Use of Prophylactic Growth Factors and Antimicrobials in Elderly Patients with Cancer: A

Size: px
Start display at page:

Download "Use of Prophylactic Growth Factors and Antimicrobials in Elderly Patients with Cancer: A"

Transcription

1 Supportive Care in Cancer Use of Prophylactic Growth Factors and Antimicrobials in Elderly Patients with Cancer: A Systematic Review of the Medicare Database Romina Sosa, Shuling Li, Julia T. Molony, Jiannong Liu, Scott Stryker, Allan J. Collins Corresponding Author Allan J Collins, MD, FACP Chronic Disease Research Group, Minneapolis Medical Research Foundation

2 Supplementary Table S1. Administrative codes used to identify chemotherapy Type of Codes Codes ICD-9-CM procedure codes for administration CPT codes for administration excluding HCPCS codes for administration C8953-C8955, G0355-G0362 excluding G0356, G3001, Q0083-Q0085 ICD-9-CM diagnosis code V58.1, V66.2, V67.2 Revenue codes 0331, 0332, 0335 DRG codes 410 and 492 on inpatient claims with discharge date before October 1, 2007; and on inpatient claims with discharge date on or after October 1, 2007 HCPCS codes for chemotherapeutic A9522, A9523, A9534, A9542-A9545, C1081, C1083, agents * C1166, C1167, C1178, C9017, C9110, C9117, C9118, C9127, C9205, C9213-C9215, C9253, C9257, C9259, C9260, C9265, C9414, C9415, C9417-C9429, C9431- C9433, C9437, C9439, C9440, J0594, J7527,, J8510, J8520, J8521, J8530, J8560-J8562, J8565, J8600, J8610, J8700, J8705, J9000-J9999 (excluding J9155, J9202, J9212, J9215-J9219, J9225, J9226, J9395), Q2017, Q2024, Q2025, Q2049, S0116, S0172, S0178, S0182 CPT, Current Procedural Terminology; DRG, diagnosis-related group; HCPCS, Healthcare Common Procedure Coding System; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification. * Includes Aldesleukin, Alemtuzumab, Arsenic trioxide, Asparaginase (erwinaze), Azacitidine, BCG (intravesical) per instillation, Bendamustine, Bevacizumab (Avastin), Bleomycin, Bortezomib, Brentuximab vedotin, Busulfan, Cabazitaxel, Capecitabine, Carboplatin, Carmustine, Cetuximab, Chlorambucil (Leukeran), Cisplatin, Cladribine, Clofarabine, Cyclophosphamide, Cytarabine liposome, Dacarbazine, Dactinomycin, Daunorubicin, Denileukin diftitox, Diethylstilbestrol diphosphate, Docetaxel, Doxorubicin, Elliotts b solution, Epirubicin, Eribulin mesylate, Etoposide, Everolimus, Floxuridine, Fludarabine, Fluorouracil, Gefitinib, Gemcitabine, Gemtuzumab ozogamicin, Ibritumomab tiuxetan (Zevalin), Idarubicin,

3 Ifosfamide, Interferon alfa-2a and alfa-2b, Ipilimumab, Irinotecan, Ixabepilone, Lomustine, Mechlorethamine, Melphalan, Mesna, Methotrexate, Mitomycin, Mitoxantrone, Nelarabine, Ofatumumab, Oxaliplatin, Paclitaxel, Panitumumab, Pegaspargase, Pemetrexed, Pentostatin, Plicamycin, Porfimer sodium, Pralatrexate, Procarbazine hydrochloride, Rituximab, Romidepsin, Streptozocin, Temozolomide, Temsirolimus, Teniposide, Thiotepa, Topotecan, Tositumomab (Bexxar), Trastuzumab, Valrubicin, Vinblastine, Vincristine, and Vinorelbine.

4 Supplementary Table S2. International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis codes used to define comorbid conditions Comorbid Conditions ICD-9-CM Diagnosis Codes Chronic kidney disease 016.0, 095.4, 189.0, 189.9, 223.0, , 250.4, 271.4, 274.1, , 403.X1, 404.X2, 404.X3, 440.1, 442.1, 447.3, 572.4, , 591, 642.1, 646.2, , , 753.2, and Atherosclerotic heart disease , V45.18, and V45.82 Cerebrovascular accidents/transient ischemic attacks Chronic obstructive pulmonary disease 491.xx-494.xx, 496.xx, 510.xx Congestive heart failure , 422.xx, 425.xx, 428.xx, 402.x1, 404.x1, 404.x3, V42.1 Diabetes mellitus 250.xx, 357.2, 362.0x, Dysrhythmia 426.xx-427.xx, V45.0, and V53.3 Gastrointestinal disorders , 530.7, 531.xx-534.xx, , , 578 Liver disease 570.xx, 571.xx, 572.1, 572.4, , V42.7, Other cardiovascular disease 420.xx-421.xx, 423.xx-424.xx, 429.xx, , V42.2, and V43.3 Peripheral vascular disease ; 447; ; 557 Anemia HIV infection 042, Thyroid disease 240.x-246.x Peptic ulcer disease 531.x-539.x Rheumatoid disease (rheumatoid arthritis) 714.x Osteoarthritis 715.x Other cancer ; ; (excluding for breast cancer, for lung cancer, and 200 and 202 for non-hodgkin lymphoma)

5 Supplementary Table S3. List of oral antimicrobial agents Antimicrobial Class Antibacterials Penicillins Cephalosporins Macrolides Tetracyclines Fluoroquinolones Aminoglycosides Sulfonamides Other Antifungals Antivirals Drug Name Amoxicillin, Dicloxacillin sodium, Amoxicillin and Clavulanate, Ampicillin Cefadroxil, Cephalexin, Cefaclor, Cefprozil, Cefuroxime Axetil, Cefdinir, Cefditoren, Cefixime, Cefpodoxime, Ceftibuten Erythromycin, Azithromycin, Clarithromycin, Fidaxomicin Demeclocycline, Doxycycline, Minocycline, Tetracycline Ciprofloxacin, Levofloxacin, Moxifloxacin, Norfloxacin, Ofloxacin, Gemifloxacin Neomycin, Paromomycin Sulfadiazine, Sulfamethoxazole-Trimethoprim Vancomycin, Telithromycin, Clindamycin, Linezolid Terbinafine, Flucytosine, Griseofulvin, Ketoconazole, Nystatin, Fluconazole, Itraconazole, Posaconazole, Voriconzaole Adefovir dipivoxil, Amantadine HCl, Acyclovir, Famciclovir, Valacyclovir, Boceprevir, Entecavir, Oseltamivir, Ribavirin, Rimantadine HCl, Telaprevir, Valganciclovir

