CURRICULUM VITAE Clinical Fellow in Psychology, Harvard Medical School, Department of Psychiatry at Beth Israel Hospital, Boston, MA

Transcription

1 CURRICULUM VITAE Prepared: 10/12/2014 PART I: Name: Office Address: Place of Birth: GENERAL INFORMATION Dorothy Powe Holinger 1108 Beacon Street, Suite 4 C Brookline, MA Telephone: 617) Fax: (617) dholinge@bidmc.harvard.edu dpholinger@alumni.brown.edu Providence, RI Education: 1979 A.B. Brown University 1984 M.S. University of Michigan 1990 Ph.D. University of Michigan Postdoctoral Training: Fellowships National Institute of Mental Health (NIMH) Postdoctoral Clinical Research Training Fellow in Biological Psychiatry in the Brain Imaging Laboratory, Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, Boston, MA Clinical Fellow in Psychology, Harvard Medical School, Department of Psychiatry at Beth Israel Hospital, Boston, MA Licensure and Certification: Licensed Psychologist and Health Service Provider, Massachusetts Board of Registration (#6367). Academic Appointments: Research Fellow in Biological Psychiatry, in the Brain Imaging Laboratory, Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA Instructor in Psychiatry, Harvard Medical School, Consolidated Department of Psychiatry, Boston, MA Instructor in Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA Harvard Summer School Faculty, Department of Psychology, Harvard University, Cambridge, MA Instructor in Psychiatry, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA.

2 Page 2 Hospital or Affiliated Institution Appointments: Research Fellow in Biological Psychiatry, in the Brain Potential Imaging Laboratory, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA Research Associate in Psychology, Laboratories of Psychiatric Research, McLean Hospital, Harvard Medical School, Department of Psychiatry, Belmont, MA Clinical Fellow in Psychology, Department of Psychiatry at Beth Israel Hospital, Harvard Medical School, Boston, MA Visiting Research Scientist in Psychology, Department of Psychiatry at the Bedford VA Medical Center Boston University, Bedford, MA Attending Psychologist, Emergency Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA Staff Psychologist, Departments of Psychiatry and Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA Staff Psychologist, Department of Neurology, Neurophysiology Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Professional Societies: Association For Psychological Science Sigma Xi, The Scientific Research Society American Psychological Society Society for Neuroscience Editorial Boards and Review Service: Ad Hoc Reviewer Awards and Honors: Journal of Geriatric Psychiatry and Neurology Journal of Psychiatric Research Schizophrenia Research Neuroreport Cognitive Brain Research Brain Imaging and Behavior University Fellowship in Psychology, University of Michigan, Ann Arbor, MI The Department of Psychology Dissertation Fellowship, University of Michigan, Ann Arbor, MI The Horace Rackham School of Graduate Studies Dissertation Award, University of Michigan, Ann Arbor, MI NIMH National Research Service Award (NRSA) Clinical Research Training Fellow Sigma Xi, University of Michigan, Ann Arbor, MI NIMH Research Award (R03) 2012 Fellow, Association For Psychological Science

