Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy
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1 Journal of the Formosan Medical Association (2011) 110, 655e660 Available online at journal homepage: BRIEF COMMUNICATION Recurrence of nasopharyngeal carcinoma in the parotid region after parotid-gland-sparing radiotherapy Deng-Shan Lin a, Yee-Min Jen b, Jih-Chin Lee a, Shao-Cheng Liu a, Yaoh-Shiang Lin a,c, * a Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan b Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan c Medical Affairs Bureau, Ministry of National Defense, Taipei, Taiwan Received 20 May 2010; received in revised form 24 June 2010; accepted 27 August 2010 KEYWORDS nasopharyngeal carcinoma; parotid-gland-sparing radiotherapy; periparotid recurrence This study reported our experience of the clinical characteristics of periparotid recurrence of nasopharyngeal carcinoma (NPC) after parotid-gland-sparing radiotherapy. We retrospectively reviewed the charts of 296 patients with NPC who underwent parotid-gland-sparing radiotherapy at the Tri-Service General Hospital from 1998 to Eighty-three patients underwent three-dimensional conformal radiotherapy, and 205 patients underwent intensity-modulated radiotherapy; parotid glands were spared bilaterally in all patients. None of these patients had undergone previous radiotherapy or surgical treatment of the head and neck. Disease recurred in a spared parotid gland in three patients (1.04%). Two of these patients had undergone three-dimensional conformal radiotherapy and the third underwent intensity-modulated radiotherapy. All three patients had undergone parotidectomy. Adjuvant radiotherapy or concurrent chemoradiation was administered. One patient died of metastatic disease 26 months after diagnosis of recurrence; the others were well with no evidence of disease at 63 and 6 months after initial recurrence. Periparotid recurrence is an uncommon pattern of locoregional failure after parotid-gland-sparing radiotherapy for NPC. Early diagnosis and aggressive therapy for patients with periparotid recurrence may improve outcomes. Copyright ª 2011, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved. * Correspondence to: Dr Yaoh-Shiang Lin, Department of Otolaryngology-Head and Neck Surgery, TrieService General Hospital, 325 Cheng-Kung Road, Section 2, Taipei 114, Taiwan. address: yskuolin@mail.ndmctsgh.edu.tw (Y.-S. Lin) /$ - see front matter Copyright ª 2011, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved. doi: /j.jfma
2 656 D.-S. Lin et al. In nearly all patients with nasopharyngeal carcinoma (NPC) who are treated with conventional radiotherapy, salivary gland damage with subsequent xerostomia has been unavoidable. 1,2 To reduce or prevent xerostomia in patients with NPC for whom radiotherapy is mandatory, investigators have used various approaches, including parotidgland-sparing three-dimensional conformal radiotherapy (3DCRT) 3,4 and intensity-modulated radiotherapy (IMRT), to decrease the dose of radiation delivered to the parotids and increase the dose delivered to the gross disease in the nasopharynx. 5e10 One concern with parotid-gland-sparing radiotherapy is that reducing exposure of the salivary tissue to radiation could result in inadequate radiation exposure to microscopic disease in the region of a spared parotid gland. In 2008, Donald et al first reported on two patients with NPC and one with squamous cell carcinoma of the tonsil who had periparotid failure after definitive parotid-gland-sparing IMRT. 10 These three cases were the only published cases of periparotid treatment failure in patients with head and neck cancer who underwent definitive parotid-glandsparing radiotherapy. In our institute, three patients who were treated with parotid-gland-sparing radiotherapy later developed periparotid recurrence of NPC. We report our experience with these patients and discuss the clinical implications of periparotid recurrence of NPC. Patients and methods Patients We performed a retrospective chart review of 387 patients with NPC who underwent radiotherapy at the Tri-Service General Hospital, Taipei, Taiwan from 1998 to Among them, 296 patients underwent parotid-gland-sparing radiotherapy, and only 288 patients who completed the full radiotherapy course were included. Eighty-three patients underwent parotid-gland-sparing 