Malaysian Healthy Ageing Society
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1 Organised by: Co-Sponsored: Malaysian Healthy Ageing Society
2 Nutritional Therapy for Cancer Dato Steve Yap Fellowship, Integrative Cancer Therapies (USA) Fellowship, Anti-Aging Regenerative Medicine (USA) DSY Wellness & Longevity Center & Mohamad Roji Sarmidi Living Active, Wellness Centre Universiti Teknologi Malaysia 22 March 2012 FIRST WORLD CONGRESS ON HEALTY AGEING Kualal Lumpur
3 Presentation Introduction: Halmarks of Cancer Hypoxia, Mitochondria & Metabolism Nutrients
4 Figure 1 Hallmarks of Cancer Hanahan, D, & Weinberg RA (2011). Hallmarks of cancer:the next generation. Source: Cell, Volume 144, Issue 5, Pages (DOI: /j.cell ) Copyright 2011 Elsevier Inc. Terms and Conditions
5 Hallmarks of Cancer Hallmarks of cancer Increased glucose consumption and high rates of glycolysis Resistance to the toxicity of local acidification Evasion of anoikis Cancer-associated inflammation R.A. Gatenby, R.J. Gillies, A microenvironmental model of carcinogenesis, Nat Rev Cancer 8 (2008) F. Colotta, P. Allavena, A. Sica, C. Garlanda, A. Mantovani, Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability, Carcinogenesis (2009).
6 Why cancer cells do what they do Hostile cellular environment Adaptation & survival Switch to default primitive state J.S. Fang, R.D. Gillies, R.A. Gatenby, Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression, Semin Cancer Biol 18 (2008) E. Laconi, S. Doratiotto, P. Vineis, The microenvironments of multistage carcinogenesis, Semin Cancer Biol 18 (2008)
7 Cellular Hypoxia Vladimir Gogvadze, Sten Orrenius and Boris Zhivotovsky, Mitochondria in cancer cells: what is so special about them?trends in Cell Biology Vol.18 No.4 [J.F. De Los Santos, G.M. Thomas, Anemia correction in malignancy management: threat or opportunity?, Gynecol Oncol 105 (2007)
8 Microc apillar y O2 O2 O2
9 Expression of HIF-1 in human cancer: causes and consequences. Vaupel P The Oncologist 2004;9: by AlphaMed Press
10 HIF-1-mediated switch from aerobic to anaerobic metabolism in hypoxic tumors for energy preservation. Vaupel P The Oncologist 2004;9: by AlphaMed Press
11 Schematic displaying the vicious circle of tumor hypoxia and malignant progression [6]. Vaupel P The Oncologist 2004;9: by AlphaMed Press
12 Nutritional Therapy Strategy Nutritional Therapy Strategy Enhance overall health Restore homeostasis Optimize metabolism
13 Raising Metabolism Optimize Basal Body Temperature o F Normalize Thyroid Function Reduce Oxidation & Inflammation Raising Metabolism Nutrient Dense & Low GI Foods
14 Cell Membranes Nutrients Cell Membranes nutrients Linoleic Acid (LA) Alpha-Linolenic Acid (ALA) Eicosapentanoic Acid (EPA; 20:5) Docosahexanoic Acid (DHA; 22:6) Phosphatidylcholine (PC) Phosphatidylserine (PS)
15 Mitochondrial Nutrients Mitochodrial Nutrients Acetyl-L-Carnitine Coenzyme-Q10 Alpha-Lipoic acid Linoleic acid Biotin Nicotinamide Riboflavin Pyridoxine Pyrroloquinoline Quinone (PQQ) Jiankang Liu a,f,, Weili Shen b, Baolu Zhao c, Ying Wang d, Karin Wertz d, Peter Weber d, Peifang Zhang e, Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity : Hope from natural mitochondrial nutrients, Advanced Drug Delivery Reviews 61 (2009)
16 Mitochondrial Toxin Mitochondrial Toxins Arsenite Cynide Fluoride Oligomycin Carbon monoxide Sodium benzoate
17 Na+/K+ - ATPase Sodium- Potassium Pumps Magnesium Potassium SCFA enhances the absorption of Mg, K and Na in colon
18 Liver Nutrients Vit C Mg Arginine Tumeric Silybum marianum
19 Collagen Synthesis Vit C Lysine Proline Glycine
20 Antiinflammatory Nutrients EPA Papain Quercetin Anthocyanins Curcumin Methylsulphonylmethane (MSM) Gamma-linolenic acid, VCO Bromelain
21 EGCG Green tea (-)- epigallocatechin- 3-gallate (EGCG) Inhibit hypoxia-induced HIF-1a Reduce vascular endothelial growth factor (VEGF) Limit angiogenesis Qunzhou Zhang, Xudong Tang, QingYi Lu, et al. Green tea extract and ( )-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1 α protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells Mol Cancer Ther 2006;5: Published online May 26, 2006.
22 THANK YOU P r o v i d i n g we l l n e s s s o l u t i o n fo r h e a l t h i e r b o d y
23
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