Mark Karim Lane, M.D.

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1 Curriculum Vitae Mark Karim Lane, M.D. Date July 1, 2017 Cntact Infrmatin Address: 1208 Wright Drive Clawsn, MI Mbile: Pst Graduate Educatin and Training Adult Jint Recnstructin Fellw (August 2018 July 2019) Department f Orthpaedic Surgery, University f Missuri Schl f Medicine, Clumbia, Missuri Resident Physician (Instructr) (July Present) Department f Orthpaedic Surgery, The Detrit Medical Center/Wayne State University Schl f Medicine Orthpaedic Surgery Residency Prgram, Detrit, Michigan, PGY-5 (Chief Resident) Educatin Dctr f Medicine (May 2013) Nrtheast Ohi Medical University, Rtstwn, Ohi Master f Science (September 2004) Marietta Cllege, Marietta, Ohi, Physician Assistant Studies (ARC-PA Accredited Prgram) Bachelr f Science (May 2001) Marietta Cllege, Marietta, Ohi, Sprts Medicine/Athletic Training Majr with Bilgy minr Curses University f Michigan Pathlgy Review Curse - Ann Arbr, Michigan Nvember 2016 Enneking Pathlgy Review Curse - Gainesville, Flrida April 2016 University f Michigan Pathlgy Review Curse - Ann Arbr, Michigan Nvember 2015 Arthrscpy Assciatin f Nrth America Arthrscpy Curse - Chicag, Illinis Octber 2015 University f Michigan Pathlgy Review Curse - Ann Arbr, Michigan Nvember 2014 AO Basic Fracture Curse - Atlanta, Gergia Octber 2014 Prvidence Hspital Basic Micrsurgery Curse Suthfield, Michigan July 2014 Western Michigan University AO Techniques Curse - Kalamaz, Michigan September 2013 Advanced Trauma Life Supprt - Detrit, Michigan July 2013 Certificatins Advanced Trauma Life Supprt- ATLS Current CITI Cmpliant Current Advanced Cardiac Life Supprt - ACLS Current Physician Assistant Certified - PA-C Basic Life Supprt - BLS Current

2 Athletic Trainer Certified - ATC Emergency Medical Technician - EMT-B Current Medical Licensures State f Michigan Medical Training License (# , issued 2013). Active status. USMLE Steps I, II and III passed. Prfessinal Sciety Memberships Mid-America Orthpaedic Assciatin- Member since Octber 2016 American Academy f Orthpaedic Surgens- Member since July 2013 Arthrscpy Assciatin f Nrth America- Member since Nvember 2016 American Medical Assciatin- Member since January 2012 Hnrs and Awards Tp Scientific Paper - Dallas B. Phemister, M.D. Award, Mid-America Orthpaedic Assciatin fr "Prximity f Lateral Critical Structures in All-Epiphyseal Outside-In Femral Tunnel Drilling fr Pediatric Anterir Cruciate Ligament Recnstructin," Bnita Springs, Flrida, 2016 Clerkship Hnrs - Nrtheast Ohi Medical University, Rtstwn, Ohi, 2012 Dean's List - Marietta Cllege, Marietta, Ohi, Varsity Letterman- NCAA Divisin III Men's Sccer, Marietta Cllege, Marietta, Ohi, Team Cverage Experience Natinal Fighting Champinship (MMA). Cage Side Physician Assistant, Duluth, Gergia, Graysn High Schl Ftball. Team Physician Assistant, Lganville, Gergia, Berkmar High Schl Ftball. Team Physician Assistant, Lilburn, Gergia, Cllins Hill High Schl Ftball/Wrestling/Basketball. Team Physician Assistant, Suwanee, Gergia, Administrative Service Chief Resident Detrit Medical Center/Wayne State University Schl f Medicine Orthpaedic Surgery Prgram, Resident Cuncil Member - Detrit Medical Center, Detrit, Michigan, Present Cmmunity Service Guest speaker at Prvidence Health System Summer Research Prgram- Suthfield, Michigan, 2015 and 2016 Cmmunity Service Explratry Experience, Washingtn Cunty Public Library - Marietta, Ohi, January 2012 Hsea Feed the Hungry - Atlanta, Gergia (2007 and 2008). Preceptr fr Quest High Schl Internship Prgram - Snellville, Gergia, Publicatins Peer-Reviewed