6 Supplementary Table S4. Distribution of chemotherapy regimens or top five most frequently used agents, by cancer type and febrile neutropenia risk category of chemotherapy regimen Cancer Type, Risk Category, or Agents n % Breast cancer (n = 9110) High risk (n = 923) Dose dense AC + sequential T (doxorubicin, cyclophosphamide, paclitaxel) TAC (docetaxel, doxorubicin, cyclophosphamide) Docetaxel + trastuzumab AT (doxorubicin, paclitaxel) AT (doxorubicin, docetaxel) ^ ^ Docetaxel every 14 days * * Intermediate risk (n = 908) Paclitaxel every 21 days CMF classic (cyclophosphamide, methotrexate, fluorouracil) Paclitaxel, Trastuzumab Docetaxel every 21 days FEC (fluorouracil/epirubicin/cyclophosphamide) Other risk (n = 7279) Top five agents by number of patients received during the course Cyclophosphamide/docetaxel Bevacizumab Capacitabine Trastuzumab/docetaxel/carboplatin Trastuzumab Lung cancer (n = 12,032) High risk (n = 37) Topotecan Intermediate risk (n = 5130) Carboplatin/paclitaxel Etoposide/carboplatin Cisplatin/etoposide Cisplatin/vinorelbine Docetaxel Cisplatin/docetaxel Cisplatin/paclitaxel Cisplatin/irinotecan Other risk (n = 6865) Top five agents by number of patients received during the course Docetaxel/carboplatin Pemetrexed Carboplatin/pemetrexed Gemcitabine/carboplatin Paclitaxel/carboplatin/bevacizumab

7 Non-Hodgkin lymphoma (n = 6306) High risk (n = 1035) CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) + rituximab HyperCVAD (cyclophosphamide, vincristine, doxorubicin, dexamethasone) + rituximab RICE (rituximab, ifosfamide, carboplatin, etoposide) * * MINE (mesna, ifosfamide, novantrone, etoposide) * * CHOP-14 (cyclophosphamide, doxorubicin, vincristine, prednisone) * * ESHAP (etoposide, methylprednisolone, cisplatin, cytarabine) * * Intermediate risk (n = 24) FM (fludarabine, mitoxantrone) GDP (gemcitabine, dexamethasone, cisplatin) * * EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin) * * GDP (gemcitabine, dexamethasone, cisplatin)+rituximab * * Other risk (n = 5247) Top five agents by number of patients received during the course n % Rituximab Cyclophosphamide/rituximab/vincristine Rituximab/bendamustine Bevacizumab Rituximab/fludarabine * Values for cells with ten or fewer patients are suppressed. ^ Value is suppressed to avoid deriving another cell with ten or fewer patients.

Primary malignant neoplasms, not lymphatic or hematopoietic. Secondary malignant neoplasms (i.e.metastatic) Malignant neoplasm, unknown site

Primary malignant neoplasms, not lymphatic or hematopoietic. Secondary malignant neoplasms (i.e.metastatic) Malignant neoplasm, unknown site Supplementary Table 1. ICD-9-CM codes used to define cancer ICD-9 Diagnosis code 140.xx-172.xx 174.xx-195.xx 196.xx 198.xx 199.xx 200.xx-208.xx Description Primary malignant neoplasms, not lymphatic or

More information

MEDICAL NECESSITY GUIDELINE

MEDICAL NECESSITY GUIDELINE PAGE: 1 of 10 IMPORTANT REMINDER This Clinical Policy has been developed by appropriately experienced and licensed health care professionals based on a thorough review and consideration of generally accepted

More information

Exhibit B United States Patent Application 20020012663 Kind Code A1 Waksal, Harlan W. January 31, 2002 Treatment of refractory human tumors with epidermal growth factor receptor antagonists Abstract A

More information

Guidelines on Chemotherapy-induced Nausea and Vomiting in Pediatric Cancer Patients

Guidelines on Chemotherapy-induced Nausea and Vomiting in Pediatric Cancer Patients Guidelines on Chemotherapy-induced Nausea Vomiting in Pediatric Cancer Patients COG Supportive Care Endorsed Guidelines Click here to see all the COG Supportive Care Endorsed Guidelines. DISCLAIMER For

More information

ELECTRONIC HEALTH RECORD (EHR) ENHANCEMENTS FOR MARCH 15, 2016 SUMMARY

ELECTRONIC HEALTH RECORD (EHR) ENHANCEMENTS FOR MARCH 15, 2016 SUMMARY ELECTRONIC HEALTH RECORD (EHR) ENHANCEMENTS FOR MARCH 15, 2016 SUMMARY Problem Opening PACS Images on ipads or ibooks has Been Fixed Changes have been made in PROD to enable user credentials to be passed

More information

Objective: To provide a standard procedure for the recycling of unused medication and the disposal of medicines across all BCPFT Hospital sites.

