ynthetic and Systems iology orum on Microbial Threats arch Stephen Albert Johnston
|
|
|
- Noreen Woods
- 6 years ago
- Views:
Transcription
1 ynthetic and Systems iology orum on Microbial Threats arch Stephen Albert Johnston
2 HTP Screening Systems Based on Synthetic Genes and Proteins Sequence Genes Proteins Modifications Omics Integration (Systems) Manipulation Synthetic / Systems Capabilities Useful Complexity of Useful Things Complexity of Life Product
3 Proteome Screening for 1 1 Vaccines n Genes Proteins n Addressable Array Pattern
4 Screening Sera on Proteome Arrays sera All Antibody Reactive Proteins Vaccine Candidates Organism % proteins on the array % Reactive Brucella melitensis % 0.92% Burkholderia pseudomallei % 14.11% Coxiella burnetii 83.99% 0.57% Coxiella burnetii (strain:nine mile- RSA493) 75.00% 2.21% Francisella tularensis(schus4) 100% 2.24% Mycobacterium tuberculosis (H37Ev) % 0.32% Plasmodium falciparum 43.49% 9.21% Plasmodium vivax 1.65% 0.33% Pseudomonas aeruginosa 4.37% 1.00% Vaccinia(Western Reserve strain) 94.17% 26.46% Varicella zoster (Chickenpox, Shingles) 94.52% 31.51%
5 But for T-cells IVT Genes Proteins 1704 Kathryn Sykes
6 T-cell Responses to the Proteome infect 1 T-cells Kathryn Sykes/Rick Lyons
7 Expression Library Immunization Challenge with Pathogen All Genes Kathryn Sykes/Linda Dixon
8 Parapox and B2L genes Genes 250 Kathryn Sykes Michael McGuire
9 B2L
10 B2L
11 Evolutionary Pharmaco Remediation History Now Inflammatory Aspirin Premise: Genes from 5 10k years ago are not right Cholesterol Statin Sex Viagra Innate Immunity B2WL
12 Synthetic / Systems Capabilities Sequence Genes Proteins Modifications Omics Integration (Systems) Manipulate Antibodies For Human Proteome $750M + 10 years
13 Progress Thru Chemistry Antibodies Backwards Protein Splenocytes Monoclonal αβ 3 months $3K Peptide 1 Peptide 2 Linker Array of Human Proteins Protein X Is the Ligand for Protein X 5 days $1K
14 AKT1 Synbody K D = 1.5 nm Binds AKT1 in presence of 2,500 times excess protein Selectively binds AKT1 vs AKT2 vs AKT3 Chris Deihnelt
15 Antibacterial/AntiViral Therapeutic Development Bacteria Or Virus Bind to 10,000 peptide library Select Binding or Lytic Peptides High affinity Synbody Domenyuk, V., et. al, manuscript in preparation. Chris Deihnelt Zhao Zhang Valeriy Domenyuk
16 ImmunoSignaturing * Antibod y Spot Fluor Subject 1 14
17 Arrays are 1x3 glass microscope slides printed in a two-up format Reproducibility = 0.96 to R 2 Detection limit = 1.12-fold Scatterplot shows distinction between 3 naïve and 3 infected mice.
