Test Bank for Robbins and Cotran Pathologic Basis of Disease 9th Edition by Kumar

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Test Bank for Robbins and Cotran Pathologic Basis of Disease 9th Edition by Kumar"

Transcription

1 Link full download: Test Bank for Robbins and Cotran Pathologic Basis of Disease 9th Edition by Kumar Chapter 07: Neoplasia Test Bank MULTIPLE CHOICE 1. Which of the following tumors occurs most often in the ovary? 2. Chondroma 3. Hemangioma 4. Leiomyoma 5. Transitional cell papilloma 6. Cystadenoma ANS: E, Cystadenomas, which may contain serous fluid or mucin and are thus called serous or mucinous cystadenomas, are typically found in the ovary. These benign tumors have malignant counterparts known as cystadenocarcinomas. 2. Which one of the following carcinomas is locally invasive but rarely forms metastases in lymph nodes and distant sites? 3. Basal cell carcinoma of the skin 4. Squamous cell carcinoma of the skin 5. Oat cell carcinoma of the lung 6. Transitional cell carcinoma of the urinary bladder 7. Adenocarcinoma of the stomach ANS: A, Basal cell carcinomas of the skin, the most common malignant tumor in the human body, is a locally invasive malignant tumor, which, if untreated, could

2 ultimately kill the host. However, these tumors are usually diagnosed early and removed adequately, so that they almost never metastasize. 3. Pseudomyxoma peritonei is a complication of which tumor? 4. Serous cystadenoma of the ovary 5. Mucinous cystadenoma of the ovary 6. Ovarian fibroma 7. Myxoma of the heart 8. Myxosarcoma of the lower extremity ANS: B, Pseudomyxoma of the ovary usually results from peritoneal seeding of mucin-secreting tumors of the ovary or the gastrointestinal tract, and most often the appendix. Although the ovarian tumor is benign, the implants of the tumor cells seeding the peritoneal cavity can be difficult to eradicate. The cells continue to secrete mucin and fill the abdominal cavity, colloquially known as jelly-belly. 4. Which mechanism affecting the genes or chromosomes accounts for the activation of the c-myc protooncogene in Burkitt lymphoma cells? 5. Overexpression 6. Amplification 7. Point mutation 8. Translocation 9. Inactivation of its promotor ANS: D, Translocation of the c-myc protooncogene from its normal site on chromosome 8 to chromosome 14 results in the formation of the myc oncogene and plays a major role in the pathogenesis of Burkitt lymphoma. 5. Homogeneous staining regions (HSR) of chromosome 2p, the site of the N- myc gene, are adverse prognostic signs if found in neuroblastoma cells. HRS are evidence of gene 6. deletion 7. amplification

3 8. point mutation 9. translocation 10. inversion ANS: B, Homogeneous staining regions and double minutes are signs of gene amplification. Amplification of the N-myc oncogene in neuroblastoma cells is a poor prognostic finding. 6. In which cell function is BRCA1, a gene mutated in women with familial breast carcinoma, involved? 7. Cell adhesion 8. Growth inhibition 9. Signal transduction 10. Cell surface channel 11. Transcriptional regulation and DNA repair ANS: E, BRCA1 and BRCA2 are tumor suppressor genes whose true function has not been fully elucidated. It is thought that they participate in the transcriptional regulation and interact with proteins that regulate double-strand DNA repair. 7. Germ line mutation of E-cadherin is found in familial cases of 8. lymphoblastic lymphoma 9. Ewing sarcoma 10. neuroblastoma 11. gastric carcinoma 12. seminoma ANS: D, E-cadherin is a cell-to-cell adhesion molecule that serves to hold many epithelial cells together. This surface adhesion molecule is often lost in adenocarcinomas, accounting for the invasive growth of these neoplasms. Germ line mutation of the E-cadherin gene has been found in families with gastric carcinoma.

4 8. Germ line mutation of the Von Hippel Lindau (VHL) gene is associated with formation of retinal angiomas and 9. glioblastoma multiforme 10. oligodendroglioma 11. neurinomas 12. ependymomas 13. cerebellar hemangioblastomas ANS: E, Von Hippel Lindau syndrome was originally described as a syndrome comprising angiomas of the retina and hemangioblastomas of the cerebellum. It is linked to the germ line mutation of the VHL tumor suppressor gene. These patients are at risk of developing renal cell carcinoma and pheochromocytomas. Mutations of the VHL gene also have been found in sporadic renal carcinomas unrelated to Von Hippel Lindau syndrome. 9. Microsatellite instability, a marker of DNA mismatch repair, is typically found in 10. hereditary nonpolyposis colon cancer 11. familial adenomatous polyposis coli 12. T-cell lymphoma 13. B-cell lymphoma 14. myelogenous leukemia ANS: A, Mutations of human DNA mismatch repair genes play a pathogenetic role in the development of colonic cancers in families with hereditary nonpolyposis colon cancer (HNPCC). Due to the error in mismatch repair, the microsatellite sequences (normally fixed for life and the same in every tissue) expand. They account for the microsatellite instability, a hallmark of all conditions with defective DNA mismatch repair. 10. Matrix metalloproteinases secreted by tumor cells are important for which feature of malignant tumors? 11. Desmoplasia 12. Anaplasia 13. Invasiveness

