Science and Applications of Nutritional Ketosis
|
|
|
- Lizbeth Stone
- 6 years ago
- Views:
Transcription
1 Science and Applications of Nutritional Ketosis Dominic P. D Agostino, PhD Associate Professor Laboratory of Metabolic Medicine University of South Florida, Morsani College of Medicine
2 We Thank Our Sponsors Disclaimer 1. Co-owner of Ketone Technologies LLC 2. Presentation includes data on various technologies patented by University of South Florida and licensed to industry partners 3. Information contained in this presentation is not meant to be taken as medical advice
3 Research: Understanding Human Physiology to Enhance Safety, Performance and Resilience in Extreme Environments NASA EVAs NASA NEEMO 21
4 CNS Oxygen Toxicity Seizures 2.8 ATA O 2 (~ 55 ft sea water)
5 Methods Atomic Force Microscopy (AFM) Fluorescence Microscopy Laser Scanning Confocal Microscopy Electrophysiology Radio Telemetry (EEG, EMG, EKG) Adapted to hyperbaric chambers ROS O 2 Mitochondria
6 Oxygen Pressure Free Radicals Neuro-Inflammation Hyper-Excitability Seizures (Drug-Resistant) Brain Neuron
7 Strategies Tested to Prevent Seizures Antioxidants Fail Epilepsy Drugs Fail Fasting Ketosis (>200% protection!)
8 How Does Fasting Change Brain Metabolism? Owen OE, Morgan AP, Kemp HG, Sullivan JM, Herrera MG, Cahill GF Jr. Brain metabolism during fasting. J. Clin.Invest., Ketones HB Ketone bodies undergo the greatest changes of all fuels during total starvation Ketones replace glucose Glucose as the predominant fuel for brain metabolism Diagram from: Oliver E. Owen. Ketone Bodies as a Fuel for the Brain during Starvation, Biochemistry And Molecular Biology Education Vol. 33, No. 4, 2005:
9 Ketogenic Diet Ketones (energy!) Body Fat Glucose Insulin
10 Ketone Terminology Ketone Bodies Ketosis Nutritional Ketosis Ketoacidosis Keto- Adaptation Exogenous Ketones Energy substrates from fatty acid oxidation Blood β-hydroxybutyrate (BHB) >0.5 mmol/l Urine Acetoacetate (AcAc) > 15 mg/dl Dietary strategy to elevate blood ketones Pathologically high ketones (>10 to 25+ mmol/l) (from Insulin Insufficiency) Time-dependent physiological shift towards using fat and ketones for fuel Synthetic or naturally derived substances to elevate ketone metabolites in blood
11 Academic and Clinical Ketogenic Mentors and Pioneers Jong Rho, MD Chair Neurology Univ. Calgary Eric Kossoff, MD Neurology Johns Hopkins
12 2008 Mike Dancer: Diagnosed with Terminal Epilepsy
13 Applications of Nutritional Ketosis (Proven and Emerging) Epilepsy and Seizures disorders J Child Neurol Aug;24(8): CNS O 2 Toxicity AJP-Integrative and Comp Physiol, 2013 May 15;304(10):R Weight loss and Type-2 Diabetes Nutrition Jan;31(1):1-13) Autism J Child Neurol Aug;28(8): Angelman s Syndrome Neurobiol. Disease 2016 Dec;96: Alzheimer s disease Nutr Metabolism 2009 Aug 10;6:31 Parkinson s disease Curr Treat Options Neurol Nov;10(6): Lou Gehrig s disease (ALS) BMC Neurosci Apr 3;7:29 Traumatic Brain Injury J Neurotrauma Sep;28(9): Exercise Performance Cell Metabolism. Sep 13;24(3): PCOS Nutr Metab (Lond) Dec 16;2:35 Acne Skin Pharmacol Physiol. 2012;25(3):111-7 Cancer Carcinogenesis. 2014, Mar;35(3):
14 Exogenous Ketones Produce Rapid & Sustained Ketosis Estimated Human Dose Therapeutic Ketosis Radiation Protection Performance Enhancement 1g/kg/day Therapeutic Ketosis (KD) D Agostino, D.P., et.al. AJP Regulatory, Integrative and Comparative Physiology, 2013 May 15;304(10):R Kesl SL, et al. FASEB Journal (2014) vol. 28 no. 1 Supplement 643.5
15 Exogenous Ketones Prevent CNS Oxygen Toxicity Seizures Potential Applications Crew Performance and Safety Single Dose 575 % Seizure Resistance Butanediol Ongoing studies in seizures Ketone Ester D Agostino, D.P., et.al. AJP Regulatory, Integrative and Comparative Physiology, 2013 May 15;304(10):R Physical Performance Radiation Protection Cognitive Performance
16 Ketone Research (past, present, in preparation!) CNS O 2 Toxicity Seizures Neurological Disorders Rare Genetic Disorders Anxiety Behavior Motor Performance Extreme Environments NASA NEEMO 22 Kilimanjaro Climb Pharmacokinetics Glucose Regulation Metastatic Cancer Cancer Cachexia Wound Healing Inflammation Longevity Metabolic Efficiency
17 3,500 Effect of Acute Ketosis (BHB salts) on Oxygen Consumption Fixed Power Output (180 Watts) 3,400 3,300 3,200 3,100 3,000 2,900 Test set #1: mild nutritional ketosis Test set #2: 15.6 gm Exogenous BHB ketone mineral salt Ketones : 0.6 mm VO2 VO2 (BHB) Ketones : 2.0 mm (BHB salts) 2, mm 2.0 mm Segment Test 1 Test 2 (BHB) Difference Last 5 min 3,298 ml/min 3,032 ml/min -8.8% Last 10 min 3,255 ml/min 3,023 ml/min -7.7% Last 15 min 3,210 ml/min 3,012 ml/min -6.6% Full 20 min 3,065 ml/min 2,890 ml/min -6.0% 20 min
18 Ketosis shifts metabolic physiology from glycolysis to fat oxidation Preserved muscle glycogen 50% reduction in lactate Ketone-induced reduction in perceived exertion and greater CNS motor unit recruitment
