (as free Catalogue Number: AMP Lot Number: CAS Number: Molecular Formula: C 20 H 23 N HCl Molecular Weight: Product name Including concentration and solvent, where relevant. 2 CAS number The unique identifier assigned by the Chemical Abstracts Service. 3 Molecular weight and molecular formula If the neat material is in salt form these parameters are for the salt not free base. 4 Volume per ampoule All are overfilled to ensure the minimum stated is recoverable. 5 Expiry date Our expiry dates are determined by real time and accelerated stability testing. NOTE 3 6 Quality bar Quality accreditation under which that specific material was produced, not s full scope of quality accreditation. 8 Chemical structure Indicating exact position of isotopic labels and freely downloadable. 9 Long term storage The minimum specified storage requirements and those under which real time stability testing is performed. NOTE1 10 Uncertainty The statistical parameter that is used to describe the possible fluctuation in concentration. NOTE 2 11 Concentration Based on material weighings and purity factor (assay of the neat material). NOTE 4 The NOTES are explained on page 6. Our certificates of analysis are typically 5-10 pages long depending on the presentation of the reference materials. The first pages, described above, summarise the analytical data that follows. 4 5 Solvent: Methanol Volume per Ampoule: Not less than 1 ml 1 Long-term Storage: 2 to 8 C, dark Expiry Date: May-2019 Intended Use: The primary aim of this material is for identification, calibration and quantification. Component Concentration ( free base ) Uncertainty see product name mg/ml 2 11 U = mg/ml 3 10 Uncertainty of the concentration is expressed as an expanded uncertainty in accordance with ISO and Guide 34 at the about 95 % level of confidence using a coverage factor of k = 2 and has been calculated by statistical analysis of our production system and incorporates uncertainty of the purity, material density and balance and weighing technique. Concentration based on material weighings and material purity factor (assay of the neat material). The solution s concentration and homogeneity are verified by independent method. certifies that this standard meets the specification stated in this certificate and warrants this product to meet the stated acceptance criteria through the retest date when stored unopened as recommended. Product should be used shortly after opening to avoid concentration changes due to evaporation. Warranty does not apply to ampoules stored after opening. Release Date: Luckenwalde, June Signed: Dr. Sabine Schröder Unit for Reference Materials 1 Ampoules are overfilled to ensure a minimum 1 ml volume fill. We advise laboratories to use measured volumes of this standard solution before diluting to the desired concentration. 2 The value is based on the results of analytical techniques, which calibration and verification was carried out with standards traceable to SI-units. The value is expressed on a "free base" basis. The concentration with its uncertainty is valid in the range between 19 C and 25 C. The identity is verified by data from international scientific literature. Gravimetrically prepared using qualified balances calibrated annually by accredited calibration service. Calibration verification performed daily prior to use utilizing weights traceable to SI via other mass standards. 3 The uncertainty U is the expanded uncertainty estimated in accordance with the Guide to the Expression of Uncertainty in Measurement (GUM). It is corresponding to a level of confidence of about 95 %. Standard uncertainties are indicated with u. 7 Catalogue number AMP prefix for solutions and FOR for powders. 6 GmbH, Im Biotechnologiepark, TGZ II, D Luckenwalde, Germany 9 pages 2012 limited. All rights reserved. Standards is part of the Group. LoGiCal is a registered trademark of Standards GmbH 4 For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 5

4 Certificate of analysis explained 1 Concentration as is If the neat material is in salt form the concentration of the salt is also provided. 2 Verification of concentration Depending on the analyte, the concentration is verified by an appropriate technique such as GCMS or HPLC. 3 Identity We use a range of analytical techniques to confirm the identity of our reference substance (neat material); 1H-NMR, MS, IR, HPLC-DAD, GC. 4 Purity Purity testing is performed by HPLC or GC, water content is evaluated by Coulometric Karl Fischer titration, and residual solvent by 1H-NMR. 5 Homogeneity Homogeneity is assured by validated procedures, including ampoulation, and is verified by HPLC. 6 Physical properties Where other physical properties are known then we also use these as an identity check (e.g. melting point, appearance, and polarimetry). 