CURRICULUM VITAE. Prepared: Name: Cynthia G. Wible

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1 CURRICULUM VITAE Prepared: Name: Cynthia G. Wible Office Address: 1Harvard Medical School VA Boston Healthcare System (Brockton Campus) Psychiatry 116A 940 Belmont Street Brockton, MA (617) x31405 Fax: (617) Home Address: 4 Hutchinson Street Cambridge, MA (617) cindy@bwh.harvard.edu Web Page: Place of Birth: Franklin, PA Education: 1981 B.S. University of Pittsburgh, Department of Psychology 1985 M.A. Johns Hopkins University, Department of Psychology (Neuroscience Division) 1989 Ph.D. Johns Hopkins University, Department of Psychology (Neuroscience Division) Mentor: Dr. David Olton Postdoctoral Training: NIH Postdoctoral Fellow (Individual NRSA), Sponsor: Dr. Howard Eichenbaum, Biology, Wellesley College (now at Boston University) NIMH Postdoctoral Fellow, Clinical Research Training Program, Sponsor: Dr. Robert W. McCarley, Psychiatry, Harvard Medical School Hospital and Academic Appointments: Instructor, Department of Psychiatry, Harvard Medical School Director of Functional Magnetic Resonance Imaging, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School Hospital Appointments: Research Fellow, Department of Radiology, Brigham and Women's Hospital Professional Societies: 1983 Society for Neuroscience 1993 Biological Psychiatry 1996 Cognitive Neuroscience

2 Editorial Boards: Ad Hoc Reviewer American Journal of Psychiatry Archives of General Psychiatry Neuroimage Psychiatry Research: Neuroimaging Harvard Review of Psychiatry Schizophrenia Research Veterans Administration Merit Review Research Consortia (member): Functional Biomedical Informatics Research Network (FBIRN) Mental Illness and Neuroscience Discovery (MIND) Institute Awards and Honors: 1992 Massachusetts Mental Health Center Health and Education Fund Award 1995 Young Investigator Award, International Congress on Schizophrenia Research Major Research Interests: Brain basis of auditory and language dysfunction in schizophrenia. Hippocampal function: single unit recording and functional MRI imaging. Research Narrative: My early training was in single unit recording and lesion techniques in animals. I initially studied hippocampal function and memory. I became interested in magnetic resonance imaging (MRI) as the technology was refined and it could be used to study the brains of human subjects. My first series of MRI studies were designed to measure gray matter volume in schizophrenia, including the development of a method for subdividing the human prefrontal cortex. I also started a neurosurgical functional mapping program in order to provide functional brain maps to neurosurgeons of language and other functions for individuals undergoing brain surgery. In the initial structural MRI studies, we found intriguing correlations of volumes in schizophrenic but not control subjects, between abnormal temporal lobe structures (hippocampal/amygdala complex, superior temporal gyrus (STG)) and the inferior/orbital subdivisions of the prefrontal cortex. These regions mediate the storage and processing of representations underlying auditory language and verbal memory, functions that have been found to be disproportionately impaired in schizophrenic subjects. At that time, I was also responsible for testing new image processing technologies that were developed in the Surgical Planning Laboratory and applying them to our MRI studies. I also trained and supervised students, visiting faculty and postdoctoral fellows in MRI image processing analysis techniques and worked extensively on a digital MRI brain atlas. When the first functional magnetic resonance imaging techniques (fmri) were published I was eager to use this new technology to study schizophrenia. My early neuroscience training in single unit recording techniques gave me knowledge that allowed me to set up the procedures for doing fmri experiments at the Brigham. I started the neurosurgical functional imaging program at the Brigham and performed this service for approximately 3 years. More recently Dr. Marek Kubicki, Dr. KangUk Lee, and Dr. Ryu Hashimoto have also joined our group. I have been responsible for training them in fmri procedures and supervising their functional imaging projects. My current fmri studies target the verbal language system from early auditory processing to later semantic processing stages. The ultimate goal of these studies is to link functional brain abnormalities at the systems level to abnormalities at the cellular level. A specific neurotransmitter system may be abnormal in schizophrenia. NMDA (glutamate) receptors mediate rapid excitatory neurotransmission and NMDA abnormalities have been documented in schizophrenia. Phencyclidine (PCP) and ketamine act on NMDA receptors; these drugs also produce psychotic symptoms that are very similar to those of schizophrenia. NMDA receptors are located throughout the brain, although their concentration is higher in some regions than others. One of my focuses is to understand why some brain systems are more abnormal than others in schizophrenia and how these abnormalities lead to the symptoms of schizophrenia. Many schizophrenic patients experience hallucinations that are almost always in the form of voices; patients rarely experience hallucinations of other types of sounds or visual hallucinations. Auditory hallucinations may be produced (at least in part) by abnormal activity in those regions that are normally used to process internal thought and speech. The superior temporal region of the dominant (often left) hemisphere is a

3 major component of this system and has shown structural and functional abnormalities that have been related to the severity of auditory hallucinations. Evidence for early auditory processing deficits in schizophrenia also comes from auditory event-related potential (ERP) studies. The earliest auditory evoked potential to deviant tones, the mismatch negativity (MMN) potential, is abnormal in chronic schizophrenic patients (more in the left hemisphere), but not in first episode patients. Early auditory processing abnormalities may not be present at first break but may progress with the duration of the illness. The MMN is thought to be dependant on NMDA processing and is obliterated by NMDA antagonists. We adapted this ERP task in order to use it in conjunction with fmri procedures. Chronic schizophrenic subjects showed abnormal levels of activity in the superior temporal region (a region involved in early auditory processing) during presentation of the mismatch stimuli, but not in a control condition. This task was one of the two tasks that have been adopted by two different consortiums of schizophrenia researchers. The MIND and FBIRN consortiums are comprised of 12 or more research groups throughout the United States who have joined together to test schizophrenic patients in common fmri protocols. We were responsible for doing all of the pilot testing and setting the parameters for these consortium studies of the MMN. Speech and non-speech auditory stimuli both activate the STG bilaterally. However, language processing is left lateralized to a large extent in most (right-handed) individuals and these left receptive language regions seem to be differentially abnormal in schizophrenia. One of our current fmri studies uses synthesized speech-like sounds and is based on recent breakthroughs in understanding physiologic differences between the left and right STG that may be (at least part of) the basis of language lateralization. This study may provide a bridge between abnormalities in early auditory processing and those in language processing. Finally, neuropsychological and behavioral evidence suggests that schizophrenic subjects have abnormal spreading activation between concepts and that these abnormalities are linked to thought disorder, another hallmark symptom of schizophrenia. We are using a semantic priming task in which we examine the fmri signatures of spreading activation between concepts. Related to this study is a recently published study of semantic versus nonsemantic processing in schizophrenia (Dr. Kubicki is the first author). Schizophrenic subjects showed hyper-activation of superior and lateral temporal regions in this study and at the same time showed hypo-activation of left inferior frontal regions. This study showed that semantic/language processing is abnormal in schizophrenia and that temporal lobe hyper-activation may play an important part in language dysfunction in these subjects. Research Funding Information: Past Grant Support: NIH Individual National Research Service Award Principle Investigator Veterans Administration Merit Review Co-Investigator "Neurophysiology of Behavior" (PI: Dr. Robert McCarley) VA Center for Basic and Clinical Research Co-Investigator "The Neuroscience of Schizophrenia" (PI: Dr. Robert McCarley) NIMH 1R01 MH52807 Co-Investigator "Biological Basis of Schizotypal Personality Disorder" (PI: Robert W. McCarley) NIMH RO1 MH Co-Investigator "Neurophysiological Studies of Schizophrenia" (PI: Dr. Robert McCarley) NIH/NIMH 1R01 MH63360 Co-Investigator "Language Systems in Schizophrenia: Behavioral & ERP Data" (PI: Margaret Niznikiewicz) Current Grant Support: NIH/NIMH R01 MH Auditory-verbal functional studies of schizophrenia Principal Investigator: Cynthia Wible, Ph.D NCRR 1 R24 RR Functional Biomedical Informatics Research Network (FBIRN) Investigator: Cynthia Wible, Ph.D.

