SYLLABUS NSC NEURAL PLASTICITY AND DISORDERS OF THE NERVOUS SYSTEM SPRING 2010

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1 Syllabus NSC 4374 SPRING SYLLABUS NSC NEURAL PLASTICITY AND DISORDERS OF THE NERVOUS SYSTEM SPRING 2010 Instructor: Aage R. Møller PhD AMOLLER@UTDALLAS.EDU Class schedule: Main Campus: January 12, 2010, SOM Tuesday and Thursday 11:30-12:45 Class text: Aage R. Møller: Neural Plasticity and Disorders of the Nervous system, Cambridge University Press, 2006 ISBN Note: This book will be provided by the Instructor to a discounted price Supplementary readings: Brodal P. The Central Nervous System 3 nd ed New York, Oxford University Press, 2004 ISBN Grading: 1. Midterm Exam February 25: Covers the first section to February Final Exam April 29 Results of midterm and final exam will count equally to the final grade. Course purpose: The purpose of this class is to develop an understanding of the anatomical and functional basis for disorders of the peripheral and central nervous system, including pain. The course will include reading assignments from a book.

2 Syllabus NSC 4374 SPRING General objectives: Students will: 1. Understand the anatomical and physiological basis for neural plasticity 2. Understand the anatomical and physiological basis for pathologies of peripheral nerves. 3. Know the anatomy and physiology of sensory systems. 4. Understand the pathophysiology of sensory systems that is related to expression of neural plasticity 5. Understand the organization of normal pain circuits and the physiology of normal pain. 6. Understand the role of neural plasticity in creating central pain conditions. 7. Understand the basic principles of treatment of central pain conditions. 8. Know the anatomy and physiology of motor systems. 9. Understand disorders of motor systems that are related to expression of neural plasticity 10. Understand the normal function of cranial nerves and their disorders. Course layout This is a systems oriented course that covers the pathophysiology of the nervous system with emphasis on disorders where expression of neural plasticity play en important role. The course also covers the basis for expression of neural plasticity and how reorganization of the nervous system causes pain, tinnitus and paresthesia. The role of the little known non-classical sensory pathways is discussed and hyperactivity of motor systems is also covered. The organization of motor systems, pain circuits and sensory system are also included in the course.

3 Syllabus NSC 4374 SPRING OUTLINE 1/12/10 General organization of the nervous system Peripheral nervous system Central nervous system 1/14/10 Signs and symptoms of disorders of the nervous system Peripheral nervous system The central nervous system 1/21/10. Causes of signs and symptoms Morphological changes Metabolic changes Chemical changes 1/28/10. Functional changes Neural plasticity DISORDERS ASSOCIATED WITH MORPHOLOGICAL CHANGES 2/4/10.Causes of disorders of nerves Trauma Inflammation Compression Irritation of nerves 2/11/10. Injuries to peripheral nerves Neurapraxia Axonotmesis Neurotmesis 2/16/10. Disorders of myelin Multiple sclerosis Tumors

4 Syllabus NSC 4374 SPRING Slightly injured nerves peripheral nerve Change in conduction velocity Peripheral nerves as impulse generators 2/23/10. Cranial nerves Injuries from surgical trauma Vascular irritation 3/2/10. Disorders of sensory systems General organization of sensory systems Sensory organs Receptors Central nervous system 3/4/10. Hearing Conductive and cochlear hearing loss Injury of hair cells 3/11/10. Vision Disorders of the light conducting apparatus Retinal disorders Somatosensory system SPRING BREAK 3/23/10 Pain a. Acute pain 3/25/10. Motor systems Disorders of motoneurons Amyotrophic lateral sclerosis (ALS) Parkinson s disease Other motor dysfunction (Spasms etc) DISORDERS THAT ARE NOT ASSOCIATED WITH MORPHOLOGICAL

5 Syllabus NSC 4374 SPRING CHANGES 3/30/10 Neural plasticity Reorganization for a. compensating loss of function b. adapting to changing demands 4/1/10 Neural plasticity as cause of symptoms and signs of disease 4/6/10 Sensory systems a. Vestibular disorders b. Tinnitus c. Paresthesia 4/8/10. Motor systems a. Spasm (Hemifacial spasm) b. Synkinesis 4/13/10. Pain a. Neuropathic pain b. Phantom pain c. Anesthesia dolorosa 4/15/10. Trigeminal and glossopharyngeal neuralgia 4/20/10. Reflex sympathetic dystrophy 4/22/10. Similarities between pain and tinnitus 4/27/10. Escapable and nonescapable pain. Involvement of the hypothalamus 4/29/10. Final exam