P R O G R A M. Al XIX-lea Simpozion Na]ional RPNES. Hotel Ramada. Patologia psihoneuroendocrin` subclinic` Neuroendocrinologia ritmurilor

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1 AfisSimpozionRPNES Sibiu program:afiss2006 4/19/13 5:19 PM Page 1 Societatea Român` de PsihoNeuroEndocrinologie Al XIX-lea Simpozion Na]ional RPNES P R O G R A M Patologia psihoneuroendocrin` subclinic` Neuroendocrinologia ritmurilor 30 mai - 1 iunie 2013, Sibiu Hotel Ramada

2 SOCIETATEA ROMÂNĂ DE PSIHONEUROENDOCRINOLOGIE RPNES Al XIX LEA SIMPOZION NAŢIONAL DE PSIHONEUROENDOCRINOLOGIE 30 Mai - 1 Iunie 2013 Sibiu Patologia Psihoneuroendocrina Subclinica Neuroendocrinologia ritmurilor

3 COMITETUL DIRECTOR Preşedinte de onoare Profesor Dr. Mihail Coculescu, DSc, FRCP, FACE UMF Carol Davila Bucureşti Preşedinte executiv Conferenţiar Dr. Corin Badiu, DSc UMF Carol Davila Bucureşti PrimVicepreşedinte Prof. dr. Cătălina Tudose, DSc UMF Carol Davila Bucureşti Vicepreşedinti Prof. Dr. Dumitru Brănişteanu, DSc UMF Gr. T. Popa, Iaşi Dr. Monica Livia Gheorghiu, DSc UMF Carol Davila Bucuresti Dr. Corina Răducanu Lichiardopol, DSc UMF Craiova CP 1. Olga Ianas, DSc Institutul National de Endocrinologie C.I.Parhon, Bucuresti Secretar-Trezorier: Mariana Purice, DSc Institutul National de Endocrinologie C.I.Parhon, Bucuresti Contact: Tel./Fax: ,

4 ORGANIZATORI Societatea Româna de Psihoneuroendocrinologie RPNES Universitatea de Medicina si Farmacie Carol Davila Bucuresti Academia de Stiinte Medicale PROGRAM COMMITTEE President / Preşedinte: Prof. Dr. Mihai Coculescu UMF Carol Davila Bucuresti Acad. Prof. Victor Voicu Director Fundaţia Acta Endocrinologica Members / Membri: Dr. Olga Ianăş, Cercetător gr.i Inst. Naţ. de Endocrinologie C.I.Parhon Prof. Dr. Cătălina Tudose UMF Carol Davila Bucuresti Prof. Dr. Dumitru Brănişteanu UMF Gr. T. Popa Iasi Dr. Corina Lichiardopol-Răducanu UMF Craiova Dr. Monica Livia Gheorghiu UMF Carol Davila Bucuresti Mariana Purice, DSc Cercetator gr. I Inst. Naţ. de Endocrinologie C.I.Parhon ORGANIZING COMMITTEE President / Preşedinte: Conf. Dr. Corin Badiu UMF Carol Davila Bucuresti Members / Membri: Dr. Monica Livia Gheorghiu UMF Carol Davila Bucuresti Mariana Purice, DSc Cercetator gr. I, Institutul Naţional de Endocrinologie C.I.Parhon Referent Teodora Doija Tudor Jitianu

5 MODERATORI Conf. Dr. Corin Badiu, UMF Carol Davila Bucureşti Prof. Dr. Dumitru Brănişteanu, UMF Gr.T.Popa, Iaşi Dr. Vasile Ciubotaru, Centrul de excelenta in neurochirurgie, Sp. Bagdasar Arseni, Bucuresti Prof. Dr. Mihail Coculescu, Bucureşti, membru al Academiei de Ştiinţe Medicale Prof. Dr. Iuliana Dobrescu, UMF Carol Davila, Bucuresti Prof. Dr. Carmen Georgescu, UMF Iuliu Haţieganu, Cluj Napoca Dr. Monica Livia Gheorghiu, UMF Carol Davila, Bucureşti Dr. Corina Lichiardopol-Răducanu, UMF Craiova Prof. Dr. Dragos Marinescu, UMF Craiova Prof. Dr Cătălina Tudose, UMF Carol Davila, Bucureşti Conf. Dr. Ioan Horea Ursu, UMF Carol Davila, Bucureşti Acad Prof. Dr. Victor Voicu, membru al Academiei Romane