3DCRT and 205 underwent parotid-gland-sparing IMRT. The parotid glands were spared as much as possible with the prerequisite that dose to the target was not compromised. The parotid glands were spared bilaterally in all cases. None of these patients had undergone previous radiotherapy or surgery of the head and neck. Radiotherapy technique The 3DCRT technique has been described previously [4]. The clinical target volume (CTV) included the gross target volume (GTV) and the following: the medial pterygoid muscles, the parapharyngeal spaces, the carotid space, the sphenoid sinus, the posterior third to quarter of the nasal cavity, and the anterior quarter to third of the clivus and vertebral body. The lower margin was set at C2 in the absence of oropharyngeal extension. We added 2 mm to all the GTVs to become CTVs, and added 4 mm to all CTVs to become planning target volumes (PTVs). In patients with cavernous sinus or intracranial invasion, the cavernous sinus and the entire sellar and suprasellar regions were included. We added a 4-mm margin to the CTV to allow for setup errors, except at the brainstem and the spinal cord, where the margin was usually 2e4 mm for safety reasons. Thus, the PTV equaled the CTV plus a 4-mm margin. The lower neck and bilateral supraclavicular fossae were irradiated in all patients with 5000 cgy. A single PTV was used throughout the treatment course without reduction. For IMRT, the simultaneous integrated boost technique was used. CTV1 encompassed the gross tumor with a 0.4-cm margin, CTV2 covered the high-risk areas such as level IIeIII of the neck, and CTV3 included bilateral level IV and supraand infra-clavicular areas. A dose of 6800e7400 cgy was given for PTV1, which encompassed the gross tumor with a margin of 0.4 cm, 6000 cgy to PTV2, and 5000e5400 cgy to PTV3. Results Three patients (1.04%) had disease recurrence in a spared parotid gland. Two of them (patients 1 and 2) had undergone parotid-gland-sparing 3DCRT and the third had undergone parotid-gland-sparing IMRT. Two patients (1 and 3) had unilateral nodal disease ipsilateral to the primary tumor. Patient 2 had bilateral lymphadenopathy. Summaries of the patient characteristics before and after periparotid recurrence are provided in Tables 1 and 2. Case 1 Pre-therapy computed tomography showed no parotid lesion (Fig. 1A). Twenty-one months after having no evidence of disease, the patient noted a swelling over her left preauricular region. Computed tomography demonstrated an enhancing enlarged node in the left periparotid and intraparotid region, suggesting tumor recurrence (Fig. 1B). Fine needle aspiration confirmed the presence of a metastatic undifferentiated carcinoma. Left parotidectomy and neck dissection were performed, and pathological examination showed metastatic undifferentiated carcinoma in the intraparotid and periparotid lymph nodes, with extranodal extension. The margin status showed no malignancy, no extracapsular extension, and no lymphovascular or perineural invasion. The patient underwent adjuvant chemotherapy, and she declined adjuvant radiotherapy. The patient died with bony and intracranial metastases 26 months after recurrence. Case 2 Pre-therapy magnetic resonance imaging (MRI) showed no parotid lesion (Fig. 2A). Six months after having no evidence of disease, the patient noted a swelling in his right pre-auricular region. A superficial nonspecific 7-mm parotid nodule had been noted within the superficial aspect of the right parotid on pretreatment MRI (Fig. 2B). Right parotidectomy and neck dissection were performed, and pathological examination showed an intraparotid lymph node of metastatic undifferentiated carcinoma. The margin status showed no malignancy, no extracapsular extension, and no lymphovascular or perineural invasion. The patient declined chemotherapy and underwent IMRT (50 Gy) of the