19 What is the Metabolic and Signaling Mechanism(s)?
20 Ketogenic Diet, Ketone Supplementation FFA Oxidation + Elevated Ketones Lowered Glucose βhb AcAc Acetone GABA/Glu Ratio 2-3x Higher TCA Cycle Intermediates 2-3x Higher Carnosine Anserine Glucose (Insulin) ROS Oxidative Stress Inflammation 5x Higher Adenosine Neuroprotective and Anticonvulsant Effect Modified from: Masino & Rho, 2013
21 Implementation of Nutritional Ketosis
22 Strategies for Inducing Nutritional Ketosis Low Carb/Ketogenic Diet (variants) Ketone Supplementation Ketogenic Intermittent Fasting Exogenous Ketones
23 Nutritional Ketosis for Performance and Wellness Page 91: The Art and Science of Low Carbohydrate Performance, Jeff Volek and Stephen Phinney
24 Strategies for Asessing Nutritional Ketosis Urine Acetoacetate (AcAc) Breath Acetone Blood (BHB) Future Devices Continuous BHB/AcAc (e.g. Dexcom)
25 Potential Medical Applications (Status Epilepticus, Cancer, Brain Injury, etc) + Exogenous Ketones Keto-Adaptation Metabolic Zone Metabolic Zone Low Glucose (3.8 mm) High Ketones 30 minutes Time (min.) Nutrition and Metabolism (Lond) Apr 22;7:33. Carcinogenesis. 2014, Mar;35(3):515-27
26 Starvation and Calorie Restriction (Adipose) Ketogenic Diet Difficult to sustain Glucose Glycogen Insulin Hepatic Ketogenesis Alternative Fuel Ketones Neuroprotective Signaling Metabolites Exogenous Ketones Glutamate (GAD) GABA (GABA Transaminase) Anaplerosis (TCA Intermediates) Longevity DAF-16/FOXO IGF-1 mtor Oxidative Stress Superoxide class 1 HDACI Inflammation NLRP3 Inflammatory Cytokines
27 Current Projects (seeking collaboration and volunteers) 1) NASA Extreme Environment Mission Operations (NEEMO 22) Project 2) Informal Study Special Operations Forces (Mountaineering) 1. Nutrition Tracking (2 wk journal prior to recruitment) 2. Body Comp (calipers, ultrasound) ** 3. Ketosis Assessment (urine, blood) 4. Sleep (OURA ring) ** 5. Stress (Polar V800) ** 6. Gut Microbiome 7. Cognitive (NIH Toolbox, Joogle) ** 8. Hormone Analysis (ZRT Labs) 9. Cardiometabolic (ZRT Labs) 10. Genetic Test + Analysis (23andMe)
28 Thank You! Laboratory of Metabolic Medicine Dr. Angela Poff Dr. Csilla Ari Dr. Chris Rogers Dr. Shannon Kesl Nate Ward Andrew Koutnik Hyperbaric Biomedical Research Lab Dr. Jay Dean Carol Landon Geoffrey Ciarlone Jacob Sherwood Chris Hinojo
29 Resources MetabolicTherapeutics.com Charliefoundation.org KetoNutrition.org Ketogenic-diet-resource.com
KETONES AS AN ALTERNATIVE FUEL FOR ALZHEIMER S DISEASE AND OTHER DISORDERS. Mary T. Newport MD Hippocrates Institute May 2014
KETONES AS AN ALTERNATIVE FUEL FOR ALZHEIMER S DISEASE AND OTHER DISORDERS Mary T. Newport MD Hippocrates Institute May 2014 Plaques and Tangles 100 billion nerve cells. 100 trillion synapses. Dozens of
IT Architect/IT-Security, Mechanical Engineer, Certified Kitesurfing Instructor, Certified Keto/Paleo Nutritionist
Disclosure Michel Lundell I live in the Swedish west-coast. IT Architect/IT-Security, Mechanical Engineer, Certified Kitesurfing Instructor, Certified Keto/Paleo Nutritionist I have Epilepsy which is the
INTRODUCTION TO NUTRITIONAL KETOSIS AND CLINICAL APPLICATIONS