6 Cuvânt înainte - Al XIX-lea Simpozion RPNES Stimati oaspeţi, Stimati colegi, În acest an la Sibiu are loc al 19-lea simpozion al Societăţii Române de PsihoNeuroEndocrinologie (RPNES), care abordeaza tema patologiei psihoneuroendocrine subclinice si neuroendocrinologia ritmurilor. Avem prilejul să audiem punctul de vedere al unor experti internaţionali în domeniu, profesorul Leonidas Duntas (Universitatea din Atena) si Prof. Assoc. Maria Fleseriu (Universitatea din Oregon). De asemenea, vor fi prezenti si vor expune personalitati de varf in psihofarmacologie- Acad. Prof. Victor Voicu, psihiatrie - Prof. Dr. Dragos Marinescu, Prof. Dr. Catalina Tudose şi multi altii. Se dezbate situaţia implementării in ţara noastră, în practica curentă de endocrinologie a ghidurilor europene şi internaţionale de consens asupra diagnosticului si tratamentului patologiei subclinice psihoneuroendocrine. În program sunt incluse şi prezentări clinice de cazuri rare şi de interes particular. Programul se adresează endocrinologilor, dar şi neurologilor, psihiatrilor şi medicilor de familie. Sibiul, capitala culturala a Europei in anul 2007, este un oras cu multiple valente, imbinand traditia si temeinicia Ardealului cu bogatia intersectiei culturale pe care putine orase o pot oferi. Dorim tuturor participanţilor să se bucure de frumuseţea peisajului şi de bucuria de a-şi reîntâni colegii şi prietenii. Comitetul de Organizare

7 Foreword to 19 th RPNES Symposium Dear Guests, Dear Colleagues, This year, the 19th Symposium of the Romanian Society of PsychoNeuroEndocrinology (RPNES) will be held in Sibiu. The meeting will approach the themes of psihoneuroendocrine subclinical disorders and neuroendocrinology of rhythms. We have the opportunity to hear the lectures of international experts, Professor Leonidas Duntas (University of Athens, Greece) and Assoc. Prof. Maria Fleseriu (University of Oregon, USA), of national experts in psychopharmacology, Acad. Prof. Victor Voicu, psychiatry Prof. Dragos Marinescu, Prof. Catalina Tudose and many others. The meeting will discuss the state of implementation in our country, of the European and international consensus guidelines on diagnosis and treatment of subclinical psychoneuroendocrine disorders. The program also includes rare clinical presentations and of particular interest. The program addresses specialities of endocrinology, and neurology, psychiatry and family physicians. Sibiu, the cultural capital of Europe in 2007, is a city with multiple facets, combining tradition and cultural merits of Transylvania with wealth intersection that few cities can offer. We want all participants to enjoy the sights and rejoin colleagues and friends. The Organizing Committee

8 PROGRAM ŞTIINŢIFIC Al 19 lea Simpozion RPNES Sibiu, Hotel Ramada, Sala Hera Ziua 1 Joi, 30 mai Ceremonie de deschidere Conferinţă plenară 1 Moderator: Dumitru Branisteanu (Iasi) 17:00-17:30 Hipotiroidismul neonatal de la screening national la neurobiologia ritmurilor Corin Badiu (Bucureşti) Sesiunea 1- Patologia subclinica a metabolismului fosfocalcic Moderatori: Dumitru Branisteanu (Iasi), Corin Badiu (Bucureşti) 17: Hiperparatiroidismul primar normocalcemic: fenotip subclinic? Ionela Pascanu, Cota Ancuta, Oana-Maria Capraru, Camelia Gliga, Anisie Nasalean, J Balazs, Corina Pop- Radu, Zsuzsanna Szanto, Raluca Pop, Radu Neagoe. (Targu Mures) 17:45-18:00 Intre genetica si epigenetica în anomalii ale metabolismului calciului Luminiţa Beldean, Monica Beldean (Sibiu) Deficitul de Vitamina D mascheaza hipercalcemia in hiperparatiroidismul primar Roxana Novac, Daniel Lazescu, Dan Ferariu, Irina Ghita, Georgiana Constantinescu, Voichita Mogos, Dumitru D. Branisteanu (Iaşi)

9 18: Dozarea PTH-ului în diluţia aspiratului după punctie cu ac fin în diagnosticul hiperparatiroidismului primar Jeanina Idriceanu, Ioana Vasiliu, Ioana Bodescu, Delia Ciobanu, Lidia Ionescu, Mihaela Negru, Voichita Mogos, Carmen Vulpoi(Iaşi) Cocktail, Hotel Ramada Sibiu, Hotel Ramada, Sala Hera Ziua 2 Vineri, 31mai 2013 Conferinta Conferinta plenara 2 Moderatori: Vasile Ciubotaru, Monica Gheorghiu (Bucureşti) Noi provocări în terapia medicala a bolii Cushing Maria Fleseriu (Portland, USA) Leziuni hipofizare non-adenomatoase. V.Gh.Ciubotaru*, Ligia Tataranu**, Adriana Dediu*, D.Paunescu*, M.Lisievici* (Bucureşti) Sesiunea 2 Cronobiologie psihoneuroendocrina Moderatori: Iuliana Dobrescu (Bucuresti), Dragos Marinescu (Craiova) Tulburari ale ritmului somn-veghe in depresii, abordare psihofarmacologica Radu Ionescu Mihaita (Bucureşti) Aspecte cronobiologice ale obezitatii Veronica Mocanu (Iaşi)

