June Hsieh Wu, Ph.D. Educational background Working Experiences:

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1 謝絹珠 June Hsieh Wu, Ph.D. 教授 Professor 個人網頁 : 電話 : ext 5116 傳真 : 信箱 學經歷 Educational background Ph.D. Department of Microbiology, Texas A&M University, College Station, Texas USA M.S. Department of Microbiology, University of Missouri, Columbia, Missouri, USA B.S. Department of Medical Technology, National Taiwan University, Taipei, Taiwan Working Experiences: Professor, Department of Microbiology and Immunology, Chang Gung University, Taiwan (2001 present) Professor and Chairman, Department of Microbiology and Immunology, Chang Gung University, Taiwan ( ) Associate Professor, Department of Microbiology and Immunology, Chang Gung University, College of Medicine, Kuei San, Tao Yuan, Taiwan ( ) Research Associate, Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA ( ) Research Associate, Department of Medical Microbiology and Immunology, School of Medicine, Texas A&M University, College Station, Texas, USA ( ) Research Assistant, Department of Medical Microbiology and Immunology, School of Medicine, Texas A&M University, College Station, Texas, USA ( ) Biochemist, Clinical Pathology, Westchester County Medical Center, Valhalla, New York, USA ( ) Medical Technologist, Clinical Diagnostic Laboratory, Northern Westchester Hospital, Mt. Kisco, New York, USA ( ) Medical Technologist, Clinical Diagnostic Laboratory, Boone County Hospital, Columbia, Missouri, USA ( ) Medical Technologist, Clinical Diagnostic Laboratory, Doctor's Hospital and Hatzel Hospital, Detroit, Michigan, USA ( ) 研究方向 Lipoprotein genetic polymorphism Physiology of lipoprotein (a) Bacterial pathogenesis Host parasite interaction Klebsiella pneumoniae 著作

2 1. Albert M. Wu, June Wu and Anthony Herp (1978) Polypeptide linkages and resulting structural features as powerful chromogenic factors in the Lowry phenol reaction. Studies on a glycoprotein containing on Lowry phenol-reactive amino acids and on its desialylated and deglycosylated products. Biochem.J. 175: Deanna Moore, June H. Wu Pushpa Kathir, Charleen M. Hamilton and Karin Ippen-Ihler (1987) Analysis of transfer genes and gene products within the trab-trac region of the Escherichia coli fertility factor F. J. Bacteriology 169: Sumit Maneewannakul, Pushpa kathir, Deanna Moore, Lan-Anh Le, June H. Wu and Karin Ippen-Ihler (1987) Location of F plasmid transfer operon genes trac and traw and identification of the traw product. J. Bacteriology 169: June H. Wu, Deanna Moore, Tammy Lee and Karin Ippen-Ihler (1987) Analysis of Escherichia coli K12 F factor transfer genes: traq, trba and trbb. Plasmid 18: June H. Wu, Pushpa Kathir and Karin Ippen-Ihler (1988) The product of the F plasmid transfer operon gene, traf, is a periplasmic protein. J. Bacteriology 170: June H. Wu and Karin Ippen-Ihler (1989) Nucleotide sequence of traq and adjacent loci in the Escherichia coli K12 F plasmid transfer operon. J. Bacteriology 171: Deanna Moore, Kesmanee Maneewannakul, Sumit Maneewannakul, June H. Wu, Karin Ippen-Ihler and David Bradley (1990) Characterization of F-plasmid conjugative transfer gene