CURRICULUM VITAE Clinical Fellow in Psychiatry, Harvard Medical School Instructor in Psychiatry, Harvard Medical School

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1 CURRICULUM VITAE Education: 1973 A.B. Brandeis University 1990 M.S. University of California, Berkeley 1992 M.D. University of California, San Francisco Postdoctoral Training: Internship Psychiatry/Medicine, University of California, San Francisco School of Medicine, San Francisco, CA Residency Psychiatry, Massachusetts General Hospital, Boston, MA Primary Care Chief Resident in Psychiatry, Massachusetts General Hospital Fellowships: Medical Psychiatry Fellowship, Brigham and Women s Hospital and West Roxbury Veterans Administration Hospital Ethel Dupont-Warren Fellowship, Consolidated Department of Psychiatry, Harvard Medical School Veterans Administration Postdoctoral Fellowship in Psychiatry Research/Neuroscience, Brockton VA Medical Center Licensure and Certification: 1993 Diplomate, National Board of Medical Examiners 1994 Massachusetts Medical License (# 79671) 1997 Diplomate, American Board of Psychiatry and Neurology (#43682) 1998 Diplomate, American Board of Psychiatry and Neurology, Forensic Psychiatry Added Qualifications (#789) Academic Appointments: Clinical Fellow in Psychiatry, Harvard Medical School Instructor in Psychiatry, Harvard Medical School Hospital Appointments: Clinical Fellow in Psychiatry, Massachusetts General Hospital Associate Physician in Psychiatry, Brigham and Women s Hospital, Boston Associate Physician in Neurology, Brigham and Women s Hospital, Boston

2 Professional Positions: Founder/Director, San Francisco Women s Clinic, San Francisco, CA Research Assistant, Cardiovascular Research Institute, University of California San Francisco, Union Carpenter, United Brotherhood of Carpenters, Local 2164, San Francisco CA Safety Inspector, California Occupational Safety and Health Administration, Oakland and San Francisco District Offices Policy Analyst,California Occupational Safety and Health Administration Headquarters, San Francisco California Supervising Psychiatrist, Chelsea Alcohol and Substance Abuse Program, Chelsea, MA Professional Advisory Committee, Visiting Nurse Association, Boston, MA Neuropsychiatrist, Brigham Behavioral Neurology Group, Boston. MA Attending Psychiatrist, Brigham Associates in Psychiatry, Boston, MA Attending Psychiatrist, Psychiatry Consultation Service, West Roxbury VA Medical Center Major Committee Assignments Psychotherapy Task Force, Department of Psychiatry, Massachusetts General Hospital Grand Rounds Committee, Department of Psychiatry, Massachusetts General Hospital Grand Rounds Committee, Department of Psychiatry, Brigham and Women s Hospital Geriatric Task Force, Partners Psychiatry, Partners Health Care Professional Societies: American Medical Association, Member Alumni-Faculty Association, University of California, San Francisco American Psychiatric Association, Member Massachusetts Psychiatric Society, Member Editorial Boards and Review Service: Ad Hoc Reviewer Schizophrenia Bulletin Biological Psychiatry Journal of Neuropsychiatry and Clinical Neuroscience Awards and Honors: 1973 Phi Beta Kappa, Brandeis University 1973 Magna cum laude, Brandeis University Clinical Honors in Psychiatry, Surgical Sub-specialties and Ophthalmology, University of California San Francisco 1997 Webb Fellowship - Academy of Psychosomatic Medicine

3 Grant Support: Ethel Dupont-Warren Fellowship, Consolidated Department of Psychiatry, Harvard Medical School - Principal Investigator Department of Veterans Affairs, Psychiatry/Neuroscience Research Fellowship NARSAD Young Investigator Award - Principal Investigator Report of Teaching Harvard Medical School 1994 Psychosomatic Conference, Facial Disfigurement - the Patient and Societal Reactions, Massachusetts General Hospital, Boston, MA 1994 Psychosomatic Conference, The Psychiatric Sequella of Huntington s Disease, Massachusetts General Hospital, Boston, MA Lecturer and Supervisor, Primary Care Medicine Teaching Program, Massachusetts General Hospital, Boston, MA 1996 Senior Resident Seminar Psychiatric Care of the Patient with Cancer Massachusetts General Hospital, Boston, MA Preceptor, Introduction to Clinical Medicine, Harvard Medical School Supervisor, Psychiatry Residents and Fellows, Psychiatry Consultation Service, West Roxbury VA Medical Center Supervision of Research Assistants Iris Fischer Engkeat Teh Stephanie Farone Ashley Kricun Danielle Synderman Jonathan Sutton Christopher Allen Eric Berry Elizabeth David Sarah Toner Presentations 1995 Paper presented on psychiatric and medical illnesses associated with severe burns Academy of Psychosomatic Medicine, Palm Springs, CA 1998 Paper presented on the shape analysis of white matter abnormalities in schizophrenia. Academy of Psychosomatic Medicine, Orlando, FL 2000 Paper presented on White Matter Abnormalities in Schizophrenia, at the 153 nd Annual Meeting of the American Psychiatric Association, Chicago, IL Paper presented on Anti-Seizure Medications in Psychiatry and "Psychiatric" Medications in Neurology: Clinical and Theoretical Implications. New York Academy of Sciences, NY, NY. May 20, 2000

