Katarzyna Równy. Combination of antioxidants, plant extract enhancing VDR synthesis and NB-UVB therapy for vitiligo skin care
|
|
- Thomasina Lawrence
- 5 years ago
- Views:
Transcription
1 Combination of antioxidants, plant extract enhancing VDR synthesis and NB-UVB therapy for vitiligo skin care Katarzyna Równy Scientific dr Irena Eris Centre for Science and Research
2 Research approach 4 paths of investigation 1. Mitochondrial activation 2. IL-6 suppression 3. Silencing of Bmal1 and Per1 circadian genes 4. Antioxidative activity
3 Research approach 4 paths of investigation 1. Mitochondrial activation 2. IL-6 suppression 3. Silencing of Bmal1 and Per1 circadian genes 4. Antioxidative activity
4 Vitiligo and mitochondria we suggest that, in vitiligo, mitochondria might be the target of different stimuli, such as reactive oxygen species generation ( ) all of which are capable of inducing melanocyte degeneration Dell'Anna MLI et al. Mitochondrial impairment in peripheral blood mononuclear cells during the active phase of vitiligo. J Invest Dermatol Oct; 117(4):908-13).
5 Mitochondrial potassium channels found in the inner mitochondrial membranes of various cells (neurons, myocardium) regulate mitochondrial membrane potential, respiration and synthesis of reactive oxygen species the activation is cytoprotective (open channels in myocardium heart attack rate )
6 Identification of mitok ATP channels in skin cells - PUBLICATIONS
7 IN VITRO STUDY Finding a substance modulating the activity of ATP-regulated potassium channel. screening active ingredients to test
8 NARINGENIN flavonoid abundant in genus Citrus anti-oxidant, free radical scavenger anti-inflammatory anti-allergic
9 RESULTS ACTIVATION OF THE mitok ATP CHANNEL BY NARINGENIN UVA UVA + Naryngenin
10 RESULTS IN VITRO STUDIES NARINGENIN BENEFITS Regulatory effect in mitochondria membrane potential after UVA Regulatory effect on Ca 2+ level (with and w/o UVA) Reduction of ROS (with and w/o UVA) Induction of skin antioxidant defence system (MnSOD with and w/o UVA) Reduction in oxidative skin protein damages after UVA Protection of mitochondrial proteins against UVA Regulatory effect on mitochondrial biogenesis after UVA
11 Research approach 4 paths of investigation 1. Mitochondrial activation 2. IL-6 suppression 3. Silencing of Bmal1 and Per1 circadian genes 4. Antioxidative activity
12 Why IL-6? reported to play a role in immunological processes in vitiligo, can be an indicator of the disease in vitiligo patients level IL-6 in serum is 2x higher than in control patients reported to suppress melanocites proliferation Bellei B, Pitisci A, Ottaviani M, Ludovici M, Cota C, Luzi F, Dell'Anna ML, Picardo M. Vitiligo: a possible model of degenerative diseases. PLoS One. 2013;8(3):e Moretti S, Fabbri P, Baroni G, Berti S, Bani D, Berti E, Nassini R, Lotti T, Massi D. Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis. Histol Histopathol Jul;24(7): Pastuszka M., Dermatologia Praktyczna, 2015, nr 5(40)
13 Viability [% of control] Reduction of IL-6 levels in cells - naringenin as IL-6 suppressor Viability and IL-6 levels in HaCaT cells with or w/o UVB radiation (30 mj/cm 2 ) IL-6 concentration [pg/ml] Control 0,001 0,01 0,033 [%] naringenin
14 IL-6 concentration [pg/ml] Reduction of IL-6 levels in cells - tioproline and rosmarinic acid synergistic IL-6 decreasing activity in keratinocytes (HaCaT) Rosmarinic Acid RA + tioproline 5mM RA + tioproline 7mM Patent application , P Rosmarinic Acid concentration [mg/l]
15 Research approach 4 paths of investigation 1. Mitochondrial activation 2. IL-6 suppression 3. Silencing Bmal1 and Per1 circadian genes 4. Antioxidative activity
16 Silencing of circadian genes Decreasing Bmal1 and Per1 activity Increased melanin production (activation of tyrosinase and MITF) Increased number of melanocyte dendrites UVB radiation decreases PER1 expression. ESDR, 2014 Carcidian genes activity reported in keratinocytes (Bmal1, PER1 - DNA repair).