10 Boala Cushing periodică - o afecţiune rară Ioana Bodescu, Viorel Scripcariu, Jeanina Idriceanu, Ioana Vasiliu, Felicia Crumpei, Cristina Cristea, Alina Rusu, Voichita Mogos, Carmen Vulpoi (Iaşi) Rolul ceasurilor circadiene in reglarea axei hipotalamo-hipofizo-gonadice Corina Lichiardopol (Craiova) Pauză de cafea 11:30-12:00 Conferinţă Plenară 3 Moderator: Maria Fleseriu (Portland, USA) Paradoxul macroprolactinoanelor Mihai Coculescu, Raluca Trifanescu, Dan Soare, (Bucureşti) Simpozion - Importanta ritmurilor biologice in schimbarea de paradigma a tratamentului antidepresiv Moderator: Mihai Coculescu (Bucureşti) Rolul glandei pineale si a melatoninei in reglarea ritmurilor biologice Corin Badiu (Bucureşti) Patologia ritmurilor biologice si a depresiei din perspectiva psihiatriei biologice Dragos Marinescu (Craiova) Schimbarea de paradigma in tratamentul depresiei Maria Ladea (Bucureşti) 13:00-14:30 Prânz

11 Vizionare postere Sesiunea 3- Simpozion: Patologia subclinica in tumorile endocrine Moderatori: Vasile Ciubotaru (Bucuresti), Corina Lichiardopol (Craiova) Hipercorticismul iatrogen subclinic corelat cu scaderea sperantei de viata la pacientii cu adenoame hipofizare nefunctionale Simona Găloiu, Ionela Baciu, Sorin Ioacără, Cristina Durac, Monica Gheorghiu, Corin Badiu, Catalina Poiana, Mihai Coculescu (Bucureşti) Carcinomul tiroidian papilar cu risc scazut: atitudini terapeutice. Ruxandra Dobrescu, Dumitru Ioachim, Anca Simioniuc, Corin Badiu, Andrei Goldstein (Bucuresti) Neoplazia pancreatică neuroendocrină cu evoluţie silenţioasa îndelungată Ioana Vasiliu, Felicia Crumpei, Eugen Târcoveanu, Constantin Volovăţ, Jeanina Idriceanu, Ioana Bodescu, Valentina Adomnicăi, Voichiţa Mogoş, Carmen Vulpoi (Iaşi) Feocromocitomul oligosimptomatic in practica clinica Simona Jercalau, Alexandra Gabur, Victor Tomulescu, Corin Badiu (Bucureşti) Complicatii metabolice si cardiovasculare la pacientii cu incidentaloame suprarenaliene Monica Gheorghiu, Alina Voicu, Mihaela Giurcaneanu, Andra Caragheorgheopol, Catalina Poiana (Bucuresti)

12 Conferinţă Plenară 4 Moderator: Dragos Marinescu (Craiova) Perceptia timpului si modificarea ritmurilor biologice in patologia psihiatrica Catalina Tudose, Florin Tudose (Bucuresti) Pauză de cafea Conferinţă Plenară 5 Moderator: Corin Badiu (Bucuresti) Patologia tiroidiana subclinica si afectiunile neuropsihiatrice Leonidas Duntas (Atena, Grecia) Sesiunea 4 - Patologia subclinica a tiroidei Moderatori: Leonidas Duntas (Grecia), Corina Lichiardopol (Craiova) Hipotiroidism subclinic prin tirodita Hashimoto si intarziere severa a cresterii Dumitru D. Branisteanu, Georgiana Constantinescu, Roxana Novac, Irina Ghita, Andreea Oprea, Voichita Mogos (Iaşi) ADHD, autismul si deficitul de iod Horea Ursu (Bucuresti) Cina festiva

13 Ziua 3 Sâmbătă, 1 Iunie 2013 Sibiu, Hotel Ramada, Sala Hera Conferinţă Plenară 6 Moderator : Mihail Coculescu (Bucuresti) Rolul corelatiilor PK/PD în analiza hiperprolactinemiei induse de tratamentul cu antipsihotice Victor Voicu, Andrei Medvedovici, Aurelian Ranetti, Dalia Miron, Flavian Stefan Rădulescu (Bucuresti) Sesiunea 5 Farmacologie si patologia subclinica endocrina Moderatori Acad. Victor Voicu, Catalina Tudose (Bucuresti) Efecte secundare endocrine si metabolice ale medicamentelor antipsihotice de a doua generatie la adolescenti Iuliana Dobrescu, Cristina Petrescu Ghenea, Ilinca Mihailescu, Florina Rad, Cristina Anghel, Carmen Trutescu (Bucureşti) Cronoperturbarea si afectiunile cronice la varstnici G.I. Prada, I.G. Fita. R. Nacu (Bucureşti) Terapia cu hormon de crestere: niciodata sa nu spui niciodata Irina Ghita, Georgiana Constantinescu, Roxana Novac, Andreea Oprea, Voichita Mogos, Dumitru D. Branisteanu (Iasi) Aspecte neuropsihice în hipotiroidia clinică şi subclinică