7 Absolute methods We use elemental analysis (carbon titration) and/ or quantitative NMR in the characterisation of our reference materials. NOTE 1: Long term storage Unless otherwise stated, storing reference materials in pure organic solvent at temperatures below those specified is not detrimental. Some analytes may come out of solution at lower temperatures and so the reference material should be warmed to room temperature and mixed prior to use. Products in aqueous solvent should not be stored at temperatures below 0 o C unless explicitly stated. NOTE 2: Uncertainty In accordance with the Guide to the Expression of Uncertainty in Measurement (GUM), our certificates of analysis list the expanded concentration uncertainty at the about 95 % level of confidence using a coverage factor of k = 2. They incorporate uncertainty of the purity, material density and balance and weighing technique. Our concentration uncertainties are valid in the range between 19 C and 25 C. NOTE 3: Expiry Date (Retest date) We run accelerated stability studies backed up with additional stability testing at regular time points after initial production real time stability tests. From the data obtained during these investigations, we determine the ideal long-term storage conditions of our reference materials. Additionally the stability of every lot is regularly investigated through a routine quality control testing program. These results can be used to reassign expiry dates and on occasion may lead to changes in the storage temperature. NOTE 4: Concentration The concentration is based on gravimetric material weighings using weights traceable to SI units - and material purity factor (assay of the neat material). The concentration listed is as is for neat materials or free base/acid for salt forms, meaning no further correction is required Additional information Concentration ( as is ) mg/ml Verification of Concentration and Homogeneity Lot Number Verified Concentration (mg/ml) Result Acceptance Criteria % RSD - Homogeneity Result Acceptance Criteria ± 3 % % Concentration verified by HPLC Solution Standard Assay Parameters External Calibration (100 % amount) Analysis Method HPLC Column: Hypersil Gold (C18), 5 µm, 150 x 4.6 mm Number of Measurements: 6 Injector: Auto; 1.5 µl; 1.0 mg/ml in Methanol Flow: 1.0 ml/min, 40 C Detector: 220 nm Conditions: mob. Phase A: Water % H 3 PO 4, mob. Phase B: % H 3 PO min A/B 70/30, min A/B to 30/70, min A/B to 70/30, min A/B 70/30 (v/v) Neat Material Data Product Name: Amitriptyline Hydrochloride CAS Number: Molecular Formula: C 20 H 23 N HCl Molecular Weight: Compound Lot: Test Method Result Melting Point (DSC) ( C)* SOP C 1 H-NMR Spectrum* SOP conform / complies to structure IR Spectrum* SOP conform / complies to structure Mass Spectrum (ESI)* SOP conform / complies to structure Assay by carbon titration (free * Elementary Analysis % The expanded uncertainty according to the assay is U = 0.41 % (about 95 % level of confidence using a coverage factor of k = 2). Assay by carbon titration ( as is )* % *: Validated method performed by ISO/IEC accredited testing lab The assay of the neat material is verified by the 100 % method using HPLC, corrected with water (KFT) and residual solvents AMP Lot Number GmbH, Im Biotechnologiepark, TGZ II, D Luckenwalde, Germany page 2/ limited. All rights reserved. Standards is part of the Group. LoGiCal is a registered trademark of Standards GmbH 6 For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 7

5 Acetylcodeine 1.0 mg/ml in AMP CERA Acetylmorphine 0.1 mg/ml in AMP CERA Acetylmorphine 1.0 mg/ml in AMP CERA Acetylmorphine-D mg/ml in AMP CERA Acetylmorphine-D mg/ml in AMP CERA-010 Alprazolam 1.0 mg/ml in Methanol AMP CERA-903 Alprazolam-D5 0.1 mg/ml in Methanol AMP CERA-902 Alprazolam-D mg/ml in Methanol AMP CERA-910 Amiodarone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERA Aminoclonazepam 0.1 mg/ml in AMP CERA Aminoclonazepam 1.0 mg/ml in AMP CERA Aminoclonazepam-D4 0.1 mg/ml in AMP CERA Aminoflunitrazepam 0.1 mg/ml in AMP CERA Aminoflunitrazepam 1.0 mg/ml in AMP CERA Aminoflunitrazepam-D7 0.1 mg/ml in AMP CERA Aminoflunitrazepam-D7 1.0 mg/ml in AMP CERA Aminonitrazepam 0.1 mg/ml in AMP CERA Aminonitrazepam 1.0 mg/ml in AMP CERA-913 Amitriptyline Hydrochloride 1.0 mg/ml in Methanol (as free Amitriptyline-D3 Hydrochloride 0.1 mg/ml in Methanol (as free AMP AMP CERA-923 CERA-085 Amobarbital 1.0 mg/ml in Methanol AMP CERA-020 rac-amphetamine 1.0 mg/ml in Methanol AMP CERA-007 rac-amphetamine-d 5 Hydrochloride (D-label on ring) 0.1 mg/ ml in Methanol (as free rac-amphetamine-d 5 Hydrochloride (D-label on side chain) 0.1 mg/ml in Methanol (as free rac-amphetamine-d 5 Hydrochloride (D-label on side chain) 1.0 mg/ml in Methanol (as free rac-amphetamine-d 6 Hydrochloride 0.1 mg/ml in Methanol (as free rac-amphetamine-d 6 Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP AMP AMP CERA-002 CERA-005 CERA-013 CERA-044 CERA-045 rac-amphetamine-d 8 Hydrochloride 0.1 mg/ml in Methanol (as free rac-amphetamine-d8 Hydrochloride 1.0 mg/ml in Methanol (as free