17 Naringenin Per1 ans Bmal1 silencer
18 Research approach 4 paths of investigation 1. Mitochondrial activation 2. IL-6 suppression 3. Silencing of Bmal1 and Per1 circadian genes 4. Antioxidative activity
19 Antioxidative activity patented synergy tioproline and rosmarinic acid strong synergistic effect TioP (0,6 mg/ml) + RA (0,6 mg/ml) PATENT , P ,75% according to Hidalgo equation 2,47 according to Kull s equation
20 VDR vitamin D receptor and vitiligo VDR activator: increases synthesis of VDR in cells by 32% effect similar to calcitriol (active vit. D) Doss et al.: Vitamin D Receptor Expression in Vitiligo. Indian J Dermatol Nov-Dec;60(6):544-8
21 VITI-MELO DAY VITI-MELO NIGHT PATENT TioP + RA ANTIOXIDANT ACTIVITY protects mitochondria from free radicals one of vitiligo triggers PATENT APPLICATION TioP + RA ANTI-INFLAMATORY ACTIVITY Minimizes melanocytes damage PATENT APPLICATION NARINGENIN silences the genes correlated to vitiligo symptoms and activates mitochondrial potassium channels
22 Antioxidative activity - THE EMULSIONS IN VITRO Product (index) RPF (10 21 DPPH/1g of emulsion) , ,19
23 CLINICAL STUDY in vivo evaluation of the efficacy of skin care products for vitiligo-affected skin
24 CLINICAL STUDY - materials and methods 38 patients with vitiligo use emulsion every evening for a period of 3 months 3 lesions per patient NB-UVB (311 nm) therapy only cream only combination of NB-UVB + cream 3 independent dermatological clinics: - evaluation of the localisation and area of vitiligo lesions in % VASI score (Vitiligo Area Scoring Index) 10-point analogues scale (skin elasticity and dryness) Patient s self-evaluation
25 CLINICAL STUDY - results NIGHT CREAM CLINICAL ASSESSMENT USING THE VITILIGO AREA SCORING INDEX (VASI) Patient assignment NB-UVB Night cream Night cream + NB-UVB Day 84 Improvment rates 5 out of 18 patients using light therapy (28% of test subjects) 3 out of 28 patients using the cream (11% of test subjects) 15 out of 28 patients using the cream in combination with light therapy (53% of test subjects) Average degree of repigmentation 11% Average degree of repigmentation 12.5% Average degree of repigmentation 30% (up to 70%)
26 CLINICAL STUDY - results The most spectacular improvement was observed when using the cream-gel for the night in combination with NB-UVB therapy. before after 3 months
27 CLINICAL STUDY - results NIGHT CREAM EFFECTIVENESS CONFIRMED BY CLINICAL TEST ON VITILIGO SKIN prevents the enlargement of white patches in 100% of test subjects 100% it moisturises the skin 78% nourishes the skin and replenishes lipids 63% regenerates the skin and restores its elasticity
28 CONCLUSIONS For the first time the mitok ATP were characterized in skin cells Naringenin acts as a modulator of mitok ATP in fibroblats Cosmetic products containing naringenin, tioproline and rosmarinic acid can safely and effectively restore vitiligious skin condition and enhance medical treatment with NB-UVB therapy. ACKNOWLEDGMENT This study was supported by a grant MERIS PBS1/B8/1/2012 from National Centre of Research and Development.
29 THANK YOU FOR YOUR ATTENTION! Please visit our stand!
Karolina Bazela, PhD Dr Irena Eris Cosmetic Laboratories, Centre for Science and Research, Piaseczno, Poland
Activation of mitok ATP in skin cells for vitiligo skin treatment Karolina Bazela, PhD Dr Irena Eris Cosmetic Laboratories, Centre for Science and Research, Piaseczno, Poland POTASSIUM CHANNELS Potassium
More informationVITAMIN D AND THE SKIN JOYCE FARAH MD MS FAAD FARAH DERMATOLOGY AND COSMETICS, LLC ASSISTANT PROFESSOR OF MEDICINE AND ENT UPSTATE MEDICAL UNIVERSITY
VITAMIN D AND THE SKIN JOYCE FARAH MD MS FAAD FARAH DERMATOLOGY AND COSMETICS, LLC ASSISTANT PROFESSOR OF MEDICINE AND ENT UPSTATE MEDICAL UNIVERSITY VIT D RECEPTORS ROLE IN MAINTAINING NORMAL FOLLICULAR
More informationHYDRACARE LIGHTENING BUSINESS OPPORTUNITY
HYDRACARE LIGHTENING BUSINESS OPPORTUNITY + + AIMS MORE THAN 99.9 % OF NATURAL ORIGIN HYDRACARE LIGHTENING EVOIL HYDRACARE LIGHTENING showed whitening activity, at 100% concentration, when dosed 4 times
More informationPRODUCT DATA SHEET. Updated: 07/2012 Approved: Dr. Victoria Donat
PRODUCT DATA SHEET is a Refined Vegetable Oil composition enriched with other ingredients and specifically developed to enhance anti stretch activity. The composition helps to prevent and eliminate stretch
More informationForeseen Shield Nopal
Foreseen Shield Nopal A STORY The Nopal Opuntia ficus indica, Cactaceae A Mexican legendary cactus Born in the centre of Mexico, that cactus with an original shape caracterized by its organization with
More informationBV OSC BARNET. A Quasi Drug Whitening Benchmark. Superior Skin Penetration Compared to Other Whiteners Reduces Age Spots Great Stability in Formulas
BARNET CLARIFYING BV OSC A Quasi Drug Whitening Benchmark RO O O H OR CHCH 2 OR OR Superior Skin Penetration Compared to Other Whiteners Reduces Age Spots Great Stability in Formulas The information contained
More informationEVOIL AST PRODUCT DATA SHEET
PRODUCT DATA SHEET EVOIL AST is a Refined Vegetable Oil composition enriched with other ingredients to enhance anti stretch activity. The composition helps to prevent and eliminate stretch marks and wrinkles.
