Curriculum Vitae. Date Prepared: October 1, Marek Kubicki, M.D., Ph.D.

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1 Curriculum Vitae Date Prepared: October 1, 2003 Name: Marek Kubicki, M.D., Ph.D. Education: 1990 B.S. Biochemistry Medical University, Lodz 1994 M.D. Medical University, Lodz 1998 Ph.D. MRI Physics Medical University, Lodz Predoctoral Training: Internship in General Medicine at Polish Mothers Memorial Hospital- Research Institute, Lodz Radiology residency training at Polish Mothers Memorial Hospital- Research Institute, Department of Diagnostic Imaging, Lodz 1997 MR Neuroimaging fellowship; Erazm Hospital, Brussel- Belgium 1997 MR H1 Spectroscopy fellowship; Cleveland Clinic, Fort Lauderdale- USA 1998 F-MRI fellowship; Surgical Planning Laboratory, Brigham and Womens Hospital, Harvard Medical School, Boston- USA Other Training: 1996 Refresher course in Radiology ESDIR- Budapest- Hungary 1996, 1997 Magnetic Resonance Imaging- Workshops Kraków- Poland 1997 First Advanced Course - Magnetic Resonance Techniques in Multiple Sclerosis - Milan- Italy th Advanced Course during Congress of the European Society of Neuroradiology - Oxford- England 1998 European Seminars In Diagnostic and Interventional Radiology- Athens- Greece 1998 First Annual Course on Neuroanatomic and Neuroradiologic Applications in Neurology and Neurosurgery Munich - Germany nd Postgraduate Course of Pediatric Radiology Jerusalem Israel Academic Appointments: 1995 Teaching Assistant, Department of Diagnostic Imaging, Institute of Radiology, Polish Mothers Memorial Hospital, Lodz Assistant Professor in Radiology, Department of Diagnostic Imaging, Institute of Radiology, Polish Mothers Memorial Hospital, Lodz Research Fellow, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Harvard Medical School Visiting Assistant Professor in Radiology, Department of Radiology, Brigham & Women s Hospital, Harvard Medical School Visiting Assistant Professor, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Harvard Medical School Instructor, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Harvard Medical School

2 Professional Societies: 1995 Polish Radiological Society- member Local Branch of the Young Radiologists Society- president Cognitive Neuroscience Society- member Awards and Honors: 1997 Batory Foundation Award 1998 The European Seminars in Diagnostic and Interventional Radiology Young Radiologist Award Polish State Research Committee Grant The Kosciuszko Foundation Research Award 1995 Member, Polish Radiological Society 1995 President, Local Branch of the Polish Young Radiologists Society 2000 Mysell Award, Department of Psychiatry, Harvard Medical School, Boston, MA NARSAD Young Investigator s Award 2001 Young Scientist Award, 11th Biennal Winter Workshop on Schizophrenia, Davos, Switzerland 2001 Grable Investigator, Grable Foundation, Pittsburgh, PA 2003 NIMH Young Investigator Award NARSAD Young Investigator s Award NIMH RO3 Grant Brgham and Womed Transitional Grant in Science? Editorial Boards: Ad hoc reviewer Psychiatry Research: Neuroimaging American Journal of Psychiatry Archives of General Psychiatry Cerebral Cortex Schizophrenia Bulletin Biological Psychiatry Neuroscience Letters NeuorImage Invited Lectures and Presentations: 1997 Paper presented on Multiple Sclerosis lesions volume measurement using FLAIR sequences comparing to the standard T2 weighted sequences at the Congress of European Society of Neuroradiology, Oxford, England Paper presented on Multiple Sclerosis: comparative MR imaging morphometry of white matter lesions, using FLAIR versus T2 weighted sequences with clinical correlation at the Meeting of Radiologic Society of North America Chicago, IL 1998 Invited Speaker: Transcranial doppler sonography- new approach. Polish School of Sonography, Lodz- Poland. Invited Speaker: H1 Spectroscopy- New MRI method. Childrens Health Center, Warsaw- Poland. Invited Speaker: MRI in neuroradiology. Childrens Health Center, Warsaw- Poland Paper presented on Proton magnetic resonance spectroscopy of pediatric brain tumors at 36 th Annual Congress of European Society of Pediatric Radiology, Jerusalem, Israel 2000 Invited Speaker: Magnetization Transfer Contrast- MRI technique and applications. Brigham and Womens Hospital, HMS, Boston, MA Paper presented on Uncinate fasciculus in schizophrenia: A diffusion tensor study at Congess of the American Psychiatric Association, Chicago, IL