18 Normal donors Valley Fever patients Flu vaccine recipients Day 21
19 Immmunosignatures Applied to Chronic Disease Normal Glioblastoma (untreated) Unsupervised Sorting Other Diseases Analyzed Alzheimer s Disease (Published) Diabetes, T1, T2 Lupus Pancreatitis Cancers Breast Lung Ovarian Pancreatic Panins Myeloma AUC = Phil Stafford Bart Legutki
20 Chip-based High Density Diversity Neal Woodbury J. Rajasekaran
21 Current 100k Peptide Chips/cm 2 15 features 3 features 100k random sequences, 12 amino acids long, 8 different amino acids 3/17/
22 Tiling the Human Pathogen Proteome on a Single Chip 1000 human pathogens represented Tiled peptides 1000 human pathogens represented Tiled Rapid peptides identification Rapid identification Possible support for vaccine Possible support for vaccine development Testing the level of vaccine immune Testing the level of vaccine immune response response tularemia flu anthrax small pox A potentially transformative platform for global biosurveillance 3/17/
23 Uses 1M+ elements / cm HTP production 1B Low Cost All Human Proteins Tiled as Peptides 10 8 ligands/chip: αβ on Chip All Human Pathogens Tiled as Peptides
24 Future is Bright HTP Genomics Proteomics Synthetic/ Systems Knowledge Useful Things Inventive HTP Assays Chemical Diversity
25 Credits Phil Stafford Chris Diehnelt Kathryn Sykes Zhao Zhang Bart Legutki George Poste Neal Woodbury
26 Cancer Leading Killer in US $250B / Year WHO: Worldwide Epidemic Pathogen Contribution Unknown
27 Prophylactic Cancer Vaccine to Prevent All Cancers
28 Tumor Sequencing Tumor # Normal DNA RNA Breast 17 Value Diagnostic Geevac 2 Knowledge
29 Complexity
30 Personal Therapeutic Vaccine Personal Vaccine HTP Sequencing of Tumor 1 week Neotumor Antigens Create Vaccine 2 days Requirements: Early Detection Sequence from Small Sample Time: short Expense: cheap
Synbodies as Anti- Infective Agents
Synbodies as Anti- Infective Agents MIPT Stephen Albert Johnston Center for Innovations in Medicine Current Center for Innovations in Medicine Projects OBJECTIVE INVENTION COMPANY Health Monitoring/ Immunosignatures
Immunosignatures: A Tool for Managing Disease
Immunosignatures: A Tool for Managing Disease Neal Woodbury and Stephen Albert Johnston Center for Innovations in Medicine The Biodesign Institute at Arizona State University 1 Contact Information Stephen
Screening donors and donations for transfusion transmissible infectious agents. Alan Kitchen
Screening donors and donations for transfusion transmissible infectious agents Alan Kitchen Aim Not to teach you microbiology To provide and awareness of the big picture To provide an understanding of
Combating Agent X: Accelerating Global Vaccine Production Against New Pandemic Threats
Combating Agent X: Accelerating Global Vaccine Production Against New Pandemic Threats Dr. George Poste Chief Scientist, Complex Adaptive Systems Initiative and Del E. Webb Chair in Health Innovation Arizona
Lecture 11. Immunology and disease: parasite antigenic diversity
Lecture 11 Immunology and disease: parasite antigenic diversity RNAi interference video and tutorial (you are responsible for this material, so check it out.) http://www.pbs.org/wgbh/nova/sciencenow/3210/02.html
Topic 7 - Commonality
II. Organism Topic 7 - Commonality From Viruses to Bacteria to Genetic Engineering Prebiotic Period Refers to before life Early Earth contained little O 2 O 2 prevents complex molecules Complex organic
Thank you for not chewing gum!
March 25 th, 2015 What do I need today? 1. Pencil 2. Science Notebook 3. Epidemiology note sheet Learning Target: Today we will continue to learn about the fascinating world of disease and epidemiology
Dr. Jim LeDuc Director Galveston National Laboratory University of Texas Medical Branch. 29 October 2015
National Academy of Sciences Committee on Federal Regulations and Reporting Requirements: A new framework for research universities in the 21 st Century Select Agents Dr. Jim LeDuc Director Galveston National
NIAID Oversight of Clinical Research and Funding Opportunities
NIAID Oversight of Clinical Research and Funding Opportunities The Fundamentals of International Clinical Research Workshop Dar es Salaam, Tanzania Polly R. Sager, Ph.D. Division of Microbiology and Infectious
Mount Sinai Medical Center Environmental Health & Safety (EnvHS)
Mount Sinai Medical Center Environmental Health & Safety (EnvHS) Chemical / Infectious / Biological and Radiological Materials Shipment Approval Form I. GENERAL INFORMATION Shipment Date Requestor s Name
Gene Vaccine Dr. Sina Soleimani
Gene Vaccine Dr. Sina Soleimani Human Viral Vaccines Quality Control Laboratory (HVVQC) Titles 1. A short Introduction of Vaccine History 2. First Lineage of Vaccines 3. Second Lineage of Vaccines 3. New
Study Guide 23, 24 & 47
Study Guide 23, 24 & 47 STUDY GUIDE SECTION 23-3 Bacteria and Humans Name Period Date 1. One bacterial disease that is transmitted by contaminated drinking water is a. Lyme disease b. gonorrhea c. tuberculosis
Bacterial Mechanisms of Pathogenicity. 2 nd Lecture
Bacterial Mechanisms of Pathogenicity 2 nd Lecture Preferred Portal of Entry Just because a pathogen enters your body it does not mean it s going to cause disease. pathogens - preferred portal of entry
NIAID Biodefense Research Agenda
NIAID Biodefense Research Agenda Deborah G. Katz, M.S., R.N. Deputy Director Office of Biodefense Research Affairs National Institute of Allergy and Infectious Diseases Princeton University September 8,
VACCINATION. DR.FATIMA ALKHALEDY M.B.Ch.B;F.I.C.M.S/C.M.