4 Report of Teaching: Teaching Fellow, The Johns Hopkins University: 1983 The Mechanisms of Animal Behavior 40 undergraduates 1984 Physiological Psychology 60 undergraduates 1985 Neurophysiological Basis of Memory 35 undergraduates 1985 Introduction to Cognition 30 undergraduates 1986 Skill Learning, Human Engineering, and Artificial Intelligence 25 undergraduates 1986 Neurophysiological Basis of Memory 25 undergraduates Lecturer: 1984 Laboratory in Statistical Analysis The Johns Hopkins University 13 undergraduates teaching 3 hours/week for one semester 1984 The Neural Basis of Memory The Johns Hopkins University 10 undergraduates teaching 3 hours/week for a one month intersession semester 1985 Introduction to Psychology Towson State University 27 undergraduates teaching 3 hours/week for one semester 1985 Vision: Psychological and Neural Aspects The Johns Hopkins University 14 undergraduates teaching 3 hours/week for a one month intersession semester 1986 Memory and the Brain Maryland Science Center 30 high school students teaching 3 hours for 2 weekends 1986 Physiological Psychology Goucher College 5 undergraduates teaching 3 hours/week for one semester 1987 Psychology of Learning Towson State University 30 undergraduates teaching 3 hours/week for one semester 1990 The Neurobiology of Learning and Memory Wellesley College 12 undergraduates teaching 3 hours/week for one semester Advisory and Supervisory Responsibilities:

5 Preceptorships

6 Hiroto Hokama, M.D., Ph.D., Research Fellow, Visiting Scholars Program, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School (received the Neal Mysell Award, 1994, for most outstanding poster presentation at the Second Annual Research Day, Department of Psychiatry, Harvard Medical School). (Currently Assistant Professor, Department of Psychiatry, University of Ryukyu, Okinawa) Chandlee Dickey, M.D., Research Fellow and now Instructor, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School (Ethel Dupont Warren Fellowship ; NARSAD Young Investigator Award ; NIMH Sponsored, Schizophrenia Young Investigator Award 1997; VA Postdoctoral Fellowship in Neuropsychiatry Research/Neurosciences ; VA Career Development Award ) Dan Iosifescu, M.D., Research Fellow, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School (Hackett Award, 2000, for paper written as first author on elastic matching while in the laboratory). (Currently Chief Resident in Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School) Julianna Pare-Blagoev, M.S., Ph.D., Completed an intership assisting in the acquisition and analysis of fmri data. She finished a Masters in child development at Tufts University followed by a doctoral program in the Human Development and Psychology division of the Harvard Graduate School of Education Marek R. Kubicki, M.D., Ph.D., Visiting Assistant Professor, Visiting Scholars Program, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School (supported by a fellowship from the Kosciuszko Foundation, Poland, and from NIMH funds; received the Neal Mysell Award, 2000, for most outstanding poster presentation at the Eighth Annual Research Day, Department of Psychiatry, Harvard Medical School; NARSAD Young Investigator Award ) Min-Seong Koo, M.D. Postdoctoral Fellow, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School KangUk Lee, M.D. Postdoctoral Fellow, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School Ryu Hashimoto, Postdoctoral Fellow, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School. Thesis Supervision of Graduates Terri Huh, graduate student in Psychology, University of Massachusetts. She is doing her thesis on fmri studies of schizophrenia and auditory/language dysfunction Duke Han, graduate student in Psychology, University of Massachusetts. He is doing his thesis work on fmri studies of schizophrenia and abnormalities in