14 Mihaela Vlad, Mihaela-Andreea Tirla, Maria Oprea, Ioana Zosin (Timisoara) Apoplexia hipofizara subclinica - o entitate controversata Pauza de cafea Monica Livia Gheorghiu, Iulia Vargatu, Claudiu Stan, Dan Hortopan, Anda Dumitrascu, Catalina Poiana, Corin Badiu, Mihai Coculescu (Bucuresti) Sesiunea 6-Patologia subclinica psihoendocrina gonadica Moderatori: Iuliana Dobrescu, Horia Ursu (Bucureşti) Importanta evaluării calitătii vietii la femeile cu tulburare depresivă si histerectomie Mihail Cristian Pîrlog, Ileana P. Marinescu (Craiova) Particularităţi neuropsihoendocrine în evoluţia şi tratamentul tulburării depresive la femei Ileana P. Marinescu, Dragoş Marinescu (Craiova) Aspecte fenotipice si patogenetice in sindromul de ovare polichistice ca factor de risc al bolii vasculare subclinice Georgescu CE, Ilie IR, Marian I, Hazi G, Duncea I (Cluj) Bursa de neuroendocrinologie Grigore Coculescu Variabilitatea genetica a receptorului AVP V1A la femeile cu SOPC si sindrom metabolic din Romania. Madalina Vintila (Bucuresti) Adunarea generala RPNES Închiderea simpozionului

15 LUCRĂRI POSTER P1. Remisiune sau recurentă postoperator? - Poate avea valoare predictivă variatia concentratiei serice a hormonului adenocorticotrop (ACTH) după interventie chirurgicală transsfenoidală pentru boala Cushing (BC)? Liana Chicea 1, Chris Yedinak 2, Nadia Hameed 2, Jessica Brzana 2, Maria Fleseriu 2 1.University Hospital, Sibiu, Romania, Department of Internal Medicine 2.Northwest Pituitary Center, Departments of Medicine &Neurological Surgery, Oregon Health & Science University, Portland, USA P2. Tulburari de ritm circadian la varstnic Nacu Raluca, Gabriel I. Prada Institutul National de Geriatrie si Gerontologie Ana Aslan, Bucuresti Romania P3. Markerul de transcriptie SOX2 in relatie cu fenotipul adenoamelor hipofizare Cristina Stancu 1, Anca Cimpean 3, Monica Gheorghiu 2, Cristina Capatana 2, Dan Hortopan 2, Victor Ciubotaru 4, Marius Raica 3, Mihail Coculescu 1,2 1Endocrinology Department, Carol Davila University of Medicine and Pharmacy, 2 C. I. Parhon National Institute of Endocrinology, Bucharest, 3Histology Department, Victor Babes University of Medicine and Pharmacy, Timisoara, 4Neurosurgery Department, Bagdasar Arseni Hospital Bucharest, Romania P4. Anevrisme intracraniene asimptomatice la pacienţi cu macroprolactinoame. Raluca Trifănescu 1,2, Dan Soare 1, Corin Badiu 1,2, Dan Hortopan 2, Anda Dumitraşcu 2, Mihail Coculescu 1,2 & Cătălina Poiană 1,2 1-Univestitatea de Medicină şi Farmacie Carol Davila, Bucureşti, 2-Institutul Naţional de Endocrinologie C.I. Parhon, Bucureşti, P5. Estimarea riscului de fractura sold pe baza FRAX: corelatii intrun studiu cross-sectional cu ultradensitometria osoasa calcaneana la pacientele in postmenopauza C.Poiană1,2, M.Carşote1,2, V.Rădoi1, M.Alexandra2, A.Geleriu2, R.Samoila2, G.Voicu2, D.Paun1,2 1-Universitatea de Medicină şi Farmacie Carol Davila, Bucureşti, România 2-Institutul Naţional de Endocrinologie C.I. Parhon, Bucureşti, România

16 P6. Riscul de fractura apreciat prin FRAX (folosind indicele de masa corporala) si ultradensitometria osoasa calcaneana - un studiu transversal in 244 de femei in menopauza M.Carşote 1,2, V.Rădoi 1, M.Alexandra2, A.Geleriu 2, M.Popescu 2, R.Dusceac 2, C.Poiană 1,2, 1-Univestitatea de Medicină şi Farmacie Carol Davila, Bucureşti, România 2-Institutul Naţional de Endocrinologie C.I. Parhon, Bucureşti, România P7. Sexualitatea femeilor tinere cu boala tiroidiana autoimuna si functia tiroidiana optima in sarcina: ajustarea valorilor TSH in zona eutiroidiei. Dana Stoian,Magdalena Caraivan, Mihaela Craciunescu CENTRUL MEDICAL DR D., Timisoara, Romania P8. Eficacitatea inlocuirii unui analog de somatostina cu altul la pacientii cu acromegalie. Madalina Vintila 1, Monica Livia Gheorghiu 1,2, Mariana Purice 2, Mihai Coculescu 1, 2 & Catalina Poiana 1, 2 1-Univestitatea de Medicină şi Farmacie Carol Davila, Bucureşti, România 2-Institutul Naţional de Endocrinologie C.I. Parhon, Bucureşti, România P9. Relatia fier-hormoni sexuali in melanomul cutanat Nicolae I.(1), Caragheorgheopol A.(2), Soveja R. (1), Nicolae CD(3), Ardeleanu I.(4), Schipor S.(2) (1) Spitalul de Boli Infectioase si Tropicale "Victor Babes", (2) Institutul National de Endocrinologie "C. I. Parhon", (3) Universitatea de Medicina si Farmacie "Carol Davila", (4) Institutul de Ocrotire a Mamei si Copilului "Alfred Russescu", Bucuresti P10. Efectul IFN alpha2b asupra prolactinei serice la pacientii cu melanom cutanat Schipor S.(1), Nicolae I.(2), Padure A. (1), Nicolae CD(3), Manda D., Ardeleanu I.(4), Caragheorgheopol A.(1) (1) Institutul National de Endocrinologie "C. I. Parhon", (2) Spitalul de Boli Infectioase si Tropicale "Victor Babes", (3) Universitatea de Medicina si Farmacie "Carol Davila", (4) Institutul de Ocrotire a Mamei si Copilului "Alfred Russescu", Bucuresti P11. Riscul cardiovascular crescut la pacientii cu gusa polinodulara si hipertiroidism subclinic Abigail Mensah 1, Simona Galoiu 1,2, Florin Alexiu 1, Dan Niculescu 1,2, Emilia Gudovan 1, Adina Dragomir 1, Horea Ursu 1,2