trau. J. Bacteriology 172: San-Hwan Chen, Xiaoxia Li, Warren S. L. Liao, June H. Wu and Lawrence Chan (1990) RNA editing of apolipoprotein B mrna sequence specificity determined by in vitro coupled transcription editing. J. Biol. Chem 265: June H. Wu, Clay F Semenkovich, San-Hwan Chen, Wen-Hsiung Li and Lawrence Chan (1990) Apolipoprotein B mrna editing: Validation of a sensitive assay and developmental biology of RNA editing in the rat. J. Biol. Chem. 265: June H. Wu, J. T. Kao, M. S. Wen and D. Wu (1993) Prediction of risk of coronary Heart disease by plasma levels of high density lipoprotein cholesterol, apolipoprotein A1, apolipoprotein B and lipoprotein (a) in a general Chinese population. Clinical Chemistry 39/2: June H. Wu, A. Herp and A. M. Wu (1993) Defining carbohydrate specificity of Ricinus communis agglutinin as Galβ1 4GlcNAc(II)> Galβ1 3GalNAc(I)> Galα1 3Gal(B)>Galβ1 3GalNAc(T). Molecular Immunology 30/4: J.H. Wu, M. S. Wen, S. K. Lo and D. Wu (1993) DNA polymorphisms of apolipoprotein B in the population of Taiwan. J. Formos Med Assoc 92: A. M. Wu, J. H. Wu, and F.S Shen (1994) Interaction of a novel Tn (GalNAcαl Ser/Thr) glycoprotein with Gal, GalNAc and GlcNAc specific lectins. Biochem. Biophys. Res. Comm. 198: J. H. Wu, M. S. Wen, S. K. Lo and M. S. Chern (1994) Increased frequency of apolipoprotein B signal peptide sp24/24 in patients with coronary artery disease. General allele survey in the population of Taiwan and comparison with Caucasians. Clinical Genetics 45: A. M. Wu, F. S Shen, A Herp and J. H. Wu (1994) Interaction of hamster submaxillary sialyl-tn glycoproteins with Gal, GalNAc and GlcNAc specific lectins. Molecular Immunology 31: M. Duk, E. Lisowska, J. H. Wu and A. M. Wu (1994) The biotin/avidin-mediated microtiter plate lectin assay with the use of chemically modified glycoprotein ligand. Analytical Biochem. 221: A. M. Wu, S. C. Song, J. H. Wu and U. Pfuller (1995) A sheep hydatid cyst glycoprotein as receptors for three toxic lectins, as well as Abrus precatorius and Riciuns communis agglutinins. Biochim. Biophys. Acta 1243: A. M. Wu, W. M. Watkins, S. C. Song, A. Herp and J. H. Wu (1995) Native and asialo-tamm-horsfall glycoproteins as important ligands for the detection of GalNAcβ1 and Galβl 4GlcNAc active lectins. Biochem. Biophys. Res. Comm. 209: A. M. Wu, F. S. Shen, A. Herp, S. C. Song and J. H. Wu (1995) Fraction A of armadillo submandibular glycoportein and its desialylated product as sialy-tn and Tn receptors of lectins. FEBS Letters 360: J. H. Wu (1995) Sequences of apolipoprotein B 3'hypervariable repeat alleles. Gene 159: A. M. Wu, S. C. Song, P. Y. Hwang, J. H. Wu and U. Pfueller (1995) Interaction of Mistletoe toxic lectin-i with sialoglycoproteins. Biochem. Biophys. Res. Comm. 214: A. M. Wu, A. Herp, S. C. Song, J. H. Wu and K.S. Chang (1995) Interaction of native and asialo rat