INTRODUCTION TO NUTRITIONAL KETOSIS AND CLINICAL APPLICATIONS Jeff S. Volek, Ph.D., R.D. Professor Department of Human Sciences Kinesiology Program Columbus, OH 43210 volek.1@osu.edu LEARNING OBJECTIVES
E. Haritov, E. Angeleska and N. Boyadjieva Department of pharmacology and toxicology, Medical Faculty, Medical University So a
:.,..,, KETOGENIC DIET AND EPILEPSY: THE ROLE OF KETONE BODIES IN THE INFLUENCE N NEURONAL EXCITABILITY E. Haritov, E. Angeleska and N. Boyadjieva Department of pharmacology and toxicology, Medical Faculty,
KETOGENIC DIET ISMAIL HALAHLEH, MSC. نقیب اخصاي یي التغذیة الفلسطینیین
KETOGENIC DIET ISMAIL HALAHLEH, MSC. نقیب اخصاي یي التغذیة الفلسطینیین INTRODUCTION WHAT IS KETOGENIC DIET???? KETOGENIC DIET The ketogenic diet (KD) is a diet that is high in fat, low in carbohydrate,
HISTORY OF THE KETOGENIC DIET
Laura Roche RD Horizon Health Authority May 29, 2018 AGENDA History of the Ketogenic Diet Diet Pathophysiology Side Effects Pros and Cons How and Why the Diet works Ketogenic Diet for Type 2 Diabetes Ketogenic
THE GLUCOSE-FATTY ACID-KETONE BODY CYCLE Role of ketone bodies as respiratory substrates and metabolic signals
Br. J. Anaesth. (1981), 53, 131 THE GLUCOSE-FATTY ACID-KETONE BODY CYCLE Role of ketone bodies as respiratory substrates and metabolic signals J. C. STANLEY In this paper, the glucose-fatty acid cycle
Carbohydrates. Three Types of Carbs Fiber. Does not impact the blood sugar. Cleaners Controllers May be eaten on a Ketogenic diet
The Keto Challenge Carbohydrates Carbohydrates Three Types of Carbs STARCHES (complex carbs) Take a little longer to digest b Slower rise in blood glucose levels Trigger the Fat Truck (Slower, but still
Oxidation of Long Chain Fatty Acids
Oxidation of Long Chain Fatty Acids Dr NC Bird Oxidation of long chain fatty acids is the primary source of energy supply in man and animals. Hibernating animals utilise fat stores to maintain body heat,
Lipid Metabolism. Remember fats?? Triacylglycerols - major form of energy storage in animals
Remember fats?? Triacylglycerols - major form of energy storage in animals Your energy reserves: ~0.5% carbs (glycogen + glucose) ~15% protein (muscle, last resort) ~85% fat Why use fat for energy? 1 gram
Dietary Treatments for Epilepsy From Minnesota to Scotland.and beyond!
Dietary Treatments for Epilepsy From Minnesota to Scotland.and beyond! Eric H. Kossoff, MD Associate Professor, Neurology & Pediatrics Medical Director, Ketogenic Diet Program Johns Hopkins Hospital 1921
Chapter 3: The basics of fuel utilization
Chapter 3: The basics of fuel utilization Although this chapter does not discuss the ketogenic diet in great detail, the information presented is helpful in understanding the following chapters. There
Physiology Unit 1 METABOLISM OF LIPIDS AND PROTEINS
Physiology Unit 1 METABOLISM OF LIPIDS AND PROTEINS Alternate Fuel Sources When glucose levels are low Proteins and Triglycerides will be metabolized Tissues will use different fuel sources depending on:
CHY2026: General Biochemistry. Lipid Metabolism
CHY2026: General Biochemistry Lipid Metabolism Lipid Digestion Lipid Metabolism Fats (triglycerides) are high metabolic energy molecules Fats yield 9.3 kcal of energy (carbohydrates and proteins 4.1 kcal)
Ketogenic Diet. Nikolas Hedberg, D.C., D.A.B.C.I., D.A.C.B.N Hedberg Institute. What is Ketosis?