Objective: To provide a standard procedure for the recycling of unused medication and the disposal of medicines across all BCPFT Hospital sites. WARDS/DEPARTMENTS By: 0 01/09/019 1 of 3 Objective: To provide a standard procedure for the recycling of unused medication and the disposal of medicines across all BCPFT Hospital sites. Scope: All Black

More information

Committee Approval Date: December 12, 2014 Next Review Date: July 2015

Committee Approval Date: December 12, 2014 Next Review Date: July 2015 Medication Policy Manual Policy No: dru378 Topic: Akynzeo, netupitant/palonosetron Date of Origin: December 12, 2014 Committee Approval Date: December 12, 2014 Next Review Date: July 2015 Effective Date:

More information

West of Scotland Cancer Network Guideline for Managing Chemotherapy Induced Nausea and Vomiting

West of Scotland Cancer Network Guideline for Managing Chemotherapy Induced Nausea and Vomiting West of Scotland Cancer Network Guideline for Managing Chemotherapy Induced Nausea and Vomiting Definitions Acute nausea and vomiting Delayed nausea and vomiting Anticipatory nausea and vomiting Initial

More information

SCI. SickKids-Caribbean Initiative Enhancing Capacity for Care in Paediatric Cancer and Blood Disorders

SCI. SickKids-Caribbean Initiative Enhancing Capacity for Care in Paediatric Cancer and Blood Disorders 1.0 Introduction The (SCI) is a not-for-profit collaboration between the Hospital for Sick Children (SickKids), Toronto, Canada, and seven Caribbean health care institutions across six countries that strive

More information

Part B payment for drugs in Medicare 0

Part B payment for drugs in Medicare 0 Part B payment for drugs in Medicare 0 Introduction: The recent pilot proposal 1 on Part B drug payment from the Center for Medicare and Medicaid Innovation of CMS has met strong resistance 2 from the

More information

Vivida Health Specialty Pharmacy Drugs (Injectable) Prior-Authorization Requirements Effective 1/1/19

Vivida Health Specialty Pharmacy Drugs (Injectable) Prior-Authorization Requirements Effective 1/1/19 Vivida Health Specialty Pharmacy Drugs (Injectable) Prior-Authorization Requirements Effective 1/1/19 All Non-Par Provider Requests Requires Authorization Regardless of Service J0178 J0180 J0202 J0205

More information

Co-morbidities in Elderly Breast and Lung Cancer Patients who receive Chemotherapy of NCCN defined Intermediate Risk of Febrile Neutropenia

Co-morbidities in Elderly Breast and Lung Cancer Patients who receive Chemotherapy of NCCN defined Intermediate Risk of Febrile Neutropenia Co-morbidities in Elderly Breast and Lung Cancer Patients who receive Chemotherapy of NCCN defined Intermediate Risk of Febrile Neutropenia Authors: John H. Page, Shuling Li, Julia Molony, Romina Sosa,

More information

Subject: Palonosetron Hydrochloride (Aloxi )

Subject: Palonosetron Hydrochloride (Aloxi ) 09-J0000-87 Original Effective Date: 02/15/09 Reviewed: 07/09/14 Revised: 03/15/18 Subject: Palonosetron Hydrochloride (Aloxi ) THIS MEDICAL COVERAGE GUIDELINE IS NOT AN AUTHORIZATION, CERTIFICATION, EXPLANATION

More information

Managements of Chemotherpay Induded Nausea and Vomiting

Managements of Chemotherpay Induded Nausea and Vomiting REVIEW ARTICLE Managements of Chemotherpay Induded Nausea and Vomiting Department of Surgery, The Catholic University of Korea Sung Geun Kim 23 24 Sung Geun Kim Korean Journal of Clinical Oncology Summer

More information

Part B payment for drugs in Medicare: Phase 1 of CMS s proposed pilot and its impact on oncology care

Part B payment for drugs in Medicare: Phase 1 of CMS s proposed pilot and its impact on oncology care Part B payment for drugs in Medicare: Phase 1 of CMS s proposed pilot and its impact on oncology care Raina H. Jain, Stephen M. Schleicher, Coral L. Atoria, Peter B. Bach Executive Summary The recent pilot

More information

GUIDELINES FOR ANTIEMETIC USE IN ONCOLOGY SUMMARY CLASSIFICATION

GUIDELINES FOR ANTIEMETIC USE IN ONCOLOGY SUMMARY CLASSIFICATION GUIDELINES FOR ANTIEMETIC USE IN ONCOLOGY SUMMARY More than half of all cancer patients experience nausea or vomiting during the course of their treatment. If nausea or vomiting becomes severe enough,

More information

Part B payment for drugs in Medicare 0

Part B payment for drugs in Medicare 0 Part B payment for drugs in Medicare 0 Introduction: The recent pilot proposal 1 on Part B drug payment from the Center for Medicare and Medicaid Innovation of CMS has met strong resistance 2 from the

More information

Guidelines for the Use of Anti-Emetics with Chemotherapy

Guidelines for the Use of Anti-Emetics with Chemotherapy Guidelines for the Use of Anti-Emetics with The purpose of this document is to provide guidance on the rational use of anti-emetics for prevention and treatment of chemotherapy-induced nausea and vomiting

More information

Emetogenicity level 1. Emetogenicity level 2

Emetogenicity level 1. Emetogenicity level 2 Emetogenicity level 1 15 mins Pre-Chemo Maxalon 10mg po During chemo and Post Chemo 3 days Maxalon10mg po 8 hourly Increase Maxalon 20mg po 8 hourly Change to Cyclizine 50mg po 8 hourly 3 days If nausea

More information

Protocol Number Tumour Group Protocol Name on NCCP website 22/02/ Lung Afatinib Monotherapy 244 Gastrointestinal Regorafenib Monotherapy

Protocol Number Tumour Group Protocol Name on NCCP website 22/02/ Lung Afatinib Monotherapy 244 Gastrointestinal Regorafenib Monotherapy Last Updated 22-Feb-18 Date of last update Protocol Number Tumour Group Protocol Name on NCCP website 22/02/2018 221 Afatinib Monotherapy 244 Gastrointestinal Regorafenib Monotherapy 249 Gynaecology Intrathecal

More information

Subject: Fosnetupitant-Palonosetron (Akynzeo) IV

Subject: Fosnetupitant-Palonosetron (Akynzeo) IV 09-J3000-01 Original Effective Date: 06/15/18 Reviewed: 05/09/18 Revised: 01/01/19 Subject: Fosnetupitant-Palonosetron (Akynzeo) IV THIS MEDICAL COVERAGE GUIDELINE IS NOT AN AUTHORIZATION, CERTIFICATION,

More information

Protocol Number Intrathecal Methotrexate for CNS 01/02/2018 Prophylaxis in GTN Gynaecology 249

Protocol Number Intrathecal Methotrexate for CNS 01/02/2018 Prophylaxis in GTN Gynaecology 249 Last updated Feb 9, 2018 Revision due Protocol Name on NCCP website Tumour Group Protocol Number Intrathecal Methotrexate for CNS 01/02/2018 Prophylaxis in GTN Gynaecology 249 Two Day Etoposide CISplatin

More information

DOXOrubicin, Cyclophosphamide (AC 60/600) 21 day followed by weekly PACLitaxel (80) Therapy (AC-T) 261 CARBOplatin (AUC4-6) Monotherapy-21 days

DOXOrubicin, Cyclophosphamide (AC 60/600) 21 day followed by weekly PACLitaxel (80) Therapy (AC-T) 261 CARBOplatin (AUC4-6) Monotherapy-21 days Last updated Oct 17, 2018 Tumour Group Protocol Number Protocol Name on NCCP website Breast 200 Trastuzumab (IV) Monotherapy 21 days 201 Trastuzumab (IV) Monotherapy 7 days 202 DOCEtaxel Monotherapy 100mg/m2

More information

Haematology, Oncology and Palliative Care Directorate.