More informationSKIN WHITENING. XII November 2017 N 8. Maurizio Ceccarelli & Coll. Protocol for skin pigmentation treatment.
XII November 2017 N 8 SKIN WHITENING Maurizio Ceccarelli & Coll. Protocol for skin pigmentation treatment. The skin responds to injury by increasing the thickness of the stratum corneum and pigmenting.
More informationExperience The Magic of Science. DermaPep UL. Multi-functional whitening active. Experience the magic of science
Experience The Magic of Science Multi-functional whitening active DermaP ep Experience the magic of science Anti-aging DermaPep A35 DermaPep A42 DermaPep A44 DermaPep A53 Whitening DermaPep A35 DermaPep
More informationCHRONOCYCLIN. Cosmetic application. day and night skin care
Cosmetic application day and night skin care Temporary or long-term cutaneous damages overworked, tired, lack of sun exposure, jet lag anti-aging benefits Skin awakening Stimulation of cutaneous natural
More informationSKINFLAMM-AGING. pollution UVB/UVA. free radicals. immune cells. damage signals. antioxidants
RESTORE YOUTHFUL SKIN Inflammation is becoming a mainstream concept for consumers Aging skin is inflamed skin and the easiest way to reverse the aging process is through controlling inflammation with anti-oxidants
More information. Optimized Vitamin D activity. Resynchronized circadian rhythms. Stimulated circadian genes. . Day and night skin care
Living organisms are regulated by an internal clock of 4 hours the biorhythm that controls circadian genes expression periodically. The purpose of this rhythmic activation of the circadian genes is to
More informationMelanin 6/22/2009. Group of compounds that serves predominantly as pigment.
Tessa Sinnige Liliana Joachín-Rodríguez Directed by: David Egan Melanin Group of compounds that serves predominantly as pigment. Pheomelanin (red/yellow) * Eumelanin (brown/black) * Neuromelanin (dark
More informationFull Energy Vanilla. Stimulating cellular functions PRODUCT BENEFITS. Energy. Energizing. Regenerating
Full Energy Vanilla A STORY The vanilla Vanilla planifolia, Orchidaceae A universal sweet aroma more and more desired The most famous orchid for our taste is a long epiphytic climbing plant with waxy ephemeral
More informationYeast Essence Skin Care Actives. Yeast Essence C90 Yeast Essence E100 Yeast Essence N80 Yeast Essence Z20. Angel Yeast Co., Ltd.
Yeast Essence Skin Care Actives Yeast Essence C90 Yeast Essence E100 Yeast Essence N80 Yeast Essence Z20 Angel Yeast Co., Ltd. Yeast Essence C90 Proposed INCI name: Sodium carboxymethyl beta glucan, water
More informationGP4G. Diguanosine Tetraphosphate. ISP Vincience Global Skin Research Center
GP4G Diguanosine Tetraphosphate ISP Vincience Global Skin Research Center 1 655, Route du Pin Montard -B.P. 212-06904 Sophia Antipolis Cedex France - Tel: (33) -4 92 94 16 06 - Fax: (33) -4 92 94 16 00
More informationACTIVE.LITE. Patent-Pending Technology + Visibly Perceivable Results in Less than 14 Days. Tomorrow s Vision Today!