3 sublingual glycoproteins with lectins. Life Science 57: A. M. Wu, S. C. Song, P. Y. Hwang, J. H. Wu, K.S.Chang (1995) Binding studies on the combining site of a GalNAc alpha l- lectin specific lectin with Thomsen-Friedenreich activity prepared from green marine algae Codium fragil subspecies tomentosoides. Eur.J.Biochem. 223: A. M. Wu, S. C. Song, J. H. Wu and E. A. Kabat (1995) Affinity of Bandeiraea (Griffonia) simplicifolia lectin-i, isolectin B4 (BSI- B4) for Galαl 4Gal ligand. Biochem. Biophys. Res. Comm. 216: A. M. Wu, J. H. Wu, W. M. Watkins, C. P. Chen and M. C. Tsai (1996) Binding properties of a blood group Le(a+) active sialoglycoprotein, purified from human ovarian cyst, with applied lectins. Biochim. Biophys. Acta 1316: J. H. Wu, W. M. Watkins, C. P. Chen and M. C. Tsai (1996) Interaction of a human blood group Sd(a-) Tamm-Horsfall glycoprotein with applied lectins. FEBS letters 384: J. H. Wu, M. S. Chern. S. K. Lo, M. S. Wen and J. T. Kao (1996) Apolipoprotein B 3'hypervariable repeat genotype: association with plasma lipid concentration, coronary artery disease, and other restriction fragment polymorphisms. Clin Chem 42: A. M. Wu, J. H. Wu, S. C. Song, E. A. Kabat (1996) Bandeiraea (Griffonia) simplicifolia lectin-l, isolectin 4, reacting with Tn (GalNAcαl Ser/Thr) or galabiose (Galαl-4 Gal) containing ligands. FEBS Letters. 389: A. M. Wu, S. C. Song, S C Chang, J. H. Wu, K. S. S. Chang, E. A. Kabat (1997) Further characterization of the binding properties of a GalNAc specific lectin from Codium fragile subspecies tomentosoides. Glycobiology 7: J.H. Wu, S.C. Song, Y.Y. Chen, M.C. Tsai, E.A. Kabat, A.M. Wu (1998) Multiantennary Galβ 4GlcNAc and Galβ1 3GalNAc clusters as important ligands for a lectin isolated from the sponge Geodia cydonium. FEBS Letters 427: Y.C. Huang, T.Y. Lin, H.S. Leu, J.L. Wu, J.H. Wu (1998) Yeast carriage on hands of hospital personnel working in intensive care units. J. Hosp Infect 39: A.M. Wu, J.H. Wu, W.M. Watkins, C.P. Chen, S.C. Song, Y.Y. Chen (1998) Differential binding of human blood group Sd(a+) and Sd(a-) Tamm-Horsfall glycoproteins with Dolichos biflorus and Vicia villosa-b4 agglutinins. FEBS Letters 429: J.T. Yang, C.N. Chang, T.H. Lee, J.C. Hsu, T.N. Lin, J.H. Wu* (1998) Dexamethasone inhibits ischemia-induced transient reduction of neurotrophin-3 mrna in rat hippocampal neurons. NeuroReport 9: A.M. Wu, J.H. Wu, S.C. Song, M.C. Tsai, A herp (1998) Studies on the binding of wheat germ agglultinin (Triticum vulgaris) to O-glycans. FEBS letters 440: Y. C. Huang, T.Y. Lin, H.L. Peng, J.H. Wu, H.Y. Chang, H.S. Leu (1998) An outbreak of Candida albicans fungemia in a neonatal intensive care unit. Sacnd J Infect Dis 30: J.H. Wu, R.P. Hsieh, M.S. Chen, M.S. Wen, C.H. Tseng (1999) Association of 1617 C T genetic variation in exon 11 of human low-density lipoprotein receptor and plasma lipid concentration. Atherosclerosis 143: A.M. Wu, J.H. Wu, Y.Y. Chen, S.C. Song, E.A. kabat (1999) Further characterization of the combining sites of Bandeiraea (Griffonia) simplicifolia lectin-i, isolectin A 4. Glycobiology 9: J.T. Yang, C.N. Chang, H. Hsu, K.C. Wei, T.K. Lin, J.H. Wu* (1999) The increase in CSF NGF concentration is positively correlated with poor prognosis of postoperative hydrocephalic patients. Clin Biochem 32: Y.C. Huang, T.L. Lin, H.S. Leu, H.L. Peng, J.H. Wu, H.Y. Chang (1999) Outbreak of Candida parapsilosis fungemia in neonatal intensive care units: Clinical