Ketogenic Diet Nikolas Hedberg, D.C., D.A.B.C.I., D.A.C.B.N. What is Ketosis? Glycogen stores are depleted from the liver and skeletal muscle. The body produces ketones from fatty acids. The body is able
Chapter 24 Lecture Outline
Chapter 24 Lecture Outline Carbohydrate Lipid and Protein! Metabolism! In the catabolism of carbohydrates, glycolysis converts glucose into pyruvate, which is then metabolized into acetyl CoA. Prepared
Low Carbohydrate Diets and The Brain
Low Carbohydrate Diets and The Brain Eric H. Kossoff, MD Medical Director, Ketogenic Diet Center Associate Professor, Neurology and Pediatrics Johns Hopkins Hospital Baltimore, Maryland July 9, 2010 Topics
The Glucose Ketone Index Calculator: A Simple Tool to Monitor Therapeutic. Efficacy for Metabolic Management of Brain Cancer
Nutrition & Metabolism (in press) The Glucose Ketone Index Calculator: A Simple Tool to Monitor Therapeutic Efficacy for Metabolic Management of Brain Cancer Joshua J. Meidenbauer, Purna Mukherjee and
AMINO ACID METABOLISM. Sri Widia A Jusman Dept. of Biochemistry & Molecular Biology FMUI
AMINO ACID METABOLISM Sri Widia A Jusman Dept. of Biochemistry & Molecular Biology FMUI Amino acids derived from dietary protein absorbed from intestine through blood taken up by tissues used for biosynthesis
nothing is perfect Problems with triheptanoin and clinical trials
nothing is perfect Problems with triheptanoin and clinical trials MILAN, Italy, 7th 8th ctober 2016 Joerg Klepper The State-and-Region Agreement asks for a declaration by Moderators, Speakers, Teachers
LIPID METABOLISM. Sri Widia A Jusman Department of Biochemistry & Molecular Biology FMUI
LIPID METABOLISM Sri Widia A Jusman Department of Biochemistry & Molecular Biology FMUI Lipid metabolism is concerned mainly with fatty acids cholesterol Source of fatty acids from dietary fat de novo
Sugar, Cancer, & the Ketogenic Diet: Can I Eat a Piece of Cake?
Sugar, Cancer, & the Ketogenic Diet: Can I Eat a Piece of Cake? Angela Martens, RD amartens5@cancercare.mb.ca Presenter Disclosure Faculty: Angela Martens, RD Relationships with commercial interests: Grants/Research
Ketogenic Program. Nutrition Masters Course. Milene Brownlow, PhD Elnaz Karimian Azari, PhD Metagenics Institute. All rights reserved.
Ketogenic Program Nutrition Masters Course Milene Brownlow, PhD Elnaz Karimian Azari, PhD Learning Objectives Review the impact of dietary macronutrient composition in human health, with a focus on low-carbohydrate
Medical Biochemistry and Molecular Biology department
Medical Biochemistry and Molecular Biology department Cardiac Fuels [Sources of energy for the Cardiac muscle] Intended learning outcomes of the lecture: By the end of this lecture you would be able to:-
KETOGENIC DIET WORKSHOP
AN INTRODUCTION TO THE KETOGENIC DIET Beacon Hill Chiropractic & Massage KETOGENIC DIET WORKSHOP Your presenters: Dr. Michael Schmolke Lynne Marshall 1 Our Objectives for This Workshop Get clear on what
Dietary Approaches to Non-Lesional Epilepsy December 8, 2013
Dietary Approaches to Non-Lesional Epilepsy December 8, 2013 Eric H. Kossoff, MD Johns Hopkins University Baltimore, Maryland American Epilepsy Society Annual Meeting 1 Disclosures Nutricia, Inc. Atkins
Dietary and pharmacologic approaches to ketosis: potential therapeutic applications to neurological conditions and cancer Norman Hord, PhD, MPH, RD
Dietary and pharmacologic approaches to ketosis: potential therapeutic applications to neurological conditions and cancer Norman Hord, PhD, MPH, RD College of Public Health and Human Sciences Disclosures
Effects of Ketogenic Diet on the Microbiome and Epilepsy. ATPeeps
Effects of Ketogenic Diet on the Microbiome and Epilepsy ATPeeps Agenda Background Ketone bodies Ketogenic diet Insulin resistance Gut Microbiota Epilepsy Treatment methods Refractory epilepsy Studies
Intermittent Fasting, Carb Cycling and Weight Management. Brent Agin, MD
Intermittent Fasting, Carb Cycling and Weight Management Brent Agin, MD CEO/ Founder: Presenter Brent Agin, MD Trim Nutrition, Inc. MyPracticeConnect - Electronic Prescribing Platform & Physician Training
Ketogenic Program. Nutrition Masters Course. Milene Brownlow, PhD Elnaz Karimian Azari, PhD Metagenics Institute. All rights reserved.
Ketogenic Program Nutrition Masters Course Milene Brownlow, PhD Elnaz Karimian Azari, PhD Learning Objectives Review the impact of dietary macronutrient composition in human health, with a focus on low-carbohydrate
- biochemical principles - practical applications
The ketogenic diet in pediatric neurology practice - biochemical principles - practical applications Some points from history 1921-1928: «The efficiency of fasting» and being free of seizures 1921-1970:
6/9/2015. Tim Olsen Wins 2012 Western States 100. The Low Carbohydrate Athlete. Diet-Driven Regulation. Low-Carb Diet.