semantic priming and spreading activation between semantic representations. Thesis Supervision of Undergraduates I-han Chou, Class of 1992, Department of Psychology, Harvard College. "A magnetic resonance imaging study of the cingulate gyrus in schizophrenia. This Summa cum laude thesis was awarded the Thomas Temple Hoopes Prize for Excellence in the Work of an Undergraduate and Faculty Member. (I-han received a Ph.D. in the Cognitive Neuroscience Program at the Massachusetts Institute of Technology.) Independent Study Supervision of Undergraduates I-han Chou, Department of Psychology, Harvard College, Cambridge, MA Other Advisor and Supervisory Responsibilities James Levitt, M.D., Instructor and now Assistant Professor, Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School Jill Goldstein, Ph.D., Assistant Professor, Department of Psychiatry, Harvard Medical School Dorothy Holinger, Ph.D., Instructor, Department of Psychiatry, Harvard Medical School

7 Andy Tsai, Ph.D., Laboratory for Computer Science, MIT, worked on new methods for analyzing fmri activation Supervision of Research Assistants Jay Allard Iris Fischer 1997 Michael Murphy, Medical Student, Harvard Medical School. Currently a Resident in Pychiatry, McLean Hospital, Harvard Medical School Elizabeth David, Currently a Medical Student Magdalena Hale Spencer Aaron Baer Nicole Petrovich Senjit Sarkar Alex Preus Summer Internships, continued with the Stanley Scholars Program 1997 Jay Allard 1998 Juliana Pare-Blagoev Invited Presentations: 2002 Invited speaker; Auditory-verbal functional studies of schizophrenia, presented at the Goodglass Aphasia Center Lecture Series, Boston, MA Invited speaker; Mismatch Negativity: Background and Theoretical Issues, presented at the Annual BIRN All Hands Meeting, November, La Jolla, CA Invited speaker; Mismatch Negativity: Temporal Lobe and Schizophrenia, presented at the FBIRN Meeting, March 2, Irvine, CA. Bibliography: Original Articles: 1. Reder LM and Wible CG. Strategy use in question-answering: Memory strength and task constraints of fan effects. Memory and Cognition 1984;12: Wible CG, Crane S, Olton DS. An electrophysiological method for examining the effects of potential therapeutic agents on memory function. Annals of the New York Academy of Sciences 1985;444: Reder LM, Wible CG, Martin J. Differential memory changes with age: Exact retrieval versus plausible inference. Journal of Experimental Psychology: Learning, Memory, and Cognition 1986;12: Wible CG, Findling RL, Shapiro M, Lang EJ, Crane S, Olton DS. Mnemonic correlates of unit activity in the hippocampus. Brain Research 1986;399: Olton DS, Wible CG, Shapiro M. Mnemonic theories of hippocampal function. Behavioral Neuroscience 1986;100: McCloskey M, Wible CG, Cohen NJ. Is there a special flashbulb memory mechanism? Journal of Experimental Psychology: General 1988;117: Cohen NJ, McCloskey M, Wible CG. There is still no case for a flashbulb-memory mechanism: Reply to Schmidt and Bohannon. Journal of Experimental Psychology: General 1988;117: Olton DS, Wible CG, Pang K, Sakarai Y. Hippocampal cells have mnemonic correlates as well as spatial ones. Psychobiology 1989;17: Cohen NJ, McCloskey M, Wible CG. Flashbulb memories and underlying cognitive mechanisms: A

8 reply to Pillemer. Journal of Experimental Psychology: General 1990;119: Otto T, Eichenbaum H, Wiener SI, Wible CG. Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation. Hippocampus 1991;1(2): Wible CG, Shiber JR, Olton DS. Hippocampus, fimbria/fornix, amygdala and memory: Object discriminations in rats. Behavioral Neuroscience 1992;106(5): Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, Hokama H, Martin J, Metcalf D, Coleman M, McCarley RW. Abnormalities of the left temporal lobe and thought disorder in schizophrenia: A quantitative magnetic resonance imaging study. New England Journal of Medicine 1992;327(9): Shenton ME, O'Donnell BF, Nestor PG, Wible CG, Kikinis R, Faux SF, Pollak SD, Jolesz FA, McCarley RW. Temporal lobe abnormalities in a patient with schizophrenia who has word-finding difficulty: Use of high-resolution magnetic resonance imaging and auditory P300 event-related potentials. Harvard Review of Psychiatry 1993;1: Kikinis R, Shenton ME, Gerig G, Hokama H, Haimson J, O'Donnell BF, Wible CG, McCarley RW, Jolesz FA. Temporal lobe sulcal-gyral pattern anomalies in schizophrenia: An in vivo MR threedimensional surface rendering study. Neuroscience Letters 1994;182: Nestor PG, Shenton ME, O'Donnell BF, McCarley RW, Wible CG. Dr. Nestor and colleagues reply. Letter to the editor. American Journal of Psychiatry 1995;152(3): Wible CG, Shenton ME, Hokama H, Kikinis R, Jolesz FA, Metcalf D, McCarley RW. Prefrontal cortex and schizophrenia: A quantitative MRI study. Archives of General Psychiatry 1995;52: Shenton ME, Kikinis R, McCarley RW, Saiviroonporn P, Hokama H, Robatino A, Metcalf D, Wible CG, Portas CM, Iosifescu DV, Donnino R, Goldstein JM, Jolesz FA. Harvard brain atlas: A teaching and visualization tool. IEEE Biomedical Visualization 1995;61: Hokama H, Shenton ME, Nestor PG, Kikinis R, Levitt JJ, Metcalf D, Wible CG, O'Donnell BF, Jolesz FA, McCarley RW. Caudate, putamen, and globus pallidus volume in schizophrenia: A quantitative magnetic resonance imaging study. Psychiatry Research: Neuroimaging 1995;61: Nestor PG, Shenton ME, O Donnell BF, McCarley RW, Wible CG. Association between cognitive deficits and temporal lobe abnormalities: Reply. American Journal of Psychiatry 1995;152(3): Kikinis R, Shenton ME, Iosifescu DV, McCarley RW, Saiviroonporn P, Hokama H, Robatino A, Metcalf D, Wible CG, Portas CM, Donnino R, Jolesz, FA. A digital brain atlas for surgical planning, model driven segmentation, and teaching. IEEE Transactions in Visualization and Computer Graphics 1996;2: Wible CG, Shenton ME, Fischer IA, Allard JE, Kikinis R, Jolesz FA, Iosifescu DV, McCarley, RW. Parcellation of the human prefrontal cortex using MRI. Psychiatry Research: Neuroimaging. 1997;76: Nestor PG, Shenton ME, Wible CG, Hokama H, O'Donnell BF, Law S, McCarley RW. A neuropsychological analysis of schizophrenic thought disorder. Schizophrenia Research 1998;29: Portas CM, Goldstein JM, Shenton ME, Hokama H, Wible CG, Fischer I, Kikinis R, Donnino R, Jolesz FA, McCarley RW. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biological Psychiatry 1998;43(9):

9 24. McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt J, Fischer IA, and Shenton ME. MRI anatomy of schizophrenia. Biological Psychiatry 1999;45(9): Hirayasu Y, Shenton ME, Salisbury DF, Kwon JS, Wible CG, Fischer IA, Yurgelun-Todd D, Zarate C, Kikinis R, Jolesz FA, McCarley RW. Subgenual cingulate cortex volume in first episode psychosis. American Journal of Psychiatry 1999;156: O'Donnell BF, McCarley RW, Potts GF, Salisbury DF, Nestor PG, Hirayasu Y, Niznikiewicz MA, Wible CG, Barnard J, Bookstein F, Shenton ME. Identification of neural circuits underlying P300 abnormalities in schizophrenia. Psychophysiology 1999;36: Holinger DP, Shenton ME, Wible CG, Donnino R, Kikinis R, Jolesz FA, Galaburda AM, McCarley RW. Superior temporal gyrus volume abnormalities and thought disorder in left-handed schizophrenic men. American Journal of Psychiatry 1999;156: Niznikiewicz MA, Donnino R, McCarley RW, Iosifescu DV, Ohta H, Levitt JJ, O'Donnell BF, Nestor PG, Wible CG, Kikinis R, Jolesz FA, Shenton ME. Abnormal angular gyrus asymmetry in schizophrenia. American Journal of Psychiatry 2000;157: McCarley RW, Wible CG, Frumin M, Hirayasu Y, Levitt JJ, Shenton ME. Reply to Friedman, L. "Why vote-count reviews don't count. Biological Psychiatry 2001;49: Hirayasu Y, Tanaka S, Shenton ME, Salisbury DF, DeSantis MA, Levitt