3 Parotid recurrence of nasopharyngeal carcinoma 657 Table 1 Patient characteristics at initial diagnosis Characteristic Patient 1 Patient 2 Patient 3 Sex Female Male Male Age (yr) Lymph nodes L neck level II R neck level IIeIII L neck level IIeIII L neck level II R retropharynx Stage T4bN1M0 T2bN2M0 T4N2M0 RT technique 3DCRT 3DCRT IMRT RT dose: PTV cgy 7000 cgy 7500 cgy PTV cgy 7000 cgy 6000 cgy PTV cgy 5040 cgy 5040 cgy Chemotherapy Concurrent Cisplatin 3 Cisplatin 3 Cisplatin 3 Adjuvant Cisplatin plus 5-FU 3 Cisplatin plus 5-FU 3 Mean parotid dose/estimated dose at the recurrent site 2705 cgy/1500 cgy 6200 cgy/4000 cgy 4450 cgy/7000 cgy L Z left; R Z right; RT Z radiotherapy; 3DCRT Z three-dimensional conformal radiotherapy; IMRT Z intensity modulated radiotherapy; PTV Z planning target volume; 5-FU Z 5-fluorouracil. recurrence site. At last follow-up, the patient was well with no evidence of disease 63 months after recurrence. Case 3 Pre-therapy MRI showed no parotid lesion (Fig. 3A and 3B). The patient noted a swelling over his left pre-auricular region 52 months after initial treatment. There was an enlarged mass in the left parotid gland, measuring about 3.3 cm in the long axis, with perifocal edematous changes of the gland (Fig. 3C). Whole-body bone scan and abdominal sonography revealed no metastasis at other sites. Fine needle aspiration confirmed the presence of a metastatic undifferentiated carcinoma. Left parotidectomy was performed, and pathological examination showed an intraparotid lymph node of metastatic undifferentiated differentiated carcinoma. The margin status showed no malignancy, no extracapsular extension, and no lymphovascular or perineural invasion. The patient received 45 Gy of IMRT to the recurrence with concurrent chemotherapy and adjuvant chemotherapy. At last followup, 6 months after recurrence, the patient was well with no evidence of disease. Discussion The recurrence of head and neck cancer in spared parotid gland was first reported by Chao et al 11 in a patient with hypopharyngeal cancer who had undergone IMRT postoperatively, following partial pharyngectomy and neck dissection. It is possible that, in postoperative patients, altered lymphatic anatomy could contribute to different patterns of locoregional recurrence, and that parotid gland sparing may play only a small role. In 2008, Donald et al reported that two patients with NPC and one with squamous cell carcinoma of the tonsil developed periparotid failure after definitive parotid-gland-sparing IMRT. These three cases were the only published cases of periparotid failure in Table 2 Patient characteristics after recurrence Characteristic Patient 1 Patient 2 Patient 3 Time to recurrence (mo) Recurrence site L periparotid and intraparotid R intraparotid lymph nodes L intraparotid lymph nodes lymph nodes Imaging findings at disease recurrence Enhanced 6-mm and 4-mm nodules within left parotid gland Enhanced 7-mm nodule within right parotid gland Enhanced 3.3-cm nodule with perifocal edematous change within left parotid gland Surgery after recurrence L parotidectomy þ ND, level II R parotidectomy þ ND, level II L parotidectomy Treatment after surgery Chemotherapy Adjuvant IMRT with 5000 cgy Adjuvant IMRT with 4500 cgy and concurrent chemotherapy Outcome (months after recurrence) Died (26) No evidence of disease (63) No evidence of disease (6) L Z left; R Z right; ND Z neck dissection; IMRT Z intensity modulated radiotherapy.
4 658 D.-S. Lin et al. Figure 1 (A) Pre-therapy computed tomography showed no parotid lesion. (B) Computed tomography showed enhanced 6-mm (arrow) and 4-mm nodules within the left parotid gland. Figure 2 (A) Pre-therapy magnetic resonance imaging showed no parotid lesion. (B): Magnetic resonance imaging showed an enhanced 7-mm nodule within the right parotid gland (arrow). patients who underwent definitive parotid-gland-sparing IMRT. The authors suggested that the presence of multilevel nodal disease and periparotid nodules on pretreatment imaging should raise suspicion of subclinical disease inside the seemingly harmless nodules, although they do not meet radiographic or clinical criteria for possible gross disease [10]. In our three patients, the cause of recurrence remains elusive. Many factors may contribute to the development of recurrence, including later stage of disease, pre-existing metastasis at the periparotid area, and overprotection of the parotid gland during radiotherapy. Metastasis of NPC may also occur at the parotid nodes. The parotid gland may also be involved by extracapsular