3 2001 Paper presented on Disruption of the integrity within the cingulum bundle in Schizophrenics- MR Diffusion Tensor Study at the International Cconference of Schizophrenia, Whistler, BC Report of Research: Major Research Interests: 1.Application of New MRI Techniques to Neuropsychiatric Diseases Including Multiple Sclerosis and Schizophrenia. 2.MRI Voxel based Morphometry Studies in Schizophrenia. 3.Application of New MRI Techniques to Investigate White Matter Abnormalities in Schizophrenia 4.Investigation of Frontal-Temporal Connectivity Disruptions in Schizophrenia. 5.The Relationship Between Cognitive, Structural, and Neurophysiological Measures in Schizophrenia. 6.Functional Magnetic Resonance Studies of Semantic Processing in Schizophrenia. 7.MR Brain Diffusion Tensor Imaging in Schizophrenia and Related Disorders. Narrative Description of Research: Schizophrenia is a major public health problem that affects 1% of the general population and has devastating effects on the psychological and financial resources of the patient, family, and larger community. Unfortunately there is still no clear understanding of the pathology although recent research has made it increasingly clear that biological factors may play an important role. One promising area of research has focused on the detection of abnormalities in the brains of patients afflicted with schizophrenia. Here, both post-mortem and recent magnetic resonance (MR) structural imaging studies suggest that temporal lobe frontal lobe and limbic system abnormalities, may be implicated in the pathophysiology of schizophrenia. Many believe that these abnormalities, both structural (as characterized by structural magnetic resonance and post-mortem studies) and functional (as characterized by functional MRI and PET studies), are due to the disruptions in connectivity between frontal and temporal lobes. This theory, referred to as disconnection theory of schizophrenia, has lately gained a great deal of attention among reserachers. Until recently there were no studies to demonstrate direct evidence for the existence of an anatomical disconnection between different brain regions in schizophrenia. The goal of this investigator s research program has been to apply new imaging techniques to the study of schizophrenia in order to determine and to localize white matter brain abnormalities in this disorder which likely underlie the symptoms and disordered behavior observed in patients diagnosed with schizophrenia. Accordingly, over the past three years, this investigator has been involved in trying to define and to localize abnormalities within fronto-temporal connections in the brain of schizophrenics, using Diffusion Tensor Imaging and Magnetization Transfer Imaging. These techniques have now been used by the investigator and his colleagues to quantify: (1) the uncinate fasciculus; (2) the cingulate fasciculus; (3) the corpus callosum; and, (4) the internal capsule. Results demonstrate that schizophrenic patients, compared to normal controls, show reductions in diffusion anisotropy, a measure of coherence and organization of the fiber tracts, in fronto-temporal connections. Additionally, reduced anisotropy within one of the investigated areas (uncinate fasciculus) in patients with schizophrenia, was correlated significantly with lower scores on neuropsychological measures of learning that involved mnemonic operations of encoding and retrieval, but not with measures of executive functions of problem solving and planning. These findings suggest the importance of investigating white matter tracts in vivo in schizophrenia and they support the hypothesis of a disruption in normal connectivity between fronto-temporal brain regions. Moreover, these findings suggest that disruptions in left UF connectivity of frontal and temporal regions in schizophrenia may be associated with verbal memory impairments. Another line of investigator s research is to implement new, more automated methods for analyzing the brain, including voxel based techniques, that may replace the laborious tracing of smaller regions of the brain. Thus one of the next projects of investigator was to apply volumetric automatic voxel based analysis to brains of unmedicated patients with first episode schizophrenia. This focus is important as it allows for the comparison