VACCINATION DR.FATIMA ALKHALEDY M.B.Ch.B;F.I.C.M.S/C.M. IMMUNIZATION Immunization is defined as the procedure by which the body is prepared to fight against a specific disease. It is used to induce the
Is there an allergy epidemic and what are the possible causes?
Is there an allergy epidemic and what are the possible causes? Professor Michael Gold Department of Allergy and Immunology Women s and Children s Health Network Discipline of Paediatrics University of
EVOLUTION: WHY DOES IT MATTER? What did evolution ever do for me?
EVOLUTION: WHY DOES IT MATTER? What did evolution ever do for me? www.christs.cam.ac.uk/darwin200 Evolution is change in living things through descent with modification Evolution is change in living things
STOP! These are some Symbols below that are Violations! PLEASE CHECK ALL SIX (6) SIDES OF YOUR BOX BEFORE SHIPPING
STOP! If you are reusing a box for shipping and the symbols below are printed ANYWHERE on the box Your AHDC label will be voided. Your package will be returned and you will be assessed a $50 shipping penalty
SCHEDULE 5 PATHOGENS AND TOXINS VIRUSES
10/2012 SCHEDULE 5 PATHOGENS AND TOXINS VIRUSES Chikungunya virus Congo- crimean haemorrhagic fever virus Dengue fever virus Dobrava/Belgrade virus Eastern equine encephalitis virus Ebola virus Everglades
Pneumonia Aetiology Why is it so difficult to distinguish pathogens from innocent bystanders?
Pneumonia Aetiology Why is it so difficult to distinguish pathogens from innocent bystanders? David Murdoch Department of Pathology University of Otago, Christchurch Outline Background Diagnostic challenges
Acute respiratory illness This is a disease that typically affects the airways in the nose and throat (the upper respiratory tract).
Influenza glossary Adapted from the Centers for Disease Control and Prevention, US https://www.cdc.gov/flu/glossary/index.htm and the World Health Organization http://www.wpro.who.int/emerging_diseases/glossary_rev_sept28.pdf?ua=1
Immune System. How your body goes to war to keep you well
Immune System How your body goes to war to keep you well WATCH OUT! Millions of bacteria and viruses are everywhere. Many aim to find a host and invade the body. HOW CAN WE DEFEND AGAINST IT? The Bad Guys
Emerging Viruses. Part IIb Follow Up from Part I Vaccines and Inhibitors
Emerging Viruses Part IIb Follow Up from Part I Vaccines and Inhibitors Cellular Responses to Viral Invasion: Restriction Factors Cells fight viral infection using a series of restriction factors Restriction
Overview: Chapter 19 Viruses: A Borrowed Life
Overview: Chapter 19 Viruses: A Borrowed Life Viruses called bacteriophages can infect and set in motion a genetic takeover of bacteria, such as Escherichia coli Viruses lead a kind of borrowed life between
Machine Learning For Personalized Cancer Vaccines. Alex Rubinsteyn February 9th, 2018 Data Science Salon Miami
Machine Learning For Personalized Cancer Vaccines Alex Rubinsteyn February 9th, 2018 Data Science Salon Miami OpenVax @ Mount Sinai Focus: personalized cancer vaccines Machine learning for immunology Cancer
Selectivity in Anti-infective Minor Groove Binders
Selectivity in Anti-infective Minor Groove Binders Colin J. Suckling 1, and Fraser J. Scott 2* 1 WestCHEM Research School, Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, Scotland.