5 Parotid recurrence of nasopharyngeal carcinoma 659 Figure 3 (A) Pre-therapy magnetic resonance imaging showed no parotid lesion. (B) Treatment-planning with iso-dose curve. (C) Magnetic resonance imaging showed an enhanced 3.3-cm nodule with perifocal edematous change within the left parotid gland (arrow). spread from enlarged cervical nodes or by direct infiltration by the primary lesion in the nasopharynx. 12 It would seem not powerful enough to draw any conclusions about the exact causes of the recurrence. Among the 288 patients treated with parotid-gland-sparing radiotherapy, periparotid recurrence occurred in only three patients (1.04%). Although there may be more periparotid recurrences during extended follow-up, a significant increase in incidence seems unlikely. In our experience, patients treated with parotid-gland-sparing 3DCRT or IMRT have better overall survival and less xerostomia as compared to patients treated with conventional radiotherapy. 4 The 3-year local control rate and progression-free survival rate of our NPC patients treated with 3DCRT were 86e96% and 80.3%, respectively. 4 Therefore, parotid-gland-sparing 3DCRT or IMRT appear to be worth adopting. The best treatment for periparotid failure after parotidgland-sparing radiotherapy for NPC has not been determined. We chose parotidectomy followed by adjuvant radiotherapy or chemotherapy, or both, as our salvage procedure. Patient 1 in our series died 26 months after recurrence due to bony and intracranial metastasis; the others remained well with no evidence of disease at 63 and 6 months after recurrence, suggesting that aggressive therapy can help to optimize the prognosis for periparotid recurrence. However, regular physical examinations and imaging studies of the parotid gland are required for patients who are treated with parotid-gland-sparing radiotherapy for NPC. In conclusion, our study shows that periparotid recurrence is an uncommon type of locoregional failure after parotid-gland-sparing radiotherapy for patients with NPC. Although the etiology of periparotid recurrence is unclear, early diagnosis and aggressive treatment of periparotid recurrence may help to optimize outcomes. References 1. Franzen L, Funegard U, Ericson T, Henriksson R. Parotid gland function during and following radiotherapy of malignancies in the head and neck. A consecutive study of salivary flow and patient discomfort. Eur J Cancer 1992;28:457e Jen YM, Lin YS, Su WF, Hsu WL, Hwang JM, Chao HL, et al. Dose escalation using twice-per-day radiotherapy technique for nasopharyngeal carcinoma: does heavier dosing result in a happier ending? Int J Radiat Oncol Biol Phys 2002;54:14e22.
6 660 D.-S. Lin et al. 3. Nishioka T, Shirato H, Arimoto T, Kaneko M, Kitahara T, Oomori K, et al. Reduction of radiation-induced xerostomia in nasopharyngeal carcinoma using CT simulation with laser patient marking and three-field irradiation technique. Int J Radiat Oncol Biol Phys 1997;38:705e Jen YM, Shih R, Lin YS, Su WF, Ku CH, Chang CS, et al. Parotid gland-sparing 3-dimensional conformal radiotherapy results in less severe dry mouth in nasopharyngeal cancer patients: a dosimetric and clinical comparison with conventional radiotherapy. Radiother Oncol 2005;75:204e9. 5. Chao KS, Majhail N, Huang CJ, Simpson JR, Perez CA, Haughey B, et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol 2001;61: 275e Lee N, Xia P, Fischbein NJ, Akazawa P, Akazawa C, Quivey JM. Intensity-modulated radiation therapy for head-and-neck cancer: the UCSF experience focusing on target volume delineation. Int J Radiat Oncol Biol Phys 2003;57:49e Eisbruch A, Marsh LH, Dawson LA, Bradford CR, Teknos TN, Chepeha DB, et al. Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing. Int J Radiat Oncol Biol Phys 2004;59:28e Daly ME, Lieskovsky Y, Pawlicki T, Yau J, Pinto H, Kaplan M, et al. Evaluation of patterns of failure and subjective salivary function in patients treated with intensity modulated radiotherapy for head and neck squamous cell carcinoma. Head Neck 2007;29:211e Lin A, Kim HM, Terrell JE, Dawson LA, Ship JA, Eisbruch A. Quality of life after parotid-sparing IMRT for head-and-neck cancer: a prospective longitudinal study. Int J Radiat Oncol Biol Phys 2003;57:61e Cannon DM, Lee NY. Recurrence in region of spared parotid gland after definitive intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 2008;70: 660e Chao KS, Ozyigit G, Tran BN, Cengiz M, Dempsey JF, Low DA. Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2003;55:312e Chong VF, Fan YF. Parotid gland involvement in nasopharyngeal carcinoma. J Comput Assist Tomogr 1999;23:524e8.
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