4 Bibliography Original Reports: 1. Frumin M. Komaromy M. O'Shea JD. Pharmaceutical promotions. [Letter] New England Journal of Medicine. 327(23): Frumin M, Chisholm T, Dickey CC, Daffner KR. Psychiatric and behavioral problems. Neurology Clinics: Neurologic Emergencies Vol 16, No 2. Feske SK, Wen PY, Eds., WB Saunders Company: McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Fischer IA, Shenton ME. MRI anatomy of schizophrenia. Biological Psychiatry 1999;45: Hirayasu Y, McCarley RW, Salisbury DF, Tanaka S, Kwon JS, Frumin M, Synderman D, Yurgelun- Todd D, Kikinis R, Jolesz FA, Shenton ME. Planum temporale and heschl s gyrus volume reduction in schizophrenia: An MRI study of first-episode patients. Archives Gen Psychiatry 2000;57: Frumin M, Golland P, Kikinis R, Hirayasu Y, Salisbury DF, Hennen J, Dickey CC, Anderson M, Fischer IA, Yurgelun-Todd D, Jolesz FA, Grimson WE, McCarley RW, Shenton ME. Shape Differences in the Corpus Callosum in First Psychotic Episode Schizophrenia and First Psychotic Episode Affective Disorder. In revision to American Journal of Psychiatry. 6. Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr Res 2001;49: McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Shenton ME. Reply to Friedman, L. Why vote-count reviews don t count. Biol Psychiatry 2001;49: Chapters 1. Frumin M, Greenberg DB Approach to the Patient with Cancer, In: The MGH Guide to Psychiatry in Primary Care. Stern TA, Herman JB, Slavin Pl (eds). New York: McGraw-Hill: Shenton ME, Frumin M, McCarley RW, Maier S, Westin CF, Fischer IA, Dickey CC, Kikinis R. Morphometric Magnetic Resonance Imaging studies: Findings in Schizophrenia. In: Dougherty DD, Rauch SL (Eds.). Psychiatric Neuroimaging Research: Contemporary Strategies. American Psychiatric Association, 2001;1-60. Proceedings of Meetings: A1. Frumin M, Hirayasu Y, Golland P, Salisbury DF, Fisher IA, Kikinis R, Jolesz FA, McCarley RW, Shenton, ME. Post-acquisition brain realignment and resampling. Sixth Annual Research Day, Harvard Medical School. Sponsored by the Mysell Committee, Consolidated Department of Psychiatry, April 22, A2. Frumin M, Golland P, McCarley RW, Hirayasu Y, Salisbury DF, Kikinis R, Shenton ME. Shape differences in the corpus callosum in first episode schizophrenia and affective disorder. 37th Annual