rac-amphetamine-d 10 Hydrochloride 0.1 mg/ml in Methanol (as free rac-amphetamine-d 11 Hydrochloride 0.1 mg/ml in Methanol (as free rac-amphetamine-d 11 Hydrochloride 1.0 mg/ml in Methanol (as free (S)-(+)-Amphetamine (Dextroamphetamine) 1.0 mg/ml in Methanol Androstanolone (5α-Dihydrotestosterone; Stanolone) 1.0 mg/ ml in Androstenedione (Androst-4-ene-3,17-dione) 1.0 mg/ml in Anhydroecgonine Hydrochloride 1.0 mg/ml in Water (as free AMP AMP AMP AMP AMP AMP AMP AMP AMP CERA-017 CERA-018 CERA-038 CERA-016 CERA-019 CERA-008 CERD-073 CERA-075 CERA-036 Anhydroecgonine Methyl Ester 1.0 mg/ml in AMP CERA APB HCl (1-Benzofuran-5-ylpropan-2-amine Hydrochloride; 5-(2-Aminopropyl)benzofuran Hydrochloride) 1.0 mg/ml in Methanol (as free 6-APB HCl (1-Benzofuran-6-ylpropan-2-amine Hydrochloride; 6-(2-Aminopropyl)benzofuran Hydrochloride) 1.0 mg/ml in Methanol (as free AMP AMP CERA-104 CERA-103 Aripiprazole 1.0 mg/ml in AMP CERA-080 Asenapine Maleate 1.0 mg/ml in Methanol (as free AMP CERA-101 Atenolol 1.0 mg/ml in AMP CERA-072 Atomoxetine Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERA-095 Atropine 1.0 mg/ml in AMP CERA-046 Baclofen 0.5 mg/ml in Methanol AMP CERB-048 rac-bdb HCl (rac-3,4-methylenedioxyphenyl-2-butanamine Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERB-016 Benzoylecgonine 0.1 mg/ml in Methanol AMP CERB-007 Benzoylecgonine 1.0 mg/ml in Methanol AMP CERB-004 Benzoylecgonine-D3 0.1 mg/ml in Methanol AMP CERB For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 9

6 Benzoylecgonine-D3 1.0 mg/ml in Methanol AMP CERB-008 Benzoylecgonine-D8 0.1 mg/ml in Methanol AMP CERB-013 Benzoylecgonine-D8 1.0 mg/ml in Methanol AMP CERB-014 Benzylpiperazine Dihydrochloride (BZP Dihydrochloride) 1.0 mg/ml in Methanol (as free AMP CERB-906 Boldenone 1.0 mg/ml in AMP CERB-042 Bromazepam 1.0 mg/ml in Methanol AMP CERB-903 Brompheniramine Maleate 1.0 mg/ml in Methanol (as free AMP CERB-043 Bufotenine 1.0 mg/ml in AMP CERB-022 Buphedrone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERB-047 Buprenorphine 0.1 mg/ml in Methanol AMP CERB-902 Buprenorphine 1.0 mg/ml in Methanol AMP CERB-044 Buprenorphine 3-β-D-Glucuronide 0.1 mg/ml in Methanol AMP CERB-035 Bupropion Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERB-034 Buspirone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERB-054 Butorphanol Tartrate 1.0 mg/ml in Methanol (as free AMP CERB-037 Butylone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERB-045 γ-butyrolactone (GBL) 1.0 mg/ml in AMP CERB-018 Caffeine 1.0 mg/ml in Methanol AMP CERC-051 Camfetamine Hydrochloride (N-Methyl-3-phenylnorbornan-2- amine Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERC-127 Cannabinol 1.0 mg/ml in Methanol AMP CERC-046 (-)-Cannabidiol 1.0 mg/ml in Methanol AMP CERC-045 Carbamazepine 1.0 mg/ml in Methanol AMP CERC-053 Carbamazepine 10,11-Epoxide 1.0 mg/ml in AMP CERC-121 (R)-(+)-Cathinone Hydrochloride 1.0 mg/ml in Methanol (as free (S)-(-)-Cathinone Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP CERC-028 CERC-019 Chlordiazepoxide 1.0 mg/ml in Methanol AMP CERC-022 Chlorphenamine Maleate (Chlorpheniramine Maleate) 1.0 mg/ ml in Methanol (as free AMP CERC-036 Chlorphenamine-D6 Maleate (Chlorpheniramine-D6 Maleate) 0.1 mg/ml in Methanol (as free Chlorpromazine Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP CERC-086 CERC-904 Chlorpromazine-D3 0.1 mg/ml in Methanol AMP CERC-902 Chlorzoxazone 1.0 mg/ml in AMP CERC-074 Citalopram Hydrobromide 0.1 mg/ml in Methanol (as free Citalopram Hydrobromide 1.0 mg/ml in Methanol (as free Citalopram-D6 Hydrobromide 0.1 mg/ml in Methanol (as free Clenbuterol Hydrochloride 1.0 mg/ml in Dimethyl Sulfoxide (as free AMP AMP AMP AMP CERC-057 CERC-095 CERC-090 CERC-080 Clobazam 1.0 mg/ml in Methanol AMP CERC-909 Clomipramine Hydrochloride 1.0 mg/ml in Methanol (as free Clomipramine-D3 Hydrochloride 0.1 mg/ml in Methanol (as free AMP AMP CERC-118 CERC-116 Clonazepam 1.0 mg/ml in Methanol AMP CERC-907 Clonazepam-D4 0.1 mg/ml in Methanol AMP CERC-905 Clonidine Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERC-033 Clozapine 1.0 mg/ml in AMP CERC-059 Clozapine-D4 0.1 mg/ml in Methanol AMP CERC-091 Cocaethylene (Benzoylethylecgonine) 1.0 mg/ml in AMP CERC-010 Cocaethylene-D3 (Benzoylethylecgonine-D3) 0.1 mg/ml in Cocaethylene-D8 (Benzoylethylecgonine-D8) 0.1 mg/ml in AMP AMP CERC-009 CERC-024 Cocaine 1.0 mg/ml in AMP CERC-008 Cocaine-D3 0.1 mg/ml in AMP CERC-004 Cocaine-D3 1.0 mg/ml in AMP CERC-014 Codeine 0.1 mg/ml in Methanol AMP CERC-015 Codeine 1.0 mg/ml in Methanol AMP CERC-006 Codeine 6-β-D-Glucuronide 0.1 mg/ml in Water AMP CERC For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 11