ACTIVE.LITE Patent-Pending Technology + Visibly Perceivable Results in Less than 14 Days Tomorrow s Vision Today! AESTHETIC PERFECTION IS THE STANDARD Aesthetic skin perfection is now the consumer standard
More informationTHE EFFECTS OF REPEATED SUB-ERYTHEMAL EXPOSURES OF UVR ON HUMAN IMMUNITY
THE EFFECTS OF REPEATED SUB-ERYTHEMAL EXPOSURES OF UVR ON HUMAN IMMUNITY Joanna Narbutt Department of Dermatology Medical University of Lodz, Lodz, Poland Photoimmunosuppression ULTRAVIOLET RADIATION DNA
More informationAN ACTIVE SHELTER AGAINST POLLUTION V.16
AN ACTIVE SHELTER AGAINST POLLUTION V.16 THE SKIN IS CONSTANTLY EXPOSED The skin is an interface and thus is constantly exposed to environmental agents: Sun radiation Smoke Air pollution Free radicals
More informationmesotherapy solutions by
mesotherapy solutions by meso.prof is a comprehensive range of solutions and specific active substances in sterile ampoules for transcutaneous use. This is a range of effective, versatile, safe products,
More informationHigh Content Imaging : Meaningful pictures for relevant results in dermocosmetology
High Content Imaging : Meaningful pictures for relevant results in dermocosmetology We deliver High Content screening services with exhaustive, high quality and robust phenotypic data. Nathalie MAUBON,
More informationDermaPep A530. Multifunctional anti-inflammatory peptide for irritated and sensitive skin. Experience The Magic of Science
Experience The Magic of Science DermaPep A53 Multifunctional anti-inflammatory peptide for irritated and sensitive skin DermaP ep Experience the magic of science Anti-aging DermaPep A35 DermaPep A42 DermaPep
More informationLuisant Mela X Free from AGEs-Induced Epidermal Pigmentation
Free from -Induced Epidermal Pigmentation Find plant extract solution with NEW APPROACH TO FIGHT AGAINST MELANOGENESIS Skin Pigmentation Many people have been striving to obtain lighter, brighter and healthier-looking
More informationTargeted Chemoprevention of Progressive Marrow Failure in Patients with Fanconi Anemia using Quercetin, a Pilot study
Targeted Chemoprevention of Progressive Marrow Failure in Patients with Fanconi Anemia using Quercetin, a Pilot study Parinda Mehta, M.D. Division of Bone Marrow Transplantation and Immune Deficiency Cincinnati
More informationCanola oil and hempseed oil for atopic dermatitis skin treatment
Canola oil and hempseed oil for atopic dermatitis skin treatment Carmen Vincent, MD, PhD Dr Carmen Vincent Clinic of General and Aesthetic Dermatology Dr Irena Eris Cosmetic Laboratories, Centre for Science
More informationReactive Oxygen species ROS + Anti-oxidants. Dr. Naif Karadsheh
Reactive Oxygen species ROS + Anti-oxidants Dr. Naif Karadsheh Oxygen Toxicity & Free Radicals Biradical O 2 Radical O 2 Non-Radical Radical H 2 O 2 OH ROS O 2 Metabolism and Toxicity O 2 Consumption >90%
More informationINCI: Leucojum Aestivum Bulb Extract
INCI: Leucojum Aestivum Bulb Extract INCI: Leucojum Aestivum Bulb Extract Slow down aging: DORMINs effect Boost natural skin defenses: enhance Super Oxide Dismutase (SOD) production Skin lightening: slowdown
More informationSKIN ENERGY SUPPLEMENT INCREASING OXYGEN USE & ENERGY FROM MITOCHONDRIA. AGI Dermatics THIOTAINE
THIOTAINE DOSSIER Barnet Products Corporation 140 Sylvan Avenue Englewood Cliffs NJ 07632 Tel 201 346 4620 Fax 201 346 4333 Web barnetproducts.com Presents SKIN ENERGY SUPPLEMENT INCREASING OXYGEN USE
More information2. List routes of exposure in the order of most rapid response.
Practice Test questions: 1. What are the two areas of toxicology that a regulatory toxicologist must integrate in order to determine the "safety" of any chemical? 2. List routes of exposure in the order
More informationNAB Rhodiola Extract Your Partner in the Fight Against Urban Stress
Personal Care NAB Rhodiola Extract Your Partner in the Fight Against Urban Stress Key Product Attributes Adaptogenic plant extract that helps protect skin against the stresses of modern urban life Enhances
More informationInside Light Poet's narcissus. Regulating melanogenesis
Inside Light Poet's narcissus NAOLYS ACTIVE CELLS Inside Light Poet s narcissus A STORY The Poet s narcissus Narcissus poeticus, Amaryllidaceae The myth of a dangerous beauty In its search for innovative
More informationInside Light Poet's narcissus. Regulating melanogenesis
Inside Light Poet's narcissus Naolys active Cells Inside Light Poet s narcissus A story Inside Light Poet s narcissus Narcissus poeticus, Amaryllidaceae The myth of a dangerous beauty In its search for
More informationABSTRACT. 1 P age LIKI VON OPPEN-BEZALEL, OLGA BEN-CHITRIT, FABIEN HAVAS, DANIT FISHBEIN IBR LTD.