5 14. Apoptosis 15. Differentiation ANS: C, Matrix metalloproteinases, such as type IV collagenase, are important for the invasive growth of tumor cells. These enzymes degrade the basement membranes and the extracellular matrix, allowing the tumor cells to penetrate into the tissues, lymphatics, and blood vessels. 11. Which enzymes in the liver account for the activation of most procarcinogens into carcinogens? 12. Cytochrome P-450-dependent mono-oxidases 13. Aminotransferases 14. Hydroxylases 15. Glutathione dehydrogenase 16. Caspases ANS: A, Most of the exogenous procarcinogens are activated into carcinogens in the liver through the action of microsomal cytochrome P-450 dependent monooxidases found in the smooth endoplasmic reticulum of hepatocytes. Susceptibility to carcinogens is in part determined by the polymorphism of genes that encode these enzymes. 12. Which is the most common radiation-induced cancer in humans? 13. Thyroid cancer 14. Chronic lymphocytic leukemia 15. Breast cancer 16. Lung cancer 17. Salivary gland carcinoma ANS: B, Leukemias represent the most common radiation-induced cancer in humans, closely followed by thyroid cancer, which is the most common malignancy in young persons.

6 13. Helicobacter pylori infection predisposes to formation of gastric tumors, but the association between the bacterial infection and a gastric tumor is the strongest for 14. adenocarcinoma of the stomach 15. gastrointestinal stromal tumors 16. marginal zone lymphomas 17. T-cell lymphoma 18. Burkitt lymphoma ANS: C, The best and strongest evidence links Helicobacter pylori infection with the onset of mucosa-associated B-cell lymphomas (MALTomas) of the stomach, which are also known as marginal zone lymphomas. It is thought that H. pylori activates T cells, which in turn promote polyclonal proliferation of B cells in the gastric mucosa. In this process, some cells obviously become malignant and give rise to T-cell independent low-grade monoclonal lymphomas. 14. Clubbing of the digits, periosteal new bone formation on the metatarsals, metacarpals, and proximal phalanges, and arthritis of adjacent joints is a paraneoplastic syndrome most often associated with carcinoma of the 15. thyroid 16. larynx 17. bronchi 18. liver 19. stomach ANS: C, Clubbing of the fingers and related bone and joint changes of the hand and fingers are signs of hypertrophic osteoarthropathy, which most often occurs in patients with bronchogenic carcinoma. The pathogenesis of these changes is not known. Robbins and Cotran Pathologic Basis of Disease: 9th Edition Test Bank Kumar

Neoplasia literally means "new growth.

Neoplasia literally means new growth. NEOPLASIA Neoplasia literally means "new growth. A neoplasm, defined as "an abnormal mass of tissue the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the

More information

Dr Rodney Itaki Lecturer Anatomical Pathology Discipline. University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology

Dr Rodney Itaki Lecturer Anatomical Pathology Discipline. University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology Neoplasia Dr Rodney Itaki Lecturer Anatomical Pathology Discipline University of Papua New Guinea School of Medicine & Health Sciences Division of Pathology General Considerations Overview: Neoplasia uncontrolled,

More information

TUMOR M ARKERS MARKERS

TUMOR M ARKERS MARKERS TUMOR MARKERS M.Shekarabi IUMS Definition Many cancers are associated with the abnormal production of some molecules l which h can be measured in plasma. These molecules are known as tumor markers. A good

More information

Chapter 9, Part 1: Biology of Cancer and Tumor Spread

Chapter 9, Part 1: Biology of Cancer and Tumor Spread PATHOPHYSIOLOGY Name Chapter 9, Part 1: Biology of Cancer and Tumor Spread I. Cancer Characteristics and Terminology Neoplasm new growth, involves the overgrowth of tissue to form a neoplastic mass (tumor).

More information

NEOPLASIA! Terminology and Classification of Neoplastic cells! Asst. Prof. Prasit Suwannalert, Ph.D. Objectives:

NEOPLASIA! Terminology and Classification of Neoplastic cells! Asst. Prof. Prasit Suwannalert, Ph.D. Objectives: NEOPLASIA! Asst. Prof. Prasit Suwannalert, Ph.D. (SCPA 202: Feb 20, 2018) (Email: prasit.suw@mahidol.ac.th)! Department of Pathobiology Faculty of Science, Mahidol University! 1! Topic: Neoplasia Lecturer

More information

oncogenes-and- tumour-suppressor-genes)

oncogenes-and- tumour-suppressor-genes) Special topics in tumor biochemistry oncogenes-and- tumour-suppressor-genes) Speaker: Prof. Jiunn-Jye Chuu E-Mail: jjchuu@mail.stust.edu.tw Genetic Basis of Cancer Cancer-causing mutations Disease of aging

More information

Cancer genetics

Cancer genetics Cancer genetics General information about tumorogenesis. Cancer induced by viruses. The role of somatic mutations in cancer production. Oncogenes and Tumor Suppressor Genes (TSG). Hereditary cancer. 1

More information

Section D: The Molecular Biology of Cancer

Section D: The Molecular Biology of Cancer CHAPTER 19 THE ORGANIZATION AND CONTROL OF EUKARYOTIC GENOMES Section D: The Molecular Biology of Cancer 1. Cancer results from genetic changes that affect the cell cycle 2. Oncogene proteins and faulty

More information

Section D. Genes whose Mutation can lead to Initiation

Section D. Genes whose Mutation can lead to Initiation This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this

More information

American Society of Cytopathology Core Curriculum in Molecular Biology

American Society of Cytopathology Core Curriculum in Molecular Biology American Society of Cytopathology Core Curriculum in Molecular Biology American Society of Cytopathology Core Curriculum in Molecular Biology Chapter 1 Molecular Basis of Cancer Molecular Oncology Keisha