17 1 Institutul de Endocrinologie C.I.Parhon, Bucuresti, 2Universitatea de Medicina si Farmacie Carol Davila, Bucuresti P12. Evaluare comparativa tomografica a musculaturii extrinseci a globilor oculari la pacientii cu acromegalie si boala Basedow Graves Iulia Vargatu 1, Anda Dumitrascu 1, Monica Livia Gheorghiu 1,2 1 Institutul de Endocrinologie C.I.Parhon, Bucuresti, 2. Universitatea de Medicina si Farmacie Carol Davila, Bucuresti P13. Pubertatea intarziata-de la cronopatologie la patologie subclinica Camelia Procopiuc, Cristina Dumitrescu, Iuliana Gherlan, Andreea Brehar, Mariana Costache, Andra Caragheorgheopol Institutul National de Endocrinologie CI Parhon Bucuresti P14. Diabet insipid adipsic la un pacient cu craniofaringiom gigant 1 Sorina Herman, 1 Simona Jercalau, 1 Dan Hortopan, 1,2 Corin Badiu 1 Institutul de Endocrinologie C.I.Parhon, Bucuresti, 2 Universitatea de Medicina si Farmacie Carol Davila, Bucuresti P15. Sindrom Cushing secundar unei hiperplazii macronodulare suprarenaliene ACTH - independente Diana Costeniuc (1), Simona Jercalau (1), Ruxandra Dobrescu (1), Victor Tomulescu (3), Corin Badiu (1,2) 1 Institutul de Endocrinologie C.I.Parhon, Bucuresti, 2Universitatea de Medicina si Farmacie Carol Davila, Bucuresti 3 Spitalul Clinic Fundeni P 16 Functie tiroidiană optimă în sarcină: ajustarea valorilor TSH în zona eutiroidiei Dana Stoian*, Mădălina Caraivan**, Mihaela Crăciunescu *** *Departamentul de Obstetrică Ginecologie, Disciplina Ginecologie III- Sexologie Universitatea de Medicină și Farmacie Victor Babeș Timișoara ** Centrul DR.D, Timișoara *** Departamentul de Microbiologie, Universitatea de Medicină și Farmacie Victor Babeș Timișoara P17.Alterarea metabolismului glucidic în sindromul Cushing subclinic Alina Oprea 1, Ruxandra Dobrescu, Simona Jercalau, Andra Caragheorgheopol, Victor Tomulescu, Corin Badiu 1,2 1 Universitatea de Medicină și Farmacie Carol Davila, București, 2 Institutul de Endocrinologie C.I.Parhon, București

18 P18. Tumori suprarenale gigante care mimeaza malignitatea, Alexandra Gabur 2, Simona Jercalau 2, Victor Tomulescu, Corin Badiu 1,2 1 Universitatea de Medicină și Farmacie Carol Davila, București, 2 Institutul de Endocrinologie C.I.Parhon, București P19. Tumora pulmonara neuroendocrina cu metastaze tiroidiene: prezentare de caz Cristina Corina Pop Radu Universitatea de Medicină și Farmacie Targu Mures

19 SCIENTIFIC PROGRAMME 19 th RPNES Symposium Sibiu, Ramada Hotel, Hera Hall Day 1, Thursday, 30th May Opening ceremony Plenary Lecture 1 Chair: Dumitru Branisteanu (Iassy) 17:00-17:30 Congenital Hypothyroidysm from national screening to neurobiology of rhythms Corin Badiu (Bucharest) Session 1- Subclinical pathology of calcium-phosphate metabolism Chair: Dumitru Branisteanu (Iassy), Corin Badiu (Bucharest) 17: Normocalcemic primary hyperparathyroidism: subclinical phenotype? Ionela Pascanu, Cota Ancuta, Oana-Maria Capraru, Camelia Gliga, A Nasalean, J Balazs, Corina Pop-Radu, Zsuzsanna Szanto, Raluca Pop, Radu Neagoe (Targu Mures) 17:45-18:00 From genetics to epigenetics in calcium metabolism anomalies Luminiţa Beldean, Monica Beldean (Sibiu) Vitamin D deficiency masks hypercalcemia in primary hyperparathyroidism Roxana Novac, Daniel Lazescu, Dan Ferariu, Irina Ghita, Georgiana Constantinescu, Voichita Mogos, Dumitru D. Branisteanu (Iassy)