6/9/215 Diet-Driven Regulation High-Carb Diet Low-Carb Diet The Low Carbohydrate Athlete International Congress on Natural Medicine - Melbourne 215 Better Health/Performance/Recovery T2D Metabolic Syndrome
LILY FOUNDATION. An Introduction to Ketogenic Diets. Susan Wood. Matthew s Friends. Registered Dietitian Adults & Paediatrics
LILY FOUNDATION An Introduction to Ketogenic Diets Susan Wood Registered Dietitian Adults & Paediatrics Matthew s Friends What is a ketogenic diet? A MEDICAL treatment. Mimics fasting metabolism Alters
the fates of acetyl coa which produced by B oixidation :
Ketone bodies the fates of acetyl coa which produced by B oixidation : 1) oxidized at the TCA cycle 2)synthesis of ketone bodies Ketone bodies : 1)acetoacetate 2) acetone 3) 3_hydroxybutyrate Naming acetonacetone:
WHAT IS A KETOGENIC DIET?
WHAT IS A KETOGENIC DIET? A keto diet is well known for being a low carb diet, where the body produces ketones in the liver to be used as energy. When you eat something high in carbs, your body will break
Chemistry 1120 Exam 4 Study Guide
Chemistry 1120 Exam 4 Study Guide Chapter 12 12.1 Identify and differentiate between macronutrients (lipids, amino acids and saccharides) and micronutrients (vitamins and minerals). Master Tutor Section
Modifications of Pyruvate Handling in Health and Disease Prof. Mary Sugden
Modifications of Handling Modifications of Handling Centre for Diabetes and Metabolic Medicine Institute of Cell and Molecular Science Barts and the London School of Medicine and Dentistry 1 Potential
Karin Borges, PhD. October The urgent need for new metabolic (dietary) treatments of epilepsy
Karin Borges, PhD October 2016 The urgent need for new metabolic (dietary) treatments of epilepsy Epilepsy is a common neurological disease that is characterized by recurrent seizures due to the spontaneous
23.1 Lipid Metabolism in Animals. Chapter 23. Micelles Lipid Metabolism in. Animals. Overview of Digestion Lipid Metabolism in
Denniston Topping Caret Copyright! The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Chapter 23 Fatty Acid Metabolism Triglycerides (Tgl) are emulsified into fat droplets
Energy metabolism - the overview
Energy metabolism - the overview Josef Fontana EC - 40 Overview of the lecture Important terms of the energy metabolism The overview of the energy metabolism The main pathways of the energy metabolism
KetoActiv FAQs. Is a ketone supplement an energy source?
KetoActiv FAQs Is a ketone supplement an energy source? B-hydroxbutyrate (BHB) is a ketone body that can be utilized as an ATP (cellular energy) substrate by our cells to generate ATP (energy). Research
Energy Balance and Body Composition
Energy Balance and Body Composition THE ECONOMICS OF FEASTING THE ECONOMICS OF FEASTING Everyone knows that when people consume more energy than they expend, much of the excess is stored as body fat. Fat
ANSC/NUTR 618 LIPIDS & LIPID METABOLISM. Triacylglycerol and Fatty Acid Metabolism
ANSC/NUTR 618 LIPIDS & LIPID METABOLISM II. Triacylglycerol synthesis A. Overall pathway Glycerol-3-phosphate + 3 Fatty acyl-coa à Triacylglycerol + 3 CoASH B. Enzymes 1. Acyl-CoA synthase 2. Glycerol-phosphate
Hompes Method Lesson 29 Organic Acids Part One
Hompes Method Lesson 29 Organic Acids Part One Health for the People Ltd not for reuse without expressed permission Organic Acids - Introduction The ultimate tool for laboratory evaluations in nutritional
Lipid Metabolism * OpenStax
OpenStax-CNX module: m46462 1 Lipid Metabolism * OpenStax This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 By the end of this section, you will be able
Use of Glucagon to Prevent and Treat Fatty Liver in Transition Dairy Cows
Animal Industry Report AS 650 ASL R1903 2004 Use of Glucagon to Prevent and Treat Fatty Liver in Transition Cows Donald C. Beitz Jerry W. Young Arnold R. Hippen Rafael A. Nafikov Recommended Citation Beitz,
Intermediary metabolism. Eva Samcová
Intermediary metabolism Eva Samcová Metabolic roles of tissues Four major tissues play a dominant role in fuel metabolism : liver, adipose, muscle, and brain. These tissues do not function in isolation.
What systems are involved in homeostatic regulation (give an example)?
1 UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY GLUCOSE HOMEOSTASIS (Diabetes Mellitus Part 1): An Overview
WHY? 26/2/2010. Shimomura Y, Harris RA. J Nutr. 2006;136(1 suppl):232s-233s. BCAA buffer excessive amounts of Glutamate by converting it to Glutamine.
Branched Chain Amino Acids as Adjunctive Therapy to Ketogenic Diet Athanasios Evangeliou MD 4th Department of Pediatrics of the Aristotle University of Thessaloniki Papageorgiou Hospital Thessaloniki E-mail:
Metabolic integration and Regulation
Metabolic integration and Regulation 109700: Graduate Biochemistry Trimester 2/2016 Assistant Prof. Dr. Panida Khunkaewla kpanida@sut.ac.th School of Chemistry Suranaree University of Technology 1 Overview
Ketogenic/Low Carbohydrate diets for weight loss- What s the big deal?