More information

Histopathology: Colorectal polyps and carcinoma

Histopathology: Colorectal polyps and carcinoma Histopathology: Colorectal polyps and carcinoma These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual

More information

Karyotype analysis reveals transloction of chromosome 22 to 9 in CML chronic myelogenous leukemia has fusion protein Bcr-Abl

Karyotype analysis reveals transloction of chromosome 22 to 9 in CML chronic myelogenous leukemia has fusion protein Bcr-Abl Chapt. 18 Cancer Molecular Biology of Cancer Student Learning Outcomes: Describe cancer diseases in which cells no longer respond Describe how cancers come from genomic mutations (inherited or somatic)

More information

Neoplasia part I. Dr. Mohsen Dashti. Clinical Medicine & Pathology nd Lecture

Neoplasia part I. Dr. Mohsen Dashti. Clinical Medicine & Pathology nd Lecture Neoplasia part I By Dr. Mohsen Dashti Clinical Medicine & Pathology 316 2 nd Lecture Lecture outline Review of structure & function. Basic definitions. Classification of neoplasms. Morphologic features.

More information

Lecture 8 Neoplasia II. Dr. Nabila Hamdi MD, PhD

Lecture 8 Neoplasia II. Dr. Nabila Hamdi MD, PhD Lecture 8 Neoplasia II Dr. Nabila Hamdi MD, PhD ILOs Understand the definition of neoplasia. List the classification of neoplasia. Describe the general characters of benign tumors. Understand the nomenclature

More information

Mohammed El-Khateeb. Tumor Genetics. MGL-12 July 21 st 2013 台大農藝系遺傳學 Chapter 22 slide 1

Mohammed El-Khateeb. Tumor Genetics. MGL-12 July 21 st 2013 台大農藝系遺傳學 Chapter 22 slide 1 Mohammed El-Khateeb Tumor Genetics MGL-12 July 21 st 2013 台大農藝系遺傳學 601 20000 Chapter 22 slide 1 Cellular Basis of Cancer Cancer is a collection of diseases characterized by abnormal and uncontrolled growth

More information

Early Embryonic Development

Early Embryonic Development Early Embryonic Development Maternal effect gene products set the stage by controlling the expression of the first embryonic genes. 1. Transcription factors 2. Receptors 3. Regulatory proteins Maternal

More information

- Ovarian cancer accounts for 3% of all cancers in females - About 80% of ovarian tumors are benign, and these occur mostly in young women between

- Ovarian cancer accounts for 3% of all cancers in females - About 80% of ovarian tumors are benign, and these occur mostly in young women between Ovarian Tumors - Ovarian cancer accounts for 3% of all cancers in females - About 80% of ovarian tumors are benign, and these occur mostly in young women between the ages of 20 and 45 years and may be

More information

3 cell types in the normal ovary

3 cell types in the normal ovary Ovarian tumors 3 cell types in the normal ovary Surface (coelomic epithelium) the origin of the great majority of ovarian tumors 90% of malignant ovarian tumors Totipotent germ cells Sex cord-stromal cells

More information

Biochemistry of Cancer and Tumor Markers

Biochemistry of Cancer and Tumor Markers Biochemistry of Cancer and Tumor Markers The term cancer applies to a group of diseases in which cells grow abnormally and form a malignant tumor. It is a long term multistage genetic process. The first

More information

Cancer Fundamentals. Julie Randolph-Habecker, Ph.D. Director, Experimental Histopathology Shared Resource

Cancer Fundamentals. Julie Randolph-Habecker, Ph.D. Director, Experimental Histopathology Shared Resource Cancer Fundamentals Julie Randolph-Habecker, Ph.D. Director, Experimental Histopathology Shared Resource Cancer Overview Leading cause of death in US 1.2 million diagnosed each year More common after age

More information

Colonic Polyp. Najmeh Aletaha. MD

Colonic Polyp. Najmeh Aletaha. MD Colonic Polyp Najmeh Aletaha. MD 1 Polyps & classification 2 Colorectal cancer risk factors 3 Pathogenesis 4 Surveillance polyp of the colon refers to a protuberance into the lumen above the surrounding

More information

Oncology 101. Cancer Basics

Oncology 101. Cancer Basics Oncology 101 Cancer Basics What Will You Learn? What is Cancer and How Does It Develop? Cancer Diagnosis and Staging Cancer Treatment What is Cancer? Cancer is a group of more than 100 different diseases

More information

SCOPE OF PRACTICE PGY-5

SCOPE OF PRACTICE PGY-5 Recognize normal cytomorphology of cells derived from the respiratory, gastrointestinal, and genitourinary tracts, and body fluid (Cerebrospinal fluid, pleural and peritoneal fluid) Recognize normal cytomorphology

More information

Cancer. The fundamental defect is. unregulated cell division. Properties of Cancerous Cells. Causes of Cancer. Altered growth and proliferation

Cancer. The fundamental defect is. unregulated cell division. Properties of Cancerous Cells. Causes of Cancer. Altered growth and proliferation Cancer The fundamental defect is unregulated cell division. Properties of Cancerous Cells Altered growth and proliferation Loss of growth factor dependence Loss of contact inhibition Immortalization Alterated

More information

CARCINOGENESIS THE MOLECULAR BASIS OF CANCER

CARCINOGENESIS THE MOLECULAR BASIS OF CANCER CARCINOGENESIS THE MOLECULAR BASIS OF CANCER We know that cancer is a genetic disease and that it is a multi-step process, therefore multiple genetic events (mutations) will occur in tumors. Given that