Haematology, Oncology and Palliative Care Directorate. Anticancer Treatment for Administration on the Somerset Mobile Chemotherapy Unit The table below details the suitability of different types of anticancer treatment for administration on the Somerset Mobile

More information

Description The following are synthetic cannabinoids requiring prior authorization: dronabinol (Marinol, Syndros ), nabilone (Cesamet )

Description The following are synthetic cannabinoids requiring prior authorization: dronabinol (Marinol, Syndros ), nabilone (Cesamet ) Clinical Policy: Nabilone (Cesamet), Dronabinol (Marinol, Syndros) Reference Number: CP.CPA.242 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business: Commercial Revision Log See Important

More information

Guideline Update on Antiemetics

Guideline Update on Antiemetics Guideline Update on Antiemetics Clinical Practice Guideline Special Announcements Please check www.asco.org/guidelines/antiemetics for current FDA alert(s) and safety announcement(s) on antiemetics 2 Introduction

More information

Guideline for Classification of the Acute Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patients

Guideline for Classification of the Acute Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patients Guideline for Classification of the Acute Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patients POGO Antineoplastic Induced Nausea and Vomiting Guideline Development Panel: L.

More information

Fee-for-Service Pharmacy Provider Notice #215 ** January 2016 PDL Changes ** Existing Drug Classes

Fee-for-Service Pharmacy Provider Notice #215 ** January 2016 PDL Changes ** Existing Drug Classes Fee-for-Service Pharmacy Provider Notice #215 ** January 2016 PDL Changes ** December 19, 2016 Please be advised that the Department for Medicaid Services (DMS) is making changes to the Kentucky Medicaid

More information

Hodgkin and Non-Hodgkin Lymphoma (LYM) Post-Infusion Data

Hodgkin and Non-Hodgkin Lymphoma (LYM) Post-Infusion Data Hodgkin and Non-Hodgkin Lymphoma (LYM) Post-Infusion Data Registry Use Only Sequence Number: Date Received: CIBMTR Center Number: CIBMTR Research ID: Event date: / / Visit 100 day 6 months 1 year 2 years

More information

General Authorization Criteria for ALL Agents and Indications:

General Authorization Criteria for ALL Agents and Indications: Neulasta (peg-filgrastim; G-CSF) Neupogen (filgrastim; G-CSF) Neulasta Onpro (peg-filgrastim; G-CSF) Leukine (sargramostim; GM-CSF) General Authorization Criteria for ALL Agents and Indications: Prescribed

More information

Adverse effects of anticancer drugs (Antimetabolites agents, Alkylating agents, Antimicrotubule agents, Miscellaneous agents, Immune therapies and

Adverse effects of anticancer drugs (Antimetabolites agents, Alkylating agents, Antimicrotubule agents, Miscellaneous agents, Immune therapies and 35 Adverse effects of anticancer drugs (Antimetabolites agents, Alkylating agents, Antimicrotubule agents, Miscellaneous agents, Immune therapies and Biologically directed therapies ) 1 1- Nausea and vomiting

More information

Subject: NK-1 receptor antagonist injectable therapy (Emend, Cinvanti, Varubi )

Subject: NK-1 receptor antagonist injectable therapy (Emend, Cinvanti, Varubi ) 09-J2000-60 Original Effective Date: 06/15/16 Reviewed: 04/11/18 Revised: 01/01/19 Subject: NK-1 receptor antagonist injectable therapy (Emend, Cinvanti, Varubi ) THIS MEDICAL COVERAGE GUIDELINE IS NOT

More information

MASCC Guidelines for Antiemetic control: An update

MASCC Guidelines for Antiemetic control: An update MASCC / ISOO 17 th International Symposium Supportive Care in Cancer June 30 July 2, 2005 / Geneva, Switzerland MASCC Guidelines for Antiemetic control: An update Sussanne Börjeson, RN, PhD Linköping University,

More information

APPHON/ROPPHA Guideline for the Prevention and Management of Chemotherapy Induced Nausea and Vomiting in Children with Cancer

APPHON/ROPPHA Guideline for the Prevention and Management of Chemotherapy Induced Nausea and Vomiting in Children with Cancer APPHON/ROPPHA Guideline for the Prevention and Management of Chemotherapy Induced Nausea and Vomiting in Children with Cancer 5850/5980 University Avenue, PO Box 9700, Halifax, N.S. B3K 6R8 PEDIATRIC HEMATOLOGY/ONCOLOGY

More information

Current and Emerging Therapeutic Options in the Management of Chemotherapy-Induced Nausea and Vomiting (CINV) Objectives

Current and Emerging Therapeutic Options in the Management of Chemotherapy-Induced Nausea and Vomiting (CINV) Objectives Current and Emerging Therapeutic Options in the Management of Chemotherapy-Induced Nausea and Vomiting (CINV) Susan Urba, M.D. University of Michigan Comprehensive Cancer Center Objectives Mechanisms of

More information

Pharmacy Prior Authorization Colony Stimulating Factor (CSF)/Myeloid Growth Factor (MGF) Clinical Guideline

Pharmacy Prior Authorization Colony Stimulating Factor (CSF)/Myeloid Growth Factor (MGF) Clinical Guideline Neulasta (peg-filgrastim; G-CSF) Neupogen (filgrastim; G-CSF) Neulasta Onpro (peg-filgrastim; G-CSF) Leukine (sargramostim; GM-CSF) General Authorization Criteria for ALL Agents and Indications: Prescribed

