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11 Jaw-Yuan Wang, Mei-Chi Liu, Yuan-Chien Lin, and Jung-Yu Kan. High expression of phospho-h2ax predicts a poor prognosis in colorectal cancer. Anticancer Res 2015;35: (SCI) 292(2015_07). Jiunn-Ren Wu, Li-Pin Kao, Bin-Nan Wu, Zen-Kong Dai, Yi-Ya Wang, Chee-Yin Chai( 蔡志仁 ), and Ing-Jun Chen. Buffered L-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery. Kaohsiung J Med Sci 2015; 31: (SCI) 293(2015_08). Sheng-Hua Wu, Shu-Hung Huang, Kuang-I Cheng, Chee-Yin Chai( 蔡志仁 ), Jwu-Lai Yeh, Tai-ChengWu, Yi-Chiang Hsu, and Aij-Lie Kwan. Third-degree hindpaw burn injury induced apoptosis of lumbar spinal cord ventral horn motor neurons and sciatic nerve and muscle atrophy in rats. Biomed Res Int 2015: (SCI) 294(2015_09). Jen-Yang Tang, Edward Hsi, Ya-Chun Huang, Nicholas Chung-Heng Hsu, Wen-Chi Yang, Hsueh-Wei Chang, *Chee-Yin Chai( 蔡志仁 )(co-corresponding author), and Pei-Yi Chu. Overexpression of autophagy-related 16-like 1 in patients with oral squamous cell carcinoma. Pathol Oncol Res 2015; 21: (SCI) 295(2015_10). Yen-Hsin Kuo, Yi-Ting Chen, Hung-Pei Tsai, and *Chee-Yin Chai( 蔡 志仁 )(co-corresponding author), and Aij-Lie Kwan. Nucleophosmin overexpression is associated with poor survival in astrocytoma. APMIS 2015; 123: (SCI) 296(2015_11). Shu-Hung Huang, Sheng-Hua Wu, Su-Shin Lee, Kao-Ping Chang, Chee-Yin Chai( 蔡志仁 ), Jwu-Lai Yeh, Sin-Daw Lin, Aij-Lie Kwan, Hui-Min David Wang, and Chung-Sheng Lai. Fat grafting in burn scar alleviates neuropathic pain via anti-inflammation effect in scar and spinal cord. PLoS One 2015; 10:e (SCI) 297(2015_12). Yi-Ting Chen, Shu-Chuan Tsao, Shyng-Shiou F. Yuan, Hung-Pei Tsai, and *Chee-Yin Chai( 蔡志仁 )(corresponding author). Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation of colorectal cancer through the epidermal growth factor as a prognostic marker. Pathol Oncol Res 2015; 21: (SCI) 298(2015_13). Sheng-Hua Wu, Shu-Hung Huang, Yi-Ching Lo, Chee-Yin Chai( 蔡志 11

12 仁 ), Su-Shin Lee, Kao-Ping Chang, Sin-Daw Lin, Chung-Sheng Lai, Jwu-Lai Yeh, and Aij-Lie Kwan. Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury. Cytotherapy 2015; 17: (SCI) 299(2015_14). Ya-Chun Huang, Hsin-Su Yu, and *Chee-Yin Chai( 蔡志仁 )(co-corresponding author). Roles of oxidative stress and the ERK1/2, PTEN and p70s6k signaling pathways in arsenite-induced autophagy. Toxicol Lett 2015; 239: (SCI) 300(2015_15). Peir-In Liang, Wan-Tzu Chen, Chien-Feng Li, Ching-Chia Li, Wei-Ming Li, Chun-Nung Huang, Hsin-Chih Yeh, Hung-Lung Ke, Wen-Jeng Wu, and *Chee-Yin Chai( 蔡志仁 )(corresponding author). Subcellular localization of anillin is associated with different survival outcome in upper urinary tract urothelial carcinoma. J Clin Pathol 2015;68: (SCI) 301(2015_16). Ya-Chun Huang, Hsin-Su Yu, and *Chee-Yin Chai( 蔡志 仁 )(corresponding author). Proteins in ERK pathway are affected in