More information

Bihong Zhao, M.D, Ph.D Department of Pathology

Bihong Zhao, M.D, Ph.D Department of Pathology Bihong Zhao, M.D, Ph.D Department of Pathology 04-28-2009 Is tumor self or non-self? How are tumor antigens generated? What are they? How does immune system respond? Introduction Tumor Antigens/Categories

More information

Chapter 4 Cellular Oncogenes ~ 4.6 -

Chapter 4 Cellular Oncogenes ~ 4.6 - Chapter 4 Cellular Oncogenes - 4.2 ~ 4.6 - Many retroviruses carrying oncogenes have been found in chickens and mice However, attempts undertaken during the 1970s to isolate viruses from most types of

More information

Present State of Gene Diagnosis and Future Prospects

Present State of Gene Diagnosis and Future Prospects Clinical Medicine: Cancer Present State of Gene Diagnosis and Future Prospects JMAJ 45(3): 118 124, 2002 Eiichi TAHARA Chairman, Hiroshima Cancer Seminar Foundation Abstract: The entire base sequence of

More information

A neoplasm is defined as "an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after

A neoplasm is defined as an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after NEOPLASIA Neoplasia is a very important topic in pathology because neoplasms are both common and serious diseases. A neoplasm literally means a new growth, and this term is used interchangeably with a

More information

Cancer. Questions about cancer. What is cancer? What causes unregulated cell growth? What regulates cell growth? What causes DNA damage?

Cancer. Questions about cancer. What is cancer? What causes unregulated cell growth? What regulates cell growth? What causes DNA damage? Questions about cancer What is cancer? Cancer Gil McVean, Department of Statistics, Oxford What causes unregulated cell growth? What regulates cell growth? What causes DNA damage? What are the steps in

More information

Cell Cycle and Cancer

Cell Cycle and Cancer 142 8. Cell Cycle and Cancer NOTES CELL CYCLE G 0 state o Resting cells may re-enter the cell cycle Nondividing cells (skeletal and cardiac muscle, neurons) o Have left the cell cycle and cannot undergo

More information

What All of Us Should Know About Cancer and Genetics

What All of Us Should Know About Cancer and Genetics What All of Us Should Know About Cancer and Genetics Beth A. Pletcher, MD, FAAP, FACMG Associate Professor of Pediatrics UMDNJ- New Jersey Medical School Disclosures I have no relevant financial relationships

More information

Célia DeLozier-Blanchet

Célia DeLozier-Blanchet The Genetics Consultation in OB-GYN : Hereditary cancers Célia DeLozier-Blanchet Division of Medical Genetics, Geneva University Hospital It is probable that all cancers are genetic! genetic vs. hereditary

More information

Diseases of the breast (2 of 2) Breast cancer

Diseases of the breast (2 of 2) Breast cancer Diseases of the breast (2 of 2) Breast cancer Epidemiology & etiology The most common type of cancer & the 2 nd most common cause of cancer death in women 1 of 8 women in USA Affects 7% of women Peak at

More information

CANCER = Malignant Tumor = Malignant Neoplasm

CANCER = Malignant Tumor = Malignant Neoplasm CANCER = Malignant Tumor = Malignant Neoplasm A tissue growth: Not necessary for body s development or repair Invading healthy tissues Spreading to other sites of the body (metastasizing) Lethal because

More information

Cancer. The fundamental defect is. unregulated cell division. Properties of Cancerous Cells. Causes of Cancer. Altered growth and proliferation

Cancer. The fundamental defect is. unregulated cell division. Properties of Cancerous Cells. Causes of Cancer. Altered growth and proliferation Cancer The fundamental defect is unregulated cell division. Properties of Cancerous Cells Altered growth and proliferation Loss of growth factor dependence Loss of contact inhibition Immortalization Alterated

More information

Familial and Hereditary Colon Cancer

Familial and Hereditary Colon Cancer Familial and Hereditary Colon Cancer Aasma Shaukat, MD, MPH, FACG, FASGE, FACP GI Section Chief, Minneapolis VAMC Associate Professor, Division of Gastroenterology, Department of Medicine, University of

More information

Urinary Bladder: WHO Classification and AJCC Staging Update 2017

Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Houston Society of Clinical Pathologists 58 th Annual Spring Symposium Houston, TX April 8, 2017 Jesse K. McKenney, MD Classification

More information

HST.161 Molecular Biology and Genetics in Modern Medicine Fall 2007

HST.161 Molecular Biology and Genetics in Modern Medicine Fall 2007 MIT OpenCourseWare http://ocw.mit.edu HST.161 Molecular Biology and Genetics in Modern Medicine Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms.

