On going OIE activities on TADs Control at Regional Level implemented by OIE Asia-Pacific

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1 On going OIE activities on TADs Control at Regional Level implemented by OIE Asia-Pacific The 5th GF-TADs Regional Steering Committee Meeting for Asia and the Pacific in Tokyo, June 2011 Itsuo Shimohira Regional Representative for Asia and the Pacific

2 Major activities of the OIE Asia-Pacific related to TADs control at Regional Level

3 HPAI control project in the Region

4 HPAI Control Projects in the Region Major concern of the disease in the Region: HPAI: Resurgent and continuously reported since 2003 and even in 2009 and 2010 HPAI caused negative economic impacts and posed risks to animal and human health 1. OIE/J(S)TF Project for the Region OIE Project of HPAI control in Southeast Asia ( : Phase I) 2. Epidemiological changes of HPAI in Asia OIE/J(S)TF Project for strengthening HPAI control in Asia 1) 5 year Project for Asia ( ) 2) 2 year Project for Asia ( : Phase II)

5 OIE HPAI Control Projects in Asia 1 OIE/JTF Project for strengthening HPAI Control in Asia (5 year project under Regular Fund; ) (1) Strengthening Information networking in Asia (including HPAI control strategies) (2) Strengthening capacity of Veterinary Services (Evaluation of Veterinary Services, and Capacity building including legislation) (3) Surveillance of wild birds and domestic animals along migratory flyways, and strengthening Data-base at OIE Reference Laboratory 2 OIE/JSTF Project for strengthening HPAI Control in Asia (under Supplementary Special Fund; Phase II, ) (1) Capacity building of HPAI laboratory diagnosis and surveillance (2) Procurement of Laboratory equipment and materials participating countries: : India, Sri Lanka, Pakistan, Nepal, Bhutan and Bangladesh + Mongolia

6 OIE/JTF Project for Strengthening HPAI control in Asia III Surveillance of wild birds and domestic animals along migratory flyways Epide miolo gical Inform ation To provide supportive information for awareness and effective control measures -Surveillance of AI viruses, and epidemiological study related to flying routes of migratory birds Database Monitor and characterize the virus for preparedness and effective control Establishment of a database for AI virus to be accessible by OIE Members I Strengthening Information Networking in Asia To facilitate animal health information exchange and regional cooperation and alliance for disease control II Strengthening capacity of Veterinary Services For good governance of VSs, and thus early detection and rapid response for disease control II-1 Evaluation of performance of veterinary services (VSs) II-2 Training on legislation and diagnostic technologies for HPAI control Virus characterization AI viruses HPAI control in Asia Diagnosis National laboratories Test results Collaboration OIE Reference Laboratory (Hokkaido University) Samples Capacity building for diagnosis

7 Activities under OIE HPAI Control Project in Asia (5 years Project) 1. OIE/JTF Project for strengthening HPAI Control in Asia (5 year project; ) (1) Inception Meeting for consultation on the Project, Tokyo, Japan, April 2008 (2) Expert Meeting on HPAI control in Asia, Tokyo, 1 st :October, 2008, 2 nd : May 2009, 3 rd :June 2010 and 4 th : June 2011 (3) Information Networking Meeting, 1 st : November, 2008 in Tokyo, 2 nd : September, 2009 in Tokyo, and 3 rd September,2010 and 4 th Sept 2011 (4) Regional training workshop on legislation and disease control strategies (Combined with 2 nd Information Networking Meeting) September,2009 in Tokyo - Meeting for Improvement of the Legslation and Information Networking for enforcement of disease control measure - Visit to Animal Hygiene Service Centres of prefectural government (Kyoto) to study the enforcement of disease control measures in Japan as example. (5) Surveillance of wild birds and animals along migratory flyways, Hong Kong and Vietnam, Laos and Mongolia, Vietnam(South) and Mongolia (6) HPAI molecular Data analysis Workshop, OIE Reference Laboratory (Hokkaido University), May 2009