Sample collection and shipping. disinfection
Sample collection and shipping Transport, biosafety and disinfection 2011 Learning objectives At the end of the presentation, participants should understand: d Principles of biosafety How to transport
Unit 5: The Kingdoms of Life Module 12: Simple Organisms
Unit 5: The Kingdoms of Life Module 12: Simple Organisms NC Essential Standard: 1.2.3 Explain how specific cell adaptations help cells survive in particular environments 2.1.2 Analyze how various organisms
Viral vaccines. Lec. 3 أ.د.فائزة عبد هللا مخلص
Lec. 3 أ.د.فائزة عبد هللا مخلص Viral vaccines 0bjectives 1-Define active immunity. 2-Describe the methods used for the preparation of attenuated live & killed virus vaccines. 3- Comparison of Characteristics
Infectious Material. hazmat.dot.gov/regs/rules.htm iata.org/dangerousgoods
Infectious Material Most medical specimens sent to an esoteric laboratory such as Mayo Medical Laboratories are flown on passenger aircraft or are carried by common air carrier such as FedEx. The International
Agents of Bioterrorism: Argument for and Against a List That Needs Cropping
Agents of Bioterrorism: Argument for and Against a List That Needs Cropping Bioterrorism Preparedness: A Conference for Senior Practitioners and Professionals Dr. Arnold N. Weinberg Professor of Medicine
3. Lymphocyte proliferation (fig. 15.4): Clones of responder cells and memory cells are derived from B cells and T cells.
Chapter 15 Adaptive, Specific Immunity and Immunization* *Lecture notes are to be used as a study guide only and do not represent the comprehensive information you will need to know for the exams. Specific
Integrative Healthcare Symposium 2010 Using Transfer Factor to Strengthen Cell-Mediated Immunity
Using Transfer Factor to Strengthen Cell-Mediated Immunity Presented by 1 Introduction 1949 NYU immunologist Dr. H. Sherwood Lawrence transferred immunity to tuberculosis (TB) Injected filtered leukocyte
Disease: any change, other than an injury, that disrupts homeostasis. Pathogen: disease-causing agent such as bacteria, virus, etc.
The Immune System Disease: any change, other than an injury, that disrupts homeostasis. Pathogen: disease-causing agent such as bacteria, virus, etc. Infectious disease- caused by pathogen Germ theory
Warm Up. What do you think the difference is between infectious and noninfectious disease?
Warm Up What do you think the difference is between infectious and noninfectious disease? Infectious Diseases Chapter 14 Lesson 1: Types of Infectious Disease Infectious Diseases An infectious disease
Bacterial outer membrane vesicles (OMVs)
Bacterial outer membrane vesicles (OMVs) PhD student: Wei TAN Supervisor: Prof. Guoping Zhao Deparment of Microbiology Faculty of Medicine The Chinese University of Hong Kong Date: 1 Dec 2016 Outline Introduction
CONVENTIONAL VACCINE DEVELOPMENT
CONVENTIONAL VACCINE DEVELOPMENT PROBLEM Lethal germ Dead mouse LIVE VACCINES Related but harmless germ gives protection against lethal pathogen. Examples are the original pox vaccine and some TB vaccines
SECTION 25-1 REVIEW STRUCTURE. 1. The diameter of viruses ranges from about a. 1 to 2 nm. b. 20 to 250 nm. c. 1 to 2 µm. d. 20 to 250 µm.
SECTION 25-1 REVIEW STRUCTURE VOCABULARY REVIEW Define the following terms. 1. virus 2. capsid 3. retrovirus 4. viroid 5. prion MULTIPLE CHOICE Write the correct letter in the blank. 1. The diameter of
Chapter 39 Viruses. Viruses are tiny. They are much smaller (50 times) than a bacterium.
Chapter 39 Viruses Viruses are tiny. They are much smaller (50 times) than a bacterium. They are not made of cellsand cannot reproduceon their own. Therefore they are not alive according to our rules.