More information

Adult Intravenous Systemic Anticancer Therapy (SACT) Section A. SUMMARY of SCHEME QIPP Reference

Adult Intravenous Systemic Anticancer Therapy (SACT) Section A. SUMMARY of SCHEME QIPP Reference CA2 Nationally standardised Dose banding for Adult Intravenous Anticancer Therapy (SACT) Scheme Name CA2: Nationally Standardised Dose Banding for Adult Intravenous Systemic Anticancer Therapy (SACT) Section

More information

DRUG PROPERTIES YOU NEED TO KNOW

DRUG PROPERTIES YOU NEED TO KNOW Dr. Janet Fitzakerley Summer 2013 Med 6541 Hematopoiesis and Host Defences jfitzake@d.umn.edu www.d.umn.edu/~jfitzake Page 1 of 11 DRUG PROPERTIES YOU NEED TO KNOW 1. Mechanism of action a. chemical class

More information

VI.2 Elements for a Public Summary VI.2.1 Overview of Disease Epidemiology Acute Nausea and Vomiting (N&V) Etiologies:

VI.2 Elements for a Public Summary VI.2.1 Overview of Disease Epidemiology Acute Nausea and Vomiting (N&V) Etiologies: VI.2 Elements for a Public Summary VI.2.1 Overview of Disease Epidemiology Acute Nausea and Vomiting (N&V) Incidence: The incidence of acute and delayed N&V was investigated in highly and moderately emetogenic

More information

COST CONSIDERATIONS Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines!!!!!!!!!

COST CONSIDERATIONS Union for International Cancer Control 2014 Review of Cancer Medicines on the WHO List of Essential Medicines!!!!!!!!! UICCEMLCostingScenarios BackoftheEnvelope Calculations PreparedforWorkingGroupSession:19621November2014,Geneva MethodsSummary We have chosen a conservative approach, calculating cost per vial. We have

More information

Pharmacy Prior Authorization Colony Stimulating Factors Clinical Guideline. Neulasta Onpro (peg-filgrastim; G-CSF) Leukine (sargramostim; GM-CSF)

Pharmacy Prior Authorization Colony Stimulating Factors Clinical Guideline. Neulasta Onpro (peg-filgrastim; G-CSF) Leukine (sargramostim; GM-CSF) Neulasta (peg-filgrastim; G-CSF) Neupogen (filgrastim; G-CSF) Neulasta Onpro (peg-filgrastim; G-CSF) Leukine (sargramostim; GM-CSF) General Authorization Criteria for ALL Agents and Indications: Prescribed

More information

See Important Reminder at the end of this policy for important regulatory and legal information.

See Important Reminder at the end of this policy for important regulatory and legal information. Clinical Policy: Reference Number: CP.CPA.223 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business: Commercial Revision Log See Important Reminder at the end of this policy for important regulatory

More information

Adjuvant/Curative/Neo-adjuvant High Grade and Burkitt s Lymphoma Regimens. High Grade Lymphoma

Adjuvant/Curative/Neo-adjuvant High Grade and Burkitt s Lymphoma Regimens. High Grade Lymphoma Adjuvant/Curative/Neo-adjuvant High Grade and Burkitt s Lymphoma Regimens The following table lists the evidence-informed regimens (both IV and non-iv) for high grade and Burkitt s lymphoma used in the

More information

The AngCN Antiemetic Guidelines

The AngCN Antiemetic Guidelines The AngCN Antiemetic Guidelines Guidelines for the Management of Nausea and Vomiting in Adult Patients Receiving Chemotherapy and/or Radiotherapy AngCN Document Reference: AngCN-CCG-C31 CONTENTS 1.0 Introduction

More information

1. Purpose Documentation Description.1 4. References 8 5. Cross-References.8 6. Development of the guideline.8

1. Purpose Documentation Description.1 4. References 8 5. Cross-References.8 6. Development of the guideline.8 CLINICAL GUIDELINE For use in (clinical areas): For use by (staff groups): For use for (patients): Document owner: Status: Oncology/Haematology Unit (excluding Paediatrics) Oncologists, Haematologists,

More information

Prevention and Management of chemo-and radiotherapy-induced nausea and vomiting

Prevention and Management of chemo-and radiotherapy-induced nausea and vomiting Prevention and Management of chemo-and radiotherapy-induced nausea and vomiting Focusing on the updated MASCC/ESMO guidelines Karin Jordan Department of Hematology and Oncology, University of Heidelberg

More information

ICON Formulary - October 2018 Legend - ICON Protocols Essential (previously Standard), Core, Enhanced Core, Enhanced Enhanced

ICON Formulary - October 2018 Legend - ICON Protocols Essential (previously Standard), Core, Enhanced Core, Enhanced Enhanced ICON Formulary - October 2018 Legend - ICON Protocols Essential (previously Standard), Core, Enhanced Core, Enhanced Enhanced Class Medicine Name Nappi Strength Form Size Route Abiraterone Acetate ZYTIGA

More information

See Important Reminder at the end of this policy for important regulatory and legal information.

See Important Reminder at the end of this policy for important regulatory and legal information. Clinical Policy: (Zofran, Zuplenz) Reference Number: CP.CPA.173 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business: Medicaid Medi-Cal Revision Log See Important Reminder at the end of this

More information

To help doctors give their patients the best possible care, the American

To help doctors give their patients the best possible care, the American Patient Information Resources from ASCO What to Know ASCO s Guideline on Preventing Vomiting Caused by Cancer Treatment SEPTEMBER 2011 KEY MESSAGES The risk of nausea and vomiting depends on the specific

More information

ANTIEMETICS UTILIZATION MANAGEMENT CRITERIA

ANTIEMETICS UTILIZATION MANAGEMENT CRITERIA ANTIEMETICS [Akynzeo, Anzemet, Cesamet, Emend, Sancuso, Varubi, Zuplenz ] DRUG CLASS: UTILIZATION MANAGEMENT CRITERIA 5-HT 3 Receptor Antagonists 5-HT 3 Receptor Antagonist and Substance P/Neurokinin (NK