8 Activities HPAI Project in 2011 The 4 th OIE Regional Expert Group Meeting, Japan, June 2011(done) To share/update data and information about HPAI outbreaks including genetic information of isolated HPAI virus and possible roles/involvement of wild birds in spreading of HPAI The 4 th OIE Regional Meeting on Strengthening Animal Health Information Networking and on Legislation, Thailand, September, 2011 Field Surveillance of AIV in poultry and wild birds (including the environment), in Vietnam (September 2011), Mongolia (July and September 2011) in line with the Expert Group Meeting

9 Category Overview of the outcomes of AIV Study Countries: Laos, Mongolia and Vietnam Viral RNA was detected in 206 samples by LAMP. However only 78 samples from Domestic bird were positive for virus isolation. H9N2 (26 isolates) and H6N2 (24 isolates) viruses were the most frequently isolated viruses. One H5N1 virus was isolated from a Muscovy duck from a live bird market in South Vietnam. No H5N1 virus was isolated from the samples of from Wild birds or environment. No. of bird/sample LAMP (+) Virus (+) Virus (-) Wild bird Domestic bird 2, Environment Total 3,

10 AIV isolated in South Vietnam in Sampling place Year Subtype (number of isolates) Farm A B C D E H4N6 (2), H9N2 (1) H4N6 (2) H4N6 (2) H4N6 (1), H9N2 (3) H9N2 (14) Live bird market Slaughter house F G H I J K L M N H3N8 (1) H9N2 (6), H11N3 (2) H3N2 (1), H9N2 (1) H11N3 (1), H11N9 (1) H9N6 (1) H6N2 (24), H6N6 (1) H6N2 (2) H5N1 (1), H6N2 (5) H11N5 (1), H11N9 (2) H12N5 (2) H9N2 (1)

11 Summary of Study Results by OIE/JTF Project for strengthening HPAI Control in Asia (1) I. AIV Study: 1. The 78 viruses were isolated from 2,675 healthy domestic ducks in South Vietnam, 2. One H5N1 virus was isolated from a Muscovy duck from a live bird market in South Vietnam. 3. H9N2 (26 isolates) and H6N2 (24 isolates) viruses were the most frequently isolated viruses in South Vietnam in this study. 4. It was observed that genetic re-assortment has occurred in H9N2 viruses isolated from ducks kept in live bird markets, suggesting that live bird markets may play a role to induce this event 5. The AIV study should be more focused on sample collection from dead wild birds and fresh wild bird feces in the field.

12 Outcomes of Telemetry Study of Wild Bird Flyways ( ) Round Year Country No. of transmitter Species 1 st 2009 Mongolia (Eastern) 5 Whooper swan (5) 2 nd 2010 Mongolia (Central) 15 Whooper swan (10) Other Aseriformes (5) The 1 st Round in 2009: Due to unknown reasons, GPS location signals stopped within 3 months after the installation. The 2 nd Round in 2010: Six whooper swans were tracked until they reached sites in PR China. One Bar-headed Goose flew into a site in India 4,100 km away from the original site in Mongolia.

13 Migration routes of whooper swans in Mongolia The flyways of the six whooper swans marked in Central Mongolia went parallel with the flyways of whooper swans which had been marked in East Mongolia by USGS, and wintering grounds of both groups does not appear to be overlapped with each other. OIE Tokyo USGS

14 Migration route of Bar-headed Goose One Bar-headed Goose flew into a site in India 4,100 km away from the original site in Mongolia

15 Summary of Study Results by OIE/JTF Project for strengthening HPAI Control in Asia(2) II. Study of Wild Bird Flyways: 1. The study was conducted twice in Mongolia. Satellite transmitters were attached onto 15 whooper swans and five other 2. It was observed that six whooper swans captured in Central Mongolia flew into PR China. Three out of the six whooper swans were tracked until they reached wintering sites in Hebei and Shangdong provinces, PR China. 3. The flyways of the six whooper swans marked in Central Mongolia went parallel with the flyways of whooper swans which had been marked in East Mongolia by USGS, and wintering grounds of both groups does not appear to be overlapped with each other. 4. The telemetry study on whooper swan in Central Mongolia need to continue to help to better understand the possible role of whooper swans in the transmission/spread of HPAI H5N1 virus in East Asia.