IBR CLEARLY BRIGHT Complex with Phyto(flu)ene the COLORLESS CAROTENOIDS, IBR-Dormin and IBR-Snowflake for better, outstanding Skin Lightening, Whitening & Evening of Skin Tone LIKI VON OPPEN-BEZALEL, OLGA
More informatione n ta d i n e Photoprotection Anti-photoaging the most natural way to reinforce skin natural defenses against outdoor and indoor radiations
eno p r e se rvativ e n ta d i n e Photoprotection Anti-photoaging the most natural way to reinforce skin natural defenses against outdoor and indoor radiations Anti-oxidation Anti-inflammation Anti-immunosuppression
More informationSkin Care Actives. Yeast Essence C90 Yeast Essence E100 Yeast Essence N80 Yeast Essence Z20. Ferment Essence FC01 Ferment Essence FG01
Skin Care Actives Yeast Essence C90 Yeast Essence E100 Yeast Essence N80 Yeast Essence Z20 Ferment Essence FC01 Ferment Essence FG01 Angel Yeast Co., Ltd. Yeast Essence C90 INCI name: Sodium carboxymethyl
More informationDESCRIPTION. Dosage: % Recommended ph:
EVOIL JJB SENSATION DESCRIPTION Consists of a multifunctional emollient obtained from natural vegetable oils. High content (ca. 25 %) of long chain length fatty acid. Contains up to 75 % of unsaturated
More informationTHE NEXT GENERATION WELL-BEING EVOLUTION
THE NEXT GENERATION WELL-BEING EVOLUTION NUTRIWAY introduces the next generation of DOUBLE X, the ultimate multi-vitamin, multi-mineral and phytonutrient supplement. Everyday factors like stress, sun exposure
More informationVit. C Serum 20 Another Revolution
Micro-encapsulated Vit. C Serum 20 Another Revolution Formula The active interests in our Vit. C Serum 20 are MATRIXYL synthe 6 + Vitamin C 20% + Vitamin A + Vitamin E. Ingredient List The full ingredients
More informationSTUDY 1 & 2 PC clears acne and normalizes sebum output on its own!
RESEARCH SUMMARY STUDY 1 & 2 PC clears acne and normalizes sebum output on its own! PHOSPHATIDYLCHOLINE ( PC ) Independent studies were done in 2000 where 14 patients with acne grades one and two (study
More informationCobioDefender EMR Electromagnetic radiation protection
INCI name Aqua (and) Glycerin (and) Glycogen. Description Electromagnetic waves are a form of energy consisting in vibrations of electric and magnetic fields. We live in a sea of invisible electronic pollution,
More informationBODY SCULPTING AND FIRMING SERUM
BODY SCULPTING AND FIRMING SERUM A slender body in 28 days Anti We all want to have a beautiful body. The benefits of endurance Even in winter, when we cover training include: ourselves with thick layers
More informationDETOSKIN TM. Your ultimate ally to reach skin s excellence ANTI-AGING
Your ultimate ally to reach skin s excellence ANTI-AGING Your ultimate ally to reach skin s excellence This is a story about the Peony, the queen of flowers, so beautiful with its bright colours and delightful
More informationZuf Globus Laboratories Ltd.
Chemical Analysis of the LifeMel As for request Professor Stefan Soback, the head of the i National Residue Control Laboratory, has performed a chemical analysis of the LifeMel. The purpose of the analysis
More informationOzone in Complementary Medicine Possible Mechanism of Ozone in Rheumatic and Inflammatory Diseases
Ozone in Complementary Medicine Possible Mechanism of Ozone in Rheumatic and Inflammatory Diseases 10.11.2004 OZONOSAN 1 Mechanism of Action in Rheumatic Pain Syndroms Acute stage: Activation of cell metabolism,
More informationSkin Tone Standardization
Skin Tone Standardization Active ingredients: Ascorbyl Palmitate and Pomegranate Oil Nanovetor Vitamina C is a blend of active ingredients encapsulated in lipid particles with particle diameter larger
More informationNNAGRAM. 64, rue Anatole France LEVALLOIS-PERRET - FRANCE TEL.: ++33.(0) FAX.: ++33.(0) TENSENNA VEGETAL TENSOR
Σ NNAGRAM 64, rue Anatole France - 92300 LEVALLOIS-PERRET - FRANCE TEL.: ++33.(0)1.47.93.66.66 - FAX.: ++33.(0)1.47.33.02.20 TENSENNA VEGETAL TENSOR WHEAT PROTEINS COMPLEX 1. INTRODUCTION TENSENNA is a
More informationThe Egyptian Journal of Hospital Medicine (October 2017) Vol.69 (3), Page
The Egyptian Journal of Hospital Medicine (October 2017) Vol.69 (3), Page 2159-2164 Oxidative Stress in Segmental Versus Non Segmental Vitiligo Nader Fouad Ragab*, Mahmoud Abdel-Rahim- Abdallah*, Manal
More informationKeratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis
Histol Histopathol (2009) 24: 849-857 http://www.hh.um.es Histology and Histopathology Cellular and Molecular Biology Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation
More informationConvergent and Divergent Mechanisms in Aging and Cancer
Convergent and Divergent Mechanisms in Aging and Cancer Mariana S. De Lorenzo, PhD Department of Cell Biology & Molecular Medicine delorems@umdnj.edu LEARNING OBJECTIVES 1. To identify convergent and divergent
More informationSUN, SAVVY AND SKIN : A REVIEW OF SKIN CANCER IN SOUTH AFRICA AND BEYOND