4 between this automated procedure with the manual region of interest tracing analysis, as well as making it possible to discern whether, and where brain abnormalities are evident early in the course of the illness, prior to confounding variables such as a chronic illness and long term effects of neuroleptics. This method of analysis is also being extended to white matter, and both orientation and organization of the fiber tracts (as measured by DTI), as well as myelin component of the fiber tracts (as measured by MTR) are being quantified on a voxel by voxel basis by the investigator in yet another project. Work using functional Magnetic Resonance Imaging (fmri) has also begun in an attempt to understand further cognitive processes underlying semantic encoding and retrieval, as these processes are frequently linked to the function of both frontal (inferior frontal) and temporal (superior temporal) brain regions, and if abnormal in schizophrenia, they would directly point to frontal-temporal disconnections and lead to a better understanding of the pathophysiology of schizophrenia. Research Funding Information: Computerized Image Analyses of MR Scans in Schizophrenia Principal Investigator: Martha E. Shenton, Ph.D. Investigator: Marek Kubicki NIH/NIMH 2R01 MH Period: May 1, April 30, 2004 The goals of this grant are to define and to localize further brain abnormalities in the temporal lobe in patients afflicted with schizophrenia. Neurophysiological Studies of Schizophrenia Principal Investigator: Robert W. McCarley, M.D. Investigator: Marek Kubicki NIH/NIMH RO1 MH Period: April 1, May 31, 2003 To understand the neurophysiological basis of schizophrenia. A magnetic Resonance Diffusion Tensor Study of the Cingulate Fasciculus in Schizophenia Principal Investigator: Marek Kubicki NARSAD Period: July 1, June 30, 2003 The goal of this study is use DTI to evaluate, in vivo, the cingulate fasciculus in patients diagnosed with schizophrenia. Understanding the Nature of White Matter Abnormalities in Cingulate Fasciculus in Schizophrenia Principal Investigator: Marek Kubicki NARSAD Period: July 1, June 30, 2005 The goal of this study is to use DTI and MTR to understand better abnormalities detected previously within the cingulate fasciculus in patients diagnosed with schizophrenia. White Matter Myelin Abnormalities in Schizophrenia Principal Investigator: Marek Kubicki NIMH RO3 MH Period: October 1, 2003 September 30, 2005 The goal of this study is to use various MRI in vivo techniques to understand better white matter myelin abnormalities in patients diagnosed with schizophrenia. Report of Teaching: Medical University Lodz

5 Diagnostic Radiology, Department of Radiology, Lodz Medical University, Poland, Teaching Assistant (30 medical students, 10 hours a day, 4 semesters) Diagnostic Imaging (Physics and applications of Computer Tomography and Magnetic Resonance), Department of Radiology, Lodz Medical University, Poland, Assistant Professor (30 medical students, 10 hours a day, 4 semesters). Advisory and Supervisory Responsibilities: Thesis Supervision of Graduate Student Terri Huh, PhD candidate, Massachusetts- Boston University, MA Supervision of Undergraduate Students Trifon Fitchorov 2002 Michael Niznikiewicz Supervision of Research Assistants Ashley Krikun Elizabeth David Magdalena Spencer Hal Ersner-Hershfield Aaron Baer Bibliography: Original Reports: 1. Kubicki M, Zakrzewski K, Goraj B, Polis L. (1997). Uncommon CT appearance of subependymal giant cell astrocytoma in children. Pol Przegl Radiol 62: Kubicki M, Goraj B, Zakrzewski K. (1998). Evaluation of FLAIR for Assessment of Intracranial Tumors in Children. Pol Przegl Radiol 63: Zakrzewski K., Kubicki M., Polis L, Nowoslawska E, Liberski P. (1999). Proton magnetic resonance spectroscopy of primary pediatric brain tumors -neuropathological correlation. Folia Neuropathol. 37(3): Kubicki M, Góraj B, Zakrzewski K, Liberski P. (1999): MR Proton Spectroscopy Evaluation of Children s Brain Tumors. Pol Przegl Radiol 3: Wible CG, Kubicki M, Yoo SS, Kacher D, Salisbury DF, Anderson MC, Shenton ME, Hirayasu Y, Kikinis R, Jolesz FA, McCarley RW. (2001): A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia. Am J Psychiatry 158: Kubicki M, Westin CF, Maier S, Frumin M, Nestor PG, Salisbury D, Kikinis R, Jolesz FA, McCarley RA, Shenton ME. (2002): Uncinate Fascicul us Findings in Schizophreni a: A Magnetic Resonance Diffusion Tensor Imaging Study. Am J Psychiatry 159(5): Kubicki M, Shenton ME, Salisbury D, David E, Hirayasu Y, Kikinis R, Jolesz FA, McCarley RW. (2002): Voxel-Based Morphometry (VBM) Analysis of Gray Matter in Control and First Episode Schizophrenia Subjects. NeuroImage 17(4): Kubicki M, Westin CF, Maier SE, Mamata H, Frumin M, Ernst-Hirshefeld H, Kikinis R, Jolesz FA, McCarley RW, Shenton ME. (2002): Diffusion Tensor Imaging And Its Application To Neuropsychiatric Disorders. Harvard Review of Psychiatry 10: Niznikiewicz MA, Kubicki M, Shenton ME. (2003): Recent Structural and Functional Imaging Findings in Schizophrenia. Curr Opin Psychiatry 16: Kubicki M, Westin CF, McCarley RW, Wible CG, Frumin M, Maier SE, Kikinis R, Jolesz FA, Shenton ME: Evidence for Disruption of Limbic Integrity in Schizophrenia: A Magnetic Resonance Diffusion Tensor Imaging Study. Biol Psychiatry (In Press).