How to Spot a Virus. The origins of an immune response. Kevin Bonham Sky Brubaker Jillian Astarita
How to Spot a Virus The origins of an immune response Kevin Bonham Sky Brubaker Jillian Astarita Outline for the Evening Kevin Bonham The eyes of the immune system Sky Brubaker Different Responses for
The Crossroads of Immunology and Homeopathy. Tetyana Obukhanych, PhD HP Worldwide Choice Conference, 2016
The Crossroads of Immunology and Homeopathy Tetyana Obukhanych, PhD HP Worldwide Choice Conference, 2016 1 Conventional View of Immunity Immune system => resolution of infection Immunity = protection from
Discovery of. 1892: Russian biologist Dmitri Ivanovsky publishes. 1931: first images of viruses obtained using
Discovery of (1884: invention of the Chamberland filter with pores smaller than bacteria) 1892: Russian biologist Dmitri Ivanovsky publishes a paper in which shows that extracts from diseased tobacco plants
Regulations. Bloodborne Pathogens. Applicability. Biological Agents and Blood borne Pathogens
Regulations Biological Agents and Blood borne Pathogens OSHA 29CFR1910.1030 (1989 2004) Exposure to blood and blood products and other potentially infectious material (OPIM) Definition of OPIM-human body
Trends in vaccinology
Trends in vaccinology Mathieu Peeters, MD Joint Conference of European Human Pharmacological Societies and Joint Conference of European Human Pharmacological Societies and 20th Anniversary of AGAH March
Epitope discovery. Using predicted MHC binding CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS
Epitope discovery Using predicted MHC binding SARS corona virus The 2003 outbreak The disease Lung Pathology Inflammatory exudation in alveoli and interstitial spaces Monocytic and lymphocytic infiltration
National Institute of Allergy and Infectious Diseases Biodefense Research Agenda for NIAID Category B and C Priority Pathogens.
National Institute of Allergy and Infectious Diseases Biodefense Research Agenda for NIAID Category B and C Priority Pathogens Progress Report TABLE OF CONTENTS Introduction 1 Progress on General Recommendations
(b) Describe the role of antigen presentation in the body s specific immune response to infection by viruses. (4)
1 The human body responds to infection by viruses in a number of ways. The non-specific response involves interferon. The specific immune response requires antigen presentation to the cells of the immune
Viral Diseases. Question: 5/17/2011
Viral Diseases Question: What is the likely reason for the dramatic increase in deaths due to heart disease and cancer in 1997 compared to 1900? 1. poor lifestyle choices (high fat diets, smoking, lack
Institutional Laboratory Biosafety Manual
Appendix B. Select Agents and Toxins The Centers for Disease Control and Prevention (CDC) and the Animal and Plant Health Inspection Service (APHIS) oversee the possession, use and transfer of select agents
T-cell activation T cells migrate to secondary lymphoid tissues where they interact with antigen, antigen-presenting cells, and other lymphocytes:
Interactions between innate immunity & adaptive immunity What happens to T cells after they leave the thymus? Naïve T cells exit the thymus and enter the bloodstream. If they remain in the bloodstream,
T-cell activation T cells migrate to secondary lymphoid tissues where they interact with antigen, antigen-presenting cells, and other lymphocytes:
Interactions between innate immunity & adaptive immunity What happens to T cells after they leave the thymus? Naïve T cells exit the thymus and enter the bloodstream. If they remain in the bloodstream,
John Bell Centre for Innovative Cancer Therapeutics
Enhancing Oncolytic Virus Activity by Engineering of Artificial micrornas John Bell Centre for Innovative Cancer Therapeutics Affiliated with Affilié à 1 Oncolytic Viruses: A Therapy for Metastatic Cancers?
Human Services Child Development Multiple Choice Science Assessment Questions
Human Services Multiple Choice Science Assessment Questions All science problems address TEKS 130.247.. (3) The student investigates strategies for optimizing the development of infants of diverse backgrounds,
Flu adenovirus h1n1 h3n2 h5n1 ah1n1
Influenza influenza Flu adenovirus h1n1 h3n2 h5n1 ah1n1 Gastroenteritis Gastroenteritis stomach flu gastroenteritides gastroenterities food poisoning campylobacter colitis gastroenterocolitis gastrointestinal
Guidance on regulations for the Transport of Infectious Substances
Guidance on regulations for the Transport of Infectious Substances 2013-2014 1 - 2 3 GMOs GMMOs B B 4 P620 P650 5 )WHO( )document WHO/CDS/IHR/2010.8( 6 )UNCETDG( )modal( ICO )DGR( )ICO( )IT( ICO ICO IT
