NEW. Kinetex. Biphenyl TMS TMS TMS TMS. Selectivity that a C18 just can t give you!

Transcription

1 Core-Shell Technology NEW Kinetex enyl Biph Biphenyl TM S TM Selectivity that a C8 just can t give you! S Bip he ylhenyl Bnip Remarkable Separation Power Rugged and Reliable % Aqueous Stable

2 Kinetex Core-Shell Advantage Kinetex Core-Shell Technology produces increased efficiencies over traditional, fully porous columns on the market, yielding remarkable chromatographic resolution, higher peak capacities, and greater sensitivity, so labs can get the most out of every HPLC/UHPLC analysis. Kinetex Core-Shell Fully Porous Less Band Broadening More Band Broadening If you are not completely satisfied with Kinetex core-shell columns, send in your comparative data to a similar product with the Kinetex column within days for a FULL REFUND. Phenomenex, Inc. All rights reserved.

3 Core-Shell Technology Introducing the High Performance Kinetex Biphenyl! Biphenyl Transform your reversed phase analysis... pp. - Comprehensive pain panel testing... p. Extended lifetime with biological samples... p. Wide range of Kinetex selectivities... p. 8 Full scalability from HPLC to UHPLC... p. 9 Reproducibility and quality you can rely on... p. Ordering information... p. Phenomenex India Tel: - Fax: - indiainfo@phenomenex.com Web:

4 Transform Your Reversed Phase Analysis Think high performance, enhanced retention, and the ability to go where a traditional C8 can t. The Kinetex Biphenyl offers the high performance benefits of a core-shell particle with a unique stationary phase capable of becoming the go-to selectivity for reversed phase method development. Use Kinetex Biphenyl columns to get enhanced retention, higher sensitivity, and overall better results; especially for aromatic compounds. Mycotoxins Kinetex. µm Biphenyl.e.e.e.e..e.e.e.e. min Waters SunFire. µm C8 8,,, 9, 8,9 Enhanced Retention and Sensitivity min App ID 9 App ID 9 Conditions for all columns: Column: Kinetex. µm Biphenyl Waters SunFire. µm C8 Dimensions: x. mm Mobile Phase: A: mm Ammonium acetate with.% Acetic acid B: Methanol with mm Ammonium acetate with.% Acetic acid Gradient: Time (min) %B Flow Rate:. ml/min Temperature: C Detection: MS/MS (AB SCIEX API ) Sample:. -Acetyldeoxynivalenol. DAS. FB. HT Toxin. FB. T Toxin. Aflatoxin M 8. Aflatoxin G 9. Ochratoxin A. Aflatoxin G. Aflatoxin B. Aflatoxin B Waters and SunFire are registered trademarks of Waters Corporation. Phenomenex is in no way affiliated with Waters Corporation. Comparative separations may not be representative of all applications.

5 Enhanced Separation Power Core-Shell Technology Kinetex Biphenyl is a high efficiency core-shell product capable of adding extra separation power to your analysis of non-polar and polar compounds. Imagine what you could do with this new chromatography solution. Opiate Isomers Kinetex. µm Biphenyl Fused-Core. µm C8.e Impressive Increase in Resolution.e.e.e App ID 99 App ID 99. min. min Conditions for all columns: Column: Kinetex. µm Biphenyl Fused-Core. µm C8 Dimensions: x. mm Mobile Phase: A: Water with. % Formic acid B: Methanol with. % Formic acid Gradient: Time (min)..... %B Customer Example - Polar Therapeutic Drug Kinetex µm Biphenyl vs. Fully Porous µm C8 Flow Rate:. ml/min Temperature: C Detection: MS/MS (AB SCIEX API ) Sample:. Morphine. Hydromorphone. Norhydrocodone C8 Biphenyl ~x Increase in Retention % min Fused-Core is a registered trademark of Advanced Materials Technology, Inc. Phenomenex is in no way affiliated with Advanced Materials Technology, Inc. Comparative separations may not be representative of all applications. Share your Kinetex success stories at: KinetexShare Phenomenex India Tel: - Fax: - indiainfo@phenomenex.com Web:

6 Comprehensive Pain Panel Testing Important methods demand high performance and complete reliability. If a system or column interrupts the flow of samples, time and money can be lost. The new Kinetex Biphenyl ensures that your comprehensive screens display the needed performance with a ruggedness and reliability that will keep you at ease. Pain Panel Screen Kinetex. µm Biphenyl.e.e.8e.e.e.e.e 8.e.e.e.e Full Panel min App ID Find more Clinical applications at: ClinicalApps Conditions for all separations: Column: Kinetex. µm Biphenyl Dimensions: x. mm Part No.: B--Y Mobile Phase: A: Water with. % Formic Acid B: Methanol with. % Formic Acid Gradient: Time (min)..... %B Flow Rate:. ml/min Temperature: C Detection: MS/MS (AB SCIEX API ) Opiates Benzodiazepines Other Drugs of Abuse.e.e. App ID 8 min.e.e.e.e.e.e.e App ID 9 min.e.e.e 8.e.e.e.e App ID min Samples:. Morphine. Oxymorphone. Hydromorphone. Naloxone. Codeine. -MAM. Oxycodone 8. Naltrexone 9. Hydrocodone. Norfentanyl. Tramadol. Normeperidine. Meperidine. Norbuprenorphine. Fentanyl. Buprenorphine. Propoxyphene 8. Norpropoxyphene 9. EDDP. Methadone Samples:. Flurazepam. Midazolam. Lorazepam. Clonazepam. Oxazepam. Hydroxyalprazolam. Nordiazepam 8. Flunitrazepam 9. Temazepam. Alprazolam. Diazepam Samples:. Amphetamine. Methamphetamine. MDA. MDMA. MDEA. Benzoylecgonine. Meprobamate 8. PCP 9. Carisoprodol. Sufentanil