6 11. Kubicki M, McCarley RW, Nestor PG, Huh T, Kikinis R, Shenton ME, Wible CG: An fmri Study of Semantic Processing in Schizophrenia. NeuroImage (In Press). 12. Park H-J, Kubicki M, Shenton ME, Guimond A, McCarley RW, Maier SE, Kikinis R, Jolesz F, Westin CF: Spatial Normalization of Diffusion Tensor MRI Using Multiple Channels. NeuroImage (In Press). 13, Kubicki M, Maier SE, Westin CF, Mamata H, Ersner-Hershfield H, Estepar R, Kikinis R, Jolesz FA, McCarley RW, Shenton ME: Comparison of Single-Shot Echo Planar and Line Scan Protocols for Diffusion Tensor Imaging. Academic Radiology (In Press). Reviews, Chapters and Editorials: 1.Zakrzewski K., Kubicki M., Polis L., Liberski P.P., Nowoslawska E. Proton MR Spectroscopy in diffentiation of childrens brain tumors. In Nowak S., Zukiel R. (book chapter) Modern diagnostic and theraupeutic problems in Neurosurgery. Poznañ 1999, Kubicki M, Westin CF, Maier SE, Mamata H, Frumin M, Ernst-Hirshefeld H, Kikinis R, Jolesz FA, McCarley RW, Shenton ME. (2002): Diffusion Tensor Imaging And Its Application To Neuropsychiatric Disorders. Harvard Review of Psychiatry 10: Niznikiewicz MA, Kubicki M, Shenton ME. (2003): Recent Structural and Functional Imaging Findings in Schizophrenia (review). Curr Opin Psychiatry 16: Presentations: 1. Kubicki M, Goraj B, Zakrzewski K (1997): Fast-FLAIR versus Spin-echo Technique in the Assessment of Supra and Infratentorial Tumors in Children. Neuroradiology 39: 161. European Society of Neuroradiology, Oxford Kubicki M, Goraj B, Sar W, Zigier-Zajdel M, Selmaj K (1997): MR enhancement, Magnetisation Transfer Ratio and MR Spectroscopy in investigation of the MS lesions components. Neuroradiology 39: 53. European Society of Neuroradiology, Oxford Kreisel J., Kubicki M., Zakrzewski K., Biegañski T.: Preliminary results of brain tumors MR spectroscopy in children. III Conference of Radiologic Pediatry Section of Polish Radiologic Society. Kiekrz k/poznania, Zakrzewski K, Kreisel J, Kubicki M, Polis L, Nowosawska E, Liberski P, Bieganski T (2000) Proton MR spectroscopy of posterior fossa tumors in children. Annual Congress of European Society of Pediatric Radiology, Portugal Frumin M, Westin CF, Maier SE, Kubicki M, McCarley RW, Mamata H, Teh E, Shenton ME. White matter abnormalities in schizophrenia. Eighth Annual Research Day, Harvard Medical School. Sponsored by the Mysell Committee, Consolidated Department of Psychiatry, Boston Kricun AA, Kubicki M, Yoo SS, Kacher D, Salisbury DF, Hirayasu Y, Shenton ME, McCarley RW, Wible CG. Early auditory processing deficits in schizophrenics: an fmri study. Eighth Annual Research Day, Harvard Medical School. Sponsored by the Mysell Committee, Consolidated Department of Psychiatry, Boston Kubicki M, Westin CF, Maier SE, McCarley RW, Mamata H, Frumin M, Wible CG, Teh E, Kikinis R, Jolesz FA, Shenton ME. Uncinate fasciculus in schizophrenics: A diffusion tensor study. Eighth Annual Research Day, Harvard Medical School. Sponsored by the Mysell Committee, Consolidated Department of Psychiatry, Boston Frumin M, Westin CF, McCarley RW, Maier S, Mamata H, Kubicki M, Shenton ME. White matter abnormalities in schizophrenia. APA, Chicago Wible CG, Kubicki M, Kricun A,, Yoo SS, Kacher D, Salisbury DF, Hirayasu Y, McCarley RW. FMRI using auditory mismatch negativity task in schizophrenics. Annual Convention of Society of Biological Psychiatry, Chicago Wible CG, Kricun A, Kubicki M, Yoo SS, Kacher D, Salisbury DF, Hirayasu Y, McCarley RW. Early auditory processing deficits in schizophrenics: an fmri study. Annual Meeting of Cognitive NeuroscienceSociety, San Francisco 2000.