7 Codeine 6-β-D-Glucuronide 1.0 mg/ml in Water AMP CERC-126 Codeine-D3 0.1 mg/ml in Methanol AMP CERC-005 Codeine-D3 1.0 mg/ml in Methanol AMP CERC-007 Codeine-D6 0.1 mg/ml in Methanol AMP CERC-040 Codeine-D6 1.0 mg/ml in Methanol AMP CERC-041 Cortisone 0.1 mg/ml in Methanol AMP CERC-130 rac-cotinine-d3 0.1 mg/ml in Methanol AMP CERC-017 rac-cotinine-d3 1.0 mg/ml in Methanol AMP CERC-035 (-)-Cotinine 1.0 mg/ml in Methanol AMP CERC-016 m-cpp HCl (1-(3-Chlorophenyl)piperazine Hydrochloride) 1.0 mg/ml in Methanol (as free Cyclobenzaprine Hydrochloride 1.0 mg/ml in Methanol (as free Dehydronorketamine Hydrochloride 0.1 mg/ml in (as free AMP AMP AMP CERC-089 CERC-060 CERD-046 Demoxepam 1.0 mg/ml in Methanol AMP CERD-079 Desalkylflurazepam (7-Chloro-5-(2-fluorophenyl)-1,3-dihydro- 2H-1,4-benzodiazepin-2-one) 1.0 mg/ml in Methanol AMP CERD-915 Desalkylflurazepam-D4 0.1 mg/ml in Methanol AMP CERD-924 Desethylamiodarone Hydrochloride 1.0 mg/ml in Methanol (as free Desethylamodiaquine-D5 Dihydrochloride 0.1 mg/ml in Methanol (as free Desipramine Hydrochloride 1.0 mg/ml in Methanol (as free Desipramine-D3 Hydrochloride 0.1 mg/ml in Methanol (as free Desmethylcitalopram Hydrochloride 1.0 mg/ml in Methanol (as free N-Desmethylclobazam (Norclobazam) 0.1 mg/ml in Desmethylclomipramine Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP AMP AMP AMP AMP CERD-055 CERD-040 CERD-906 CERD-903 CERD-047 CERD-049 CERD-916 Desmethylclozapine (Norclozapine) 1.0 mg/ml in Methanol AMP CERD-048 N-Desmethylcyclobenzaprine Hydrochloride (Norcyclobenzaprine Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERD-088 Desmethyldoxepin (cis/trans) 1.0 mg/ml in Methanol AMP CERD-007 Desmethylflunitrazepam 0.1 mg/ml in Methanol AMP CERD-919 Desmethylflunitrazepam 1.0 mg/ml in Methanol AMP CERD-918 Desmethylflunitrazepam-D4 0.1 mg/ml in Methanol AMP CERD-925 rac-n-desmethylselegiline Hydrochloride 1.0 mg/ml in Methanol (as free N-Desmethyltramadol Hydrochloride 1.0 mg/ml in Methanol (as free O-Desmethyltramadol Hydrochloride 1.0 mg/ml in Methanol (as free Desmethyltrimipramine Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP AMP CERD-012 CERD-023 CERT-035 CERD-920 O-Desmethylvenlafaxine 0.1 mg/ml in Methanol AMP CERV-007 Desomorphine (Dihydrodesoxymorphine; Krokodil) 1.0 mg/ml in 11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione) 1.0 mg/ml in Methanol Desoxypipradrol Hydrochloride (2-DPMP HCl) 1.0 mg/ml in Methanol (as free AMP AMP AMP CERD-083 CERD-061 CERD-082 Dexamethasone 1.0 mg/ml in Methanol AMP CERD-085 Dextromethorphan Hydrobromide Monohydrate 1.0 mg/ml in Methanol (as anhydrous free AMP CERD-013 Dextromethorphan-D3 0.1 mg/ml in Methanol AMP CERD-071 Dextropropoxyphene 1.0 mg/ml in AMP CERP-011 Dextrorphan Tartrate (O-Desmethyldextromethorphan Tartrate; ent-17-methylmorphinan-3-ol (L)-Tartrate) 1.0 mg/ml in Methanol (as free AMP CERD-034 Diazepam 1.0 mg/ml in Methanol AMP CERD-907 Diazepam-D5 0.1 mg/ml in Methanol AMP CERD-902 Diazepam-D5 1.0 mg/ml in Methanol AMP CERD-910 Digoxin 1.0 mg/ml in Methanol AMP CERD-029 Dihydrocodeine Hydrochloride 1.0 mg/ml in Methanol (as free Dihydrocodeine-D6 Hydrochloride 0.1 mg/ml in Methanol (as free AMP AMP CERD-019 CERD-021 Dihydromorphine 1.0 mg/ml in Methanol AMP CERD For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 13

8 Diltiazem Hydrochloride 1.0 mg/ml in (as free 3,4-Dimethylmethcathinone Hydrochloride (3,4-DMMC HCl) 1.0 mg/ml in Methanol (as free Diphenhydramine Hydrochloride 1.0 mg/ml in Methanol (as free Diphenhydramine-D3 Hydrochloride 0.1 mg/ml in Methanol (as free AMP AMP AMP AMP CERD-035 CERD-093 CERD-015 CERD-017 Disopyramide 1.0 mg/ml in Methanol AMP CERD-054 Dothiepin Hydrochloride (Dosulepin Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERD-092 Doxepin Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERD-927 Doxepin-D3 Hydrochloride (cis/trans) 0.1 mg/ml in Methanol (as free Doxylamine Hydrogen Succinate 1.0 mg/ml in Methanol (as free Duloxetine Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP CERD-060 CERD-045 CERD-044 Ecgonine Ethyl Ester 0.1 mg/ml in AMP CERE-019 Ecgonine Methyl Ester 1.0 mg/ml in AMP CERE-001 Ecgonine-D3 Methyl Ester 0.1 mg/ml in AMP CERE-002 EDDP Perchlorate (2-Ethyl-1,5-dimethyl-3,3- diphenylpyrrolinium Perchlorate) 0.1 mg/ml in Methanol (as Pyrrolinium) EDDP Perchlorate (2-Ethyl-1,5-dimethyl-3,3- diphenylpyrrolinium Perchlorate) 1.0 mg/ml in Methanol (as Pyrrolinium) EDDP-D3 Perchlorate (2-(2,2,2-Trideuteroethyl-1,5-dimethyl- 3,3-diphenylpyrrolinium Perchlorate) 0.1 mg/ml in Methanol (as Pyrrolinium) EDDP-D3 Perchlorate (2-(2,2,2-Trideuteroethyl-1,5-dimethyl- 3,3-diphenylpyrrolinium Perchlorate) 1.0 mg/ml in Methanol (as Pyrrolinium) (1R,2S)-Ephedrine Hydrochloride 1.0 mg/ml in Methanol (as free (1S,2R)-(+)-Ephedrine Hydrochloride 1.0 mg/ml in Methanol (as free (1S,2R)-(+)-Ephedrine-D3 Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP AMP AMP AMP AMP CERE-012 CERE-022 CERE-021 CERE-062 CERE-023 CERE-011 CERE-026 Epitestosterone 1.0 mg/ml in AMP CERE-058 Estazolam 1.0 mg/ml in Methanol AMP CERE-901 Estazolam-D5 0.1 mg/ml in Methanol AMP CERE-903 Estradiol Hemihydrate (17β-Estradiol Hemihydrate) 1.0 mg/ml in (anhydrous substance) AMP CERE-060 Estriol 1.0 mg/ml in Methanol