arsenic-treated cells. Toxicol Res 2015; 4: (SCI) 302(2015_17). Chien-Hsing Lee, Ping-Shan Lai, Yen-Pei Luk, Hsuan-Ying Chen, Chee-Yin Chai( 蔡志仁 ), Rong-Kung Tsai, Kang-Tang Fang, Ming-Hsien Tsai, Chia-Yen Hsu, Chun-Cheng Hung, Deng-Chyang Wu, Hsin-Su Yu, Chung-Hsing Chang, and Din-Ping Tsai. Real-time vascular imaging and photodynamic therapy efficacy with micelle-nanocarrier delivery of chlorin e6 to the microenvironment of melanoma. J Dermatol Sci 2015; 80: (SCI) 303(2016_01). Ya-Chun Huang, Hsin-Su Yu, and *Chee-Yin Chai( 蔡志 仁 )(corresponding author). Aldehyde dehydrogenase induction in arsenic-exposed rat bladder epithelium. Exp Toxicol Pathol 2016; 68:61-8. (SCI) 304(2016_02). Shu-Jyuan Chang, Fu Ou-Yang, Hung-Pin Tu, Chih-Hung Lin, Shu-Hung Huang, Joanna Kostoro, Ming-Feng Hou, *Chee-Yin Chai( 蔡志仁 )(co-corresponding author), and *Aij-Lie Kwan. Decreased expression of autophagy protein LC3 and stemness (CD44 + /CD24 -/low ) indicate poor prognosis in triple-negative breast cancer. Hum Pathol 2016; 48: (SCI) 305(2016_03). Chieh-Hsin Wu, Yi-Ching Tung, Tzu-Kang Lin, Chee-Yin Chai( 蔡志 12

13 仁 ), Yu-Feng Su, Tai-Hsin Tsai, Cheng-Yu Tsai, Ying-Yi Lu, and Chih-Lung Lin. Hip fracture in people with erectile dysfunction: A nationwide population-based cohort study. PLoS One 2016; 11:e (SCI) 306(2016_04). Chieh-Hsin Wu, Yi-Ching Tung, Chee-Yin Chai( 蔡志仁 ), Ying-Yi Lu, Yu-Feng Su, Tai-Hsin Tsai, Keng-Liang Kuo, and Chih-Lung Lin. Increased risk of osteoporosis in patients with peptic ulcer disease: A nationwide population-based study. Medicine (Baltimore) 2016; 95:e3309. (SCI) 307(2016_05). Yen-Man Lu, Tsu-Ming Chien, Chih-Hung Lin, Chee-Yin Chai( 蔡志仁 ), and Chun-Nung Huang. Epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan as an alternative treatment for advanced upper tract urothelial carcinoma: a case report. J Med Case Rep 2016; 10: (2016_06). Sin-Daw Lin, Shu-Hung Huang, Yun-Nan Lin, Sheng-HuaWu, Hsueh-Wei Chang, Tsai-Ming Lin, Chee-Yin Chai( 蔡志仁 ), Dar-Jen Hsieh, and Kao-Ping Chang. Injected implant of uncultured stromal vascular fraction loaded onto a collagen gel: In vivo study of adipogenesis and long-term outcomes. Ann Plast Surg 2016; 76 Suppl 1:S (SCI) 309(2016_07). Joanna Kostoro, Shu-Jyuan Chang, Yen-Chang Clark LaI, Chun-Chieh Wu, *Chee-Yin Chai( 蔡志仁 )(co-corresponding author), and Aij-Lie Kwan. Overexpression of vascular adhesion protein-1 is associated with poor prognosis of astrocytomas. APMIS 2016; 124: (SCI) 310(2016_08). Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin,... Chee-Yin Chai( 蔡志仁 ),...,and Susu M Zughaier. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016; 12: (SCI) 311(2016_09). Feng-Ching Hsieh, Cheng-Che E. Lan, Tsui-Yin Huang, Kuan-Wei Chen, Chee-Yin Chai( 蔡志仁 ), Wan-Tzu Chen, Ai-Hui Fang, Yi-Hsing Chen, and Ching-Shuang Wu. Heat-killed and live Lactobacillus reuteri GMNL-263 exhibit similar effects on improving metabolic functions in high-fat diet-induced obese rats. Food Funct 2016; 7: (SCI) 312(2016_10). Yi-Ting Chen, Shu-Chuan Tsao, Hung-Pei Tsai, Jaw-Yuan Wang, and *Chee-Yin Chai( 蔡志仁 )(corresponding author). The X-linked inhibitor of 13