More information

DRUG EXTRAVASATION. Vesicants. Irritants

DRUG EXTRAVASATION. Vesicants. Irritants DRUG EXTRAVASATION Vesicants Irritants Vesicants Antineoplastic drugs Amsacrine Dactinomycin Daunorubicin Docetaxel (rare) Doxorubicin Epirubicin Idarubicin Mechlorethamine Mitomycin Oxaliplatin (rare)

More information

2019 PHP PRIMARY CARE INCENTIVE

2019 PHP PRIMARY CARE INCENTIVE Primary Care Physicians (PCP) of Physicians Health Network (PHN) may be eligible for an incentive payment in accordance with this PHP PCP Incentive (hereinafter referred to as the PCP Incentive ). As described

More information

Antiemetic Guidelines. Guidelines for the Management of Nausea and Vomiting in Adult Patients Receiving Chemotherapy and/or Radiotherapy

Antiemetic Guidelines. Guidelines for the Management of Nausea and Vomiting in Adult Patients Receiving Chemotherapy and/or Radiotherapy Antiemetic Guidelines Guidelines for the Management of Nausea and Vomiting in Adult Patients Receiving Chemotherapy and/or Radiotherapy For approvals and version control see Document Management Record

More information

Northern Cancer Alliance

Northern Cancer Alliance Northern Cancer Alliance Anti-emetic Guidelines for Chemotherapy Induced Nausea and Vomiting (CINV) Adult Oncology & Haematology Document Control Document Title: Antiemetic Guidelines for CINV NESCN v2.2

More information

1 The Cancer Programs Regulation (AR 242/98) is amended by this Regulation.

1 The Cancer Programs Regulation (AR 242/98) is amended by this Regulation. Alberta Regulation 18/2005 Cancer Programs Act AMENDMENT REGULATION Filed: February 22, 2005 For information only: Made by the Minister of Health and Wellness (M.O. 9/2005) on February 17, 2005 pursuant

More information

AD regimen, 576 adrenal steroid inhibitor. aminoglutethimide, 23 25

AD regimen, 576 adrenal steroid inhibitor. aminoglutethimide, 23 25 A 640 Index Index abiraterone acetate, 5 7 Abraxane. See albuminbound paclitaxel ABVD regimen, 57, 540 ABV regimen, 519 520 AC docetaxel regimen, 476, 478 acetaminophen busulfan and, 71 AC regimen, 475,

More information

Acute Lymphocytic Leukemia

Acute Lymphocytic Leukemia Acute Lymphocytic Leukemia Splenectomy (Removal of Spleen) 6-Mercaptopurine (Purinethol, 6-MP) Alemtuzumab (Campath ) Arsenic Trioxide (Trisenox ) Bendamustine (Treanda ) Bexarotene (Targretin ) Bleomycin

More information

OVERVIEW OF COMMENTS RECEIVED ON LIST OF PAEDIATRIC NEEDS ONCOLOGY I (CYTOTOXIC THERAPY)

OVERVIEW OF COMMENTS RECEIVED ON LIST OF PAEDIATRIC NEEDS ONCOLOGY I (CYTOTOXIC THERAPY) European Medicines Agency Evaluation of Medicines for Human Use London, September 2006 Doc. Ref. OVERVIEW OF COMMENTS RECEIVED ON LIST OF PAEDIATRIC NEEDS ONCOLOGY I (CYTOTOXIC THERAPY) Table 1: Organisations

More information

Disclosure. Objectives. Objectives. Oncologic Emergency. Classification of Emergencies 1 3/2/2015

Disclosure. Objectives. Objectives. Oncologic Emergency. Classification of Emergencies 1 3/2/2015 Disclosure Oncologic Emergencies and Acute Supportive Care of the Critically Ill Oncology Patient By: Kimberly Regis, Pharm.D. Broward Health Medical Center Pharmacy Resident 2014-2015 I do not have a

More information

HCPCS Code/ generic (Brand) Name J7506. J8520 capecitabine (Xeloda) 1. J8521 capecitabine. J8530 cyclophosphamide. (Cytoxan) 1

HCPCS Code/ generic (Brand) Name J7506. J8520 capecitabine (Xeloda) 1. J8521 capecitabine. J8530 cyclophosphamide. (Cytoxan) 1 drug and administration compendia Current Price () J7506 Prednisone, oral, per 5 mg 12/1/07 $0.07 $0.19 N/A prednisone 2 J8520 capecitabine (Xeloda) 1 Capecitabine, oral, 150 mg 8/1/07 $5.79 $4.59 N/A

More information

Chemotherapy induced emesis: Are we doing are best? David Warr University of Toronto

Chemotherapy induced emesis: Are we doing are best? David Warr University of Toronto Chemotherapy induced emesis: Are we doing are best? David Warr University of Toronto david.warr@uhn.on.ca Conflict of interest Merck: speakers bureau and consultant Eisai: consultant Outline What is the

More information

Introduction to Antineoplastic Prescribing

Introduction to Antineoplastic Prescribing Introduction to Antineoplastic Prescribing Robert Bradbury, R.Ph., BCPS Clinical Coordinator H. Lee Moffitt Cancer Center Objectives Meet the following goals concerning antineoplastic prescribing: Understand

More information

Ovarian Cancer. compendia TREATMENT OF

Ovarian Cancer. compendia TREATMENT OF drug & compendia TREATMENT OF Ovarian Cancer With each publication, ManagedCare Oncology s drug & Compendia highlights a single medication or a group of medications that could be utilized in the management

More information

Clinical Tools and Resources for Self-Study and Patient Education

Clinical Tools and Resources for Self-Study and Patient Education Clinical Tools and Resources for Self-Study and Patient Education CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING CLINICIAN'S RESOURCE GUIDE The clinical tools and resources contained herein are provided as educational

More information

Job title: Consultant Pharmacist/Advanced Practice Pharmacist

Job title: Consultant Pharmacist/Advanced Practice Pharmacist Title : Guidelines for the Use of Antiemetics Purpose: To provide trust-wide guidance on the safe and effective use of antiemetics for the prevention and treatment of chemotherapy and radiotherapy induced

More information

Supplementary Figures

Supplementary Figures Supplementary Figures Supplementary Figure 1. Characterization of the generated hipsc lines a) Western blot analysis indicating the efficient downregulation of p53 upon knockdown in three hipsc lines (