Lichenase: a versatile, stable carrier molecule for vaccine and reagent development
Lichenase: a versatile, stable carrier molecule for vaccine and reagent development R. Mark Jones Center for Molecular Biotechnology, Fraunhofer USA New Cells, New Vaccines VII, From Protein to Product
Vaccine Design: A Statisticans Overview
GoBack : A Statisticans Overview. Surajit Ray sray@samsi.info Surajit Ray Samsi PostDoc Seminar: Nov 2: 2004 - slide #1 The Chinese are credited with making the observation that deliberately infecting
Chapter 17 Reading guide
Chapter 17 Reading guide 1. Define pathogen, epidemic, pandemic, virulence, direct contact, indirect contact, autoinoculate. 2. Describe several risk factors for disease which you can not control. 3. Describe
answer Marks Guidance 1 (a) 2 max Mark the first answer on each prompt line. ACCEPT ora throughout nucleus / nuclei ; 1 ACCEPT DNA not free
Question answer Marks Guidance 1 (a) max Mark the first answer on each prompt line. ACCEPT ora throughout 1 6 7 nucleus / nuclei ; other named organelle / membrane bound organelles ; linear chromosomes
THE UNIVERSITY OF MISSISSIPPI LABORATORY SERVICES Phone (662) FAX (662)
THE UNIVERSITY OF MISSISSIPPI LABORATORY SERVICES Phone (662) 915-5433 FAX (662) 915-5480 CONSIGNMENT OF DIAGNOSTIC SPECIMENS The following note was developed by ICAO and issued 20th December 2002. The
TECHNICAL INSTRUCTIONS FOR THE SAFE TRANSPORT OF DANGEROUS GOODS BY AIR
Doc 9284-AN/905 2005-2006 Edition ADDENDUM../02/05 INTERNATIONAL CIVIL AVIATION ORGANIZATION TECHNICAL INSTRUCTIONS FOR THE SAFE TRANSPORT OF DANGEROUS GOODS BY AIR 2005-2006 EDITION ADDENDUM The attached
Antigen Presentation to T lymphocytes
Antigen Presentation to T lymphocytes Immunology 441 Lectures 6 & 7 Chapter 6 October 10 & 12, 2016 Jessica Hamerman jhamerman@benaroyaresearch.org Office hours by arrangement Antigen processing: How are
Satora Sera rei tat. Disease Cards - Cut Along the Dotted Lines You Make Me Sick!
Satora Sera rei tat 1 2 3 Common Cold The common cold is caused by a virus. What is a virus? 50 Common Cold The virus that causes the common cold infects the lungs. What are the symptoms of a cold? 50
ZOSTAVAX Zoster Virus Vaccine Live (Oka/Merck), Refrigerator Stable.
ZOSTAVAX Zoster Virus Vaccine Live (Oka/Merck), Refrigerator Stable. Consumer Medicine Information What is in this leaflet This leaflet answers some common questions about ZOSTAVAX. It does not contain
B. Incorrect! Hypodermis is not part of the skin and lays under the dermis. D. Correct! The epidermis is the outermost region of the skin.
Microbiology - Problem Drill 17: Microbial Infections of the Skin and Eye No. 1 of 10 1. What is the name of the most external region of the skin? (A) Dermis (B) Hypodermis (C) Hyperdermis (D) Epidermis
Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION
Scott Abrams, Ph.D. Professor of Oncology, x4375 scott.abrams@roswellpark.org Kuby Immunology SEVENTH EDITION CHAPTER 13 Effector Responses: Cell- and Antibody-Mediated Immunity Copyright 2013 by W. H.
Class 2: Acquired immunity and vaccination (part 1)
Class 2: Acquired immunity and vaccination (part 1) Ed Ishiguro Department of Biochemistry and Microbiology And The UVic Speakers Bureau ishiguro@uvic.ca A quick summary Main properties of innate and acquired
TAKEDA VACCINES INNOVATION FOR GLOBAL IMPACT. RAJEEV VENKAYYA, MD President, Global Vaccine Business Unit
TAKEDA VACCINES INNOVATION FOR GLOBAL IMPACT RAJEEV VENKAYYA, MD President, Global Vaccine Business Unit OUR MISSION Develop and deliver innovative vaccines that tackle the toughest problems in public
2.1 VIRUSES. 2.1 Learning Goals
2.1 VIRUSES 2.1 Learning Goals To understand the structure, function, and how Viruses replicate To understand the difference between Viruses to Prokaryotes and Eukaryotes; namely that viruses are not classified
IMMUNOLOGICAL MEMORY. CD4 T Follicular Helper Cells. Memory CD8 T Cell Differentiation
IMMUNOLOGICAL MEMORY CD4 T Follicular Helper Cells Memory CD8 T Cell Differentiation CD4 T Cell Differentiation Bcl-6 T-bet GATA-3 ROR t Foxp3 CD4 T follicular helper (Tfh) cells FUNCTION Provide essential
Name Class Date. Infection in which a virus inserts its nucleic acid into the DNA of the host cell and is duplicated with the cell s DNA
Name Class Date 20.1 Viruses Lesson Objectives Explain how viruses reproduce. Explain how viruses cause infection. BUILD Vocabulary A. The chart below shows key terms from the lesson with their definitions.