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17 The purposes of the 4 th OIE Regional Expert Group Meeting 1.To feed back data and information obtained from the AI surveillance Programme on Wild Birds and Domestic Birds (conducted during Fiscal ) to OIE members in Asia. 2.To discuss and prepare an Action Plan and methods for the implementation of the surveillance in Fiscal To share/update data and information about HPAI outbreaks including genetic information of isolated HPAI virus and possible roles/involvement of wild birds in spreading of the disease 4.To encourage OIE Members in Asia to strengthen function of the surveillance of wild birds in relation to HPAI control and prevention 5.To encourage OIE Members in Asia to establish a network between Veterinary authorities and competent authorities on wild birds at national and regional levels in relation to HPAI control

18 Main conclusions and recognitions by the 4 th Expert group meeting 1. Wild birds may potentially have acted as temporary hosts for the introduction and secondary spread of HPAI to the poultry sector in those countries. 2. It is of importance to establish and re-enforce networks between veterinary authorities and competent authorities on wild birds including related organizations like non-governmental/international organizations on wild birds. 3. Surveillance of dead wild birds provides valuable information for the early warning/alert of HPAI outbreak to mitigate the introduction in domestic birds sectors. 4. Further studies of whooper swans will be important to assess possible variation in migration routes.

19 Activities under OIE HPAI Control Projects in Asia 2. OIE/JSTF Project for strengthening HPAI Control in Asia (Phase II: ) (1) Capacity building of HPAI diagnosis and surveillance - National Hands-on Workshop on Real-Time PCR for diagnosis of HPAI - Regional Training course for the staff of National laboratories on Genetic analysis technologies for HPAI (2) Procurement of Laboratory equipment and materials To support (1) above; Laboratory capacity building Phase II: 7 countries (East and South Asian countries) India, Sri Lanka, Pakistan, Nepal, Bhutan and Bangladesh+ Mongolia - Identification of national laboratories and listing the required laboratory diagnostic equipment and materials (2008) (7countries, 23 Laboratories are selected) - Procurement of the equipment and renovation of the laboratories(2009-march 2010)

20 Mongolia 7 countries(phase II) 8 countries (Phase I) South East Asia Pakistan Nepal Bhutan India Bangladesh Sri Lanka FAO/OIE Sub-Regional Meeting on GF-TADs for SPC Region

21 Follow-up Training for Capacity building for HPAI Diagnosis by OIE/J(s)TF project -Training of Real Time PCR in 4 countries in February-March 2010 (National Training) (Participants : 38) from Bangladesh(6), Bhutan(12), Nepal(10), Sri Lanka(10) (Training subjects) - General guidance of Real-Time PCR for the diagnosis of HPAI - Hands-on Training of Real-Time PCR Compare SYBR Green Method and Taq Man Method - Follow up Hands on Training of DNA sequencer in Myanmar in November Individual Training of the Lab staff from Mongolia in collaboration with OIE Reference Lab (Hokkaido Univ.) in July 2011 and On the Job training in September 2011

22 Other activities for TADs control

23 Preparedness for Emerging Animal Diseases & Zoonoses OIE/FAO-APHCA Regional Workshop on Brucellosis, to be held in Thailand, November 2010 OIE/FAO-APHCA Regional Workshop on Prion diseases including BSE, RO Korea, February 2010 OIE/FAO-APHCA Regional Workshop on the OIE BSE risk status recognition, Thailand, September 2010 (Requested from ASEAN and Follow-up Workshop) OIE/FAO-APHCA Regional Workshop on Bluetongue diagnosis and control, Indonesia, March 2011 Lectures and practice of the diagnosis of Bluetongue