14 apoptosis protein is an independent prognostic marker for rectal adenocarcinoma after preoperative chemoradiotherapy. Virchows Arch 2016; 468: (SCI) 313(2016_11). Sheau-Fang Yang, Ming-Feng Hou, Fang-Ming Chen, Fu Ou-Yang, Yang-Chang Wu, *Chee-Yin Chai( 蔡志仁 )(co-corresponding author), and Yao-Tsung Yeh. Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy. BMC Cancer 2016; 16:20. (SCI) 314(2016_12). Shiou-Fu Lin, Chun-Chieh Wu, and *Chee-Yin Chai( 蔡志仁 )(corresponding author). Increased FLI-1 expression is associated with poor prognosis in non-small cell lung cancers. Appl Immunohistochem Mol Morphol 2016; 24: (SCI) 315(2016_13). Yi-Ting Chen, Shu-Chuan Tsao, Hung-Pei Tsai, Jaw-Yuan Wang, and *Chee-Yin Chai( 蔡志仁 )(corresponding author). Serine protease inhibitor Kazal type 1 (SPINK1) as a prognostic marker in stage IV colon cancer patients receiving cetuximab based targeted therapy. J Clin Pathol 2016; 69: (SCI) 316(2016_14). Hsin-I Chen, Hung-Pei Tsai, Yi-Ting Chen, Shu-Chuan Tsao, and *Chee-Yin Chai( 蔡志仁 )(corresponding author). Autophagy and apoptosis play opposing roles in overall survival of esophageal squamous cell carcinoma. Pathol Oncol Res 2016; 22: (SCI) 317(2016_15). Kung-Kai Kuo, King-Teh Lee, Ker-Kong Chen, Ya-Han Yang, Ying-Chu Lin, Ming-Ho Tsai, Kenly Wuputra, Yen-Liang Lee, Chia-Chen Ku, Hiroyuki Miyoshi, Yukio Nakamura, Shigeo Saito, Chun-Chieh Wu, Chee-Yin Chai( 蔡志仁 ), Richard Eckner, Chen-Lung Steve Lin, Sophie S-W Wang, Deng-Chyang Wu, Chang-Shen Lin, and Kazunari K. Yokoyama. Positive feedback loop of OCT4 and c-jun expedites cancer stemness in liver Cancer. Stem Cells 2016;34: (SCI) 318(2016_16). Shen-Nien Wang, Li-Ting Wang, Ding-Ping Sun, Chee-Yin Chai( 蔡志仁 ), Edward Hsi, Hsing-Tao Kuo, Kazunari K. Yokoyama, and Shih-Hsien Hsu. Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC. Oncotarget 2016; 7: (SCI) 319(2016_17). Sophie SW Wang, Kenly Wuputra, Chung-Jung Liu, Yin-Chu Lin, Yi-Ting Chen, Chee-Yin Chai( 蔡志仁 ), Chen-Lung Steve Lin, Kung-Kai Kuo, Ming-Ho Tsai, Shin-Wei Wang, Ker-Kong Chen, Hiroyuki Miyoshi, Yukio Nakamura, 14

15 Shigeo Saito, Tadashi Hanafusa, Deng-Chyang Wu, Chang-Shen Lin, and Kazunari K Yokoyama. Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer. Oncotarget 2016; 7: (SCI) 320(2016_18). Bin-Nan Wu, Kung-Kai Kuo, Yu-Hsun Chen, Chain-Ting Chang, Hung-Tu Huang, Chee-Yin Chai( 蔡志仁 ), Zen-Kong Dai, and Ing-Jun Chen. Theophylline-Based KMUP-1 improves steatohepatitis via MMP-9/IL-10 and lipolysis via HSL/p-HSL in obese mice. Int J Mol Sci 2016; 17:1345; doi: /ijms (SCI) 321(2016_19). Chun-Chieh Wu, Sheau-Fang Yang, Wan-Tzu Chen, Hung-Pei