AMP CERE-074 Estrone 1.0 mg/ml in Methanol AMP CERE-075 Ethcathinone Hydrochloride (N-Ethylcathinone Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERE-080 Ethosuximide 1.0 mg/ml in Methanol AMP CERE EMC HCl (4-Ethylmethcathinone Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERE-090 Ethylmorphine 1.0 mg/ml in Methanol AMP CERE-052 Ethylone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERE-071 Ethylone-D5 Hydrochloride 0.1 mg/ml in Methanol (as free β-ethylmethcathinone Hydrochloride (Pentedrone Hydrochloride) 1.0 mg/ml in Methanol (as free Ethylphenidate Hydrochloride 1.0 mg/ml in (as free AMP AMP AMP CERE-072 CERP-087 CERE-088 Etizolam 1.0 mg/ml in Methanol AMP CERE-081 Eutylone Hydrochloride (1-(3,4-Methylenedioxyphenyl)-2- ethylamino-butan-1-one Hydrochloride) 1.0 mg/ml in Methanol (as free Fenfluramine Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP CERE-087 CERF-009 Fentanyl 0.1 mg/ml in Methanol AMP CERF-002 Fentanyl 1.0 mg/ml in Methanol AMP CERF-013 Fentanyl-D5 0.1 mg/ml in Methanol AMP CERF-001 Flephedrone Hydrochloride (4-Fluoromethcathinone Hydrochloride) 1.0 mg/ml in Dimethyl Sulfoxide (as free AMP CERF-015 Fluconazole 2.0 mg/ml in Methanol AMP CERF-031 Flucytosine 2.0 mg/ml in Methanol AMP CERF-030 Flunitrazepam 1.0 mg/ml in Methanol AMP CERF-907 Flunitrazepam-D7 0.1 mg/ml in Methanol AMP CERF For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 15

9 4-Fluoroamphetamine Hydrochloride 1.0 mg/ml in Methanol (as free 3-Fluoromethcathinone Hydrochloride (1-(3-Fluorophenyl)- 2-(methylamino)propan-1-one Hydrochloride) 1.0 mg/ml in Dimethyl Sulfoxide (as free 4-Fluorotropacocaine (3-Pseudotropyl 4-Fluorobenzoate; 3β-(p-Fluorobenzoyloxy)tropane) 1.0 mg/ml in AMP AMP AMP CERF-018 CERF-016 CERF-026 Fluoxetine Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERF-918 Fluoxymesterone 1.0 mg/ml in AMP CERF-909 Fluphenazine Dihydrochloride 1.0 mg/ml in Methanol (as free AMP CERF-903 Flurazepam 1.0 mg/ml in Methanol AMP CERF-003 Haloperidol 1.0 mg/ml in Methanol AMP CERH-030 Haloperidol-D4 0.1 mg/ml in Methanol AMP CERH-002 Heroin (Diacetylmorphine) 1.0 mg/ml in AMP CERH-038 Heroin-D9 (Diacetylmorphine-D9) 0.1 mg/ml in AMP CERH-036 Heroin-D9 (Diacetylmorphine-D9) 1.0 mg/ml in AMP CERH-037 Hexobarbital 1.0 mg/ml in Methanol AMP CERH-013 Hydrochlorothiazide 1.0 mg/ml in Methanol AMP CERH-001 Hydrocodone 1.0 mg/ml in Methanol AMP CERH-003 Hydrocodone-D3 0.1 mg/ml in Methanol AMP CERH-005 Hydrocodone-D6 0.1 mg/ml in Methanol AMP CERH-047 Hydromorphone 1.0 mg/ml in Methanol AMP CERH-004 Hydromorphone-D3 0.1 mg/ml in Methanol AMP CERH Hydroxy-10,11-dihydrocarbamazepine 1.0 mg/ml in AMP CERD-091 α-hydroxyalprazolam 0.1 mg/ml in Methanol AMP CERA-905 α-hydroxyalprazolam 1.0 mg/ml in Methanol AMP CERA-907 α-hydroxyalprazolam-d mg/ml in Methanol AMP CERA-904 α-hydroxyalprazolam-d mg/ml in Methanol AMP CERA Hydroxyethylflurazepam 0.1 mg/ml in Methanol AMP CERF Hydroxyethylflurazepam 1.0 mg/ml in Methanol AMP CERF Hydroxyethylflurazepam-D4 0.1 mg/ml in Methanol AMP CERH-919 α-hydroxymidazolam 0.1 mg/ml in Methanol AMP CERH Hydroxyphenazepam 1.0 mg/ml in Methanol AMP CERH Hydroxyrisperidone 1.0 mg/ml in Methanol AMP CERH-076 trans-11-hydroxy-δ 9 -THC ((6aRS,10aRS)-11-Hydroxy-Δ₉tetrahydrocannabinol) 0.1 mg/ml in Methanol trans-11-hydroxy-δ 9 -THC ((6aRS,10aRS)-11-Hydroxy-Δ₉tetrahydrocannabinol) 1.0 mg/ml in Methanol AMP AMP CERH-026 CERH-027 α-hydroxytriazolam 0.1 mg/ml in Methanol AMP CERT-915 α-hydroxytriazolam 1.0 mg/ml in Methanol AMP CERT-911 Ibuprofen 1.0 mg/ml in Methanol AMP CERI-009 Imipramine Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERI-902 Imipramine-D3 Maleate 0.1 mg/ml in Methanol (as free AMP CERI Iodo-2-aminoindane Hydrochloride (5-IAI HCl) 1.0 mg/ml in Methanol (as free AMP CERI-014 Itraconazole 2.0 mg/ml in Dimethyl Sulfoxide AMP CERI-015 JWH-018 ((Naphthalen-1-yl)(1-pentylindol-3-yl)methanone) 0.1 mg/ml in AMP CERS-025 Ketamine Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERK-002 Ketamine-D4 Hydrochloride 0.1 mg/ml in Methanol (as free AMP CERK-003 Ketoconazole 2.0 mg/ml in Methanol AMP CERK-004 Lamotrigine 1.0 mg/ml in Methanol AMP CERL-019 LAMPA (Lysergic Acid N-Methyl-N-propylamide) mg/ml in LAMPA (Lysergic Acid N-Methyl-N-propylamide) 1.0 mg/ml in Levamisole Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP CERL-007 CERL-004 CERL-025 Levetiracetam 1.0 mg/ml in Methanol AMP CERL-020 Lidocaine 1.0 mg/ml in Methanol AMP CERL-018 Loratadine 0.1 mg/ml in Methanol AMP CERL-014 Lorazepam 1.0 mg/ml in AMP CERL-901 Lorazepam-D mg/ml in AMP CERL-902 Lorazepam-D mg/ml in AMP CERL-911 Lormetazepam 1.0 mg/ml in Methanol AMP CERL For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 17