implications and genotyping analysis. Infection 27: A.M. Wu, J.H. Wu, Y.Y. Chen, M.S. Tsai, A. Herp (1999) Forssman pentasaccharide and polyvalent Galβ1 4GlcNAc as major ligands with affinity for Caragana arboreseens agglutinin. FEBS Letters 463: J.H. Wu, J.T. Kao, M.S Wen, S.K. Lo (2000) DNA polymorphism at apolipoprotein A1-CIII loci in Taiwanese: correlation of plasma apociii with triglyceride level and body mass index. J Formos Med Assoc 99: A.M. Wu, J.H. Wu, M.S. Tsai, A. Herp (2000) Carbohydrates specificities of an agglutinin isolated from Trichosanthes kirlowii. Life Sciences 66: J.H. Wu, Y.T. Lee, H.C. Hsu, L.L. Hsieh, M.S. Wen, M.S. Chern, D.Wu (2001) Further characterization of

4 apolipoprotein B genetic variations in Taiwanese. Human Biology 73: A.M. Wu, J.H. Wu, M.S. Tsai, H. Kaltner, H.J. Gabius. (2001) Carbohydrate specificity of a galectin from chicken liver (CG-16). Biochem J. 358: A.M. Wu, J.H. Wu, M.S. Tsai, G.V. Hegde, S.R. Inamdar, B.M. Swamy, A. Herp (2001) Carbohydrate specificity of a phytopathogenic lectin isolated from the fungus Sclerotium rolfsii. Life Science 69: A.M. Wu, J.H. Wu, M.S. Tsai, A. Herp, L.P. Chow, J.Y. Lin. (2001) Carbohydrate spe;cificity of a toxic lectin, Abrin A, from the seeds of Abrus precatorius (Jequirity bean). Life Science 69: J.T. Yang C.N. Chang, T.H. Lee, T.N. Lin, J.C. Hsu. Y.H. Hsu, J.H. Wu* (2001) Hyperbaric oxygen treatment decreases post-ischemic neurotrophin-3 mrna down-regulation in the rat hippocampus. NeuroReport 12: J.H. Wu, Y.T. Lee, H.C. Hsu, L.L. Hsieh (2001) Influence of CETP gene variation on plasma lipid levels and coronary heart disease: a survey in Taiwan. Atherosclerosis 159: J.T. Yang, C.N. Chang, T.H. Lee, J.C. Hsu, T.N. Lin, Y.H. Hsu, J.H. Wu* (2002) Effect of dexamethasone on the expression of brain-derived neurotrophic factor and neurotrophin-3 messenger ribonucleic acids after forebrain ischemia in the rat. Crit Care Med 30: A.M. Wu, J.H. Wu, M.S. Tsai, J.H. Liu, S. Andre. K. Wasano, H. Kaltner, H-J. Gabius (2002) Fine specificity of domain-1 of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4-N). Biochem J. 367: J.H. Wu, S.K. Lo, M.S. Wen, J.T. Kao (2002) Characterization of apolipoprotein E genetic variation in Taiwanese: association with coronary heart disease and plasma lipid levels. Human Biology 74: J.H. Wu, I.N. Lee (2003) Studies of apolipoprotein (a) promoter from subjects with different plasma lipoprotein (a) concentrations. Clin Biochem 36: A.M. Wu, J.H. Wu, A. Herp, J.H. Liu (2003) Effect of polyvalencies of glycotopes on the binding of a lectin from the edible mushroom, Agaricus bisporus. Biochem J. 371: A.M. Wu, J.H. Wu, L.H. Lin S.H. Lin J.H. Liu (2003) Binding profile of Artocarpus integrifolia agglutinin (Jacalin). Life Sciences 72: T.H. Lee, J.T. Yang, H. Kato, J.H. Wu, S.T. Chen (2004) Expression of brain-derived neurotrophic factor immunoreactivity and mrna in the hippocampal CA1 and cortical areas after chronic ischemia in rats. J. Neuroscience Res. 76: A.M. Wu, J.H. Wu, J.H. Liu, T. Singh, S. Andre, H. Kaltner, H-J. Gabius (2004) Effects of polyvalency of glycotopes and natural modification of human blood