3 1. "Mrbidity and Mrtality f Bilateral Femral Shaft Fractures." Lane, MK; Nahm, NJ; Vallier, HA. ORTHOPEDICS July 1;38(7): e "Prximity f Lateral Critical Structures in All-Epiphyseal Outside-In Femral Tunnel Drilling fr Pediatric Anterir Cruciate Ligament Recnstructin" Lane, MK; Mutch, JAJ; Ratkwiak, K.; Lems, S; Kalra, K. Arthrscpy and Related Surgery. In press, February, "The Diagnsis and Treatment f a Rare Case f Acute Bilateral Upper Arm Exercise Induced Cmpartment Syndrme." Traub, BC; Lane, MK; Traub, JA. In submissin. February, Onging Research Thesis 1. "Efficacy f Vancmycin fr Preperative Antibitic Prphylaxis in Ttal Jint Arthrplasty" Lane, MK; Manli, A; Darwiche, HF. 2. Analysis f Jint Arthrplasty Antibitic Prphylaxis Timing in a High Vlume Academic Center. Lane, MK; Darwiche, HF. "The Effectiveness f Distance Learning Prgrams in Advanced Medical Pharmaclgy" Masters Degree Thesis. Presented as "Asynchrnus Pharmaclgy - Can It Be Dne?" Assciatin f Physician Assistant Prgrams, 2005 Educatinal Frum, Puert Ric, (Nvember 2005). Presented in defense f Masters Degree thesis and then by physician assistant prgram faculty at AAPA Educatinal Frum. Pdium Presentatins Prximity f Lateral Critical Structures in All-Epiphyseal Outside-In Femral Tunnel Drilling fr Pediatric Anterir Cruciate Ligament Recnstructin" Lane, MK; Mutch, JAJ; Ratkwiak, K.; Lems, S; Kalra, K. Accepted fr pdium presentatin. AAOS (American Academy f Orthpaedic Surgens), San Dieg, CA, March "Prximity f Lateral Critical Structures in All-Epiphyseal Outside-In Femral Tunnel Drilling fr Pediatric Anterir Cruciate Ligament Recnstructin" Lane, MK; Mutch, JAJ; Ratkwiak, K.; Lems, S; Kalra, K. Pdium Presentatin. MOS (Michigan Orthpaedic Sciety), Mackinac Island, MI, June "Prximity f Lateral Critical Structures in All-Epiphyseal Outside-In Femral Tunnel Drilling fr Pediatric Anterir Cruciate Ligament Recnstructin" Lane, MK; Mutch, JAJ; Ratkwiak, K.; Lems, S; Kalra, K. Pdium Presentatin. MAOA (Mid-America Orthpaedic Assciatin), Bnita Springs, FL, April "Prximity f Lateral Critical Structures in All-Epiphyseal Outside-In Femral Tunnel Drilling fr Pediatric Anterir Cruciate Ligament Recnstructin" Lane, MK; Mutch, JAJ; Ratkwiak, K.; Lems, S; Kalra, K. Pdium Presentatin. COA/AOC (Canadian Orthpaedic Assciatin), Vancuver, Canada. June "Prximity f Lateral Critical Structures in All-Epiphyseal Outside-In Femral Tunnel Drilling fr Pediatric Anterir Cruciate Ligament Recnstructin" Lane, MK; Mutch, JAJ; Ratkwiak, K.; Lems, S; Kalra, K. Accepted fr Pdium Presentatin. ISAKOS (Internatinal Sciety f Arthrscpy Knee Surgery and Sprts Medicine), 10th Cngress. Lyn, France. June Psters Effects f Off Ice Sprts and Training n Functinal Perfrmance f Yuth Hckey Players Hultman, KL; Lane, MK; Bbba, V; Cizmic, Z; Dimvsky, R; Zarling, B; Lems, SE. Presented at MOS (Michigan Orthpaedic Sciety), Mackinac Island, MI, June Educatinal Presentatins S Yu Think Yu Want T Be An Orthpaedic Surgen Presented t high schl and cllege students participating in a summer research prgram. Prvidence Hspital Medical Center, Suthfield, Michigan. April 2015 and July 2016.