Ketogenic/Low Carbohydrate diets for weight loss- What s the big deal? Presented by Claudia Harper APD Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders The University of Sydney Page
Interview with Dominic D Agostino, Ph.D., Assistant Professor, University of South Florida And Dr. Angela Poff, Ph.D.
Interview with Dominic D Agostino, Ph.D., Assistant Professor, University of South Florida And Dr. Angela Poff, Ph.D. PEGGY: Hello, I m Peggy Sarlin, and today I m in the medical research laboratory of
DEPARTMENT OF SCIENCE
DEPARTMENT OF SCIENCE COURSE OUTLINE Fall 2015 BC 2000 INTRODUCTORY BIOCHEMISTRY INSTRUCTOR: Philip Johnson PHONE: 780-539-2863 OFFICE: J224 E-MAIL: PJohnson@gprc.ab.ca OFFICE HOURS: Tuesdays 1000-1120
The Hunger Games Reviewing the Evidence on Intermittent Fasting. Monique Piderit, RD
The Hunger Games Reviewing the Evidence on Intermittent Fasting Monique Piderit, RD (SA) @MoniquePiderit Outline 1. Defining Intermittent Fasting Calorie restriction vs. Intermittent Fasting Different
Lipid and Amino Acid Metabolism
CHEM 3331 Fundamentals of Biochemistry Chapter 14 Lipid and Amino Acid Metabolism Organic and Biochemistry for Today Spencer L. Seager / Michael R. Slabaugh Mr. Kevin A. Boudreaux Angelo State University
Ketosis: The Lost Metabolic State
Ketosis: The Lost Metabolic State For optimal metabolic and gut health Presented by Carole Freeman, Certified Nutritionist & Keto Diet Implementation Expert 1 You are in the Right Place You re passionate
Presented by: Mariam Boulas Veronica Dascalu Pardis Payami
Presented by: Mariam Boulas Veronica Dascalu Pardis Payami Introduction Carbohydrates are made up of carbon, oxygen, and hydrogen with this proportion: CH 2 O Major source of energy fuel in the body glucose
BASIC SCIENCES & BIOCHEMISTRY FOR BETZPAENIC BRIMBLERS
BASIC SCIENCES & BIOCHEMISTRY FOR BETZPAENIC BRIMBLERS Lymphatic Vessels One main lymph vessel receives lymph from the right upper arm and the right side of the head and the thorax and empties into the
THE NEGATIVE NITROGEN BALANCE IN POST- OPERATIVE PAEDIATRIC PATIENTS
THE NEGATIVE NITROGEN BALANCE IN POST- OPERATIVE PAEDIATRIC PATIENTS Pages with reference to book, From 55 To 58 Tansu F. Salman ( Department of Paediatric Surgery, Istanbul Faculty of Medicine, University
Protein & Amino Acid Metabolism
Pathophysiology 101-823 Unit 4 Metabolism & Metabolic Disease Protein & Amino Acid Metabolism Paul Anderson FALL 2008 Learning Objectives 1. List the metabolic functions of proteins & amino acids. 2. Explain
Transcript of Dominic D Agostino: Ketosis & Oxygen Toxicity - #187. Bulletproof Radio podcast #187
Transcript of Dominic D Agostino: Ketosis & Oxygen Toxicity - #187 Bulletproof Radio podcast #187 The Bulletproof Executive 2013 Warning and Disclaimer The statements in this report have not been evaluated
Companion to Biosynthesis of Ketones & Cholesterols, Regulation of Lipid Metabolism Lecture Notes
Companion to Biosynthesis of Ketones & Cholesterols, Regulation of Lipid Metabolism Lecture Notes The major site of acetoacetate and 3-hydorxybutyrate production is in the liver. 3-hydorxybutyrate is the
Metabolism: From Food to Life
CHAPTER 7 Metabolism: From Food to Life Chapter Summary Metabolism is the sum total of all chemical and physical processes by which the body catabolizes and anabolizes molecules. Metabolic pathways are
Chapter 7- Metabolism: Transformations and Interactions Thomson - Wadsworth
Chapter 7- Metabolism: Transformations and Interactions 2008 Thomson - Wadsworth Simple Overview of Energy Metabolism The sum of all chemical reactions that go on in living cells Introduction Energy Heat-
Integration of Metabolism 1. made by: Noor M. ALnairat. Sheet No. 18
Integration of Metabolism 1 made by: Noor M. ALnairat Sheet No. 18 Data :24/11/2016 SLIDE 2: Metabolism Consist of Highly Interconnected Pathways The basic strategy of catabolic metabolism is to form ATP,
Energy Metabolism. Chapter Cengage Learning. All Rights Reserved.