20 18: PTH measurement in diluted aspirate after fine needle biopsy in primary hyperparathyroidism diagnosis Jeanina Idriceanu, Ioana Vasiliu, Ioana Bodescu, Delia Ciobanu, Lidia Ionescu, Mihaela Negru, Voichita Mogos, Carmen Vulpoi (Iassy) Cocktail, Hotel Ramada Sibiu, Hotel Ramada, Hera Hall Day 2, Friday, 31st May 2013 Lecture Plenary Lecture 2 Chair: Vasile Ciubotaru, Monica Gheorghiu (Bucharest) New chalenges in medical treatment of Cushing disease Maria Fleseriu (Portland, USA) Non-adenomas pituitary lesions V.Gh.Ciubotaru*, Ligia Tataranu**, Adriana Dediu*, D.Paunescu*, M.Lisievici* (Bucharest) Session 2 Psychoneuroendocrine chronobiology Chair: Iuliana Dobrescu (Bucharest), Dragos Marinescu (Craiova) Psychopharmacological perspective of sleep-wake rhythm disorders in depression Radu Ionescu Mihaita (Bucharest) Chronobiological aspects of obesity Veronica Mocanu (Iassy)

21 Periodic Cushing disease a rare disorder Ioana Bodescu, Viorel Scripcariu, Jeanina Idriceanu, Ioana Vasiliu, Felicia Crumpei, Cristina Cristea, Alina Rusu, Voichita Mogos, Carmen Vulpoi (Iassy) The role of circadian clocks in hypothalamic-pituitarygonadal axis control Corina Lichiardopol (Craiova) Coffee break 11:30-12:00 Plenary Lecture 3 Chair: Maria Fleseriu (Portland, USA) The paradox of macroprolactinomas Mihai Coculescu, Dan Soare, Raluca Trifanescu (Bucharest) Symposium The importance of biologycal rhythms in paradigm shift of antidepressant treatment Chair: Mihai Coculescu (Bucharest) The role of pineal gland and melatonin in biological rhythms control Corin Badiu (Bucharest) The pathology of biological rhythms and depression from a biological psychiatry view Dragos Marinescu (Craiova) The paradigm shift in depression treatment Maria Ladea (Bucharest) 13:00-14:30 Lunch break Posters

22 Session 3 - Symposium: Subclinical pathology in endocrine tumors Chair: Vasile Ciubotaru (Bucharest), Corina Lichiardopol (Craiova) Iatrogenic subclinical hypercortisolism linked to low life expectancy in patients with nonfunctioning pituitary adenoma Simona Găloiu, Ionela Baciu, Sorin Ioacără, Cristina Durac, Monica Gheorghiu, Corin Badiu, Catalina Poiana, Mihai Coculescu (Bucharest) Treatment attitudes in papillary thyroid carcinoma with low risc Ruxandra Dobrescu, Dumitru Ioachim, Anca Simioniuc, Corin Badiu, Andrei Goldstein (Bucharest) Pancreatic neuroendocrine neoplasia with long silent evolution Ioana Vasiliu, Felicia Crumpei, Eugen Târcoveanu, Constantin Volovăţ, Jeanina Idriceanu, Ioana Bodescu, Valentina Adomnicăi, Voichiţa Mogoş, Carmen Vulpoi (Iassy) Oligosymptomatic phaeochromocytoma in clinical practice Simona Jercalau, Alexandra Gabur, Victor Tomulescu, Corin Badiu (Bucharest)

23 Metabolic and cardiovascular complications on patients with adrenal incidentaloma Monica Gheorghiu, Alina Voicu, Mihaela Giurcaneanu, Andra Caragheorgheopol, Catalina Poiana (Bucharest) Plenary Lecture 4 Chair: Dragos Marinescu (Craiova) Time perception and changes of biological rhythms in psychiatric disorders Catalina Tudose, Florin Tudose (Bucharest) Coffee break Plenary Lecture 5 Chair: Corin Badiu (Bucharest) Subclinical thyroid pathology and neuropsychiatric disorders Leonidas Duntas (Athens, Greece) Sesiunea 4 - Subclinical thyroid pathology Chair: Leonidas Duntas (Greece), Corina Lichiardopol (Craiova) Subclinical hypothyroidism in Hashimoto thyroiditis and severe growth retardation Dumitru D. Branisteanu, Georgiana Constantinescu, Roxana Novac, Irina Ghita, Andreea Oprea, Voichita Mogos (Iassy) ADHD, autism and iodine deficiency Horea Ursu (Bucharest) Gala dinner