7 11. Kubicki M, Westin CF, McCarley RW, Maier SA, Kikinis R, Shenton ME. Cingulum Bundle in Schizophrenics: Diffusion Tensor Study. Supplement to Radiology. 2000; 217: 296. RSNA, Chicago Kubicki M, Westin CF, Maier S, Mamata H, Frumin M, Jolesz FA, McCarley RW, Shenton ME. Frontotemporal white matter connections in schizophrenia, a diffusion tensor MR study. ASNR 39th Anual Meeting, April 2001, Boston, MA 13. Kubicki M, Shenton ME, David E, Jolesz FA, McCarley RW. Gray Matter Changes in First Episode Schizophrenia: Voxel-Based Morphometry MR study. ASNR 39th Anual Meeting, April 2001, Boston, MA 14. McCarley RW, Kubicki M, David E, Salisbury D, Shenton ME. Voxel Based Morphometry Analysis of Gray Matter in First episode schizophrenia. Annual Meeting of American Psychiatric Association, New Orlean In: New Research Abstracts; Kubicki M, Shenton ME, David E, Frumin M, Salisbury D, Hirayasu Y, McCarley RW; A Comparison of Voxel-Based Morphometry (VBM) with Region-of-Interest (ROI) Analysis of Gray Matter in Control and First Episode Schizophrenia Subjects. Biol. Psychiatry, New Orlean Kubicki M, Westin CF, Maier S, Frumin M, McCarley RW, Shenton ME. Integrity of the Limbic System in Schizophrenic Subjects- Cingulum Bundle MR Diffusion Tensor Study. Biol. Psychiatry, New Orlean In: Biol. Psychiatry 2001;49:125S. 17. Kubicki M, Westin CF, Maier S, Mamata H, Frumin M, Teh E, McCarley RW, Shenton ME. Diminished asymmetry within frontal-temporal connections in schizophrenics, a diffusion tensor study. ICOS, Whistler, BC 2001, In: Supplement to Schizophrenia Research 49: Kubicki M, Huh T, Jolesz F, McCarley RW, Wible CG; A Functional Imaging Study of Semantic Encoding in Schizophrenia. Cognitive NeuroScience Society 9th Annual Meeting, San Francisco In Journal of Cognitive NeuroScience Supplement, 2002, M Kubicki M, Huh T, Jolesz F, McCarley RW, Wible CG; A Functional Imaging Study of Semantic Encoding in Schizophrenia. Biol. Psychiatry, Philadelphia In Biol Psych 2002; 51:59S. 20. Kubicki M, Fitchorov T, Westin CF, Frumin M, Ersner-Hershfield H, Jolesz F, McCarley RW, Shenton ME; White Matter Abnormalities in Schizophrenia: Evidence from Diffusion Tensor and Myelin Saturation Techniques. Biol. Psychiatry, Philadelphia In Biol Psych 2002; 51:169S. 21. Frumin M, Westin CF, Maier S, Kubicki M, Kikinis R, Jolesz F, McCarley RW, Shenton ME; A diffusion Tensor Imaging Study of the Corpus Callosum in Schizophrenia. Biol. Psychiatry, Philadelphia Biol Psych 2002; 51:139S. 22. Spencer MH, Han SD, Kubicki M, Nestor P, Huh T, Jolesz F, Kikinis R, McCarley RW, Wible CG; fmri of semantic priming: Effects of connectivity of the semantic network and SOA. Eleventh Annual Research Day, Harvard Medical School. Sponsored by the Mysell Committee, Consolidated Department of Psychiatry, Boston Ersner-Hershfield H, Levitt JJ, McCarley RW, Kubicki M, Westin CF, Kikinis R, Jolesz F, Shenton ME; An MRI diffusion tensor imaging study of the anterior limb of the internal capsule. Eleventh Annual Research Day, Harvard Medical School. Sponsored by the Mysell Committee, Consolidated Department of Psychiatry, Boston Kubicki M, Westin CF, Frumin M, Ersner-Hershfield H, Jolesz F, McCarley RW, Shenton ME; DTI and MTR Abnormalities in Schizophrenia- Voxel Wise Analysis of White Matter Integrity. ICOS, Colorado Springs 2003, In: Supplement to Schizophrenia Research 60: 199.