JJ, Wible CG, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW. Prefrontal gray matter volume reduction in first episode schizophrenia. Cerebral Cortex 2001;11(4): Wible CG, Kubicki M, Yoo S-S, Kacher DF, Salisbury DF, Anderson MC, Shenton ME, Hirayasu Y, Kikinis R, Jolesz FA, McCarley RW. A functional magnetic resonance imaging study of auditory mismatch in schizophrenia. American Journal of Psychiatry 2001;158: Wible CG, Anderson J, Shenton ME, Hirayasu Y, Tanaka S, Levitt J, O'Donnell BF, Kikinis R, Jolesz FA, McCarley RW. Prefrontal cortex, negative symptoms, and schizophrenia: An MRI study. Psychiatry Research: Neuroimaging 2001;108(2): Anderson, J E, Wible CG, McCarley RW, Jakab M, Kasai K, Shenton ME. An MRI study of temporal lobe abnormalities and negative symptoms in chronic schizophrenia. Schizophrenia Research 2002;58(2-3): Kubicki M, Westin CF, McCarley RW, Wible CG, Frumin M, Maier SE, Kikinis R, Jolesz FA, Shenton ME. Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biological Psychiatry 2003;54(11): Kubicki M, McCarley RW, Nestor PG, Huh T, Kikinis R, Shenton ME, Wible CG. An fmri Study of Semantic Processing in Men with Schizophrenia. NeuroImage 2003;20(4): Han SD, Nestor PG, Wible CG. fmri of lexical-semantic priming in a chronic schizophrenia patient. Applied Neuropsychology. 2006;13(1): Wible CG, Han SD, Spencer MH, Kubicki M, Niznikiewics MH, Jolesz FA, McCarley RW, Nestor P. Connectivity among semantic associates: An fmri study of semantic priming. Brain and Language 2006; 97(3): Han SD, Nestor PG, Spencer MH, Cohen A, Niznikiewicz, M, McCarley RW, Wible CG. Functional Neuroimaging of Word Priming in Males with Chronic Schizophrenia. NeuroImage, in press.

10 Proceedings of Meetings: 1. O'Donnell BF, Ohta H, McCarley RW, Hokama HH, Wible CG, Law S, Nestor PG, Kikinis R, Jolesz FA, Shenton ME. The auditory P3a and P3b ERP components in schizophrenia: Relationship to frontal and temporal lobe MRI volumes. In: Ogura C, Koga Y, Shimokochi M (eds.) Recent Advances in Event Related Brain Potential Research. Amsterdam: Elsevier Science B.V. 1996: Book Chapters: 1. Olton DS, Wible CG, Markowska AL. A comparative analysis of the role of the hippocampal system in memory. In Lister RG and Weingartner HJ (eds.), Perspectives on Cognitive Neuroscience. New York: Oxford University Press; Eichenbaum H, Otto T, Wible CG, Piper J. Building a model of the hippocampus in olfaction and memory. In Davis JL and Eichenbaum H (eds.), Olfaction: a Model System for Computational Neuroscience. Cambridge, MA: MIT Press; Eichenbaum H, Cohen NJ, Otto T, Wible CG. Memory representation in the hippocampus: Functional domain and functional organization. In Squire LR, Lynch G, Weinberger NM, McGaugh JL (eds.), Memory: Organization and Locus of Change. New York: Oxford University Press; Shenton ME, Kikinis R, McCarley RW, Saiviroonporn P, Hokama HH, Robatino A, Metcalf D, Wible CG, Portas CM, Iosifescu DV, Donnino R, Goldstein JM, Jolesz FA. Harvard brain atlas: A teaching and visualization tool. IEEE Biomedical Visualization p O'Donnell BF, Ohta H, McCarley RW, Hokama H, Wible CG, Law S, Nestor PG, Kikinis R, Jolesz FA, Shenton ME. The auditory P3a and P3b ERP components in schizophrenia: Relationship to frontal and temporal lobe MRI volumes. In Ogura C, Koga Y, Shimokochi M (eds.), Recent Advances in Event- Related Brain Potential Research. Amsterdam: Elsevier Science B.V.; p Wible CG, Shenton ME, McCarley RW. Functional neuroanatomy of the limbic system and planum temporale. In Krishnan RR and Doraiswamy PM (eds.), Brain Imaging in Clinical Psychiatry. New York: Marcel Dekker; p Shenton ME, Wible CG, McCarley RW. A review of magnetic resonance imaging studies of brain abnormalities in schizophrenia. In Krishnan RR and Doraiswamy PM (eds.) Brain Imaging in Clinical Psychiatry. New York: Marcel Dekker; p