group ABH/Lewis sugars at the Galβ1-terminated core saccharides on the binding of domain-i of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4-N). Biochimie 86: A.M. Wu, J.H. Wu, J.H. Liu, T. Singh (2004) Recognition profile of Bauhinia purpurea agglutinin (BPA) Life Sciences 74: A.M. Wu, J.H. Wu, T. Singh, J.H. Liu, A. Herp (2004) Lectinochemical studies on the affinity of Anguilla anguilla agglutinin for mammalian glycotopes Life Sciences 75: A.M. Wu, J.H. Wu, T. Singh, K.C. Chu, W.J. Peumans, P. Rouge, E.J.M. Vam Damme (2004) A novel lectin (Morniga M) from mulberry (Morus nigra) bark recognizes oligomannosyl residues in N-glycans. J. Biomed Sci. 11: T. Singh, U. Chatterjee, J.H. Wu, B.P. Chatterjee, A.M. Wu (2005) Carbohydrate recognition factors of a Tα (Galβ1 3GalNAcα1 Ser/Thr) and Tn (GalNAcα1 Ser/Thr) specific lectin isolated from the seeds of Artocarpus Iakoocha. Glycobiology 15: J.T. Yang, T.H. Lee, H.H. Weng, C.N. Chang, W.C. Chen, W.C. Cheng, J.H. Wu* (2005) Dexamethasone enhances NT-3 expression in rat hippocampus after traumatic brain injury. Experimental Neurology 192: A.M. Wu, J.H. Wu, H.W. Kuo, A. Herp (2005) Further characterization of the binding properties of two monoclonal antibodies recognizing human Tn red blood cells. J Biomed Sci 12: C.N. Chang, J.T. Yang, T.H. Lee, W.C. Cheng, Y.H. Hsu, J.H. Wu* (2005) Dexamethasone enhances the upregulation of nerve growth factor mrna expression in ischemic rat brain. J. Clin Neuroscience 12: J.H. Wu, C.G. Tsai (2005) Infectivity of hepatic strain Klebsiella pneumoniae in diabetic mice. Exp. Biol. Med. 230: A.M. Wu, J.H. Wu, T Singh, P.Y. Hwang, M.S. Tsai, A. Herp (2005) Lectinochemical studies on the binding properties of a toxic lectin (ricin) isolated from the seeds of Ricinus communis. Chang Gung Med

5 J 28: T. Singh, J.H. Wu, W.J. Peumans, P. Rouge, E.J.M. Van Damme, R.A. Alvarez, A.M. Wu (2006) Carbohydrate specificity of an insecticidal lectin isolated from the leaves of Glechoma hederacea towards mammalian glycoconjugates. Biochem J. 393: J.H. Wu, T. Singh, A. Herp, A.M. Wu (2006) Carbohydrate recognition factors of the lectin domains present in the Ricinus communis toxic protein (ricin). Biochimie 88: A.M. Wu, J.H. Wu, T. Singh, L.J. Lai, Z. Yang, A. Herp (2006) Recognition factors of Ricinus communis agglutinin 1 (RCA1). Molecular Immunol 43: J.H. Wu, L.C. Hong, Y.Y. Tsai, H.W. Chen, W.X. Chen, T.S. Wu (2006) Mitogen-activated protein kinase (MAPK) signaling pathways in HepG2 cells infected with a virulent strain of Klebsiella pneumoniae. Cellular Microbiology 8: A.M. Wu, R. Singh, J.H. Wu, M. Lensch, S Andre, H.J. Gavius (2006) Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation. Glycobiol 16: T.H. Lee, J.T. Yanf, H. Kato, J.H. Wu (2006) Hypertension downregulates the expression of brain-derived heurotrophic factor in the ischemia-vulnerable hippocampal CA1 and cortical areas after carotid artery occlusion. Brain Res 1112: A.M. Wu, J.H. Wu, T. Singh, J.H. Liu, M.S. Tsai, N. Gilboa-Garger (2006) Interactions of the fucose-specific Pseudominas aeruginosa lectin, PA-IIL, with mammalian glycoconjugates bearing polyvalent Lewis a and ABH blood