24 Day 3, Saturday, 1th June 2013 Sibiu, Ramada Hotel, Hera Hall Plenary Lecture 6 Chair : Mihail Coculescu (Bucharest) The role of PK/PD correlations in the analysis of antipsychotics drugs induced hyperprolactinemia Victor Voicu, Andrei Medvedovici, Aurelian Ranetti, Dalia Miron, Flavian Stefan Rădulescu (Bucharest) Session 5 - Psychopharmaclogy and subclinical endocrine disorders Chair Acad Victor Voicu, Catalina Tudose (Bucharest) Endocrine and metabolic side effects of second generation antipsychotic drugs on teen-agers Iuliana Dobrescu, Cristina Petrescu Ghenea, Ilinca Mihailescu, Florina Rad, Cristina Anghel, Carmen Trutescu (Bucharest) Chronoppathology and chronical diseases in elderly G.I. Prada, I.G. Fita. R. Nacu (Bucharest) Growth hormone therapy: never say never Irina Ghita, Georgiana Constantinescu, Roxana Novac, Andreea Oprea, Voichita Mogos, Dumitru D. Branisteanu (Iassy) Neuropsychical aspects in overt and subclinical hypothyroidism

25 Mihaela Vlad, Mihaela-Andreea Tirla, Maria Oprea, Ioana Zosin (Timisoara) Subclinical pituitary apoplexy a controversial entity Monica Livia Gheorghiu, Iulia Vargatu, Claudiu Stan, Dan Hortopan, Anda Dumitrascu, Catalina Poiana, Corin Badiu, Mihai Coculescu (Bucharest) Coffee break Subclinical psychoendocrine gonadal disorders Chair: Iuliana Dobrescu, Horia Ursu (Bucharest) The importance of life quality evaluation in women with depression and histerectomy Mihail Cristian Pîrlog, Ileana P. Marinescu (Craiova) Neuropsychoendocrine features in depresive disorder evolution and treatment in women Ileana P. Marinescu, Dragoş Marinescu (Craiova) Phenotypic and pathogenetic aspects in polycystic ovary syndrome as risc factor for subclinical vascular disease Georgescu CE, Ilie IR, Marian I, Hazi G, Duncea I (Cluj)

26 Grigore Coculescu Neuroendocrinology award Genetic variation of AVP receptor 1A in Romanian women with PCOS and Metabolic Syndrome Madalina Vintila (Bucharest) General meeting of RPNES Farewell and closure of the symposium POSTERS P1.Plasma adrenocorticotropic hormone (ACTH) dynamics after transsphenoidal surgery for Cushing s disease (CD): can we predict remission or recurrence? Liana Chicea 1, Chris Yedinak 2, Nadia Hameed 2, Jessica Brzana 2, Maria Fleseriu 2 1.University Hospital, Sibiu, Romania, Department of Internal Medicine 2.Northwest Pituitary Center, Departments of Medicine &Neurological Surgery, Oregon Health & Science University, Portland, USA

27 P2. Disorders of the circadian rhythm in elderly Nacu Raluca, Gabriel I. Prada Ana Aslan National Institute of Geriatry & Gerontology Bucharest, P3. SOX2 transcription marker in relation with phenotype of pituitary adenomas Cristina Stancu 1, Anca Cimpean 3, Monica Gheorghiu 2, Cristina Capatana 2, Dan Hortopan 2, Victor Ciubotaru 4, Marius Raica 3, Mihail Coculescu 1,2 1Endocrinology Department, Carol Davila University of Medicine and Pharmacy, 2 C. I. Parhon National Institute of Endocrinology, Bucharest, 3Histology Department, Victor Babes University of Medicine and Pharmacy, Timisoara, 4Neurosurgery Department, Bagdasar Arseni Hospital, Bucharest, Romania P4. Asymptomatic intracranial aneurysms in patients with macroprolactinomas Raluca Trifănescu 1,2, Dan Soare 1, Corin Badiu 1,2, Dan Hortopan 2, Anda Dumitraşcu 2, Mihail Coculescu 1,2 & Cătălina Poiană 1,2 1 Carol Davila University of Medicine and Pharmacy, 2 C.I. Parhon National Institute of Endocrinology, Bucharest, Romania P5. The hip fracture risk assessment based on FRAX: correlations with heel quantitative ultrasound in a cross-sectional study on postmenopausal women M.Carşote 1,2, V.Rădoi 1, M.Alexandra 2, A.Geleriu 2, R.Samoila 2, G.Voicu 2, R.Dusceac 2, D.Paun 1,2, C.Poiană 1,2 1-Carol Davila, UMPh, Bucharest, Romania 2- C.I. Parhon National Institute of Endocrinology, Bucharest, Romania 6.The fracture risk assessment based on FRAX (using body mass index) and heel quantitative ultrasound - a transversal study on 244 women in menopause M.Carşote 1,2, V.Rădoi 1, M.Alexandra 2, A.Geleriu 2, M.Popescu 2, R.Dusceac 2, C.Poiană 1,2 1-Carol Davila, UMPh, Bucharest, Romania 2- C.I. Parhon National Institute of Endocrinology, Bucharest, Romania P7. Sexuality of young women with autoimmune thyroid disease. Maintaining optimal thyroid function in pregnancy: TSH values in normal limits Dana Stoian,Magdalena Caraivan, Mihaela Craciunescu MEDICAL CENTER DR D., Timisoara, Romania