SUN, SAVVY AND SKIN : A REVIEW OF SKIN CANCER IN SOUTH AFRICA AND BEYOND Dr Lester M. Davids Redox Laboratory, Dept of Human Biology University of Cape Town Crafting a Road Map for Research on Sun Exposure
More informationno2ctuelle Rejuvenate your skin while you sleep. MANUAL PAGES
no2ctuelle Rejuvenate your skin while you sleep. MANUAL PAGES Did you know? 2 hours less sleep in 2 generations! The time we spend sleeping has dropped dramatically. In two generations, we have lost two
More informationSupporting Information. Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells
Supporting Information Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells Neha Kaushik, 1 Su Jae Lee, 2 Tae Gyu Choi 3, Ku Youn Baik,
More informationOriginal Article. Keywords Vitiligo Vanillic acid Phototherapy. Introduction
IJMS Vol 40, No 6, November 2015 Original Article Evaluation of the Efficacy of Topical Ethyl Vanillate in Enhancing the Effect of Narrow Band Ultraviolet B against Vitiligo: A Double Blind Randomized,
More informationNarrow-band UVB PHOTOTHERAPY for Skin Diseases
Narrow-band UVB PHOTOTHERAPY for Skin Diseases By Dr. Manal Bosseila Cairo University, Egypt HISTORICAL ASPECT In 1978: Irradiation cabin with broad band UVB tubes was introduced for psoriasis & uremic
More informationDelentigo The age spot solution
Delentigo The age spot solution Characteristics of Age Spots / Senile Lentigo Found on UV-exposed areas of the skin Diameter: 1 mm - few cm Color: light brown black More than 90% of Caucasian subjects
More informationSunflower Shoot Active Time fighting and energizing
Sunflower Shoot Active Time fighting and energizing Sunflower Shoot Active Time fighting and energizing Reversing the Aging Process with Sunflower Shoots Sunflower Shoot Active is a purified extract of
More informationMELASMA Photoprotection and light devices
MELASMA Photoprotection and light devices Pr. Thierry Passeron, MD, PhD Department of Dermatology & INSERM 05 team University Hospital of Nice, France Conflicts of interest Research grants and/or honoraria:
More informationMechanisms of Cell Injury
Causes of Cell Injury 1- oxygen deprivation (anoxia) 2- physical agents 3- chemical agents 4- infections agents 5- immunologic reactions 6- genetic defects 7- nutritional imbalances Mechanisms of Cell
More informationAntioxidant Activity of the plant Andrographis paniculata (Invitro)
Chapter 4 Antioxidant Activity of the plant Andrographis paniculata (Invitro) 4.1 INTRODUCTION Antioxidants prevents or repairs the cells against reactive oxygen species, reduces damage caused by free
More informationIBR-Phyto(flu)ene, COLORLESS CAROTENOIDS TECHNOLOGIY OVERVIEW
PRODUCT CATALOG IBR-Phyto(flu)ene, COLORLESS CAROTENOIDS TECHNOLOGIY OVERVIEW Biologically, carotenoids are an important group of compounds with more than 700 members. are found widely throughout nature,
More informationGLOSSARY of research terms
GLOSSARY of research terms SETTING PRIORITIES FOR VITILIGO RESEARCH - WORKSHOP Thursday 25 th March 2010 Types of studies Case Series: A study reporting on a consecutive collection of patients, treated
More informationAntioxidant Products
Antioxidant Products Introduction Introduction Antioxidant Total Antioxidant Status (TAS) Ransel Ransod Glutathione Reductase Antioxidants help defend living organisms against free radical attack. Many
More informationNanoWhite Triple activity for skin brightening
NanoWhite Triple activity for skin brightening Market Overview Skin discolorations are today considered to be an aging sign like wrinkles, a decreased cell renewal rate or loss of firmness. Whitening =
More informationREVINAGE. The real bio-retinol
REVINAGE The real bio-retinol Aging of the world United Nations 2015 Report Aging Who wants to get old? Retinoids o Family of compounds related to vitamin A and its derivatives o They interact with specific
More informationLecture 19 Summary Gestational Diabetes and Complications of Diabetes. Gestational diabetes;
Lecture 19 Summary Gestational Diabetes and Complications of Diabetes Gestational diabetes; - Type of diabetes that only develops during pregnancy Usually diagnosed in late pregnancy Causes high blood
More informationIgG. IgG. narrow-band UVB co-culture. E- P-cadherin PCNA. Abstract Vitiligo vulgaris is an acquired
行 : B IgG (3/3) Title: Effects of narrow-band UVB and IgG antibodies from patients with vitiligo vulgaris on migrationproliferation and melanogenesis in melanocytes and melanoblasts (3/3) : NSC 93-2314-B002-070
More informationREVITALIZING POWER OF NATURE CONCENTRATED IN A PURE ACTIVE INGREDIENT
revitalizing of aged cells stimulation of cell viability boost of anti-oxidative power (SOD1) moisturizing stimulation of procollagen I synthesis increase of skin elasticity soothing and calming wound
More informationMissed a week? Check out our Ask LNE & Spa archives. Do you have an industryrelated question? Ask LNE & Spa!