Energy Metabolism Chapter 7 Introduction Energy Heat, mechanical, electrical, and chemical Metabolism How the body uses foods to meet its needs Chemical Reactions in the Body Energy metabolism How body
Part III => METABOLISM and ENERGY. 3.4 Lipid Catabolism 3.4a Fatty Acid Degradation 3.4b Ketone Bodies
Part III => METABOLISM and ENERGY 3.4 Lipid Catabolism 3.4a Fatty Acid Degradation 3.4b Ketone Bodies Section 3.4a: Fatty Acid Degradation Synopsis 3.4a - Triglycerides (or fats) in the diet or adipose
Integration Of Metabolism
Integration Of Metabolism Metabolism Consist of Highly Interconnected Pathways The basic strategy of catabolic metabolism is to form ATP, NADPH, and building blocks for biosyntheses. 1. ATP is the universal
number Done by Corrected by Doctor Faisal Al-Khatib
number 22 Done by Baraa Ayed Corrected by Yaseen Fatayer Doctor Faisal Al-Khatib 1 P a g e Today we are going to cover these concepts: Oxidation of odd number fatty acids Oxidation of very long fatty acids
Energy stores in different organs for a 155 lb male, in Calories
Energy stores in different organs for a 155 lb male, in Calories Organ Glucose/ Glycogen Triacyl Glycerols* Liver 400 450 400 Brain 8 0 0 Mobile Proteins Muscle 1,200 450 24,000 Adipose Tissue 80 135,000
UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
1 UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY GLUCOSE HOMEOSTASIS An Overview WHAT IS HOMEOSTASIS? Homeostasis
Index. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Acetyl CoA oxidation of in postpartum period, 287 Acidifying feeds in transition dairy cow management, 374 Adipose tissues derivatives of, 307
High protein diets and performance: Exploring the next generation of protein applications
High protein diets and performance: Exploring the next generation of protein applications Background to protein composition and structure Made from 20 naturally occurring amino acids The ratio of amino
Not Your Typical Case of Ketotic Hypoglycemia
Not Your Typical Case of Ketotic Hypoglycemia Linda Steinkrauss, RN, MSN, CPNP Objectives By the end of this session, attendees should be able to: 1. Discuss the difference between idiopathic ketotic hypoglycemia
DOWNLOAD OR READ : THE KETO CURE A LOW CARB HIGH FAT DIETARY SOLUTION TO HEAL YOUR BODY AND OPTIMIZE YOUR HEALTH PDF EBOOK EPUB MOBI
DOWNLOAD OR READ : THE KETO CURE A LOW CARB HIGH FAT DIETARY SOLUTION TO HEAL YOUR BODY AND OPTIMIZE YOUR HEALTH PDF EBOOK EPUB MOBI Page 1 Page 2 the keto cure a low carb high fat dietary solution to
Disclosures. Nutrition & Menopause. What changes? Mindless Eating 10/6/2017. I have no disclosures
I have no disclosures Disclosures Nutrition & Menopause Making changes when you can t eat like a 25 year old, and get away with it.. What changes? Social situation Family and family meals Activity levels
In glycolysis, glucose is converted to pyruvate. If the pyruvate is reduced to lactate, the pathway does not require O 2 and is called anaerobic
Glycolysis 1 In glycolysis, glucose is converted to pyruvate. If the pyruvate is reduced to lactate, the pathway does not require O 2 and is called anaerobic glycolysis. If this pyruvate is converted instead
Hormonal Regulations Of Glucose Metabolism & DM
Hormonal Regulations Of Glucose Metabolism & DM What Hormones Regulate Metabolism? What Hormones Regulate Metabolism? Insulin Glucagon Thyroid hormones Cortisol Epinephrine Most regulation occurs in order
National Metabolic Biochemistry Network Guidelines for the investigation of hypoglycaemia in infants and children
National Metabolic Biochemistry Network Guidelines for the investigation of hypoglycaemia in infants and children Aim To provide guidance on the biochemical investigation of hypoglycaemia in infants and
Biochemistry: A Short Course
Tymoczko Berg Stryer Biochemistry: A Short Course Second Edition CHAPTER 27 Fatty Acid Degradation Dietary Lipid (Triacylglycerol) Metabolism - In the small intestine, fat particles are coated with bile
Managing Weight and the Role of Carbohydrates in the Diet of an Athlete. Susan M. Kleiner PhD, RD, FACN, CNS FISSN
Managing Weight and the Role of Carbohydrates in the Diet of an Athlete Susan M. Kleiner PhD, RD, FACN, CNS FISSN Disclosure Dr. Kleiner is the co CEO of Vynna, LLC, a sports nutrition product company
The Anti-Seizure Effects of Ketone Bodies. Glia Club - Dennis T., Ella O., Erika P, Subathra R.
ia The Anti-Seizure Effects of Ketone Bodies Glia Club - Dennis T., Ella O., Erika P, Subathra R. Overview 1. Introduction a. Epilepsy b. What is the Ketogenic diet? c. Ketone bodies 2. Potential mechanisms
Integrative Metabolism: Significance
Integrative Metabolism: Significance Energy Containing Nutrients Carbohydrates Fats Proteins Catabolism Energy Depleted End Products H 2 O NH 3 ADP + Pi NAD + NADP + FAD + Pi NADH+H + NADPH+H + FADH2 Cell
Roles of Lipids. principal form of stored energy major constituents of cell membranes vitamins messengers intra and extracellular
Roles of Lipids principal form of stored energy major constituents of cell membranes vitamins messengers intra and extracellular = Oxidation of fatty acids Central energy-yielding pathway in animals. O
Opening screen: What is a nutrient?