More information

Co-morbidities in Elderly Breast Cancer Patients treated with Chemotherapy

Co-morbidities in Elderly Breast Cancer Patients treated with Chemotherapy Co-morbidities in Elderly Breast Cancer Patients treated with Chemotherapy Authors: Romina Sosa, Julia Molony, Shuling Li, Richard Barron, Phuong Khanh Morrow, Scott Stryker, Jiannong Liu, Allan J. Collins,

More information

Chemotherapy Induced Nausea and Vomiting (CINV) Anti-emetic Guidelines

Chemotherapy Induced Nausea and Vomiting (CINV) Anti-emetic Guidelines North of England Cancer Network Chemotherapy Induced Nausea and Vomiting (CINV) Anti-emetic Guidelines Adult Oncology & Haematology Quality and safety for every patient every time For more information

More information

Patient-Centered Management of Chemotherapy-Induced Nausea and Vomiting

Patient-Centered Management of Chemotherapy-Induced Nausea and Vomiting Clear and accurate communication between patients and health care teams is the key to successfully controlling chemotherapy-induced nausea and vomiting. Roseate Spoonbill_2005. Photograph courtesy of Henry

More information

Trust Guideline for Prevention and Control of Chemotherapy and Radiotherapy Induced Nausea and Vomiting in Adults

Trust Guideline for Prevention and Control of Chemotherapy and Radiotherapy Induced Nausea and Vomiting in Adults A Clinical Guideline For Use in: Organisation-wide By: For: Key words: Name of document author: Job title of document author: Name of document author s Line Manager: Job title of author s Line Manager:

More information

Systemic Anticancer Therapy Drug Interactions Table

Systemic Anticancer Therapy Drug Interactions Table Systemic Anticancer Therapy Drug Interactions Table 1 This guide is intended to cover the most common interactions involving Systemic Anticancer therapies, e.g. cytotoxic agents, monoclonal antibodies

More information

Welcome. Coding uidelines Coding Guidelines Coding. Coding Guidelines Coding Guidelines. Contact Us. Edition #1 March 2018

Welcome. Coding uidelines Coding Guidelines Coding. Coding Guidelines Coding Guidelines. Contact Us. Edition #1 March 2018 Coding Guidelines Coding Guidelines uidelines Coding Guidelines Coding Coding Coding Guidelines Guidelines Coding uidelines Coding Guidelines Coding Coding Chemotherapy Guidelines and Radiation Coding

More information

Guidelines for the Management of Extravasation (Version 5 May 2012)

Guidelines for the Management of Extravasation (Version 5 May 2012) Guidelines for the Management of Extravasation (Version 5 May 2012) Quality and safety for every patient every time Document Control Prepared By Chemo Nurse Group Chemo Nurse Group/ South Tees FT NECDAG

More information

DRUG PROPERTIES YOU NEED TO KNOW

DRUG PROPERTIES YOU NEED TO KNOW jfitzake@d.umn.edu www.d.umn.edu/~jfitzake Page 1 of 8 DRUG PROPERTIES YOU NEED TO KNOW 1. Mechanism of action a. chemical class b. resistance 2. Pharmacokinetics 3. Therapeutic uses 4. Major side effects/toxicities

More information

intolerance to, contraindication to, or therapeutic failure on a minimum 3 month trial of Inflectra*

intolerance to, contraindication to, or therapeutic failure on a minimum 3 month trial of Inflectra* What s New Medical Pharmaceutical Policy March 2018 Updates MBP 5.0 Remicade (infliximab), Inflectra (infliximab-dyyb), Renflexis (infliximab-abda)- Updated policy Remicade (infliximab), Inflectra (infliximab-dyyb)

More information

Hazardous Medication List

Hazardous Medication List Hazardous Medication List REDUCING OCCUPATIONAL EXPOSURE TO HAZARDOUS MEDICATION FOR ALL STAFF Table of Contents Hazardous Medication List Key Points... 1 Hazardous Medication List... 2 Special Handling

More information

Antiemetics: Guidelines, Interactions and more.

Antiemetics: Guidelines, Interactions and more. Antiemetics: Guidelines, Interactions and more. Chemotherapy-induced side effects -the patient s view Loss of hair The thought of coming for chemo Affects family/partner Affects work/home duties Jude Lees

More information

Title Developed By. Implementation Contact person(s) Review Date Group Responsible. NICaN Policy: Management of Chemotherapy Extravasation; Version 3

Title Developed By. Implementation Contact person(s) Review Date Group Responsible. NICaN Policy: Management of Chemotherapy Extravasation; Version 3 Title Developed By Management of Chemotherapy Extravasation NICaN Regional Pharmacy Group Version History Version 3: 2009 (See appendix 6) Version 2: January 2006 Version 1: June 2005 Consultation Period

More information

Working Formulary January 2013 Oncology Chemotherapy Regimens

Working Formulary January 2013 Oncology Chemotherapy Regimens Working Formulary January 2013 Oncology Chemotherapy Regimens In the currently changing commissioning landscape, this document is intended to represent the up to date list of non clinical trial chemotherapy

More information

Guidelines for the Management of Extravasation

Guidelines for the Management of Extravasation Guidelines for the Management of Extravasation (Version 5.5-04 Nov 2016) Quality and safety for every patient every time Document Control Prepared By Chemo Nurse Group Chemo Nurse Group/ South Tees FT

More information

H&HD ANTINEOPLASTIC DRUG CARD ASSEMBLY INSTRUCTIONS

H&HD ANTINEOPLASTIC DRUG CARD ASSEMBLY INSTRUCTIONS H&HD ANTINEOPLASTIC DRUG CARD ASSEMBLY INSTRUCTIONS Each of you should have 37 new cards: 7 orange cards for antimetabolites 11 white cards for miscellaneous drugs (2 DNA synthesis inhibitors, 1 enzyme,

More information

Standard Regimens for Haematology

Standard Regimens for Haematology Regimens for Haematology ChlVPP Chlorambucil 6mg/m 2 PO D1 to 14 Vinblastine 6mg/m 2 (max 10mg) IV on D1 & 8 Procarbazine 100mg/m 2 PO on D1 to 14 Prednisolone 40mg PO D1 to 14 ABVD Doxorubicin 25mg/m