Ask LNE & Spa Les Nouvelles Esthétiques & Spa is the leading source of information for the esthetics industry, and now offers you the opportunity to connect with the foremost authorities in our business
More informationBreakthrough Innovations from SkinMedica
Breakthrough Innovations from SkinMedica Jeanine Downie, MD Director Image Dermatology, Montclair, NJ 1 SOLAR RADIATION IS MORE THAN JUST UV! 400 760 100 1x10 6 wavelength (nm) Most sunscreens only provide
More informationJournal Club: The Use of Fish Oil Lipid Emulsion for Gastrointestinal Surgery Patients
S a m m i M o n t a g F i s h O i l E m u l s i o n J o u r n a l C l u b - P a g e 1 Journal Club: The Use of Fish Oil Lipid Emulsion for Gastrointestinal Surgery Patients Introduction/Background I. Surgical
More informationAntioxidative Skin Care Products : Marketing Claims or Reality?
Antioxidative Skin Care Products : Marketing Claims or Reality? K. Jung, M. Seifert, Th. Herrling Gematria Test Lab GmbH Pestalozzistr. 5-8, 87 Berlin, Germany Key words: antioxidants, natural actives,
More informationAN ACTIVE SHELTER TO PROTECT C ELLS CELLS
AN ACTIVE SHELTER TO PROTECT CELLS v5 WHERE IS THE MARKET GOING TO? Niche segments, such as teenagers and men, are growing in the skin care market. They are also following the trends settled by women s
More informationshehab Moh Tarek ... ManarHajeer
3 shehab Moh Tarek... ManarHajeer In the previous lecture we discussed the accumulation of oxygen- derived free radicals as a mechanism of cell injury, we covered their production and their pathologic
More informationWhite jade injection that you rub on CINDETOX WHITE CREAM. Glutathione 1000ppm With Peptide. Glutathione + Thioctic acid + Vitamin C
White jade injection that you rub on CINDETOX WHITE CREAM Glutathione 1000ppm With Peptide Glutathione + Thioctic acid + Vitamin C 1. CINDELTOX Whitening Cream? CINDELTOX cream is a cosmetics for hospitals
More informationCorrespondence should be addressed to Amir Kalafi;
ISRN Dermatology, Article ID 472546, 6 pages http://dx.doi.org/10.1155/2014/472546 Clinical Study Evaluation of the Efficacy of Topical Tetracycline in Enhancing the Effect of Narrow Band UVB against Vitiligo:
More informationImpact of Sleep on Skin Aging and other Dermatologic Conditions
Impact of Sleep on Skin Aging and other Dermatologic Conditions Elma (Chat) D. Baron, MD Professor, Dermatology UPMASA Annual Convention July 2017 Albany, New York 1 Disclosures Research contracts Novartis
More informationHypopigmenting agents
An in-depth review on the biological and chemical aspects of hyperpigmentation and contemporary strategies for achieving even skin tone Hypopigmenting agents Melanin Pigment that provides color to skin,
More informationThe Science of Staying Healthy
The Science of Staying Healthy Signum Dermalogix, Inc. The Science of Staying Healthy ignum Dermalogix is a spin out of Signum Biosciences, a private biotech company founded in 2004 based on technologies
More informationInnovative Injectables With Novel Peptide and Sustained Release Technology For Face, Eye & Body Contouring
Innovative Injectables With Novel Peptide and Sustained Release Technology For Face, Eye & Body Contouring 2265 Novel Peptide and Sustained Release Technology Body Contouring Safe and eflcient Localized
More informationSun protection and moisture boost with up to 70 % Aloe vera
Sun protection and moisture boost with up to 70 % Aloe vera Refreshing care for your summer skin with LR ALOE VIA Sun Care Summer, sun, fun! But only with the perfect sun protection for your skin! Because
More informationBiochemistry: A Short Course
Tymoczko Berg Stryer Biochemistry: A Short Course Second Edition CHAPTER 20 The Electron-Transport Chain 2013 W. H. Freeman and Company Chapter 20 Outline Oxidative phosphorylation captures the energy
More informationAn in vitro method for screening skin-whitening products
j. Cosmet. Sci., 49, 361-367 (November/December 1998) An in vitro method for screening skin-whitening products GOPA MAJMUDAR, GEORGE JACOB, YOLANDA LABOY, and LOUIS FISHER, Mary Kay Holding Corporation,
More informationTHINKING OUTSIDE THE BOX Ted Rosen, MD Baylor College of Medicine Houston, Texas
THINKING OUTSIDE THE BOX Ted Rosen, MD Baylor College of Medicine Houston, Texas RADICAL TOPICAL THERAPEUTIC PEARLS {SOMETIMES BASED ON BASICS} Hong Kong Jade Market 2014 ZINC! DISCLOSURE OF RELATIONSHIPS
More informationThe 3rd Generation Comthing SGS
The 3rd Generation Comthing SGS Triple Anti-Irritant Complex, Full Recovery The Formation Mechanism of Sensitive Skin Sensitive skin: remarkably sensitive to external stimuli (Physical and chemical stimuli,
More informationIdentification and characterization of genes responsive to apoptosis: Application of DNA chip technology and mrna differential display
Histol Histopathol (2000) 15: 1271-1 284 http://www.ehu.es/histol-histopathol Histology and H istopat hology Cellular and Molecular Biology Invited Revie W Identification and characterization of genes
More informationPredicting the Response to Phototherapy for Psoriasis Patients
A*STAR-NHG-NTU Skin Research Grant Joint Workshop 17 October 2015 Predicting the Response to Phototherapy for Psoriasis Patients Is it possible? Dr Eugene Tan Consultant Dermatologist National Skin Centre
More informationAssoc. Prof. Dr. Aslı Korkmaz* and Prof. Dr. Dürdane Kolankaya**
The possible protective effects of some flavonoids that found honey by experimental ischemia/reperfusion (I/R) induced nitrosative damage in kidney of male rats Assoc. Prof. Dr. Aslı Korkmaz* and Prof.