Nutrition and lifestyle introduction Opening screen: List examples of the issues affecting youth athletics today. Click the NEXT button: What is the goal of nutrition scientists? What is the goal of sport
MITOCW watch?v=qmqif0yj4lm
MITOCW watch?v=qmqif0yj4lm The following content is provided under a Creative Commons license. Your support will help MIT OpenCourseWare continue to offer high quality educational resources for free. To
CEREBRAL BLOOD FLOW AND METABOLISM
Supported by: HURO/0901/069/2.3.1 HU-RO-DOCS CEREBRAL BLOOD FLOW AND METABOLISM Part 11. Cerebral blood flow Supplies cerebral metabolism demanded by neuronal function Is required for the production and
Module C CHEMISTRY & CELL BIOLOGY REVIEW
Module C CHEMISTRY & CELL BIOLOGY REVIEW Note: This module is provided for A&P courses that do not have a prerequisite class which includes chemistry and cell biology. Content covered by required prerequisite
INTEGRATION OF METABOLISM
SIBC511- INTEGRATION OF METABOLISM Assistant Professor Dr. Chatchawan Srisawat INTEGRATION OF METABOLISM INTEGRATION OF METABOLISM Dietary intake Fed state Fasting state The metabolism of carbohydrate,
38 yo obese F w/crohns presents with nausea/vomiting. 1/24/13 Jess Hwang
38 yo obese F w/crohns presents with nausea/vomiting 1/24/13 Jess Hwang 1 week prior to admission Seen in ED with fevers, nausea, vomiting, worsening rash Hypotensive to 70/40 with lactate of 4.5 Acute
Ketogenic Diet: Which Patients Benefit?
Ketogenic Diet: Which Patients Benefit? John Watson; Reviewed by: Anya Romanowski, MS, RD March 20, 2018 The Disease-Fighting Diet When it comes to addressing disease, most diets have a precautionary pitch:
Lecture 5: Cell Metabolism. Biology 219 Dr. Adam Ross
Lecture 5: Cell Metabolism Biology 219 Dr. Adam Ross Cellular Respiration Set of reactions that take place during the conversion of nutrients into ATP Intricate regulatory relationship between several
Transfer of food energy to chemical energy. Includes anabolic and catabolic reactions. The cell is the metabolic processing center
Metabolism There are a lot of diagrams here. DO NOT, I repeat, DO NOT get overly anxious or excited about them. We will go through them again slowly!! Read the slides, read the book, DO NOT TAKE NOTES.
Mitochondrial Dysfunction, Neurodegenerative Diseases and Malignancy October 18, 2017 George Steele MD
Mitochondrial Dysfunction, Neurodegenerative Diseases and Malignancy October 18, 2017 George Steele MD INTRODUCTION: Mitochondrial dysfunction is associated with memory loss and dementia, Parkinson s disease
Glucagon Regulation of Plasma Ketone Body Concentration
Glucagon Regulation of Plasma Ketone Body Concentration in Human Diabetes DAVID S. ScHADE and R. PHiIp EATON From the Department of Medicine, University of New Mexico School of Medicine, Albuquerque, New
Initiation of Diets: Inpatient & Outpatient
Kaiser Permanente Los Angeles Medical Center Center Initiation of Diets: Inpatient & Outpatient Epilepsy & Brain Mapping Program, Huntington Memorial Hospital, Pasadena CA Danine Mele-Hayes, RD History
Examining the Effects of Exogenous Ketones on Exercise Metabolism and Performance in Male Varsity Athletes
Examining the Effects of Exogenous Ketones on Exercise Metabolism and Performance in Male Varsity Athletes by Riley Sonnenburg A thesis presented to the University of Waterloo in fulfillment of the thesis
DEPARTMENT OF SCIENCE COURSE OUTLINE Fall 2018 BC 2000 INTRODUCTORY BIOCHEMISTRY 3 (3-0-0) 45 HOURS FOR 15 WEEKS
DEPARTMENT OF SCIENCE COURSE OUTLINE Fall 2018 BC 2000 INTRODUCTORY BIOCHEMISTRY 3 (3-0-0) 45 HOURS FOR 15 WEEKS INSTRUCTOR: Beatrice Amar Ph.D. PHONE: 780-539-2031 OFFICE: J208 E-MAIL: Bamar@gprc.ab.ca
The benefits that come from limiting protein are the big difference between the ketogenic diet and the Atkins diet.
The benefits that come from limiting protein are the big difference between the ketogenic diet and the Atkins diet. At face value, the keto diet and the Atkins diet seem to be pretty similar since they