Shock and Trauma Resuscitation
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1 Shock and Trauma Resuscitation Bonjo Batoon, MS, CRNA
2 Disclaimer Resuscitation is continuously evolving There is no one right way Knowing is half the battle G.I. Joe Having to appropriate resources/information is other half How I feel or think now may be very different tomorrow
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4 Shock by definition A clinical state of acute circulatory failure with inadequate oxygen utilization and/or delivery by the cells resulting in cellular dysoxia/hypoxia Intensive Care Med 2014;40:1795 A state of inadequate tissue perfusion A cellular and end-organ disorder Not a disorder of the macro-circulation Decreased BP does not equal shock BP does not = flow
5 Oxygen Debt
6 Types of shock Hemorrhagic- Most common Non-hemorrhagic Cardiogenic Neurogenic Septic Tension pneumothorax Poisoning
7 Signs & Symptom of Shock Tachycardia Tachypnea Decreased capillary refill Hypotension Narrow pulse pressure Altered mental status Elevated lactate Coagulopathy Cyanosis, pallor, diaphoresis Hypothermia Decreased urine output Absent pulse oximetry signal* +FAST/CT*
8 Classification of Shock
9 Lethal Triad Coagulopathy Acidosis Hypothermia
10 More than the Lethal Triad Hess JR, Brohi K, Dutton RP; et al. The coagulopathy of trauma: a review of mechanisms, J Trauma
11 Resuscitation Goals Early recognition of the shock state Oxygenate and ventilate Restore the circulating volume Restore organ perfusion Restore homeostasis / repay oxygen debt Stop the bleeding- Surgeon s job Treat coagulopathy Continuous monitoring of the response
12 Components to Resuscitation Airway Breathing Circulation Exposure
13 Anticipation of Respiratory Consequences of Injuries Tension pneumothorax Flail chest Hemothorax Pneumothorax Chest wall Asymmetry Diaphragmatic rupture Atelectasis Aspiration Pulmonary contusion Thermal / Smoke
14 Signs of Airways Problems Lacerated pharyngeal tissue Cervical hematoma Active oral bleeding Copious secretions Foreign bodies Displaced bone Dyspnea JVD Hoarseness Stridor Dysphonia Subcutaneous air Hemoptysis Cervical deformity Edema Tracheal deviation
15 Challenges to Airway Management Blood/secretions/ emesis Airway injuries Body habitus C-spine issues Positioning limitations
16 Airway DL Bougie Video laryngoscopy AFOI RSI vs MRSI Cricoid pressure-?? C-spine issues Surgical cricothyrotomy/trach when all else fails
17 Anesth Analg Mar;118(3):580-6
18 Cricoid Pressure Utschig et al. (2016). Annals of Emergency Medicine, Volume 68, Issue 4, S9 - S10 Position of Esophagus NO CP With CP Directly behind trachea 20% 4% Partially behind trachea (left) 60% 26% Completely behind trach (left) 20% 70%
19 When to Intubate? GCS <8 Combative Hypoxia Poor / Inadequate Ventilations Lack of airway reflexes Pain control Social issues Deteriorating condition Manipulation of long bones when muscle relaxation is required
20 So You Want to Intubate? Induction drugs Propofol 2/mg Kg IV Etomidate mg/Kg IV Ketamine 2-4mg/Kg IV Ketamine 4-10mg/Kg IM Be acutely aware of all of the pt s issues, allergies, and resuscitation status Induction can kill Muscle relaxation Succinylcholine mg/kg 30 second onset Will cause patients to fasciculate (depolarizing block) Approximately 5-12 minute duration of action Rocuronium 1.2 mg/kg second onset -> may need to gently mask ventilate ( modified RSI ) Patients will not fasciculate (non-depolarizing block) Approximately minutes duration of action
21 Airway Confirmation Visualization End tidal CO 2 Condensation Auscultation Chest excursion O 2 saturation Radiography
22 6088 pts required intubation within the first 1hr of admission 21 (0.3%) received surgical airway Unanticipated difficult airway was the leading cause of surgical airway 4 pts died but none died as a result of failed intubation
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24 Breathing Secure airway most important Adequately oxygenate Monitor CO2 Consider lower Vt in hypotensive pts Ventilation strategies?? Pressure vs VC Massive transfusion- TRALI, TACO, ARDS
25 Circulation Adequate IV access Peripheral 16G or greater RIC aka mini cordis Know flow rates for each cathether Preferably central access IJ vs SC vs femoral Cordis vs double lumen catheters vs triple lumen
26 Exposure 34 C was the critical point at which enzyme activity slowed significantly, and at which significant alteration in platelet activity was seen. Fibrinolysis was not significantly affected at any of the measured temperatures Watts, Dorraine Day, et al. The Journal of Trauma and Acute Care Surgery 44.5 (1998): Keeping pt warm Warm blood products Bair hugger type devices Warm operating room
27 Hypothermia and Coagulopathy Effects on Clotting Factor Activity o C II V VII VIII IX X XI XII 25 o o o o o o o Johnston et al. J Trauma 1994; 37:
28 Monitoring Basic Advanced A line CVP? PPV- FloTrac TEE Labs- CBC, coags, lytes, ABGs POC Hemoque- Hgb istat- lytes/gases ROTEM/TEGcoagulation