4 "Ttal Knee Arthrplasty" Patient educatin presentatin fr Cmmunity Outreach Department, Dekalb Medical Center Jint Slutins Center. Presented at Park Springs Retirement Cmmunity, Stne Muntain, Gergia. Nvember 19, Research Experience Sutheastern Clinical Trials, Decatur, Gergia, September December 2008 Sub-investigatr fr multiple drug manufacturer studies. Gained a tremendus amunt f experience wrking as a physician assistant by participating in patient selectin, cnsenting, intraperative and/r pstperative drug administratin, dcumentatin f adverse drug reactins and effects, and fllw-up physical examinatin fr bth inpatient and utpatient surgeries in the pst perative perid. A Randmized, Duble-Blind, Active and Placeb-Cntrlled, Parallel-Grup, Multicenter Study t Evaluate the Efficacy and Safety f Multiple Dses f CG5503 Immediate-Release Frmulatin in the Treatment f Acute Pain Frm Ttal Hip Replacement Surgery Fllwed by a vluntary Open-Label Extensin, Jhnsn & Jhnsn. A Phase IIb, Randmized, Parallel-Grup, Duble-Blind, Duble-Dummy, Multicenter, Multi-Natinal, Multi-Dse Study f DU-176b Cmpared t Dalteparin in Patients Underging Elective Ttal Hip Replacement, Daiichi Sanky Pharma A Phase II, Multicenter, Duble-Blind, Placeb-Cntrlled, Dse-Ranging, Parallel-Grup Study f Alimpan fr the Preventin r Reductin f Opid-Induced Gastrintestinal Side Effects in Subjects Underging Ambulatry Shulder Surgery, Adlr A Phase III, Multicenter, Randmized, Duble-Blind Study t Evaluate the Safety and Efficacy f a Single Administratin f SKY0402 as a Femral Nerve Blck in the Management f Pstperative Pain in Subjects Underging Recnstructin f the Anterir Cruciate Ligament, Skye Pharma Evaluatin f the Factr Xa Inhibitr, PRT054021, Against Enxaparin in a Randmized Trial fr te Preventin f Venus Thrmbemblic Events after Unilateral Ttal Knee Replacement (EXPERT), Prtla A Randmized, Duble-Blind, Placeb-Cntrlled Study f the Efficacy and Safety f Subcutaneus r Subacrmial SABER-Bupivacaine in Patients Underging Mini-Open Rtatr Cuff Repair, Duet Recrd 4 Study: Regulatin f Cagulatin in Orthpedic Surgery t Prevent DVT and PE; a cntrlled, duble-blind, randmized study f BAY in the extended preventin f VTE in patients underging elective ttal knee replacement., Bayer Recrd 1 Study: Regulatin f Cagulatin in Orthpedic Surgery t Prevent DVT and PE; a cntrlled, duble-blind, randmized study f BAY in the extended preventin f VTE in patients underging elective ttal hip replacement., Bayer A Dse Ranging Trial fr the Evaluatin f the Safety, Tlerability and Efficacy f Odiparcil in the Preventin f Venus Thrmbemblism fllwing Ttal Knee Replacement Surgery., GlaxSmithKline A Study f the Efficacy and Safety f 8 mg Hydrmrphne Hydrchlride Extended-Release (HHER) Cmpared t Placeb in Subjects with Persistent Pain, Purdue Pharma L.P. A Phase IIa, Multi-Center, Multi-Natinal, Open-Label, Dse Ranging Study f the Efficacy, Safety, and Tlerability f Oral DU-176b Administered Once r Twice Daily in the Treatment f Adult Patients Underging Ttal Hip Arthrplasty, Daiichi A Phase III, Randmized, Open-Label Study t Assess the Safety and Efficacy f Aquavan Injectin Versus Midazlam HCI fr Sedatin in Patients Underging Minr Surgical Prcedures, Guilfrd R PAI-2001 A 4-week Randmized Multicenter, Duble-Blind, Placeb and Active-Cntrlled, Parallel-Grup, Frced-Titratin Phase IIb Study Cmparing Efficacy and Safety f Ascending Dses f CG5503 Prlnged Release up t 233 mg BID and Oxycdne Prlnged Release up t 20 mg BID t Placeb in Subjects with Mderate t Severe Chrnic Pain due t Ostearthritis f the Knee, Jhnsn & Jhnsn

5 A Phase II Randmized, Duble-Blinded (BMS and Enxaparin), Active-Cntrlled (Enxaparin and Warfarin), Parallel-Arm, Dse-Respnse Study f the Oral Factr Xa Inhibitr BMS in Subjects Underging Elective Ttal Knee Replacement Surgery, Bristl-Myers Squibb Related Prfessinal Wrk Experience Dekalb Medical Center, Decatur, Gergia Emergency Medicine Physician Assistant (PA-C), April June 2013 Evaluate, diagnse, and treat a wide variety f emergency department illness and trauma, make apprpriate referrals when required. EXCEL Orthpaedics, Decatur, Gergia Orthpaedic Surgery Physician Assistant (PA-C), September June 2013 Evaluate, diagnse, and treat general rthpaedic and sprts medicine cnditins. Perfrm a wide variety f prcedures including jint and trigger pint injectins, arthrgrams, fracture and jint dislcatin reductins, first assist in surgery, and surgical wund clsure. Respnsible fr inpatient hspital runds, cnsults, and emergency department call. Prvided sprts medical cverage fr athletic events fr several Atlanta area high schls. SprtsMed, Marietta, Ohi Certified Athletic Trainer (ATC), January January 2002 Perfrmed acute injury evaluatin as well as physical therapy fr pst-perative patients fllwing jint arthrplasty, rtatr cuff repair, ACL recnstructin, and ther sprts related injuries. Health Pr Ambulance, Marietta, Ohi Emergency Medical Technician (EMT-B), January January 2002 Prvided emergency medical services t area and reginal hspitals as well as area extended care facilities. YMCA, Marietta, Ohi Persnal Trainer, January January 2001 Wrked with individuals t develp persnal wrkut regiments; als wrked with and mnitred prgress f patients underging Phase III Cardipulmnary Rehabilitatin at Marietta Memrial Hspital Wellness Center. Teaching Experience Emry University Schl f Medicine Family Practice Residency, Snellville, Gergia, July December 2008 Assisted attending physician in precepting f PGY 1 and PGY 2 family practice residents in basic rthpaedic prcedures, physical examinatin, interpretatin f plain film x-rays, and diagnsis and treatment f cmmn rthpaedic cnditins. Grss Anatmy Teaching Assistant, Marietta Cllege PA Prgram, Marietta, Ohi, June August 2004 Respnsible fr tutring f underclassman grss anatmy students, prepared mck practical exams, assisted in dissectin fr frmal practical exams.

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