University of Hawaii Biosafety Program Laboratory Inventory and Declaration Form
ANNUAL MICROORGANISM INVENTORY DECLARATION FORM (Part A) The principal investigator for each laboratory working with microorganisms, including select agent toxins must complete this form on an annual basis.
Antibacterials and Antivirals
Structure of a Bacterium: Antibacterials and Antivirals Capsule: protective layer made up of proteins, sugars and lipids Cell wall: provides the bacteria with its shape and structure Cell membrane: permeable
Intercell and Novartis form world leading strategic partnership to drive vaccines innovation
Intercell and Novartis form world leading strategic partnership to drive vaccines innovation Alliance creates opportunity for two strong innovators to combine development efforts in attractive areas Intercell
Unit 4 Student Guided Notes
Structure of Viruses Discovery of the Virus Unit 4 Student Guided Notes Many human epidemics were well documented and observed in history, but. The following 3 discoveries shaped our knowledge of viruses
LECTURE OUTLINE. B. AGENT: Varicella-zoster virus. Human herpes virus 3. DNA virus.
Viral Vaccines II LECTURE OUTLINE 5/24/04 I. CASE HISTORY A 5-year old comes home from school with a red skin rash on his chest that spreads to over 300 itchy blisters that spread further to his face,
Potential cross reactions between HIV 1 specific T cells and the microbiome. Andrew McMichael Suzanne Campion
Potential cross reactions between HIV 1 specific T cells and the microbiome Andrew McMichael Suzanne Campion Role of the Microbiome? T cell (and B cell) immune responses to HIV and Vaccines are influenced
Viral genome sequencing: applications to clinical management and public health. Professor Judy Breuer
Viral genome sequencing: applications to clinical management and public health Professor Judy Breuer Why do whole viral genome sequencing Genome sequencing allows detection of multigenic resistance in
Potential etiologies of infection in these patients are diverse, including common and uncommon opportunistic infections.
In the name of God Principles of post Tx infections 1: Potential etiologies of infection in these patients are diverse, including common and uncommon opportunistic infections. Infection processes can progress
Bacteriophage Reproduction
Bacteriophage Reproduction Lytic and Lysogenic Cycles The following information is taken from: http://student.ccbcmd.edu/courses/bio141/lecguide/unit3/index.html#charvir Bacteriophage Structure More complex
Herpes And Papilloma Viruses
Herpes And Papilloma Viruses 1 / 6 2 / 6 3 / 6 Herpes And Papilloma Viruses Herpesviridae is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members
Unit 13.2: Viruses. Vocabulary capsid latency vaccine virion
Unit 13.2: Viruses Lesson Objectives Describe the structure of viruses. Outline the discovery and origins of viruses. Explain how viruses replicate. Explain how viruses cause human disease. Describe how
The chemical fate of biological pollutants in treatment processes
The chemical fate of biological pollutants in treatment processes http://pubs.rsc.org/en/content/articlehtml/2011/sm/c1sm060 92a http://www.epa.gov/nerlcwww/polio.htm Source: Centers for Disease Control
PART A. True/False. Indicate in the space whether each of the following statements are true or false.
MCB 55 Plagues and Pandemics Midterm I Practice questions Read each question carefully. All the questions can be answered briefly, in the space allotted. PART A. True/False. Indicate in the space whether
Yorkhill Laboratories Policy for the Packaging and Transport of Biological Samples (sent from laboratories) H&S/Doc/07. Yorkhill Hospitals
Management Procedure Packaging and Transport of This document together with Standard Operating Procedures, instruction manuals, etc, forms part of, and is representative of the Quality Management System
Nanoparticulate Vaccine Design: The VesiVax System
Nanoparticulate Vaccine Design: The VesiVax System Gary Fujii, Ph.D. President and CEO Molecular Express, Inc. May 16, 2006 Orlando, Florida Influenza Each year up to 20% of the world's population contracts
Nature Immunology: doi: /ni Supplementary Figure 1. Gene expression profile of CD4 + T cells and CTL responses in Bcl6-deficient mice.