group glycotopes. Biochimie 88: L.J. Lai, X. Xiao, J.H. Wu* (2007) Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury model. J biomed Sci 14: T. Singh, J.H. Wu, W.J. Peimans, P. Rouge, E.J.M. Van Damme, A.M. Wu (2007) Recognition profile of Morus nigra agglutinin (Morniga G) expressed by monomeric ligands, simple clusters and mammalian polyvalent glycotopes. Mol Immunol 44: (SCI) 75. A.M. Wu, J.H. Wu, M.S. Tsai, Z. Yang, N. Sharon, A. Herp (2007) Differential affinities of Erythrina cristagalli lectin (ECL) toward monosaccharides and polyvalent mammalian structural units. Glycoconj J 24: Z. Yang, M.S. Tsai, J.H. Wu, A. Herp, A.M. Wu (2008) Defining the carbohydrate specificities of Erythrina corallodendron lectin (ECorL) as polyvalent Galβ1-4GlcNAc (II)>monomeric II>monomeric Gal and GalNAc. Chang Gung Med J 31: J.H. Wu, A.M. Wu, C.G. Tsai, X.Y. Chang, T.S. Wu (2008) Contribution of fucose containing capsules in Klebsiella pneumoniae to bacterial virulence in mice. Exp Biol Med 233: K.L Chien, W.H. Fang, H.C. Wen, H.P. Lin, Y.L. Lin, S.W. Lin, J.H. Wu, J.T.Kao (2008) APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese. Clinica Chimica Acta 390: J.T. Yang, C.N. Chang, J.H. Wu, C.Y. Chung. H.H. Weng, W.C. Cheng, T.H. Lee (2008) Cigarette smokingdecreases neurotrophin-3 expression in rat hippocampus after transient forebrain ischemia. Neurosci Res 60: S.H. Maa, H.L. Lee, Y.C. Huang, J.H. Wu, T.S. Tsou, K. MacDonald, I. Abraham (2008). Incidence Density and Relative Risk of Nosocomial Infections in Taiwan s Only Children s Hospital, Infection Control and Hospital Epidemiology, 29(8), Z. Yang, M.S. Tsai, J.H. Wu, A. Herp, A.M. Wu (2008) Defining the carbohydrate specificities of Erythrina corallodendron lectin (ECorL) as polyvalent Galβ1-4GlcNAc (II)>monomeric II>monomeric Gal and GalNAc. Chang Gung Med J 31: AM Wu, JH Wu, Z Yang, T Singh, IJ Goldstein, N Sharon (2008) Defferential contributions of recognition factors of two plant lectins Amaranthus caudatus lectin and Arachis hypogea agglutinin, reacting with Thomsen-Friedenreich disaccharide (Galβ1 3 GalNAcα1-Ser/Thr) (2008) Biochimie 90: Z. Yang, J.H. Wu, H.W. Kao, R Kannagi, A.M. Wu (2009) Expression of sialyl Lex, sialyl Lea, Lex and Ley glycotopes in secreted human ovarian cyst glycoproteins. Biochimie 91: AM Wu, JH Wu, T Singh, B Singha, D Sudakevitz, N Gilboa-Garber (2009) Multivalent human blood group ABH and Lewis glycotopes are key recognition factors for a LFuc>Man binding lectin from phytopathogenic Ralstonia solanacearum. Biochimic et Biophysica Acta 1790: AM Wu, JH Wu, JH Liu, YY Chen, B Singha, LP Chow, JY Lin (2009) Roles of mammalian structural units, ligand cluster and polyvalency in the Abrus precatorius agglutinin and glycoprotein recognition process Mol Immunol 46: JH Wu, AM Wu, Z Yang, YY Chen, B Sngha, LP Chow, JY Lin (2010) Recognition intensities of