10 LSD (Lysergic Acid Diethylamide) mg/ml in AMP CERL-005 LSD (Lysergic Acid Diethylamide) 1.0 mg/ml in AMP CERL-001 Maprotiline Hydrochloride 1.0 mg/ml in Methanol (as free rac-mbdb HCl (rac-n-methyl-1-(3,4-methylenedioxyphenyl)- 2-butanamine Hydrochloride) 1.0 mg/ml in Methanol (as free rac-mbdb-d5 (rac-n-methyl-1-(3,4-methylenedioxyphenyl)-2- butanamine-d5) 0.1 mg/ml in Methanol rac-mda (rac-3,4-methylenedioxyamphetamine) 1.0 mg/ml in Methanol rac-mda-d5 (rac-3,4-methylenedioxyamphetamine-d5) 0.1 mg/ml in Methanol rac-mda-d5 (rac-3,4-methylenedioxyamphetamine-d5) 1.0 mg/ml in Methanol MDAI (5,6-Methylenedioxy-2-aminoindane) 1.0 mg/ml in rac-mdea (rac-3,4-methylenedioxy-n-ethylamphetamine) 1.0 mg/ml in Methanol rac-mdea-d5 (rac-3,4-methylenedioxy-nethylamphetamine-d5) 0.1 mg/ml in Methanol rac-mdea-d5 (rac-3,4-methylenedioxy-nethylamphetamine-d5) 1.0 mg/ml in Methanol rac-mdea-d₆ (rac-3,4-methylenedioxy-nethylamphetamine-d₆) 0.1 mg/ml in Methanol rac-mdma (rac-3,4-methylenedioxymethamphetamine) 1.0 mg/ml in Methanol rac-mdma-d5 (rac-3,4-methylenedioxymethamphetamine-d5) 0.1 mg/ml in Methanol rac-mdma-d5 (rac-3,4-methylenedioxymethamphetamine-d5) 1.0 mg/ml in Methanol MDPPP HCl (3,4-Methylenedioxy-α-pyrrolidinopropiophenone Hydrochloride) 1.0 mg/ml in Methanol (as free AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP AMP CERM-920 CERM-102 CERM-104 CERM-012 CERM-010 CERM-027 CERM-144 CERM-065 CERM-067 CERM-068 CERM-081 CERM-013 CERM-011 CERM-029 CERM-176 Melatonin 1.0 mg/ml in Methanol AMP CERM-095 Mephedrone Hydrochloride (4-MMC HCl; 4-Methylmethcathinone Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERM-138 Mephedrone-D3 Hydrochloride (4-MMC-D3 HCl; 4-Methylmethcathinone-D3 Hydrochloride) 0.1 mg/ml in Methanol (as free AMP CERM-139 Meprobamate 1.0 mg/ml in Methanol AMP CERM-039 Mesterolone 1.0 mg/ml in AMP CERM-130 Metformin Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERM-072 rac-methadone 0.1 mg/ml in Methanol AMP CERM-019 rac-methadone 1.0 mg/ml in Methanol AMP CERM-007 rac-methadone-d3 0.1 mg/ml in Methanol AMP CERM-008 rac-methadone-d3 1.0 mg/ml in Methanol AMP CERM-021 rac-methadone-d9 0.1 mg/ml in Methanol AMP CERM-088 rac-methadone-d9 1.0 mg/ml in Methanol AMP CERM-089 rac-methamphetamine 0.1 mg/ml in Methanol AMP CERM-022 rac-methamphetamine 1.0 mg/ml in Methanol AMP CERM-009 rac-methamphetamine-d5 0.1 mg/ml in Methanol AMP CERM-004 rac-methamphetamine-d5 1.0 mg/ml in Methanol AMP CERM-023 rac-methamphetamine-d 9 Hydrochloride 0.1 mg/ml in Methanol (as free rac-methamphetamine-d 9 Hydrochloride 1.0 mg/ml in Methanol (as free rac-methamphetamine-d 11 Hydrochloride 0.1 mg/ml in Methanol (as free rac-methamphetamine-d 11 Hydrochloride 1.0 mg/ml in Methanol (as free rac-methamphetamine-d 14 Hydrochloride 0.1 mg/ml in Methanol (as free rac-methamphetamine-d 14 Hydrochloride 1.0 mg/ml in Methanol (as free Methamphetamine Hydrochloride ((S)-(+)-Methamphetamine Hydrochloride) 1.0 mg/ml in Methanol (as free (S)-(-)-Methcathinone Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP AMP AMP AMP AMP AMP CERM-090 CERM-091 CERM-059 CERM-060 CERM-092 CERM-093 CERM-020 CERM-055 Methaqualone 1.0 mg/ml in Methanol AMP CERM-015 Methaqualone-D7 0.1 mg/ml in Methanol AMP CERM-014 (S)-(-)-Methcathinone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERM For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 19

11 Methedrone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERM-147 Methohexital 1.0 mg/ml in Methanol AMP CERM-041 Methotrexate 1.0 mg/ml in Dimethyl Sulfoxide AMP CERM-136 Methoxetamine Hydrochloride 1.0 mg/ml in Methanol (as free 5-MeO-DALT (5-Methoxy-N,N-diallyltryptamine) 1.0 mg/ml in 3-MeO-PCP HCl (3-Methoxyphencyclidine Hydrochloride) 1.0 mg/ml in Methanol (as free 4-MeO-PCP HCl (4-Methoxyphencyclidine Hydrochloride) 1.0 mg/ml in Methanol (as free Methylenedioxypyrovalerone Hydrochloride (MDPV HCl) 1.0 mg/ml in Methanol (as free 3',4'-Methylenedioxy-α-pyrrolidinobutiophenone Hydrochloride (MDPBP HCl) 1.0 mg/ml in Methanol (as free Methylephedrine ((1R,2S)-Methylephedrine) 1.0 mg/ml in Methanol Methylethcathinone Hydrochloride (4-Methyl-N-ethylcathinone Hydrochloride; 4-MEC HCl) 1.0 mg/ml in Methanol (as free AMP AMP AMP AMP AMP AMP AMP AMP CERM-156 CERM-165 CERM-162 CERM-163 CERM-146 CERM-154 CERM-129 CERM-155 Methylone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERM-140 Methylone-D3 Hydrochloride 0.1 mg/ml in Methanol (as free Methylphenidate Hydrochloride 1.0 mg/ml in Methanol (as free Methyltestosterone (17α-Methyltestosterone) 1.0 mg/ml in AMP AMP AMP CERM-141 CERM-083 CERM-906 Metoprolol Tartrate 1.0 mg/ml in Methanol (as free AMP CERM-123 Metronidazole 2.0 mg/ml in Methanol AMP CERM-183 Mianserin Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERM-919 Mianserin-D3 0.1 mg/ml in Methanol AMP CERM-901 Midazolam 1.0 mg/ml in Methanol AMP CERM-908 Midazolam-D 4 Maleate 0.1 mg/ml in Methanol (as free AMP CERM-918 Milnacipran Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERM-145 Mirtazapine 1.0 mg/ml in Methanol AMP CERM-128 Modafinil 1.0 mg/ml in AMP CERM-084 Morphine 0.1 mg/ml in Methanol AMP CERM-030 Morphine 1.0 mg/ml in Methanol AMP CERM-005 Morphine 