3 Page 3 PART II: RESEARCH, TEACHING, AND OTHER CONTRIBUTIONS Report of Research: Major Research Interests: 1. Neurocognitive, Electrophysiological, Structural and Histometric Measures in Schizophrenia 2. P300, Handedness, and Gender in Schizophrenia 3. Methodological Issues in P300 Studies 4. MRI Study of the Superior Temporal Gyrus and Handedness in Schizophrenia 5. Electrophysiological, Structural and Histometric Studies of the Auditory-Language Cortex 6. Neuroanatomy of Behavioral Disorders 7. Neurocognitive, Neurophysiological, Structural, Cytoarchitectonic, and Molecular Measures in Williams Syndrome Narrative Report of Research: My research interest in schizophrenia has focused on brain abnormalities in the superior temporal gyrus (STG) of the temporal lobe. The STG, the auditory-language-related region of the brain, has a long history of being implicated in schizophrenia and conceptually linked with its positive symptoms. Given the complexity of schizophrenia and approaches that can identify and examine more than one level of dysfunction, I have used three technologies to investigate the STG: in living subjects, (1) Electrophysiology (P300 evoked-potential voltage measures) and (2) MRI (tissue volume measures); and in postmortem brains, (3) Histology (neuronal-cell measures). In addition, I have investigated the differentiating effects of handedness and gender in studies of schizophrenia and found that indeed, handedness and gender do show differentiating differences at electrophysiological and MRI levels. More specifically, P300 in right-handed schizophrenic males showed left-sided P300 voltage reductions whereas in left-handed schizophrenic males, there was a right-sided P300 voltage reduction. With regard to gender and P300 in right-handed schizophrenic females, results did not show lateralized asymmetric reductions, rather, voltages were lower at the central sites. Moreover, there were fewer left-handed schizophrenic females compared to schizophrenic males suggesting that left-handedness may occur as an anomaly more frequently in schizophrenic males. At a brain structural level, the MRI data of left-handed schizophrenic males show right-lateralized tissue volume reduction in the STG. In concert, these structural data support the findings of right-lateralized P300 temporal region voltage reductions in the left-handed schizophrenic males. And finally, at a third level, a microscopic level, preliminary histological data show cell differences in the STG in postmortem schizophrenic male brains, namely decreased cell packing density and cell size differences compared to the postmortem control brains. These STG cell alterations not only support electrophysiological voltage reductions, but also support data from other researchers reports of STG tissue volume reductions in right-handed schizophrenic males. Because of the numerous neuropathological abnormalities in schizophrenia reported in the STG, an area not only specialized for hearing and language, but also conceptually related to its classic symptoms, my interest in the importance and uniqueness of STG research in schizophrenia has been threefold. First, my data show that gender and handedness have differentiating effects on neurophysiological and gross anatomical abnormalities in the living brain in schizophrenia. Second, neurodevelopmental factors related to these effects may have a critical influence on the STG. Third, the preliminary histological data of cellular differences contribute a new level of STG analysis, one heretofore lacking, to the existing database of STG abnormalities in schizophrenia. In sum, the congruent findings of electrophysiological, structural, and histological anomalies in the temporal region, specifically the STG, in schizophrenia, show that gender and handedness have differentiating effects within schizophrenia, and also a histological basis for brain-behavior abnormalities reported in the STG in schizophrenia. The significance of this research is the elucidation of the neuropathology of schizophrenia by identifying neural correlates at three different

4 Page 4 levels of brain organization and function, and demonstrating the differentiating effects of gender and handedness within this debilitating disorder. Extending my interest in the STG, my recent research efforts focused on measurements of postmortem neurons in both primary auditory and visual areas in Williams Syndrome. Williams is a mental retardation syndrome affecting 1 in 25,000 births and associated with genes that are hemideleted on Chromosome 7. This syndrome is a compelling neurodevelopmental disorder because of the juxtaposition of cognitive strengths and weaknesses. Williams subjects show relative preservation of language, have excellent face recognition, and often have remarkable hearing and musicality. Yet they show severe visuospatial deficits, deficits that co-exist with cognitive and auditory strengths suggesting that the dorsal part of the brain, especially area 7 in the parietal lobe, is more affected than ventral auditory and language areas. In contrast, the cognitive strengths, language preservation, and auditory acuity in Williams point to primary auditory cortex, area 41, as being less affected. This hypothesis was supported in my finding that area 41 was relatively preserved in Williams postmortem brains compared to controls. Earlier work showed neuronal anomalies in primary visual cortex in Williams. The results in primary visual cortex show significant differences in the opposite direction than the more recent evidence found in primary auditory cortex, all of which point to a neuronal substrate underlying visual spatial impairment and one underlying the relatively preserved auditory-language function in Williams subjects. My most recent endeavor was teaching a course at the Harvard Summer School. The course, Brain and Behavior: Research Methods and Technologies, was an introduction to various research methods and technologies used to investigate the relationship between brain and behavior. From an introduction to how the brain begins in embryogenesis to primary and association cortices in the adult brain, the focus was the study of selected brain and behavior abnormalities using electrophysiological, neuroanatomical, and neuronal measuring tools to address research questions in selected abnormalities, such as schizophrenia and Williams Syndrome. To augment the importance and excitement of the research in brain and behavior, several investigators presented their research to the students. In addition, students visited clinical and research laboratories, and also observed a postmortem brain dissection. The aim was to integrate the knowledge obtained from exploring various levels of analysis into a coherent understanding of brain and behavior. Research Funding Information: Past Grant Support Research Fellow, N.I.H., NIMH R01 MH 40799, Neurophysiological Studies of Schizophrenia (PI: Dr. Robert McCarley) Co-P.I., EJLB Montreal Neurological Institute, An Anatomical and Biological Study of Temporal Lobe Asymmetries and Handedness in Schizophrenia (PI: Dr. Albert Galaburda) P.I., N.I.H., NIMH R03 MH 55179, P300 and Handedness in Schizophrenic Females Co-P.I., N.I.H. NICHD PO1 HD Williams Syndrome: Bridging Cognition and Genes (Program Director: Dr. Ursula Bellugi): Brain Cytoarchitectonic Characterization of Williams Syndrome (PI: Dr. Albert Galaburda) P.I., Tessie Wolf Family Foundation, Neuroanatomy of Behavioral Disorders