6 submolecular structures mammalian glycol-structural units, ligand cluster and polyvalency in abrin-a-carbohydrate interactions. Biochimie 92: YC Fu, JT Yang, HW Chen JH Wu* (2010) Effect of lipoprotein (a) on annexin A5 binding to cell membrane. Clinica Chemica Acta 411: PC Pan, HW Chen, PK Wu, YY Wu, CH Lin, JH Wu (2011) Mutation in fucose synthesis gene of Klebsiella pneumoniae affects capsule composition and virulence in mice. Exp Biol Med 236: Abstract, Conference paper and other: 1. Identification of F tra operon products encoded by the trab-trah segment of the F transfer operon (1984) at 13th annual Gulf Coast Molecular Biology Conference, Smithville, Texas. 2. A physical and genetic map of the central region of the F tra operon: Genes involved in the elaboration of F pili (1984) at 13th annual Gulf Coast Molecular Biology Conference, Smithville, Texas. 3. The identification of traq and other new genes in the transfer operon of the E. coli K12 F factor (1986) at meeting on "Molecular Genetics of Bacteria and Phages" at Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 4. S. H. Chen, J. H. Wu, X. Li, W. S. L. Liao and L. Chan (1989) RNA editing in mammals is not confined to apolipoprotein B. The Journal of Cell Biology 109:96a. 5. ApoB genetic studies of CAD and non-cad patients in Taiwan by PCR technique (1991) at 24th annual Hugh Lofland Atherosclerosis Conference, Seattle, Washington. 6. J. H. Wu, M. S. Wen, D. Wu (1991) The genetic polymorphism of apolipoprotein B in population of Taiwan is different from that of Caucasians. The Journal of Cell Biology 115:148a. 7. J.H. Wu, M.S. Wen, S.M. Tseng (1992) Plasma lipoprotein (a) level and coronary heart disease in Taiwanese population. The Second International Conference of Lipoprotein (a) Abstract book p J.H. Wu, M.S. Wen, S.C. Kao, S.K. Lo, M.S. Chen (1993) Increased frequency of apolipoprotein B signal peptide sp24/24 in patients with coronary artery diseases Molecular Biology of the Cell 4:190a. 9. J.H. Wu (1994) Nucleotide sequence variation of apolipoprotein B 3'variable number tandemly repeat (VNTR) alleles at XIV Washington International Spring Symposium for Cardiovascular Disease '94:Cellular and Molecular Mechanisms, Prevention, Treatment. At Washington DC, USA. 10. J. H. Wu, S. C. Kao and M. S. Wen (1994) The number of kringle IV and promoter activity are related to plasma lipoprotein (a) concentration. Molecular Biology of the Cell 5:541a. 11. J. H. Wu, S. C. Kao and M. S. Wen (1996) Effect of apolipoprotein B3' hypervariable repeat genotype on plasma lipid concentration. The FASEB Journal 10:A J. H. Wu, S. K. Lo, M. S. Wen, M. S. Chern, J. T. Kao, L. H. Ko (1996) Association of apolipoprotein AI-CIII genetic polymorphism with plasma lipid concentration and Coronary artery disease. Molecular Biology of the Cell 7:1738a. 13. J. H. Wu, R. J. Hsu, A. M. Wu (1997). Lectin binding properties of Lp(a) at 29th Hugh Lofland Conference on artery wall metabolism in atherosclerosis, Honolulu, Hawaii. 14. J.H. Wu (1998) Genetic polymorphisms of apolipoprotein B in Taiwanese population. Invited Speaker at DAE Symposium on Recent Advances in Genetic Epidemiology and Population Monitoring, Madras, India. 