28 P8. Switching somatostatin analogues in acromegaly - clinical efficacy Madalina Vintila 1, Monica Livia Gheorghiu 1, 2, Mariana Purice 2, Mihai Coculescu -1, 2,* Catalina Poiana - 1, 2,* 1 C. Davila University of Medicine and Pharmacy, Bucharest, Romania, 2 CI Parhon National Institute of Endocrinology, * authors with equal contribution P9. Iron sexual hormones relationship in cutaneous melanoma Nicolae I.(1), Caragheorgheopol A.(2), Soveja R. (1), Nicolae CD(3), Ardeleanu I.(4), Schipor S.(2) (1) Spitalul de Boli Infectioase si Tropicale "Victor Babes" (2) Institutul National de Endocrinologie "C. I. Parhon", (3) Universitatea de Medicina si Farmacie "Carol Davila", (4) Institutul de Ocrotire a Mamei si Copilului "Alfred Russescu", Bucuresti P10. Effect of IFN alpha2b on serum prolactin in patients with cutaneous melanoma Schipor S.(1), Nicolae I.(2), Padure A. (1), Nicolae CD(3), Manda D., Ardeleanu I.(4), Caragheorgheopol A.(1) (1) Institutul National de Endocrinologie "C. I. Parhon", (2) Spitalul de Boli Infectioase si Tropicale "Victor Babes", (3) Universitatea de Medicina si Farmacie "Carol Davila", (4) Institutul de Ocrotire a Mamei si Copilului "Alfred Russescu", Bucuresti P11. High cardiovascular risk in patients with multinodular goiter and subclinical hyperthyroidism. Abigail Mensah 1, Simona Galoiu 1,2, Florin Alexiu 1, Dan Niculescu 1,2, Emilia Gudovan 1, Adina Dragomir 1, Horea Ursu 1,2 1 CI Parhon National Institute of Endocrinology, 2 C. Davila University of Medicine and Pharmacy, Bucharest, Romania P12. Imaging comparison of extraoccular muscles involvement in patients with acromegaly and Graves' disease 1 Iulia Vargatu, Anda Dumitrascu, 1,2 Monica Livia Gheorghiu 1 CI Parhon National Institute of Endocrinology 2 C. Davila University of Medicine and Pharmacy, Bucharest, Romania P13. Delayed puberty - between chronopathology and subclinical disease Camelia Procopiuc, Cristina Dumitrescu, Iuliana Gherlan, Andreea Brehar, Mariana Costache, Andra Caragheorgheopol CI Parhon National Institute of Endocrinology, Bucharest, Romania

29 P14. Adipsic diabetes insipidus in a case of a giant craniopharyngioma. 1 Sorina Herman,, 1 Simona Jercalau, 1 Dan Hortopan, 1,2 Corin Badiu 1 CI Parhon National Institute of Endocrinology 2 C. Davila University of Medicine and Pharmacy, Bucharest, Romania P15. Cushing Syndrome secondary to ACTH - independent macronodular adrenal hyperplasia Diana Costeniuc (1), Simona Jercalau (1), Ruxandra Dobrescu (1), Victor Tomulescu (3), Corin Badiu (1,2) 1 CI Parhon National Institute of Endocrinology 2 C. Davila University of Medicine and Pharmacy, Bucharest, Romania 3 Fundeni Clinical Hospital P 16 Optimal thyroid function in pregnancy: targeting TSH into euthyroid range Dana Stoian*, Mădălina Caraivan**, Mihaela Crăciunescu *** *Department of Obstetrics Gynecology, Sexology Victor Babeș Timișoara ** Centrul DR.D, Timișoara *** Departamentul de Microbiologie, Universitatea de Medicină și Farmacie Victor Babeș Timișoara P17.Abnormalities of glucose metabolism in subclinical Cushing syndrome Alina Oprea 1, Ruxandra Dobrescu, Simona Jercalau, Andra Caragheorgheopol, Victor Tomulescu, Corin Badiu 1,2 1 C. Davila University of Medicine and Pharmacy, Bucharest, Romania, 2 CI Parhon National Institute of Endocrinology P18. Giant benign adrenal tumors mimicking malignancy Alexandra Gabur, Simona Jercalau, Victor Tomulescu, Corin Badiu 1,2 1 C. Davila University of Medicine and Pharmacy, Bucharest, Romania, 2 CI Parhon National Institute of Endocrinology P19. Tumora pulmonara neuroendocrina cu metastaze tiroidiene: prezentare de caz Cristina Corina Pop Radu University of Medicine and Pharmacy, Targu Mures, Romania

30 SPONSORS Ana Holding Băneasa SA Coca-Cola SA, România Danson SRL Ferring GRAL medical HRA Pharma Ipsen Merck Serono Chimimportexport Plurimex Medsana Novartis - Oncology Polisano Savana S.C.M.P. Servier Silver Sponsor Sanofi-Aventis Zentiva Partener Media Profesional: Viaţa Medicală

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