29 Clotting Dynamics
30 Components to Resuscitation Crystalloids Colloids Blood products
31 Crystalloids LR NS Plasmalyte Crystalloids are not and should not be the mainstay of trauma resuscitation!!
32 Immediate resus Delayed resus Mortality 38% 30% EBL ml 3127± ± 3546 Prehospital LR 870± ± 309 Trauma center LR 1608± ± 722 OR LR 6772± ± 4863
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35 No ideal resuscitation fluid Clinician dependent No clear benefit colloid over crystalloid Albumin safe Increased cost Increased mortality TBI Safe in most other uses HES Increased renal replacement therapy Increased adverse effects critically ill Dose dependent decrease in fibrin polymerization coagulopathies
36 Colloids Starches Coagulopathy r/t decreased fibrin polymerization Hespan max dose 20ml/kg Albumin Allergic rxs
37 Blood Products RBCs- uncrossmatched/crossmatched FFP Plts Cryoprecipitate- high in fibrinogen Other hemostatic agents TXA, PCCs, fibrinogen concentrate, fviia
38 Component Therapy Dutton, R. P. (2012), Resuscitative strategies to maintain homeostasis during damage control surgery. Br J Surg, 99: doi: /bjs.7731
39 Resuscitation Strategies Permissive hypotension Ratio based resuscitation RBC:FFP; RBC:FFP:PLTs Point of Care ROTEM/TEG Coagulation concentrates Laboratory based resuscitation Lab delays Lost samples
40 Mortality TXA 14.5% vs placebo 16% TXA given 1gram/10minute Followed by 1gram infusion over 8hrs Design: Selectively randomized?!
41 TXA TXA ISS Mortality 17.4% 23.9% Mortality MT 14.4% 28.1% TXA group less over all coagulopathy
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43 TXA/cryo Cryo TXA TXA/Cryo Mortality 23.6% 21.4% 18.2% 11.6% ISS Retrospective analysis TXA/cryo implemented last 18 months of study Benefit may be additive Known anti-inflammatory effects of TXA Unknown mechanism
44 Dutton, RP. Damage Control Anesthesia. Trauma Care. 2005;15:
45 Dutton, RP. Damage Control Anesthesia. Trauma Care. 2005;15:
46 Dutton, RP. Damage Control Anesthesia. Trauma Care. 2005;15:
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49 Pitfalls Airway issues Recall Coagulopathy Hypothermia Pain Anticoagulants Pneumothorax Missed injuries Substance abuse Under resuscitation Over resuscitation Aspiration The UNKNOWN