15. J. Wu, Y.T. Lee, H.C. Hsu (2000). Frequency distribution of apob and CETP polymorphism, plasma lipids and coronary heart disease in Taiwanese population. Atherosclerosis 151: 謝絹珠 : 醫學細胞分子生物學 Molecular Basis of Medical Cell Biology by Gerald M Fuller, Denis Shields (1998) 譯本監修 (2001) 17. J.H. Wu, S.Y. Jiang, I.N. Lee (2001) Sequence microheterogeneity of apolipoprotein (a) promoter affects the promoter activity and enhancer influences. Molecular Biology of the Cell 12 : Suppl 109a-110a. 18. J.H. Wu, I. Lee, S. Jiang (2002) the intron sequences of APO(a) repeat region regulate homologous and heterologous promoters. Molecular Biology of the Cell 13: Suppl 249a. 19. J.H. Wu, A.M. Wu, Y. Tsau (2003) Capsular sugars of bacteria Klebsiella pneumoniae. The 43 rd Annunal Meeting, American Society for Cell Biology. Late Abstract. 20. C. Tsaim J.H. Wu* (2004) Infections in diabetic mice by Klebsiella pneumoniae of liver abscess isolates. Molecular Biology of the Cell 15 Suppl: 464a. 21. Li Chuen Hong, June H. Wu (2005) Activation of MAPK signaling pathways in HepG2 cells infected with Klebsiella pneumoniae of liver abscess isolates. At 105 th General Meeting, American Society for Microbiology, Atlanta Georgia USA.

7 21. J.H. Wu, L. Hong, E. Tsai (2005) Activation of signaling molecules in Klebsiella pneumoniae-infected human hepatoma cells, HepG2. At 45 th Annual Meeting, American Society for Cell Biology, San Francisco, CA, USA 22. J.H. Wu, C.G. Tsai, A.M. Wu, T.S. Wu (2006) Studies of capsular carbohydrates in Klebsiella pneumoniae isolated from diabetic patient. The FEBS J 273: Suppl 1 : 263a At 31 st FEBS Congress Istanbul, Turkey. 23. W. Tang J.H. Wu (2006) Interaction of intron sequences os apolipoprotein (a) repeats with HepG2 nuclear extract. At 46 th Annual Meeting, The American Society for Cell Biology, San Diego, CA, USA 24. J.H. Wu, X.Y Chang A.M. Wu (2007) In search of virulence factor of Klebsiella pneumoniae isolated from diabetic patient with liver abscess. At 107 th General Meeting, American Society for Microbiology, Toronto, Canada. 25. Y.C Fu, J.H. Wu (2007) The role of annexins in interaction of lipoprotein (a) with endothelial cells. 47 th Annual Meeting, American Society for Cell Biology, Washington DC, USA. 26. Y.C Fu, J.H. Wu (2008) Role of sugars on lipoprotein (a) in its interaction with endothelial cells.the FEBS Journal 275 (Suppl 1):244. At 33 rd FEBS Congress and 11 th IUBMB Conference, Athens, Greece. 27. J.H. Wu (2008) Cell death in HepG2 cells infected with a virulent Klebsiella pneumoniae. At 48 th Annual Meeting of American Society for Cell Biology, San Francisco, USA. 28. J.H. Wu, Y.C. Fu, A.M. Wu (2009) Interaction of lipoprotein (a) and annexin A5 affects anticoagulant function of annexin A5. At 15 th European Carbohydrate Symposium, Vienna, Austria. 29. J.Wu, W.X. Chen (2009) Signal transduction in HepG2 cells infected with a bacterium Klebsiella pneumoniae. The FEBS J. 276 (Suppl 1): 257. At 34 th FEBS Congress, Prague, Czech Republic 30. BJ Pan, JH Wu (2010) Klebsiella pneumoniae with fucose synthesis gene mutation displays reduced virulence. The FEBS Journal 277 (Suppl 1): 91. At 35 th FEBS Congress, Gothenburg, Sweden. 31. PY Yang, JH Wu (2010) Molecules involved in the death of HepG2 cells infected with Klebsiella pneumoniae. The 50 th Annual Meeting, American Society for Cell Biology. Philadelphia, Pennsylvania, USA.