7 Improved Retention of Clinical Samples Core-Shell Technology Pain Panel - Opiates Kinetex. µm Biphenyl Fused-Core. µm C8.e Dramatic Improvement in Retention,e.e,e.e. min App ID 9,e, min App ID 9 Conditions for all columns: Column: Kinetex. µm Biphenyl Fused-Core. µm C8 Dimensions: x. mm Mobile Phase: A: Water with. % Formic acid B: Methanol with. % Formic acid Gradient: Time (min).. %B 9 9 Extended Lifetime with Biological Samples Flow Rate:. ml/min Temperature: C Detection: MS/MS (AB SCIEX API ) Sample:. Morphine. Oxymorphone. Hydromorphone. Naloxone. Codeine. Oxycodone. Naltrexone 8. Hydrocodone 9. Norfentanyl. Tramadol. Normeperidine. Meperidine. Meprobamate. Norbuprenorphine. Fentanyl. Buprenorphine. Carisoprodol 8. Sufentanil 9. Methadone Kinetex Biphenyl Stability in Urine (First injections) Retention Time (min) 8 Injection # 8 Fused-Core is a registered trademark of Advanced Materials Technology, Inc. Phenomenex is in no way affiliated with Advanced Materials Technology, Inc. Comparative separations may not be representative of all applications. -Aminoclonazepam -Aminoflunitrazepam Alprazolam Amphetamine Benzoylecgonine Buprenorphine Clonazepam Codeine Estazolam Flunitrazepam Hydrocodone Hydromorphone Lorazepam MDMA Methadone Midazolam Morphine Norbuprenorphine Nordiazepam Norhydrocodone Oxazepam Temazepam Triazolam Phenomenex India Tel: - Fax: - indiainfo@phenomenex.com Web:

8 Wide Range of Kinetex Selectivities Choose from an extensive selection of phases for greater flexibility in UHPLC/ HPLC method development. Kinetex columns come in a variety of stationary phases to cover a full spectrum of applications ranging from acids and bases, to isomers and extremely polar compounds. Steroids Kinetex. µm Biphenyl Kinetex. µm C8 Kinetex. µm XB-C8 8 9 min 9 min App ID 9 App ID 98 App ID 99 Conditions for all columns: Column: Kinetex. µm Biphenyl Kinetex. µm C8 Kinetex. µm XB-C8 Kinetex. µm Phenyl-Hexyl Dimensions: x. mm Mobile Phase: A: Water B: Acetonitrile Gradient: to % B in minutes Flow Rate:.8 ml/min Temperature: C Detection: nm Samples:. Estriol. Hydrocortisone. Prednisone. Cortisone. Corticosterone. β-estradiol. Cortisone Acetate 8. -Hydroxyprogesterone 9. -Hydroxyprogesterone. Deoxycorticosterone min Kinetex. µm Phenyl-Hexyl 9 8 App ID 9 min Take your pick from six stationary phases! Phase Selectivity Kinetex Biphenyl Excellent reversed phase and aromatic retention and selectivity Kinetex C8 General hydrophobic selectivity and increased retention of polar basic compounds Kinetex XB-C8 Excellent hydrophobic selectivity and increased retention of polar acidic compounds Kinetex C8 Less hydrophobic than a C8 phase Kinetex Phenyl-Hexyl Greater retention and separation of aromatic hydrocarbons Kinetex HILIC Increased polar retention under HILIC conditions Want more? - Applications - Development tips - Method comparisons Request your full Kinetex product guide at: KinetexRequest 8

9 Full Scalability from HPLC to UHPLC With four fully scalable particle sizes, Kinetex Core-Shell Technology allows you to easily develop and transfer methods to and from any LC platform you choose. Kinetex. µm and. µm Biphenyl are coming soon! Core-Shell Technology Kinetex µm C8 µm or better efficiencies at µm pressures for HPLC and PREP LC methods µm App ID min Kinetex. µm C8 Achieve sub- µm performance on HPLC and UHPLC systems. µm App ID min Kinetex. µm C8 % higher efficiency than fully porous. µm columns. µm App ID min Kinetex. µm C8 Incredible UHPLC efficiency and performance gains. µm App ID min * Gingerols analyzed on x. mm columns. Phenomenex India Tel: - Fax: - indiainfo@phenomenex.com Web: 9