More information

Invited Re vie W. Molecular genetics of ovarian carcinomas. Histology and Histo pathology

Invited Re vie W. Molecular genetics of ovarian carcinomas. Histology and Histo pathology Histol Histopathol (1 999) 14: 269-277 http://www.ehu.es/histol-histopathol Histology and Histo pathology Invited Re vie W Molecular genetics of ovarian carcinomas J. Diebold Pathological Institute, Ludwig-Maximilians-University

More information

Page 1 of 8 TABLE OF CONTENTS

Page 1 of 8 TABLE OF CONTENTS Page 1 of 8 TABLE OF CONTENTS Patient Evaluation and Recommendation..Page 2 Testing and Follow-up..Page 3 Genetic Counseling Referral Criteria.....Page 4-5 Patient Education..Page 6 Suggested Readings...Page

More information

List of Available TMAs in the PRN

List of Available TMAs in the PRN TMA RPCI_BrainCa01 RPCI_BrCa03 RPCI_BrCa04 RPCI_BrCa05 RPCI_BrCa0 RPCI_BrCa07 RPCI_BrCa08 RPCI_BrCa15 RPCI_BrCa1 RPCI_BrCa17 RPCI_BrCa18 RPCI_BrCa19 RPCI_BrCa20 RPCI_BrCa21 RPCI_BrCa24 RPCI_BrCa25 RPCI_BrCa2

More information

Part I. An Introduction to Cancer

Part I. An Introduction to Cancer Part I An Introduction to Cancer 2 Chapter 1 Cancer: Descriptive Overview Cancer is a disease in which cells propagate uncontrollably. These cells can come from many different parts of the body and the

More information

Policy Specific Section: Medical Necessity and Investigational / Experimental. October 14, 1998 March 28, 2014

Policy Specific Section: Medical Necessity and Investigational / Experimental. October 14, 1998 March 28, 2014 Medical Policy Genetic Testing for Colorectal Cancer Type: Medical Necessity and Investigational / Experimental Policy Specific Section: Laboratory/Pathology Original Policy Date: Effective Date: October

More information

Tumor Immunology. Tumor (latin) = swelling

Tumor Immunology. Tumor (latin) = swelling Tumor Immunology Tumor (latin) = swelling benign tumor malignant tumor Tumor immunology : the study of the types of antigens that are expressed by tumors how the immune system recognizes and responds to

More information

Familial and Hereditary Colon Cancer

Familial and Hereditary Colon Cancer Familial and Hereditary Colon Cancer Aasma Shaukat, MD, MPH, FACG, FASGE, FACP GI Section Chief, Minneapolis VAMC Associate Professor, Division of Gastroenterology, Department of Medicine, University of

More information

Chapt 15: Molecular Genetics of Cell Cycle and Cancer

Chapt 15: Molecular Genetics of Cell Cycle and Cancer Chapt 15: Molecular Genetics of Cell Cycle and Cancer Student Learning Outcomes: Describe the cell cycle: steps taken by a cell to duplicate itself = cell division; Interphase (G1, S and G2), Mitosis.

More information

Colon Cancer and Hereditary Cancer Syndromes

Colon Cancer and Hereditary Cancer Syndromes Colon Cancer and Hereditary Cancer Syndromes Gisela Keller Institute of Pathology Technische Universität München gisela.keller@lrz.tum.de Colon Cancer and Hereditary Cancer Syndromes epidemiology models

More information

The Development of Lymphocytes: B Cell Development in the Bone Marrow & Peripheral Lymphoid Tissue Deborah A. Lebman, Ph.D.

The Development of Lymphocytes: B Cell Development in the Bone Marrow & Peripheral Lymphoid Tissue Deborah A. Lebman, Ph.D. The Development of Lymphocytes: B Cell Development in the Bone Marrow & Peripheral Lymphoid Tissue Deborah A. Lebman, Ph.D. OBJECTIVES 1. To understand how ordered Ig gene rearrangements lead to the development

More information

Pathology of the Urachus

Pathology of the Urachus Pathology of the Urachus Gladell P. Paner, MD, (BS) MT Departments of Pathology and Surgery, Section of Urology University of Chicago, Chicago, IL USA Gladell.paner@uchospitals.edu Updates in Epithelial

More information

TUMOR-SUPPRESSOR GENES. Molecular Oncology Michael Lea

TUMOR-SUPPRESSOR GENES. Molecular Oncology Michael Lea TUMOR-SUPPRESSOR GENES Molecular Oncology 2011 Michael Lea TUMOR-SUPPRESSOR GENES - Lecture Outline 1. Summary of tumor suppressor genes 2. P53 3. Rb 4. BRCA1 and 2 5. APC and DCC 6. PTEN and PPA2 7. LKB1

More information

Chapter 3. Neoplasms. Copyright 2015 Cengage Learning.

Chapter 3. Neoplasms. Copyright 2015 Cengage Learning. Chapter 3 Neoplasms Terminology Related to Neoplasms and Tumors Neoplasm New growth Tumor Swelling or neoplasm Leukemia Malignant disease of bone marrow Hematoma Bruise or contusion Classification of Neoplasms

More information

Icd 10 prostate cancer stage 4

Icd 10 prostate cancer stage 4 Icd 10 prostate cancer stage 4 Search 19-9-2016 City of Hope's prostate cancer program in so. Calif. has pioneered treatments and research that eradicate cancer while minimizing side effects. Our. Augsburg

More information

Chapter 18- Oncogenes, tumor suppressors & Cancer

Chapter 18- Oncogenes, tumor suppressors & Cancer Chapter 18- Oncogenes, tumor suppressors & Cancer - Previously we have talked about cancer which is an uncontrolled cell proliferation and we have discussed about the definition of benign, malignant, metastasis

More information

Ovarian Cancer Causes, Risk Factors, and Prevention

Ovarian Cancer Causes, Risk Factors, and Prevention Ovarian Cancer Causes, Risk Factors, and Prevention Risk Factors A risk factor is anything that affects your chance of getting a disease such as cancer. Learn more about the risk factors for ovarian cancer.