More information3M3.WHITERIS G REVEAL. Lightener - Melano-minimiser COSMOS
3M3.WHITERIS G Lightener - Melano-minimiser REVEAL 3M3.WHITERIS G : Lightener - Melano-minimiser 3M3.WHITERIS G acts on the genes that control the three key mechanisms involved in the pigmentation of the
More informationNanoVit oa Bioactive phyto-omegas 3, 6, 9 + 7
NanoVit oa Bioactive phyto-omegas 3, 6, 9 + 7 NanoVit oa Bioactive phyto-omegas 3, 6, 9 + 7 Regeneration and Antioxidant Activity NanoVit oa is a nano-emulsion loaded with sea buckthorn pulp oil. Sea
More informationASTAXANTHIN - THE HEALTHY TEN
ASTAXANTHIN - THE HEALTHY TEN THE HEALTHY TEN TEN CLINICALLY-VALIDATED BENEFITS OF NATURAL ASTAXANTHIN BRAIN HEALTH 4 Human Clinical Studies 50 Supporting Pre-Clinical Trials EYE HEALTH 14 Human Clinical
More informationState of the art ingredients fast friendly service
ALPHA-LIPOIC ACID An Efficient Antioxidant α-lipoic acid also known as thioctic acid, plays an important role in metabolic processes. It functions as a co-factor for a number of key enzymes that help in
More informationFIGHTING AGAINST SKIN CANCER
FIGHTING AGAINST SKIN CANCER First aid for the skin UVB raiation Sunburn Skin cancer The Sun is not our enemy, it is the source of life to which we have had enough time to accommodate ourselves throughout
More informationpatented processes, commitment to ISO 9001 compliancy, and pledges Good Agriculture and Manufacturing Practices
Manufacturing Since 2004, Curaloe has been producing organically grown Aloe Vera commercially, with annual production steadily increasing every year. Our plantation cultivates more than 100,000 growing
More informationChemical and Biochemical Mechanism Of Cell Injury.
Chemical and Biochemical Mechanism Of Cell Injury. Professor Dr. M. Tariq Javed Dept. of Pathology Faculty of Vet. Science The University Of Agriculture Faisalabad Cell Injury When the cell is exposed
More informationV. 1 STEP BY STEP TO PERFECTLY EVEN SKIN TONE
V. 1 STEP BY STEP TO PERFECTLY EVEN SKIN TONE BRIGHT AND EVEN SKIN TONE NEED Aesthetic models of most cultures involve presenting an even skin tone. Hyperpigmented areas or dark spots appear as signs of
More informationNatural Active Ingredients From Plant Stem Cells to Preserve Skin Functions
ISTITUTO DI RICERCHE BIOTECNOLOGICHE Natural Active Ingredients From Plant Stem Cells to Preserve Skin Functions Roberto Dal Toso In-Cosmetics, Barcelona April 18th 2012 QUALITY AND SAFETY OF PLANT ACTIVE
More informationDeciphering multiple stressor effects of gamma radiation and uranium on Atlantic salmon (Salmo salar): Transcriptomics-based mixture modeling
Deciphering multiple stressor effects of gamma radiation and uranium on Atlantic salmon (Salmo salar): Transcriptomics-based mixture modeling Y. Song, J. Asselman, K.A.C. De Schamphelaere, B. Salbu, and
More informationCELL INJURY. Severity of Cell Injury
GENERAL PATHOLOGY LECTURE - 3 DR. M. TARIQ JAVED Professor Department of Pathology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan. 9/11/2009 1 CELL INJURY No adaptive response
More informationMechanistic Toxicology
SECOND EDITION Mechanistic Toxicology The Molecular Basis of How Chemicals Disrupt Biological Targets URS A. BOELSTERLI CRC Press Tavlor & France Croup CRC Press is an imp^t o* :H Taylor H Francn C'r,,jpi
More informationQ-SkinScience Forti5 Hair Recovery Supplement
Q-SkinScience Forti5 Hair Recovery Supplement Properties of Key Ingredients Melatonin: Induce Hair Growth and Pigmentation The anagen hair follicle (HF) produces melatonin in loco as a cyto-protective
More information