5 Meeting of the American College of Neuropsychopharmacology. December 1998, Puerto Rico. A3. Frumin M, McCarley RW, Hirayasu Y, Salisbury DF, Shenton ME. Shape differences in first-episode psychosis and affective disorder. APA New Research Abstracts 1999;103. A4. Hirayasu Y, Shenton ME, Salisbury DF, Frumin M, Fischer IA, McCarley RW. Progressive MRI volume change in schizophrenia. APA New Research Abstracts 1999;120. A5. Hirayasu Y, Shenton ME, Salisbury DF, Frumin M, Fischer IA, Farrell D, Yurgelun-Todd DA, Zarate C, McCarley RW. Progressive change in posterior superior temporal gyrus in schizophrenia. Biological Psychiatry 1999;45:117S. A6. Dickey CC, Shenton ME, Hirayasu Y, Voglmaier MM, Niznikiewicz MA, Seidman LJ, Frumin M, Fraone S, Fischer IA, Sutton J, The E, McCarley RW. Enlarged CSF and reduced cortical gray matter volumes in schizotypal personality disorder. Biological Psychiatry 1999;45:118S. A7. Dickey CC, Shenton ME, Hirayasu Y, Voglmaier MM, Niznikiewicz MA, Seidman LJ, Frumin M, Fraone SK, Fischer IA, Sutton J, McCarley RW. Enlarged CSF and Reduced Cortical Gray Matter Volumes in Schizotypal Personality Disorder. Mysell poster session, Harvard Research Day, April A8. Fraone SK, Shenton ME, Dickey CC, Hirayasu Y, Niznikiewicz MA, Voglmaier MM, Seidman LJ, Sutton J, Frumin M, McCarley RW. Trend toward reduced Heschl s gyrus volume in SPD. Mysell poster session, Harvard Research Day, April A9. Frumin M, Golland P, McCarley RW, Hirayasu Y, Salisbury DF, Fischer IA, Kikinis R, Shenton ME. Shape differences in the corpus callosum in first episode schizophrenia. Mysell poster session, Harvard Research Day, April A10. Hirayasu Y, Shenton ME, Salisbury DF, Frumin M, Tanaka S, Fischer IA, Farrell D, Synderman D, Yurgelun-Todd DA, McCarley RW. Progressive temporal volume change in first episode schizophrenia. Mysell poster session, Harvard Research Day, April A11. Dickey CC, Shenton ME, Fraone S, Niznikiewicz MA, Voglmaier MM, Seidman LJ, Hirayasu Y, Kwon JS, Fischer IA, Anderson J, Frumin M, McCarley RW. Reduced left Heschl s gyrus volume in schizotypal personality disorder. Biological Psychiatry 2000;47:13S. A12. Frumin M, Westin CF, Maier SE, Kubicki M, McCarley RW, Mamata H, The E, Shenton ME. White matter abnormalities in schizophrenia. Eighth Annual Research Day, Harvard Medical School. Sponsored by the Mysell Committee, Consolidated Department of Psychiatry, April 5, A13. Kubicki M, Westin CF, Maier SE, McCarley RW, Mamata H, Frumin M, Wible CG, The E, Kikinis R, Jolesz FA, Shenton ME. Uncinate fasciculus in schizophrenics: A diffusion tensor study. Eighth Annual Research Day, Harvard Medical School. Sponsored by the Mysell Committee, Consolidated Department of Psychiatry, April 5, A14. Frumin M, Westin CF, McCarley RW, Maier S, Mamata H, Kubicki M, Shenton ME. Presentation; White matter abnormalities in schizophrenia. American Psychiatric Association New Research Abstracts 2000:84.

6 A15. Frumin M, Using Diffusion Tensor Imaging to examine the Corpus Callosum in Schizophrenia 39th Annual Meeting of the American College of Neuropsychopharmacology. December 2000, Puerto Rico A16. Kubicki M, Westin CF, Maier S, Mamata H, Frumin M, Jolesz FA, McCarley RW, Shenton ME. Frontotemporal white matter connections in schizophrenia: A diffusion tensor MRI study. Poster presentation at The 39 th Annual Meeting of the American Society of Neuroradiology, April 23-27, Boston, MA, A17. Dickey CC, McCarley RW, Voglmaier MM, Niznikiewicz MA, Seidman LJ, Frumin M, Shenton ME. MRI measures of prefrontal gray and white matter in males and females diagnosed with schizotypal personality disorder. Schizophr Res 2001;49(Suppl.):153S. A18. Frumin M, Westin CF, Maier S, McCarley RW, Kubicki MR, Teh E, Shenton ME. Corpus callosum abnormalities in schizophrenia as measured by diffusion imaging. Schizophr Res 2001;49(Suppl.):154. A19. Kubicki MR, Westin CF, Maier S, Mamata H, Frumin M, McCarley RW, Shenton ME. Diminished asymmetry within frontal-temporal connections in schizophrenic subjects: A diffusion tensor study. Schizophr Res 2001;49(Suppl.):159. A20. Shenton ME, Kubiciki MR, Westin CF, Maier S, Frumin M, Mamata H, McCarley RW. Disruption of the integrity within the cingulum bundle in schizophrenic subjects: MR diffusion tensor study. Schizophr Res 2001;49(Suppl.):166. A21. Kubicki M, Westin CF, Maier S, Frumin M, McCarley RW, Shenton ME, McCarley RW. A Comparison of Voxel-Based Morphometry (VBM) with Region-of-Interest (ROI) Analysis of Gray Matter in Control and First Episode Schizophrenia Subjects. Biol. Psychiatry 2001;49:58S. A22. Kubicki M, Westin CF, Maier S, Frumin M, McCarley RW, Shenton ME. Integrity of the Limbic System in Schizophrenic Subjects- Cingulum Bundle MR Diffusion Tensor Study. Biol. Psychiatry 2001;49:125S. A23. Niznikiewicz MA, Spencer K, Shenton ME, Voglmaier MM, Seidman LJ, Dickey CC, Frumin M, Friedman M, McCarley RW. Semantic overactivation present early in schizotypal personality disorder: Evidence from principal component analysis. Biol Psychiatry 2001;49:228S. A24. Dickey CC, McCarley RW, Voglmaier MM, Niznikiewicz MA, Frumin M, Seidman LJ, Shenton ME. Neurobiology of schizotypal personality disorder. Biol Psychiatry 2001;49:244S.