5 Page 5 Report of Teaching: 1. Local Contributions: Harvard Medical School Thesis Supervision of Undergraduates Audrey Lucero, Class of 1996, Department of Psychology, Boston University. Distinction Thesis, P300 and Thought Disorder in Left- and Right-Handed Schizophrenic Males. Thesis was awarded Highest Distinction Chica Mori, Class of 1998, Department of Biology, Boston University. Thesis, Primary Visual Cortex in Schizophrenia. Thesis was awarded an A. Harvard University, Faculty of Arts and Sciences: Summer School Psychology Department, Brain and Behavior: Research Methods and Technologies (4-credit course) Independent Study Supervision of Undergraduates 1996 Reena Cohen, Department of Psychology, Brandeis University Volunteer in the Cognitive Electrophysiology Laboratory Chica Mori, Department of Biology, Boston University, Volunteer in the Neuroanatomy Laboratory (An author on abstract see Bibliography of CV; Also worked for Independent study credit in Biology) Gauri R. Pandit, Department of Psychology, Boston College, Boston, MA (First author on abstract see Bibliography of CV; also worked for Independent study credit) 1998 Kari Pearson, Department of Psychology, Colby College, Keene, New Hampshire Summer intern volunteer in the Cognitive Electrophysiology Laboratory 1999 Margaret Andover, Department of Psychology, Boston University Volunteer in the Cognitive Electrophysiology Laboratory Other Teaching/Advisory Responsibilities at Harvard Medical School 1998 Margaret Heffernan, Ph.D., Instructor, Department of Psychiatry, Harvard Medical School 1998 Leigh McCullough, Ph.D., Clinical Assistant Professor, Department of Psychiatry, Harvard Medical School Supervision of Research Assistants Some of the students listed below have either entered a Ph.D. program or Medical School and have made important 0 contributions to the research work, which has been recognized by co-authorship on publications or abstracts: Nickolas Sokol Aaron Lapoint SoYoung Lee Audrey Lucero Chica Mori Gauri Pandit Kari Pearson Margaret Andover Daniel McMenamin Sefanie Palmeri Phyllis Itoka Melissa Batson Elizabeth Grasso