50 Thank you!!
51 Hemostatic Resuscitation Bonjo Batoon, CRNA
52 Hemostatic Resuscitation Traditional coagulation Primary hemostasis Secondary hemostasis Cell based theory of coagulation Ratio based hemostatic resuscitation POC TEG/ROTEM
53 Primary Hemostasis
54 Secondary Hemostasis (formation of a stable clot)
55 Collagen Act Plts Intrinsic 12a 11a 9a + 8a Extrinsic Tissue Factor 7a 10a + 5a 2a Vit K dependent Clotting factors 1a + 13a Stable clot
56 Cell Based Model of Coagulation Smith A. The cell-based model of coagulation. J Vet Emerg Crit Care 2009; 19(1): 3 10
57 Cell Based Model of Coagulation TF bearing cells are extrinsic to blood until injury or inflammation Once injury occurs TF bearing cells bind quickly with fviia Small amounts of thrombin are generated Platelets begin to aggregate and become activated at the site of injury Smith A. The cell-based model of coagulation. J Vet Emerg Crit Care 2009; 19(1): 3 10
58 Cell Based Model of Coagulation Smith A. The cell-based model of coagulation. J Vet Emerg Crit Care 2009; 19(1): 3 10
59 Cell Based Model of Coagulation Smith A. The cell-based model of coagulation. J Vet Emerg Crit Care 2009; 19(1): 3 10
60 Cell Based Model of Coagulation Smith A. The cell-based model of coagulation. J Vet Emerg Crit Care 2009; 19(1): 3 10
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63 Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR) Evaluate 24-hour and 30-day mortality of massively transfused pts >10units or more PRBCs in 24hr period 1:1:1 cooler 1:1:2 cooler 6 RBCs Cooler 1 6 RBCs Cooler 2 6 RBCs 6 FFP 3 FFP 3FFP 1 pool of platelets (usually 6 pack) 0 platelets 1 pool of platelets
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66 Means to achieve hemostatis Ratio based- 1:1, 1:2, etc vs POC w/ conctrates
67 Means to achieve hemostatis Ratio based- 1:1, 1:2, etc vs POC w/ conctrates No change in ratios 1:1.8 FFP:RBC Faster availability of products Mortality decreased from 45% to 19%
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70 Kozar RA, Peng Z, Zhang R, et al. Plasma Restoration of Endothelial Glycocalyx in a Rodent Model of Hemorrhagic Shock. Anesthesia and analgesia. 2011;112(6): doi: /ane.0b013e c.
71 Kozar RA, Peng Z, Zhang R, et al. Plasma Restoration of Endothelial Glycocalyx in a Rodent Model of Hemorrhagic Shock. Anesthesia and analgesia. 2011;112(6): doi: /ane.0b013e c.
72 Kozar RA, Peng Z, Zhang R, et al. Plasma Restoration of Endothelial Glycocalyx in a Rodent Model of Hemorrhagic Shock. Anesthesia and analgesia. 2011;112(6): doi: /ane.0b013e c.
73 Glycocalyx functions Prevent leukocyte/erythrocyte from interacting with endothelium Barrier b/t receptor/ligand Prevents platelet adhesion under normal condition Maintaining vascular stability Preventing vascular permeability/tissue edema Plasma partially restores glycocalyx Hydrocortisone/antithrombin
74 Nascimento et al. Critical Care 2010, 14:202
75 Early Aggressive Use of Fresh Frozen Plasma Does Not Improve Outcome in Critically Injured Trauma Patients Scalea, Thomas M. MD; Bochicchio, Kelly M. RN, BSN, MS; Lumpkins, Kim MD; Hess, John R. MD, MPH; Dutton, Richard MD; Pyle, Anne RN, BSN, MS; Bochicchio, Grant V. MD, MPH N= 806 consecutive trauma pts Admitted to ICU over 2 yrs 45% transfused w/i first 24hrs 68% received RBCs/FFP Mean ISS 29 ± 13 Mean RBCs 7.7 ± 12 U Mean FFP 5 ± 12 U No change ICU days Hospital days Mortality Conclusion: Early and aggressive use of FFP does not improve outcome after civilian injury. This may reflect inherent differences compared with military injury; however, this practice should be reevaluated. Scalea, T. M., Bochicchio, K. M., Lumpkins, K., Hess, J. R., Dutton, R., Pyle, A., & Bochicchio, G. V. (2008). Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Annals of Surgery, 248(4), DOI: /SLA.0b013e ed
76 Europe VS USA VS
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83 RBC transfusion avoided 29% FC-PCC Only 3% standard treatment Platelets avoided 91% FC-PCC 56% standard treatment Overall reduction in allogeneic transfusions using POC
84 FFP reduction of 90%
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86 CFC FFP Rescue therapy 4% 52% Massive transfusion 12% 30% MOF 50% 66%
87 My Ideal Hemostatic Resuscitation Optimize coagulation Replace lost volume Pinpoint coag deficiencies via appropriate testing Decrease unnecessary blood product transfusion Decrease hit to glycocalyx Avoid delays in appropriate resuscitation Uncrossed matched blood products Point of care testing Quick availability of concentrates for coagulation support
88 Europe VS USA VS
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