SKINFLAMM-AGING. pollution UVB/UVA. free radicals. immune cells. damage signals. antioxidants

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1 RESTORE YOUTHFUL SKIN

2 Inflammation is becoming a mainstream concept for consumers Aging skin is inflamed skin and the easiest way to reverse the aging process is through controlling inflammation with anti-oxidants + anti-inflammatory ingredients The results are a clear, brighter complexion with reduced redness + puffiness and less visible lines + wrinkles SKINFLAMM-AGING

3 SKINFLAMM-AGING pollution UVB/UVA free radicals damage signals immune cells antioxidants Skinflamm-aging control can be both proactive and reactive The cascade of inflammation can be interrupted at multiple points within the skin Existing inflammation can be quelled

4 Viable Cell Count (x 10 4 /well) Peroxidized Lipid (abs 586nm) OXIDATIVE STRESS + AGING As our outermost barrier, skin is regularly exposed to UV radiation and air pollution These exposures produce free radicals which can wreak havoc on the cellular environment of skin Chronic exposure can lead to uneven, blotchy pigmentation and damage to the framework of skin leading to sagging and wrinkles SUPPRESSION OF HYDROXYL RADICALS SUPPRESSION OF LIPID PEROXIDATION ascorbic acid (mm) catalase (U/mL) stabilized VitC (mm) untreated non-irradiated untreated stab VitC H2O2 treatment stabilized forms of Vitamin C can help to suppress hydroxy radicals Method :: 1 Human keratinocytes are pretreated with ascorbic acid, stabilized VitC or catalase for 7 hrs 2 Hydrogen peroxide (0.4 mm) is added 3 After 2 hrs, the number of viable cells is determined by neutral red assay method irradiated stabilized forms of Vitamin C can help to suppress lipid peroxidation caused by UV exposure

5 IL-1 Produced (pg/ml) Degree of Response LUMIESSE helps mitigate inflammation + protect skin INFLAMMATION RESPONSE SLS 0.08% SLS 0.08% + 1% Active SLS 0.08% + 3% Active DI Water It has been broadly demonstrated throughout the literature that inflammation has an immense impact on the process of aging within our bodies but especially as evidenced on our skin. By controlling the inflammatory process in the skin, chemical mediators responsible for a range of destructive + negative effects on the skin can be reduced. These include enzymes that destroy collagen, elastin, and proteins that give skin structure as well as mediators involved in the process of melanin formation leading to hyperpigmentation. IL-1 INHIBITION ON ARTIFICIAL SKIN SLS ONLY SLS + 0.5% Active SLS 0.05% SLS 0.10% SLS 0.20% SLS 1.0%

6 wrinkle depth (microns) % Collagen Synthesis vs. Total Protein Synthesis LUMIESSE has anti-aging benefits STIMULATION OF COLLAGEN SYNTHESIS 16.0 Control Ascorbic Acid (0.25 mm) Stable VitC (0.25 mm) Day 1 Day 3 Day 5 Day 8 Ascorbic acid found in Vitamin C has long been a benchmark for collagen stimulation and reduction of melanin. While highly effective, stability presents a challenge. By complexing and stabilizing Vitamin C, we not only achieve enhanced stability but efficacy is boosted as well. Stabilized Vitamin C will not only inhibit the formation of melanin in the skin, it can reduce the melanin that already exists thereby preventing and correcting hyperpigmentation. The anti-wrinkle and hyperpigmentation reducing activity of Stabilized Vitamin C has been demonstrated clinically. 16 subjects Twice daily application to crow s feet area + cheek 2% Stabilized VitC Active CLINICAL REDUCTION OF WRINKLES DAY 0 DAY 45 DAY AVG L* VALUES DAY 0 DAY 45 DAY 90

7 Reduction in Melanin Content (% Stimulated Control) LUMIESSE effects melanin production melanin IN VITRO MELANIN CONTENT REDUCTION MSH-stimulated human melanocytes (72-hr treatment) Lumiesse Hydroquinone (%) (%) Kojic Acid (%) control control Unstimulated Control Stimulated Control Kojic Acid 0.4% Kojic Acid 0.8% Hydroquinone 0.1% Hydroquinone 1.0% Lumiesse 1.0 Lumiesse 3.0% *cell viability confirmed via MTT assay (n=6) the MTT assay confirms that no cytotoxicity was noted at these concentrations

8 LUMIESSE has clinically-proven, fast results % SPOT REDUCTION LUMIESSE % improvement week 8 % improvement week 4 HYDROQUINONE STABLE VC PLACEBO LUMIESSE showed better results at the 4-week mark than both hydroquinone and Stabilized VitC. As a result, consumers will begin to see spot reduction in a shorter period of use than other products on the market. instrumental data 0.0% 2.0% 4.0% 6.0% 8.0% 10.0% 12.0% 14.0% LUMIESSE showed significantly better results in overall improvement of skin tone at both the 4-week and 8-week timepoints. As a result, consumers will continue to see improvements in their skin with regular use over time. LUMIESSE HYDROQUINONE STABLE VitC SKIN TONE IMPROVEMENT % improvement week 8 % improvement week 4 PLACEBO selfassessment data 0.0% 5.0% 10.0% 15.0% 20.0% 25.0%

9 LUMIESSE has clinically-proven, fast results Summary of week 4 questions Question Placebo 2% HQ 2% StabVitC 2% Lumiesse Improved skin dryness Improved appearance of fine lines Improved skin texture Improved skin tone Improved skin color Improved skin firmness Improved skin suppleness Diminished signs of aging LUMIESSE out scored hydroquinone and stabilized VitC in many categories at week 4 indicating faster visible results self-assessment results score above 50% Diminished shine/oiliness Diminished pore size Years look younger Summary of week 8 questions Question Placebo 2% HQ 2% StabVitC 2% Lumiesse Improved skin dryness Improved appearance of fine lines Improved skin texture Improved skin tone Improved skin color LUMIESSE restored a more youthful look in 8 weeks with improved skin texture and reduction in fine lines Improved skin firmness Improved skin suppleness Diminished signs of aging Diminished shine/oiliness Diminished pore size Years look younger

10 LUMIESSE has enhanced formulation stability LUMIESSE showed enhanced stability compared to an available Stabilized Vitamin C ingredient both in solution and in formulation. As a result, there will be no color change to a formulation with LUMIESSE over time or with exposure to light. Week 0 Lumiesse 5% O/W Week 0 Control 5% O/W Week 0 Stabilized VitC 5% O/W Week 0 Lumiesse Week 0 Stabilized VitC (40%) Week 12 Lumiesse Week 12 Stabilized VitC (40%) *paremeters shown (RT, 12-weeks) additional stability conditions available upon request Week 12 Lumiesse 5% O/W Week 12 Control 5% O/W Week 12 Stabilized VitC 5% O/W

11 TRADE NAME :: INCI NAME :: RECOMMENDED USE LEVEL :: HEAVY METALS :: APPEARANCE :: LUMIESSE Butylene Glycol + Sodium Ascorbyl Glucoside + Hippophae Rhamnoides Fruit Extract + Maltodextrin + Portulaca Oleracea Extract 1-3% <20ppm total clear, yellow to light brown liquid ph (10% sol n) :: SOLUBILITY :: APPLICATIONS :: FORMULATION GUIDELINES :: aqueous lotions, creams, treatment gels, BB creams, foundations, spot treatments, under eye cream/serum ph range 5-7; add to water phase or post-addition; temperature below 40C recommended (can withstand up to 60C); no known incompatibilities