24 FAO-APHCA/OIE Regional Workshop on BSE Risk Status Recognition (under the context of WTO-SPS Agreement) and Interim BSE Working Group Meeting (Chieng Mai, Thailand, 31 August 3 September 2010)

25 Objectives of the workshop To provide information and train government officials (at policy level) in the Asian and Pacific Region on risk assessment and analysis as tool for epidemiological survey towards BSE risk status recognition To strengthen scientific networking for technical collaboration on BSE and other prion diseases in the Region.

26 Findings and Recommendations The Workshop noted that budgetary constraint is the main drawback, which forces most of the participating countries to limit their endeavors to improve BSE diagnostic capacity and to comply with the OIE International Standards, including BSE surveillance activities Reference Laboratory for BSE in Japan, upon official request(s), should consider providing technical support to national diagnostic center(s) in the participating countries to strengthen BSE diagnostic capacity at national/regional level;

27 OIE Regional Workshop on Risk Analysis for Veterinary Vaccines Practical Application Including Vaccines Related New and Emerging Technologies (Tokyo, Japan, 1-3 March 2011)

28 Workshops for Improvement of Vaccine Technology in ASEAN Region Since 2006, OIE Asia-Pacific has been organising a series of regional workshops on veterinary products under Japan Trust Fund. In response to the requests from ASEAN Members. OIE Regional Workshop on International/Regional Harmonization of Veterinary Medical Products (Bogor, Indonesia, 6-10 November 2006) OIE Regional Workshop on Harmonization of Veterinary Vaccines (Pakchong, Thailand,21-25 January 2008) OIE Regional Workshop on Vaccine Quality and GLP in ASEAN Countries (Bandung, Indonesia, January 2009)

29 Workshop on Risk Analysis for Animal Vaccines OIE Regional Workshop on Risk Analysis for Animal Vaccines (to enhance understanding and identify gaps and develop risk analysis models) was organized in February 2011 with coorganized by OIE collaboration centre in Japan - National Institute of Animal Health (NIAH) - National Veterinary Assay Laboratory (NVAL) (Purpose of the Worshop) to review the risk analysis methodologies currently applied to veterinary vaccines to develop an understanding of how to apply such methodologies to raise awareness of the recent discussions at OIE ad hoc Group on vaccines in relation to new and emerging technologies and the OIE s work

30 Main conclusions and Recommendations of the OIE Regional Workshop on Risk Analysis for Veterinary Consideration of prior risk analysis on essential vaccines for emergency use Sharing information among regional members on risk analysis conducted for registration of vaccines as well as adverse event reporting Exploration of available short term training courses/expert exchange programmes Support information sharing and provision of training opportunities by OIE Collaborating Centres

31 FMD control activities

32 Activities for FMD control in th OIE Sub-Commission Meeting of SEAFMD March 2011, Bali, Indonesia 5 th Regional Steering Committee Meeting of GF-TADs for Asia and the Pacific July 2011, Tokyo, Japan Upper Mekong FMD Control and Animal Movement Management (AMM) Working Group Meeting in 2011; Lower Mekong FMD Control and AMM Working Group Meeting; 2012

33 Prevention and Control of Transboundry Animal Diseases under OIE/JTF project (New programme for FMD control in East Asia) OIE Asia-Pacific will commence 5 year new initiative to control FMD in the region under the new Programme of OIE/JTF project (2011). Programme may include development of FMD eradication Roadmap for the East Asia and support to exchange information on viral genetic data and vaccines administration. - Establish the information network of FMD in the East Asia - Capacity building of laboratory network for FMD - Research work/surveillance of FMD in targeted area,if possible - Phylogenetic study and information sharing on genetic of FMDV The detailed activities will be decided through the discussion at The Regional Workshop and The Expert Group Meeting to be held in Japan in 2011

34 Thank you for your attention!!