6-β-D-Glucuronide 0.1 mg/ml in Water AMP CERM-096 Morphine 6-β-D-Glucuronide 1.0 mg/ml in Water AMP CERM-046 Morphine N-Oxide 0.1 mg/ml in Methanol AMP CER- IMPM Morphine-D3 0.1 mg/ml in Methanol AMP CERM-003 Morphine-D3 1.0 mg/ml in Methanol AMP CERM-006 Nalorphine Hydrochloride 1.0 mg/ml in Methanol (as free Naloxone Hydrochloride Dihydrate 1.0 mg/ml in Methanol (as anhydrous free Naltrexone Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP CERN-924 CERN-004 CERN-007 Nandrolone 1.0 mg/ml in AMP CERN-050 Naphyrone Hydrochloride (1-Naphthalen-2-yl-2-pyrrolidin-1- ylpentan-1-one Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERN-067 Naproxen 1.0 mg/ml in Methanol AMP CERN-042 Nicotinamide 1.0 mg/ml in Methanol AMP CERV-016 Nicotinic Acid 1.0 mg/ml in Methanol AMP CERV-017 Nitrazepam 1.0 mg/ml in AMP CERN-906 Nitrazepam-D5 0.1 mg/ml in AMP CERN-901 (-)-11-Nor-9-carboxy-Δ 9 -THC 0.1 mg/ml in Methanol AMP CERT-018 (-)-11-Nor-9-carboxy-Δ 9 -THC 1.0 mg/ml in Methanol AMP CERT Nor-9-carboxy-Δ9-THC-D9 0.1 mg/ml in Methanol AMP CERT Nor-9-carboxy-Δ9-THC-D9 1.0 mg/ml in Methanol AMP CERT-009 trans-11-nor-9-carboxy-δ 9 -THC 0.1 mg/ml in Methanol AMP CERT-006 trans-11-nor-9-carboxy-δ 9 -THC-D mg/ml in Methanol AMP CERT-004 trans-11-nor-9-carboxy-δ 9 -THC-D mg/ml in Methanol AMP CERT Norandrosterone 1.0 mg/ml in Methanol AMP CERE-910 Norcocaine Hydrochloride 1.0 mg/ml in (as free AMP CERN For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 21

12 Norcocaine-D3 Hydrochloride 0.1 mg/ml in (as free AMP CERN-034 Norcodeine 1.0 mg/ml in Methanol AMP CERN-005 rac-norcotinine 1.0 mg/ml in Methanol AMP CERN-079 Nordazepam (Nordiazepam) 1.0 mg/ml in Methanol AMP CERN-905 Nordazepam-D5 (Nordiazepam-D5) 0.1 mg/ml in Methanol AMP CERN-903 Nordazepam-D5 (Nordiazepam-D5) 1.0 mg/ml in Methanol AMP CERN-911 rac-norephedrine-d3 Hydrochloride 1.0 mg/ml in Methanol (as free Norfentanyl (N-Phenyl-N-(piperidin-4-yl)propanamide) 1.0 mg/ ml in Methanol Norfentanyl-D5 Oxalate (N-Pentadeuterophenyl-N-(piperidin- 4-yl)propanamide Oxalate) 0.1 mg/ml in Methanol (as free AMP AMP AMP CERN-043 CERN-031 CERN-030 Norfluoxetine Oxalate 1.0 mg/ml in Methanol (as free AMP CERN-923 Norketamine Hydrochloride 1.0 mg/ml in Methanol (as free Norketamine-D 4 Hydrochloride 0.1 mg/ml in Methanol (as free AMP AMP CERN-036 CERN-037 Normorphine 1.0 mg/ml in Methanol AMP CERN-006 Noroxycodone Hydrochloride 1.0 mg/ml in Methanol (as free Noroxycodone-D3 Hydrochloride 0.1 mg/ml in Methanol (as free Noroxymorphone Hydrochloride 0.1 mg/ml in Methanol (as free AMP AMP AMP CERN-011 CERN-032 CERN-013 Norpethidine (Normeperidine) 0.1 mg/ml in Methanol AMP CERN-017 Norpethidine-D4 (Normeperidine-D4) 0.1 mg/ml in Methanol AMP CERN-020 (+)-Norpseudoephedrine Hydrochloride (Cathine Hydrochloride) 0.1 mg/ml in Methanol (as free rac-norsertraline Hydrochloride 0.1 mg/ml in Methanol (as free Nortriptyline Hydrochloride 1.0 mg/ml in Methanol (as free Nortriptyline-D3 Hydrochloride 0.1 mg/ml in Methanol (as free AMP AMP AMP AMP CERN-046 CERN-049 CERN-907 CERN-902 Olanzapine 1.0 mg/ml in AMP CERO-024 Oxazepam 1.0 mg/ml in Methanol AMP CERO-902 Oxazepam-D5 0.1 mg/ml in Methanol AMP CERO-901 Oxazepam-D5 1.0 mg/ml in Methanol AMP CERO-904 Oxycodone 1.0 mg/ml in Methanol AMP CERO-002 Oxycodone-D3 0.1 mg/ml in Methanol AMP CERO-005 Oxycodone-D3 1.0 mg/ml in Methanol AMP CERO-006 Oxycodone-D6 0.1 mg/ml in Methanol AMP CERO-007 Oxycodone-D6 1.0 mg/ml in Methanol AMP CERO-008 Oxymorphone 1.0 mg/ml in Methanol AMP CERO-004 Oxymorphone-D3 0.1 mg/ml in Methanol AMP CERO-003 Oxymorphone-D3 1.0 mg/ml in Methanol AMP CERO-019 Paracetamol (Acetaminophen) 1.0 mg/ml in Methanol AMP CERA-064 Paracetamol-D4 (Acetaminophen-D4) 0.1 mg/ml in Methanol AMP CERP-909 Paracetamol-D4 (Acetaminophen-D4) 1.0 mg/ml in Methanol AMP CERP-917 Paroxetine Hydrochloride Hemihydrate 1.0 mg/ml in Methanol (as anhydrous free AMP CERP-916 Pentobarbital 1.0 mg/ml in Methanol AMP CERP-010 Pentobarbital-D5 0.1 mg/ml in Methanol AMP CERP-009 Pentobarbital-D5 1.0 mg/ml in Methanol AMP CERP-013 Pentylone Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERP-086 Pethidine (Meperidine) 1.0 mg/ml in Methanol AMP CERM-035 Pethidine-D4 (Meperidine-D4) 0.1 mg/ml in Methanol AMP CERM-036 Pethidine-D4 (Meperidine-D4) 1.0 mg/ml in Methanol AMP CERM-038 Phenacetin 1.0 mg/ml in AMP CERP-061 Phenazepam 1.0 mg/ml in Methanol AMP CERP-080 Phencyclidine (PCP) 1.0 mg/ml in Methanol AMP CERP-007 Phencyclidine-D5 (PCP-D5) 0.1 mg/ml in Methanol AMP CERP-003 Phencyclidine-D5 (PCP-D5) 1.0 mg/ml in Methanol AMP CERP-006 Pheniramine 1.0 mg/ml in Methanol AMP CERP-045 Phenobarbital 1.0 mg/ml in Methanol AMP CERP-008 Phenobarbital-D5 (D-label on ring) 0.1 mg/ml in Methanol AMP CERP-018 Phenobarbital-D5 (D-label on ring) 1.0 mg/ml in Methanol AMP CERP For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 23

