Advanced Course in Immunology, 15hp. AS-2008
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1 Advanced Course in Immunology, 15hp. AS Course period: 25 August - 24 October 2008 Text-book Lecture hall: Lab work hall: Diagnostic exam: Immunology 6 th edition 2007, by Goldsby, Kindt, Osborne & Kuby D502 if not stated otherwise E248 September 17 ( ) D502 Final exam: October 16 Course organizer: Eva Severinson, room F450, tel , evasev@wgi.su.se Aims of the course: The course will teach the basics of immunology with regard to both innate and acquired immunity. The induction and regulation of immune responses at organ-, cellular- and molecular levels will be thoroughly discussed. Some important immunological methods will be applied in laboratory experiments, which also will illustrate important immunological principles. The immunological knowledge acquired will, during the last week of the course, form the basis for a short project, which will be reported both orally and in written form during the last days of the course. To pass the course the following is required: Final exam passed Laboratory reports passed Project presentation passed (oral and written) Obligatory attendance at the laboratory training and at project presentations Observe: Laboratory reports should be handed in at the latest 2 weeks after completion of the lab and submission of final corrected reports should be done at the latest one week after the end of the course. Importantly, when writing lab or project reports, plagiarism from published texts in books, journals or Internet is strictly forbidden. Also, it is not allowed to copy text from other lab reports. Disclosure of plagiarism will be reported to the University authorities, and may lead to expulsion from the studies.
2 Lecturers Klavs Berzins Professor Stockholm University Carmen Fernandez Professor Stockholm University Ulrika Holmlund Ph. D Stockholm University ulrika@imun.su.se Lars Ottosson Ph. D. Karolinska Institutet lars.ottosson@ki.se Eva Severinson Professor Stockholm University (Evasev@wgi.su.se) Eva Sverremark-Ekström Docent Stockholm University (eva.sverremark@imun.su.se) Marita Troye-Blomberg Professor Stockholm University (marita@imun.su.se) Mehmet Uzunel Ph. D. Karolinska Institutet (Mehmet.Uzunel@ki.se) Halima Balogun (halima@imun.su.se) Nnaemeka Iriemenam (Nnaemeka.Iriemenam@imun.su.se) Pablo Giusti (Pablo@imun.su.se) Jubayer Rahman (Jubayer.Rahman@imun.su.se) Ylva Sjögren (ylva.sjogren@imun.su.se) Lab assistants
3 Advanced immunology, 15hp, AS-2008 Date Morning session ca Afternoon session ca August Roll-call, lecture hall G Course presentation and introduction to immunology (Ch. 1) (Eva Severinson, ES) August 26 Cells and organs of the immune system (Ch. 2) (ES) August 27 August 28 August 29 September 1 September 2 September 3 September 4 September 5 September 8 September 9 September 10 September 11 September 12 September 15 September 16 September 17 Immunoglobulins, T-cell receptors, Igsuperfamily (Ch. 4, 5, 9) (Carmen Fernandez, CF) Immunological methods (Ch. 6, 23) (KB) Antigens and immunogenicity (Ch4) (Klavs Berzins, KB) Innate aspects of the immune system (Ch. 3) (CF) Ig genes, early B cell development, generation ( ) Monoclonal antibodies (Ch. 4) of diversity (Ch. 5, 11) (CF) (CF) Transplantation antigens (Ch. 8) (Eva Sverremark-Ekström, ESE) B cell generation, activation and Theoretical lab exercise: PCR analysis of gene differentiation (Ch. 5, 11) (ES) rearrangement Antigen processing and presentation, T-cell T-cell receptors and T-cell differentiation (Ch. activation (Ch. 8, 10) (Marita Troye- 9, 10) (MTB) Blomberg, MTB) Lab exercise: lymphoid organs in the mouse, FACS analysis (all day) Cytokines, structure, function and signal transduction (Ch. 12) (ES) Cytotoxic T cells, NK cells (Ch. 14) (ESE) Note! Room E210. Leukocyte activation and migration, inflammation (Ch. 13) (ES) Immunological tolerance, regulation of the Tutorials immune response (Ch. 10, 16) (MTB) Lab exercise: analysis of membrane antigen (all day) Lab exercise: analysis of membrane antigen (all day) Diagnostic exam ( )
4 September 18 September 19 September 22 September 23 September 24 September 25 September 26 September 29 Lab exercise: isolation of specific antibodies (all day) Lab exercise: isolation of specific antibodies (all day) Immunity to infections (Ch 18) (KB) Lab exercise: mitogen activation of lymphocytes Parasite Immunology (Ch. 18) (MTB) Note! Room E Research/project work in Immunology Hypersensitivity reactions, allergy (Ch. 15) (Ulrika Holmlund) Instructions for projects/return of diagnostic exam September 30 October 1 October 2 October 3 October 6 October 7 October 8 October 9 October 10 October 13 October 14 October 15 October 16 October 17 Cancer and the immune system (Ch. 21) (ESE) Vaccines (Ch. 19) (KB) Immunodeficiencies (Ch. 20) (ESE) Transplantation immunology (Ch. 17) (Mehmet Uzunel) Autoimmunity (Ch. 16) (Lars Ottosson) Lecture to be decided Tutorial Final exam Information from BIG about courses for spring term
5 October 20 October 21 October 22 October 23 October 24 Project presentations (all day) End of course
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