More information

Computational Systems Biology: Biology X

Computational Systems Biology: Biology X Bud Mishra Room 1002, 715 Broadway, Courant Institute, NYU, New York, USA L#5:(October-18-2010) Cancer and Signals Outline 1 2 Outline 1 2 Cancer is a disease of malfunctioning cells. Cell Lineage: Adult

More information

III. Oncogenic RNA Viruses - HTLV-1 is associated with T cell Leukemia/lymphoma that is endemic in certain parts of Japan and the Caribbean - HTLV-1

III. Oncogenic RNA Viruses - HTLV-1 is associated with T cell Leukemia/lymphoma that is endemic in certain parts of Japan and the Caribbean - HTLV-1 III. Oncogenic RNA Viruses - HTLV-1 is associated with T cell Leukemia/lymphoma that is endemic in certain parts of Japan and the Caribbean - HTLV-1 has tropism for CD4+ T cell and human infection requires

More information

1.The metastatic cascade. 2.Pathologic features of metastasis. 3.Therapeutic ramifications

1.The metastatic cascade. 2.Pathologic features of metastasis. 3.Therapeutic ramifications Metastasis 1.The metastatic cascade 2.Pathologic features of metastasis 3.Therapeutic ramifications Sir James Paget (1814-1899) British Surgeon/ Pathologist Paget s disease of bone Paget s disease of the

More information

- A cancer is an uncontrolled, independent proliferation of robust, healthy cells.

- A cancer is an uncontrolled, independent proliferation of robust, healthy cells. 1 Cancer A. What is it? - A cancer is an uncontrolled, independent proliferation of robust, healthy cells. * In some the rate is fast; in others, slow; but in all cancers the cells never stop dividing.

More information

Gynecologic Cancers are many diseases. Speaker Disclosure: Gynecologic Cancer Care in the Age of Precision Medicine. Controversies in Women s Health

Gynecologic Cancers are many diseases. Speaker Disclosure: Gynecologic Cancer Care in the Age of Precision Medicine. Controversies in Women s Health Gynecologic Cancer Care in the Age of Precision Medicine Gynecologic Cancers in the Age of Precision Medicine Controversies in Women s Health Lee-may Chen, MD Department of Obstetrics, Gynecology & Reproductive

More information

The Hallmarks of Cancer

The Hallmarks of Cancer The Hallmarks of Cancer Theresa L. Hodin, Ph.D. Clinical Research Services Theresa.Hodin@RoswellPark.org Hippocrates Cancer surgery, circa 1689 Cancer Surgery Today 1971: Nixon declares War on Cancer

More information

1. The metastatic cascade. 3. Pathologic features of metastasis. 4. Therapeutic ramifications. Which malignant cells will metastasize?

1. The metastatic cascade. 3. Pathologic features of metastasis. 4. Therapeutic ramifications. Which malignant cells will metastasize? 1. The metastatic cascade 3. Pathologic features of metastasis 4. Therapeutic ramifications Sir James Paget (1814-1899) British Surgeon/ Pathologist Paget s disease of Paget s disease of the nipple (intraductal

More information

Cancer. Chapter 31 Lesson 2

Cancer. Chapter 31 Lesson 2 Cancer Chapter 31 Lesson 2 Tumors All cancers are tumors- masses of tissue. Not all tumors are cancers. Some tumors are benign- noncancerous. These tumors are surrounded by membranes that prevent them

More information

FINALIZED SEER SINQ QUESTIONS

FINALIZED SEER SINQ QUESTIONS 0076 Source 1: WHO Class CNS Tumors pgs: 33 MP/H Rules/Histology--Brain and CNS: What is the histology code for a tumor originating in the cerebellum and extending into the fourth ventricle described as

More information

Cutaneous metastases. Thaddeus Mully. University of California, San Francisco Professor, Departments of Pathology and Dermatology

Cutaneous metastases. Thaddeus Mully. University of California, San Francisco Professor, Departments of Pathology and Dermatology Cutaneous metastases Thaddeus Mully University of California, San Francisco Professor, Departments of Pathology and Dermatology DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Thaddeus Mully Course C005 Essential

More information

Genetics and Cancer Ch 20

Genetics and Cancer Ch 20 Genetics and Cancer Ch 20 Cancer is genetic Hereditary cancers Predisposition genes Ex. some forms of colon cancer Sporadic cancers ~90% of cancers Descendants of cancerous cells all cancerous (clonal)

More information

Spontaneous Neoplasms and Survival in Wistar Han Rats: Compilation of Control Group Data. March, 2003

Spontaneous Neoplasms and Survival in Wistar Han Rats: Compilation of Control Group Data. March, 2003 Spontaneous Neoplasms and Survival in Wistar Han Rats: Compilation of Control Group Data March, 2003 Information Prepared by Mary L.A. Giknis Ph.D Charles B. Clifford D.V.M, Ph.D TABLE OF CONTENTS INTRODUCTION...1

More information

Tumor suppressor genes D R. S H O S S E I N I - A S L

Tumor suppressor genes D R. S H O S S E I N I - A S L Tumor suppressor genes 1 D R. S H O S S E I N I - A S L What is a Tumor Suppressor Gene? 2 A tumor suppressor gene is a type of cancer gene that is created by loss-of function mutations. In contrast to

More information

Epidemiology of gastric cancer

Epidemiology of gastric cancer 1 Epidemiology of gastric cancer Mark E. Lockhart and Cheri L. Canon Introduction Although the incidence and mortality rate of gastric cancer are declining in the United States and Great Britain (Figures

More information

Neoplasia. Fatima Obeidat, MD Assistant Professor of Neuropathology

Neoplasia. Fatima Obeidat, MD Assistant Professor of Neuropathology Neoplasia Fatima Obeidat, MD Assistant Professor of Neuropathology 1 - Neoplasia literally means "new growth - Neoplastic cells are transformed because they continue to replicate, independent of normal