Supplementary Figure 1 Gene expression profile of CD4 + T cells and CTL responses in Bcl6-deficient mice. (a) Gene expression profile in the resting CD4 + T cells were analyzed by an Affymetrix microarray
BIOLOGICAL DIVERSITY: VIRUSES
BIOLOGICAL DIVERSITY: VIRUSES Viruses: a Group of Intracellular Parasites In the 19th century, many rabies cases plagued Europe. In London, for example, 29 deaths by "hydrophobia" were enumerated in the
VACCINATIONS AND INFLAMMATORY BOWEL DISEASE
VACCINATIONS AND INFLAMMATORY BOWEL DISEASE Bob Kizer MD Assistant Professor of Medicine Creighton University School of Medicine CONFLICTS OF INTEREST None 1 AN OPPORTUNITY FOR IMPROVEMENT IBD patients
SCIENCE WEBINAR. Autoantibody Biomarkers for Cancer and Autoimmune Disease. Eng M Tan, M. D. The Scripps Research Institute La Jolla, California
SCIENCE WEBINAR Autoantibody Biomarkers for Cancer and Autoimmune Disease Eng M Tan, M. D. The Scripps Research Institute La Jolla, California Systemic Lupus Erythematosus The Prototype Autoimmune Disease
19 2 Viruses Slide 1 of 34
1 of 34 What Is a Virus? What Is a Virus? Viruses are particles of nucleic acid, protein, and in some cases, lipids. Viruses can reproduce only by infecting living cells. 2 of 34 What Is a Virus? Viruses
Chapter 40 Section 2 The Immune System
Chapter 40 Section 2 The Immune System Science Standard 10a What is the role of the skin in providing nonspecific defenses against infection? What is the function of the immune system? The immune system
MICROBIOLOGY - An Overview
MICROBIOLOGY - An Overview Hieucam Phan, MD Pediatrics St. Luke s Hospital San Francisco, CA Microbiology 6/01 1 Introduction Major Achievements of Medical Sciences in the 20th Century Microbiology DNA
Biodefense / Human Threats and Mass Spectrometry Applications. German Henostroza MD Division of Infectious Diseases and International Medicine
Biodefense / Human Threats and Mass Spectrometry Applications German Henostroza MD Division of Infectious Diseases and International Medicine SARS(Severe Acute Respiratory Syndrome) Colera Colera Gram
Shingles vaccination for those aged 70 to 79
Shingles vaccination for those aged 70 to 79 Shingles affects a lot of people as they get older. It often causes severe pain which can last for months or sometimes years. Shingles is more common and more
Ethic Problems Related to the Microorganisms
"Bioethics in Life and Environmental Sciences" Lublin 22 March 05 April 2009 Ethic Problems Related to the Microorganisms Prof. Iskra Ivanova Sofia University St. Kliment Ohridski Faculty of Biology, Department
Physiology Unit 3. ADAPTIVE IMMUNITY The Specific Immune Response
Physiology Unit 3 ADAPTIVE IMMUNITY The Specific Immune Response In Physiology Today The Adaptive Arm of the Immune System Specific Immune Response Internal defense against a specific pathogen Acquired
Infectious Diseases Affecting the Cardiovascular and Lymphatic Systems
Infectious Diseases Affecting the Cardiovascular and Lymphatic Systems 1 Defenses Cardiovascular system Lymphatic system Protection 2 Cardiovascular system Blood vessels Arteries, capillaries, and veins
Fighting the superbugs turning the tide of antimicrobial resistance
Fighting the superbugs turning the tide of antimicrobial resistance Human mortality burden AVIAN FLU H5N1 449 ANTIBIOTIC RESISTANCE > 500.000 EBOLA 11,298 SWINE FLU H1N1 284.000 AMR is a costly and ticking
VACCINE ENGINEERING Dr.T.V.Rao MD
VACCINE ENGINEERING Dr.T.V.Rao MD DR.T.V.RAO MD 1 HISTORICAL PICTURE OF VACCINATION DR.T.V.RAO MD 2 WHAT IS A VACCINE A vaccine is any preparation intended to produce immunity to a disease by stimulating