6 Page 6 Local Invited Presentations: Grand Rounds: 1993 P300 in Schizophrenia: Reversed Temporal Lobe Asymmetries in Left- and Right- Handed Schizophrenic Subjects, Psychiatry Grand Rounds Presentation, Beth Israel Hospital, Boston, MA 1996 Electrophysiological, Structural, and Histological Abnormalities of the Temporal Lobe in Schizophrenia, Beth Israel Hospital Invited Lecture: 1991 Schizophrenia: Evoked Brain Potentials Related to Cognitive Complexity and Handedness, Yale Psychiatric Institute, New Haven, CT Psychiatry Lecture Series: 1993 Electrophysiology and Handedness in Schizophrenia, V. A. Medical Center, Bedford, MA. 2. Regional, National, or International Contributions: Invited Lectures: National 2002 Brain Cytoarchitectonic Characterization of Williams Syndrome, The Salk Institute for Biological Studies, La Jolla, CA 2002 Thematic and Integrative Links among Projects, Williams Syndrome: Bridging Cognition and Genes Program Project Retreat (The Salk Institute for Biological Studies), Rancho Santa Fe, CA 2003 Embryogenesis and the Developing Brain, Dyslexia Laboratory, Beth Israel Hospital 2004 Genes and the Developing Brain, Dyslexia Laboratory, Beth Israel Hospital Report of Clinical Activities: Psychology Intern in University of Michigan Psychological Clinic, University of Michigan, Ann Arbor Research Intern in the Laboratory for Psychopathology Research, Department of Psychiatry, University of Michigan Hospital, Ann Arbor Psychology Intern in the Department of Psychiatry, University of Michigan Hospital, Ann Arbor Psychology Intern for Psychodiagnostic Evaluations in the Department of Psychiatry, University of Michigan Hospital, Ann Arbor Research Fellow in Biological Psychiatry, in the Brain Potential Imaging Laboratory, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA Clinical Fellow in the Department of Psychiatry, Beth Israel Hospital, Harvard Medical School, Boston, MA Research Associate in Psychology, Laboratories of Psychiatric Research, McLean Hospital Harvard Medical School, Department of Psychiatry, Belmont, MA Private Clinical Practice: Psychotherapy (women s issues, anxiety, depression, grief and bereavement, developmental life issues), Brookline, MA

7 Page 7 PART III: BIBLIOGRAPHY Original Articles: 1. Benjamin M, McKeachie WJ, Lin YG, Holinger DP. Test Anxiety: Deficits in Information Processing. J Ed Psychol 1981;73(6): Holinger PC, Holinger DP, Sandlow J. Violent Deaths among Children in the United States, An Epidemiologic Study of Suicide, Homicide, and Accidental Deaths among 5-14-Year-Olds. Pediatrician: Internat J Child Adoles Health 1985;12(1): McCarley RW, Faux SF, Shenton ME, Nestor, PG, Holinger DP. Is There P300 Asymmetry in Schizophrenia? Arch Gen Psychiatry 1991;48: Holinger DP, Faux SF, McCarley RW, Shenton ME, Sokol NS, Seidman LJ, Green AI. Reversed Temporal Region Asymmetries of P300 Topography in Left- and Right-handed Schizophrenic Subjects. Electroencephalogr and Clin Neurophysiol 1992;84(6): Holinger DP, Shenton, ME, Wible, CG, Donnino, R, Kikinis, R, Jolesz, McCarley, RW. Superior Temporal Gyrus Abnormalities and Thought Disorder in Left-Handed Schizophrenic Males. Am J Psychiatry 1999;156(11): Holinger DP, Hill SA, Martin DL, Faux SF, Ives JR, Schomer DL. Reappraisal of Filter Effects on P300 Voltage and Latency. J Clin Neurophysiol 2000;17(3): Galaburda AM, Holinger DP, Bellugi U, Sherman GF. Williams Syndrome: Neuronal Size and Neuronal- Packing Density in Primary Visual Cortex. Arch Neurol 2002;59(9): Galaburda AM, Holinger DP, Mills D, Reiss A, Korenberg JR, Bellugi U. Williams Syndrome: A Summary of Cognitive, Electrophysiological, Anatomofunctional, Microanatomical and Genetic Findings. Rev Neurol 2003;36 Supp1 1:S Holinger DP, Bellugi U, Mills DL, Korenberg JR, Reiss A, Sherman GF, Galaburda AM. Relative sparing of primary auditory cortex in Williams Syndrome. Brain Res. 2005;1037(1-2): Proceedings of Meetings: 1. Holinger DP, Shevrin H, Williams WJ, Marshall RE. Evoked Potential Correlates of Categorization in Psychiatric Patients. In: Barber C, Blum T. Evoked Potentials III: The Third International Evoked Potentials Symposium. West Berlin, Germany. Boston (MA): Butterworths, 1987: Reviews, Chapters, and Editorials 1. Holinger DP, Galaburda AM, Harrison PJ. Cerebral Asymmetry. In: Roberts G, Harrison PJ, editors. The Neuropathology of Schizophrenia. Oxford, England: Oxford University Press, 2000: Thesis: Holinger, DP. Brain Potentials and Cognitive Dysfunction in Schizophrenia, Ann Arbor (MI): University of Michigan; 1990.