More information

Content. Diagnostic approach and clinical management of Lynch Syndrome: guidelines. Terminology. Identification of Lynch Syndrome

Content. Diagnostic approach and clinical management of Lynch Syndrome: guidelines. Terminology. Identification of Lynch Syndrome of Lynch Syndrome: guidelines 17/03/2009 Content Terminology Lynch Syndrome Presumed Lynch Syndrome Familial Colorectal Cancer Identification of Lynch Syndrome Amsterdam II criteria Revised Bethesda Guidelines

More information

Clinical Cancer Genetics

Clinical Cancer Genetics Clinical Cancer Genetics Lisen Axell, MS, CGC University of Colorado Cancer Center Individuals with cancer Making surgical decisions (lump vs. mast) Making treatment decisions (XRT) Concerns for additional

More information

Lung Cancer Risks. Cancer in the United States, Cancer Death Rates, US The Scheme: From Nicotine Addiction to Lung Cancer

Lung Cancer Risks. Cancer in the United States, Cancer Death Rates, US The Scheme: From Nicotine Addiction to Lung Cancer Cancer in the United States, 2004 Lung Cancer Risks Cigarette Smoking Environmental Tobacco Smoke Other Carcinogens Asbestos, Arsenic, Radon, Bis(chloromethyl) ether, Chromium, Foundry fumes, nickel, mustard

More information

Familial Adenomatous Polyposis

Familial Adenomatous Polyposis Familial Adenomatous Polyposis 1 in 10,000 incidence 100 s to 1000 s of colonic adenomas by teens Cancer risk: colon, gastric, duodenum (periampulla), small bowel, pancreas, papillary thyroid, childhood

More information

SEROUS TUMORS. Dr. Jaime Prat. Hospital de la Santa Creu i Sant Pau. Universitat Autònoma de Barcelona

SEROUS TUMORS. Dr. Jaime Prat. Hospital de la Santa Creu i Sant Pau. Universitat Autònoma de Barcelona SEROUS TUMORS Dr. Jaime Prat Hospital de la Santa Creu i Sant Pau Universitat Autònoma de Barcelona Serous Borderline Tumors (SBTs) Somatic genetics Clonality studies have attempted to dilucidate whether

More information

11/29/2017. Genetics and Cancer ERICA L SILVER, MS, LCGC GENETIC COUNSELOR. Genetics 101. Transcription vs Translation

11/29/2017. Genetics and Cancer ERICA L SILVER, MS, LCGC GENETIC COUNSELOR. Genetics 101. Transcription vs Translation Genetics and Cancer ERICA L SILVER, MS, LCGC GENETIC COUNSELOR Genetics 101 Transcription vs Translation 1 Carcinogenesis and Genetics Normal cell First mutation First mutation Second mutation Second mutation

More information

GENETIC MARKERS IN LYMPHOMA a practical overview. P. Heimann Dpt of Medical Genetics Erasme Hospital - Bordet Institute

GENETIC MARKERS IN LYMPHOMA a practical overview. P. Heimann Dpt of Medical Genetics Erasme Hospital - Bordet Institute GENETIC MARKERS IN LYMPHOMA a practical overview P. Heimann Dpt of Medical Genetics Erasme Hospital - Bordet Institute B and T cell monoclonalities Rearrangement of immunoglobin and TCR genes may help

More information

Asingle inherited mutant gene may be enough to

Asingle inherited mutant gene may be enough to 396 Cancer Inheritance STEVEN A. FRANK Asingle inherited mutant gene may be enough to cause a very high cancer risk. Single-mutation cases have provided much insight into the genetic basis of carcinogenesis,

More information

Molecular Pathobiology of Lung Cancer. William K. Funkhouser, MD PhD Department of Pathology and Lab Medicine University of North Carolina

Molecular Pathobiology of Lung Cancer. William K. Funkhouser, MD PhD Department of Pathology and Lab Medicine University of North Carolina Molecular Pathobiology of Lung Cancer William K. Funkhouser, MD PhD Department of Pathology and Lab Medicine University of North Carolina Outline Lung Anatomy Lung Carcinoma Classification & Morphology

More information

The clinical relevance of circulating, cell-free and exosomal micrornas as biomarkers for gynecological tumors

The clinical relevance of circulating, cell-free and exosomal micrornas as biomarkers for gynecological tumors Department of Tumor Biology The clinical relevance of circulating, cell-free and exosomal micrornas as biomarkers for gynecological tumors cfdna Copenhagen April 6-7, 2017 Heidi Schwarzenbach, PhD Tumor

More information

Icd 10 code metastatic adenocarcinoma endometrial

Icd 10 code metastatic adenocarcinoma endometrial Icd 10 code metastatic adenocarcinoma endometrial 1-10-2017 Free, official coding info for 2018 ICD-10-CM D07.0 - includes detailed rules, notes, synonyms, ICD-9-CM conversion,. 2018 ICD-10-CM Diagnosis

More information

See the latest estimates for new cases of salivary gland cancers in the US and what research is currently being done.