10 Reproducibility and Quality You Can Rely On Your time and energy is incredibly important and should never be spent on issues with column irreproducibility. While other manufacturers skimp on quality, Phenomenex has and always will take extra steps to ensure that you get the highest quality products, each and every time. Trust us. We are overwhelmingly passionate when it comes to making sure our products live up to the standards that you demand. Batch-to-Batch Reproducibility Drugs of Abuse - Kinetex. µm Biphenyl.e.e.e 8.e.e.e.e Batch App ID % Aqueous Stable Amphetamine - Initial Injection.e.e.e App ID 98 min min Amphetamine - Final Injection.e.e.e Batch 8.e After hr storage in % water 8.e.e.e.e App ID.e.e App ID 98 min min.e.e.e 8.e.e.e.e Batch App ID Conditions for above separations: Column: Kinetex. µm Biphenyl Dimensions: x. mm Part No.: B--AN Mobile Phase:. % Formic Acid in Water Flow Rate:. ml/min Injection Volume: µl Temperature: C Detection: MS (AB SCIEX API ) Sample: Amphetamine ( ng/ml) min * Conditions for this test can be found on page.

11 Extend Your Column Lifetime R&D Award Recipient Protect your Kinetex core-shell columns and other UHPLC columns from damaging contaminants and microparticulates with the SecurityGuard ULTRA guard cartridge system. Easy to use Extends column lifetime Pressure rated to, psi (,8 bar) From Injector SecurityGuard ULTRA UHPLC Column to Detector Cartridge* Holder Frit Compounds of Interest Material Chamber Contaminants and Particulates UHPLC Column Protection *Cartridge schematic not drawn to scale See it in action at: Ordering Information Kinetex core-shell columns come in a variety of phases, dimensions, and particle sizes. Visit for more info. Kinetex. µm Columns (mm) SecurityGuard ULTRA Cartridges SecurityGuard ULTRA Cartridges SecurityGuard ULTRA Cartridges Phases x. x. /pk x. /pk x. x. x. /pk Biphenyl B--AN D--AN AJ-99 B--Y AJ-98 B--E D--E F--E AJ-9 for. mm ID for. mm ID for. mm ID Kinetex µm Columns (mm) SecurityGuard ULTRA Cartridges SecurityGuard ULTRA Cartridges SecurityGuard ULTRA Cartridges Phases x. /pk x. /pk x. x. x. x. /pk Biphenyl B--AN AJ-99 B--Y AJ-98 B--E D--E F--E G--E AJ-9 for. mm ID for. mm ID for. mm ID SecurityGuard ULTRA cartridges require holder, Part No. AJ-9. Terms and Conditions Phenomenex reserves the right to refuse sale at its discretion. Subject to Phenomenex Standard Terms & Conditions, which may be viewed at Trademarks Phenomenex, SecurityGuard and Kinetex are trademarks of Phenomenex. SunFire and Waters are registered trademarks of Waters Corporation. API, API, and API are trademarks of AB SCIEX Pte. Ltd. Fused-Core is a registered trademark of Advanced Materials Technology, Inc. Disclaimer Phenomenex is not affiliated with Advanced Materials Technology, Inc. or Waters Corporation. Comparative separations may not be representative of all applications. Phenomenex, Inc. All rights reserved. Phenomenex India Tel: - Fax: - indiainfo@phenomenex.com Web:

12 NEW Kinetex Biphenyl Biphenyl enyl Selectivity that a C8 just can t give you! Biphenyl Australia t: -98- f: -98- auinfo@phenomenex.com Austria t: -9- f: -9- anfrage@phenomenex.com Belgium t: (French) t: 8 (Dutch) f: + ()-89 beinfo@phenomenex.com Canada t: (8) -8 f: () 8-8 info@phenomenex.com Denmark t: 8 88 f: + 8 nordicinfo@phenomenex.com Finland t: 9 89 f: + 8 nordicinfo@phenomenex.com France t: 9 f: 9 franceinfo@phenomenex.com Germany t: -88- f: -88- anfrage@phenomenex.com India t: - f: - indiainfo@phenomenex.com Ireland t: f: + -9 eireinfo@phenomenex.com Italy t: f: italiainfo@phenomenex.com Luxembourg t: + ()-8 f: + ()-89 nlinfo@phenomenex.com Mexico t: f: tecnicomx@phenomenex.com The Netherlands t: -8 f: -89 nlinfo@phenomenex.com New Zealand t: 9-89 f: 9-89 nzinfo@phenomenex.com Norway t: 8 f: + 8 nordicinfo@phenomenex.com Puerto Rico t: (8) -HPLC f: () 8-8 info@phenomenex.com Sweden t: 8 9 f: + 8 nordicinfo@phenomenex.com United Kingdom t: - f: -9 ukinfo@phenomenex.com United States t: () - f: () 8-8 info@phenomenex.com All other countries: Corporate Office USA t: () - f: () 8-8 info@phenomenex.com BR8_in Phenomenex products are available worldwide. For the distributor in your country, contact Phenomenex USA, International Department at international@phenomenex.com