Tsai, Chi-Wen Luo, Chee-Yin Chai( 蔡志仁 ), and Hsin Ling Yin. Absence of CD66a expression is associated with high microvessel density and high histologic grade in hepatocellular carcinoma. Kaohsiung J Med Sci 2016; 32: (SCI) 322(2016_20). Chieh-Hsin Wu, Chee-Yin Chai( 蔡志仁 ), Yi-Ching Tung, Ying-Yi Lu, Yu-Feng Su, Tai-Hsin Tsai, Rong-Dar Tzou, and Chih-Lung Lin. Herpes zoster as a risk factor for osteoporosis. A 15-year nationwide population-based study. Medicine (Baltimore) 2016; 95:e4024. (SCI) 323(2016_21). Chieh-Hsin Wu, Ying-Yi Lu, Chee-Yin Chai( 蔡志仁 ), Yu-Feng Su, Tai-Hsin Tsai, Feng-Ji Tsai, and Chih-Lung Lin. Increased risk of osteoporosis in patients with erectile dysfunction. A nationwide population-based cohort study. Medicine (Baltimore) 2016; 95:e3943. (SCI) 324(2016_22). Hsin-Ling Yin, Chi-Wen Luo, Zen-Kong Dai, Kai-Ping Shaw, Chee-Yin Chai( 蔡志仁 ), and Chun-Chieh Wu. Hypoxia-inducible factor-1a, vascular endothelial growth factor, inducible nitric oxide synthase, and endothelin-1 expression correlates with angiogenesis in congenital heart disease. Kaohsiung J Med Sci 2016; 32: (SCI) 325(2016_23). Hsin-Ling Yin, Chun-Chieh Wu, Chih-Hung Lin, Chee-Yin Chai( 蔡志仁 ), Ming-Feng Hou, Shu-Jyuan Chang, Hung-Pei Tsai Wen-Chun Hung, Mei-Ren Pan, and Chi-Wen Luo. Beta1 integrin as a prognostic and predictive marker in triple-negative breast cancer. Int J Mol Sci 2016; 17:1432; doi: /ijms (SCI) 15

16 326(2016_24).Chien-Hui Wen, Chih-Hung Lin, Pei-Ling Ko, Yu-Fen Kuo, Yan-Jun Chen, and *Chee-Yin Chai( 蔡志仁 )(corresponding author). Cell transfer technique for constructing cytological microarrays for immunocytochemical analysis. Cytopathology 2016; (SCI) (Accepted) 327(2016_25).Wei-Ting Liao, Jian-He Lu, Chih-Hung Lee, Cheng-Che E. Lan, Jan-Gowth Chang, Chee-Yin Chai( 蔡志仁 ), and Hsin-Su Yu. An interaction between arsenic-induced epigenetic modification and inflammatory promotion in a skin equivalent during arsenic carcinogenesis. J Invest Dermatol 2016; (SCI) (Accepted) 328(2016_26). Li-Ting Wang, Shyh-Shin Chiou, Chee-Yin Chai( 蔡志仁 ), Edward Hsi, Shen-Nien Wang, Shau-Ku Huang, and Shih-Hsien Hsu. Aryl hydrocarbon receptor regulates histone deacetylase 8 expression to repress tumor suppressive activity in hepatocellular carcinoma. Oncotarget 2016 (SCI) (Accepted) 329(2016_27). I-Chen Wu, Yu-Kuei Chen, Chun-Chieh Wu, Yu-Jen Cheng, Wei-Chung Chen, Huey-Jiun Ko, Yu-Peng Liu, Chee-Yin Chai( 蔡志仁 ), Hung-Shun Lin, Deng-Chyang Wu1, and Ming-Tsang Wu. Overexpression of ATPase Na+/K+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma. Oncotarget 2016 (SCI) (Accepted) 330(2016_28). Yi-Ting Chen, Chun-Chieh Wu, Xuan-Ping Liu, and *Chee-Yin Chai( 蔡志仁 )(corresponding author). Aberrant beta-catenin expression in urothelial carcinomas in blackfoot disease-endemic areas. Kaohsiung J Med Sci 2016; (SCI) (Accepted) * 通訊作者 (corresponding author) 16