See the latest estimates for new cases of salivary gland cancers in the US and what research is currently being done. About Salivary Gland Cancer Overview and Types If you have been diagnosed with salivary gland cancer or are worried about it, you likely have a lot of questions. Learning some basics is a good place to

More information

Appendix 4: WHO Classification of Tumours of the pancreas 17

Appendix 4: WHO Classification of Tumours of the pancreas 17 S3.01 The WHO histological tumour type must be recorded. CS3.01a The histological type of the tumour should be recorded based on the current WHO classification 17 (refer to Appendices 4-7). Appendix 4:

More information

Institute of Radiation Biology. Oncogenes and tumour suppressor genes DoReMi Course 2014

Institute of Radiation Biology. Oncogenes and tumour suppressor genes DoReMi Course 2014 Institute of Radiation Biology Oncogenes and tumour suppressor genes DoReMi Course 2014 Hippocrates: Cause is systemic excess of black humor. Paracelsus challenges the humor theory. Suggests external

More information

The mutations that drive cancer. Paul Edwards. Department of Pathology and Cancer Research UK Cambridge Institute, University of Cambridge

The mutations that drive cancer. Paul Edwards. Department of Pathology and Cancer Research UK Cambridge Institute, University of Cambridge The mutations that drive cancer Paul Edwards Department of Pathology and Cancer Research UK Cambridge Institute, University of Cambridge Previously on Cancer... hereditary predisposition Normal Cell Slightly

More information

B. Cystic Teratoma: Refer to virtual microscope slide p_223 ovary, teratoma and compare to normal virtual microscope slide 086 ovary.

B. Cystic Teratoma: Refer to virtual microscope slide p_223 ovary, teratoma and compare to normal virtual microscope slide 086 ovary. LAB 2: THE CONNECTIVE TISSUE AND EPITHELIUM The focus of this week s lab will be pathology of connective tissue and epithelium. The lab will introduce you to the four basic tissue types: epithelium, connective

More information

Molecular Diagnosis. Nucleic acid based testing in Oncology

Molecular Diagnosis. Nucleic acid based testing in Oncology Molecular Diagnosis Nucleic acid based testing in Oncology Objectives Describe uses of NAT in Oncology Diagnosis, Prediction, monitoring. Genetics Screening, presymptomatic testing, diagnostic testing,

More information

2018 SEER Solid Tumor Manual 2018 KCR SPRING TRAINING

2018 SEER Solid Tumor Manual 2018 KCR SPRING TRAINING 2018 SEER Solid Tumor Manual 2018 KCR SPRING TRAINING Eight Groups are Revised for 2018 Head & Neck Colon (includes rectosigmoid and rectum for cases diagnosed 1/1/2018 forward) Lung (2018 Draft not yet

More information

COLORECTAL PATHWAY GROUP, MANCHESTER CANCER. Guidelines for the assessment of mismatch. Colorectal Cancer

COLORECTAL PATHWAY GROUP, MANCHESTER CANCER. Guidelines for the assessment of mismatch. Colorectal Cancer COLORECTAL PATHWAY GROUP, MANCHESTER CANCER Guidelines for the assessment of mismatch repair (MMR) status in Colorectal Cancer January 2015 1 Background Mismatch repair (MMR) deficiency is seen in approximately

More information

RECURRENT ADRENAL DISEASE. Megan Applewhite Endorama 2/19/2015 SR , SC

RECURRENT ADRENAL DISEASE. Megan Applewhite Endorama 2/19/2015 SR , SC RECURRENT ADRENAL DISEASE Megan Applewhite Endorama 2/19/2015 SR 2412318, SC 3421561 Category: Adrenal Attendings: Angelos & Grogan PATIENT #1 36yo woman with a hx of Cushing s Syndrome and right adrenalectomy

More information

Session 4 Rebecca Poulos

Session 4 Rebecca Poulos The Cancer Genome Atlas (TCGA) & International Cancer Genome Consortium (ICGC) Session 4 Rebecca Poulos Prince of Wales Clinical School Introductory bioinformatics for human genomics workshop, UNSW 20

More information

Emerging" hallmarks of cancer, a. Reprogramming of energy metabolism b. Evasion of the immune system, Enabling characteristics, a.

Emerging hallmarks of cancer, a. Reprogramming of energy metabolism b. Evasion of the immune system, Enabling characteristics, a. HALLMARKS OF CANCER - Together dictate the malignant phenotype. 1. Self-sufficiency in growth signals 2. Insensitivity to growth inhibitory signals 3. Evasion of cell death 4. Limitless replicative potential

More information

In vitro scratch assay: method for analysis of cell migration in vitro labeled fluorodeoxyglucose (FDG)

In vitro scratch assay: method for analysis of cell migration in vitro labeled fluorodeoxyglucose (FDG) In vitro scratch assay: method for analysis of cell migration in vitro labeled fluorodeoxyglucose (FDG) 1 Dr Saeb Aliwaini 13/11/2015 Migration in vivo Primary tumors are responsible for only about 10%

More information

Genetics and Genomics in Endocrinology

Genetics and Genomics in Endocrinology Genetics and Genomics in Endocrinology Dr. Peter Igaz MD MSc PhD 2 nd Department of Medicine Faculty of Medicine Semmelweis University Genetics-based endocrine diseases I. Monogenic diseases: Multiple

More information

L/O/G/O. Ovarian Tumor. Xiaoyu Niu Obstetrics and Gynecology Department Sichuan University West China Second Hospital

L/O/G/O. Ovarian Tumor. Xiaoyu Niu Obstetrics and Gynecology Department Sichuan University West China Second Hospital L/O/G/O Ovarian Tumor Xiaoyu Niu Obstetrics and Gynecology Department Sichuan University West China Second Hospital Essentials classification of ovarian tumor clinical manifestation of ovarian tumor metastatic

More information