13 Phenobarbital-D5 (D-label on side chain) 0.1 mg/ml in Methanol Phenobarbital-D5 (D-label on side chain) 1.0 mg/ml in Methanol AMP AMP CERP-004 CERP-017 Phentermine 1.0 mg/ml in Methanol AMP CERP-023 (1RS,2SR)-Phenylpropanolamine Hydrochloride (D,L- Norephedrine Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERP-038 Phenytoin 1.0 mg/ml in Methanol AMP CERP-063 PMA HCl (p-methoxyamphetamine Hydrochloride) 1.0 mg/ml in Methanol (as free PMMA HCl (p-methoxymethamphetamine Hydrochloride) 1.0 mg/ml in Methanol (as free PPP HCl (α-pyrrolidinopropiophenone Hydrochloride) 1.0 mg/ ml in Methanol (as free Prasterone (DHEA; Dehydroepiandrosterone) 1.0 mg/ml in AMP AMP AMP AMP CERP-050 CERP-051 CERP-100 CERD-063 Prazepam 1.0 mg/ml in Methanol AMP CERP-906 Prazepam-D5 0.1 mg/ml in Methanol AMP CERP-905 Pregabalin 1.0 mg/ml in Methanol AMP CERP-066 Pregnenolone 0.1 mg/ml in AMP CERP-104 Progesterone 1.0 mg/ml in AMP CERP-069 Promethazine Hydrochloride 1.0 mg/ml in Dimethyl Sulfoxide (as free Promethazine-D 3 Hydrochloride 0.1 mg/ml in Dimethyl Sulfoxide (as free AMP AMP CERP-111 CERP-112 Propofol 1.0 mg/ml in Methanol AMP CERP-076 rac-propoxyphene-d mg/ml in AMP CERP-913 rac-propoxyphene-d mg/ml in AMP CERP-914 rac-propoxyphene-d5 0.1 mg/ml in AMP CERP-901 rac-propoxyphene-d5 1.0 mg/ml in AMP CERP-904 Propranolol Hydrochloride 1.0 mg/ml in Methanol (as free Protriptyline Hydrochloride 1.0 mg/ml in Methanol (as free (+)-Pseudoephedrine Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP AMP CERP-055 CERP-903 CERP-035 (-)-Pseudoephedrine 1.0 mg/ml in Methanol AMP CERP-036 Pseudoephedrine-D3 Hydrochloride 0.1 mg/ml in Methanol (as free AMP CERP-056 Pyridoxine Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERV-018 Quetiapine Fumarate 1.0 mg/ml in Methanol (as free AMP CERQ-001 Ranitidine Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERR-004 Risperidone 1.0 mg/ml in Methanol AMP CERR-006 Ritalinic Acid Hydrochloride 1.0 mg/ml in Methanol (as free Salbutamol Sulphate (Albuterol Sulphate) 1.0 mg/ml in Methanol (as free AMP AMP CERR-011 CERA-067 Salicylic Acid 1.0 mg/ml in AMP CERS-019 Secobarbital 1.0 mg/ml in Methanol AMP CERS-002 Selegiline Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERS-003 Sertraline Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERS-021 Sibutramine Hydrochloride Monohydrate 1.0 mg/ml in Methanol (as anhydrous free AMP CERS-011 Sildenafil 1.0 mg/ml in Methanol AMP CERS-010 Stanozolol 1.0 mg/ml in AMP CERS-906 Sufentanil Citrate 0.1 mg/ml in Methanol (as free AMP CERS-008 Tadalafil 1.0 mg/ml in AMP CERT-072 Temazepam 1.0 mg/ml in Methanol AMP CERT-907 Testosterone 1.0 mg/ml in AMP CERT-037 TFMPP HCl (1-(3-Trifluoromethylphenyl)piperazine Hydrochloride) 1.0 mg/ml in Methanol (as free AMP CERT-045 (-)-Δ 9 -THC (Dronabinol) 1.0 mg/ml in Methanol AMP CERT-005 Theobromine 0.1 mg/ml in Methanol AMP CERT-013 Theophylline 1.0 mg/ml in Methanol AMP CER- IMPC (Thiophen-2-yl)-2-methylaminopropane Hydrochloride (Methiopropamine Hydrochloride; MPA HCl) 1.0 mg/ml in Methanol (as free Thiamine Hydrochloride (Vitamin B1) 1.0 mg/ml in Methanol (as free AMP AMP CERM-164 CERV For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 25

14 Thioridazine Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERT-905 Tilidine 0.1 mg/ml in AMP CERT-068 Tilidine Hydrochloride Hemihydrate 1.0 mg/ml in Methanol (as anhydrous free AMP CERT-068 Tolbutamide 1.0 mg/ml in AMP CERT-036 Topiramate 1.0 mg/ml in AMP CERT-039 Topiramate 1.0 mg/ml in Methanol AMP CERT-039 Tramadol Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERT-027 Tramadol-13C-D3 Hydrochloride 0.1 mg/ml in Methanol (as free Trazodone Hydrochloride 1.0 mg/ml in Methanol (as free AMP AMP CERT-029 CERT-030 Trenbolone 1.0 mg/ml in AMP CERT-043 Triazolam 1.0 mg/ml in Methanol AMP CERT-910 Triazolam-D4 0.1 mg/ml in Methanol AMP CERT-908 Trimipramine 1.0 mg/ml in Methanol AMP CERT-904 Trimipramine Maleate 1.0 mg/ml in Methanol (as free AMP CERT-904 Trimipramine-D3 Maleate 0.1 mg/ml in Methanol (as free UR-144 ((1-Pentylindol-3-yl)(2,2,3,3-tetramethylcyclopropyl) methanone; KM X-1) 0.1 mg/ml in AMP AMP CERT-071 CERS-062 Valproic Acid 1.0 mg/ml in Methanol AMP CERV-006 Varenicline Tartrate 1.0 mg/ml in Methanol (as free AMP CERV-008 Venlafaxine Hydrochloride 1.0 mg/ml in Methanol (as free Venlafaxine-D6 Hydrochloride 0.1 mg/ml in Methanol (as free AMP AMP CERV-004 CERV-009 Verapamil Hydrochloride 1.0 mg/ml in Methanol (as free AMP CERV-002 Voriconazole 2.0 mg/ml in Methanol AMP CERV-032 Warfarin 1.0 mg/ml in AMP CERW-003 Zaleplon 1.0 mg/ml in Methanol AMP CERZ-004 Ziprasidone Hydrochloride Monohydrate 1.0 mg/ml in Methanol (as anhydrous free AMP CERZ-002 Zolpidem Tartrate 1.0 mg/ml in Methanol (as free AMP CERZ-901 Zonisamide 1.0 mg/ml in Methanol AMP CERZ-005 Zopiclone 1.0 mg/ml in AMP CERZ-003 Zopiclone-D4 0.1 mg/ml in AMP CERZ For the latest products, visit lgcstandards.com Buy your reference materials online at lgcstandards.com/drugandmetabolitestandards 27

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