More information

Richard J. Gralla, MD Medical Director Quality of Life Research Associates New York, NY

Richard J. Gralla, MD Medical Director Quality of Life Research Associates New York, NY Oncology Consultations Improving the Management of Chemotherapy-Induced Nausea and Vomiting (CINV) A CE-Certified Activity Featuring Consultations With Supported by an educational grant from Eisai. Dannemiller

More information

DRUGS YOU NEED TO KNOW

DRUGS YOU NEED TO KNOW jfitzake@d.umn.edu Page 1 of 7 DRUGS YOU NEED TO KNOW ALKYLATING AGENTS (blue cards) BUSULFAN CARMUSTINE (BCNU) CYCLOPHOSPHAMIDE DACARBAZINE LOMUSTINE (CCNU) MECHLORETHAMINE MELPHALAN THIOTEPA NATURAL

More information

Medication Review. Cancer Chemotherapy Drugs. Pharmacy Technician Training Systems Passassured, LLC

Medication Review. Cancer Chemotherapy Drugs. Pharmacy Technician Training Systems Passassured, LLC Medication Review Cancer Chemotherapy Drugs Pharmacy Technician Training Systems Passassured, LLC Medication Review, Cancer Chemotherapy Drugs PassAssured's Pharmacy Technician Training Program Medication

More information

Supportive care session 1:

Supportive care session 1: Board review in oncology pharmacy 2013 Managing Disease or Treatment Related Complication Supportive care session 1: Chemotherapy induced-nausea and vomiting Suthan Chanthawong, B. Pharm, RPh. Objectives

More information

Antiemesis. NCCN Clinical Practice Guidelines in Oncology. Antiemesis. Version Continue

Antiemesis. NCCN Clinical Practice Guidelines in Oncology. Antiemesis. Version Continue Table of Contents Clinical in Oncology Version 2.2010 Continue www.nccn.org Version 2.2010, 04/07/2010 2010 National Comprehensive Cancer Network, Inc. All rights reserved. These guidelines and this illustration

More information

The following are J Code requirements

The following are J Code requirements The following are J Code requirements J Codes 20610 Arthrocentesis, aspiration and/or injection; major joint or bursa (eg, shoulder, hip, knee joint, subacromial bursa) A9579 Injection, gadolinium based

More information

CPT Service Description Effective Date

CPT Service Description Effective Date Medical Oncology Program Review Code List 2 nd Quarter 2018 This list is subject to change once per quarter. Changes will be posted to the BCBSNC website at www.bcbsnc.com by the 10th day of January, April,

More information

PHARMACY PEARLS CHANIN WRIGHT, PHARMD

PHARMACY PEARLS CHANIN WRIGHT, PHARMD PHARMACY PEARLS CHANIN WRIGHT, PHARMD OBJECTIVES From the pearls heard, discuss with someone near you What is something you can apply to your setting Traumatic brain injury in children Goals Correct and

More information

Corporate Medical Policy

Corporate Medical Policy Antiemetic Injection Therapy Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: antiemetic_injection_therapy 5/2015 3/2017 3/2018 3/2017 Description of Procedure

More information

2. Date of most recent breast cancer diagnosis / / 3. Pathlogy: Padget s Phyllodes Tubular Medullary Mucinous

2. Date of most recent breast cancer diagnosis / / 3. Pathlogy: Padget s Phyllodes Tubular Medullary Mucinous Breast Cancer Patients: Begin on page 1, then skip to page 3 Lymphoma Patients: Begin on page 2 1. Newly diagnosed with Breast carcinoma Stage: (includes inflammatory breast and newly diagnosed recurrent

More information

Contents Trials. Dose guidelines. Calvert formula Issue Date: January Author: No: Copy. Pagee 1 of 21. Issue.

Contents Trials. Dose guidelines. Calvert formula Issue Date: January Author: No: Copy. Pagee 1 of 21. Issue. Chapter 1: General information Contents Chapter 1: General information... 1 General observations... 2 Protocol Additions 2013... 2 Cancer Drugs Fund... 2 Off Protocol Treatment Policy... 2 Trials... 2

More information

Chemotherapy-induced Nausea and Vomiting: The Pharmacist s Role in Integrating Clinical Guidelines into Patient Care

Chemotherapy-induced Nausea and Vomiting: The Pharmacist s Role in Integrating Clinical Guidelines into Patient Care Chemotherapy-induced Nausea and Vomiting: The Pharmacist s Role in Integrating Clinical Guidelines into Patient Care Presented as a Live Webinar Wednesday, April 13, 2016 12:00 p.m. 1:00 p.m. ET Tuesday,

More information

Chemotherapy 101 for Radiation Oncology Workers

Chemotherapy 101 for Radiation Oncology Workers Chemotherapy 101 for Radiation Oncology Workers James Sinclair, M.D. CCARE/Medical Director Scripps Cancer Center March 9, 2013 Category 1) Alkylating agents Alkylating agents directly damage DNA to prevent

More information

REVIEW Guideline for the Classification of the Acute Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patients

REVIEW Guideline for the Classification of the Acute Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patients Pediatr Blood Cancer 2011;57:191 198 REVIEW Guideline for the Classification of the Acute Emetogenic Potential of Antineoplastic Medication in Pediatric Cancer Patients L. Lee Dupuis, MScPhm, ACPR, FCSHP,

More information

Lisa M. Hess Diane Michael Daniel S. Mytelka Julie Beyrer Astra M. Liepa Steven Nicol

Lisa M. Hess Diane Michael Daniel S. Mytelka Julie Beyrer Astra M. Liepa Steven Nicol Gastric Cancer (2016) 19:607 615 DOI 10.1007/s10120-015-0486-z ORIGINAL ARTICLE Chemotherapy treatment patterns, costs, and outcomes of patients with gastric cancer in the United States: a retrospective

More information

Gazyva (obinutuzumab)

Gazyva (obinutuzumab) STRENGTH DOSAGE FORM ROUTE GPID 1000mg/40mL Vial Intravenous 35532 MANUFACTURER Genentech, Inc. INDICATION(S) Gazyva (obinutuzumab) is a CD20- directed cytolytic antibody and is indicated, in combination

More information