8 Page 8 Abstracts: A1. Holinger DP. P300: Schizophrenic Responses to "Oddball" Semantic Categorization Tasks. Psychophysiology. 1989;26(4A):33. A2. Holinger DP, DuRand, CJ, O'Donnell, BF, McCarley RW. Lateralized P300 Voltage Asymmetries in LH and RH Schizophrenics: An Update. APA New Research Abstracts. 1994:138. A3. Shenton ME, Hokama H, Kikinis K, Ballinger M, Holinger DP, Galaburda AM, Jolesz FA, McCarley RW. Use of 3D MR Surface Renderings for Measuring Planum Temporale. Biological Psychiatry 1994:382. A4. Holinger DP, Rosen, GD, and Galaburda, AM. Decreased Neuronal Density in Supragranular Layers of Area Tpt of the Superior Temporal Gyrus of Schizophrenics. Neuroscience Abstracts 1995;21(1):238. A5. Ives JR, Shanaman MV, Al-Aweel IC, Holinger DP, Jacob PM, Edelman RR, Warach S, and Schomer DL. 32-Channel Cognitive EPs Concurrently Recorded with Time-Locked Functional Imaging (fmri). American Clinical Neurophysiology Society A6. Holinger DP, Mori, C, and Galaburda, AM. Schizophrenia: Neuronal Measures in Left and Right Language and Visual Cortices. Neuroscience Abstracts 1997;23(2):2198. A7. Pandit GR, Holinger DP, Ives JR, Gruber L, and Schomer DL. P300 and Handedness in Women. EPIC XII Conference. July, A8. Galaburda AM, Holinger DP, McMenamin D, Sherman GF. The Dorsal-Ventral Dichotomy in Histometric Cortical Findings in Williams Syndrome. Neuroscience Abstracts A9. Holinger DP, Sherman GF, Bellugi, U, Galaburda AM. Postmortem Neuronal Measures in Area 7 of the Parietal Lobe in Williams Syndrome. Neuroscience Abstracts A10. Galaburda AM, Holinger DP, Bellugi U, Korenberg JR, Itoka P. GTF2I Immunostaining in area 17 in Williams Syndrome. Neuroscience Abstracts A11. Cestnik L, Holowka S, Galaburda AM, Marantz AP, Holinger DP. The Relationship between visual attention and nonword reading in developmental dyslexia: An MEG study. Neuroscience Abstracts A12. Holinger DP, Bellugi U, Korenberg JR, Mills DL, Reiss AL, Galaburda AM. Neuronal measures in area of inferior parietal lobule in Williams Syndrome support dorsal-ventral hypothesis. Neuroscience Abstracts A13. Galaburda, Bellugi U, Korenberg JR, Mills DL, Reiss AL, Holinger DP. GTF2I Immunostaining in dorsal parietal cortex in Williams Syndrome. Neuroscience Abstracts A14. Holinger DP, Bellugi U, Mills DL, Korenberg JR, Reiss A, Sherman GF, Galaburda AM. Relative sparing of primary auditory cortex in Williams Syndrome. Mysell Research Day, Harvard Medical School 2005.