FOU Yr.2015 (2014) Akane Diols PROPANEDIOL METHYLPROPANEDIOL
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1 Final 2016 CIR Priority List with Ingredient Groupings (CIR will choose from these groupings to create a feasible number of reports. Not all of these groupings will be acted upon in 2016) Group/INGREDIENT NAME Akane Diols PROPANEDIOL METHYLPROPANEDIOL All of the ingredients in this report are structurally related as simple, small diols. However, diols with regiochemistry 1,2-substitution have been previously reviewed. 1. 1,4-Butanediol (4) 2. 2,3-Butanediol 3. Butyl Ethyl Propanediol 4. 1,10-Decanediol (14) 5. Hexanediol 6. Isopentyldiol (129) 7. Octanediol 8. 1,5-Pentanediol 1 Fatty Acids and Soaps (Fatty Acid Salts) LINOLEIC ACID 532 Related prior report: Final Safety Assessment of 1,2-Glycols (JT 31(Suppl. 2): , 2012) All of the ingredients in this report are structurally related as simply fatty acids and their simple inorganic salts (soaps). Hydroxyfatty acids and their simple salts are also included in this report. Related Prior Reports (color coded when included): Arachidonic Acid - JACT 12(5): , 1993 Fatty Acids and Sodium/Potassium Soaps from plant oils Final Plant Oils Report 03/04/2011 Hydroxystearic Acid - IJT 18(S1):1-10, 1999 (10) 1. Aluminum Distearate (26) 2. Aluminum Isostearate 3. Aluminum Isostearates/ Palmitates 4. Aluminum Isostearates/ Stearates 5. Aluminum Isostearates/ Laurates/Palmitates 6. Aluminum Isostearates/ Laurates/Stearates 7. Aluminum Lanolate 8. Aluminum Stearate (48) 9. Aluminum Stearates (4) 10. Aluminum Tristearate (7)
2 2 Group/INGREDIENT NAME Isostearic Acid - IJT 24(Suppl. 1):1-102, 2005 (Not reopened; JACT 2(7):61-74, 1983) Oleic Acid,Lauric Acid, Palmitic Acid, Myristic Acid, and Stearic Acid - IJT 25(Suppl. 2) :1-89,2006 (Not reopened; JACT 6(3): , 1987) Pelargonic Acid - IJT-30(SUPPL. 3)2011 Ricinoleic Acid - IJT 26(Suppl. 3):31-77, 2007 Lithium Stearate, Aluminum Distearate, Aluminum Stearate, Aluminum Tristearate, Ammonium Stearate,, Magnesium Stearate, Potassium Stearate, Sodium Stearate, and Zinc Stearate - IJT 22(Suppl. 1):1-35, 2003 (Not reopened; JACT 1(2): , 1982) Aluminum dimyristate, Aluminum Isostearates/ Myristates, aluminum myristate, aluminum myristates/palmitates, calcium myristate, cetyl myristate, and magnesium myristate (and myristate esters) - IJT 29(Suppl. 3) : ,2010 DEA-Isostearate, DEA-Linoleate, DEA-Myristate, and DEA Stearate (and other DEA salts) Final Report 2011 MEA-Undecylenate and MEA-Tallowate Final Report 2012 TEA-Fatty Acid Salts - IJT 32(Suppl. 1):59-83, Ammonium Isostearate 12. Ammonium Oleate 13. Ammonium Stearate (4) 14. Arachidic Acid (3) 15. Beeswax Acid 16. Behenic Acid (130) 17. C14-28 Alkyl Acid (18)* 18. C10-40 Isoalkyl Acid 19. C14-28 Isoalkyl Acid (18)* 20. C32-36 Isoalkyl Acid 21. Calcium Behenate (2) 22. Calcium Laurate 23. Calcium Stearate (370) 24. Calcium Undecylenate 25. Capric Acid (3) 26. Caproic Acid 27. Caprylic Acid (5) 28. Erucic Acid 29. Isomerized Linoleic Acid (19) 30. Isomerized Safflower Acid 31. Isostearic Acid (237) 32. Lauric Acid (454) 33. Linolenic Acid (176) 34. Lithium Stearate (91) 35. Magnesium Lanolate 36. Magnesium Laurate (9) 37. Magnesium Palmitate 38. Magnesium Stearate (569) 39. Magnesium Tallowate 40. Myristic Acid (323) 41. Oleic Acid (1075)
3 Group/INGREDIENT NAME (Total # in Ingredient Group) 42. Ozonized Oleic Acid 43. Palmitic Acid (1141) 44. Potassium Behenate (5) 45. Potassium Borageate 46. Potassium Camelliate 47. Potassium Caprate 48. Potassium Caprylate 49. Potassium Caprylate/Caprate 50. Potassium Castorate (2) 51. Potassium Hydrogenated Tallowate (1) 52. Potassium Isostearate (5) 53. Potassium Lanolate 54. Potassium Laurate (25) 55. Potassium Linoleate 56. Potassium Linseedate 57. Potassium Oleate (53) 58. Potassium Olivate/ Sunflowerseedate 59. Potassium Palm Kernelate (17) 60. Potassium Palmitate 61. Potassium Stearate (123) 62. Potassium Sunflowerseedate 63. Potassium Tallate 64. Potassium Tallowate 65. Potassium Undecylenate 66. Sodium Arganate 67. Sodium Beeswax 68. Sodium Behenate (14) 69. Sodium Camellia Japonica 3
4 Group/INGREDIENT NAME (Total # in Ingredient Group) Seedate 70. Sodium Caprate 71. Sodium Caprylate 72. Sodium Castorate (2) 73. Sodium Dilinoleate 74. Sodium Hydrogenated Tallowate 75. Sodium Isostearate (10) 76. Sodium Lanolate 77. Sodium Lardate 78. Sodium Laurate (76) 79. Sodium Laurate/ Linoleate/Oleate/ Palmitate 80. Sodium Linoleate 81. Sodium Oleate (21) 82. Sodium Palmitate (83) 83. Sodium Stearate (557) 84. Sodium Tallowate (136) 85. Sodium Tamanuseedate 86. Sodium Undecylenate 87. Stearic Acid (5200) 88. Undecanoic Acid 89. Undecylenic Acid 90. Zinc Laurate (78) 91. Zinc Palmitate 92. Zinc Stearate (2119) 93. Zinc Undecylenate (1) 94. Hydroxystearic Acid (111) 95. Hydroxycapric Acid (1) 96. Hydroxycaprylic Acid (5) Hydroxydecanoic Acid (18) 4
5 Group/INGREDIENT NAME Acryloyldimethyltaurate Polymers HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER 446 (383) 421 (383) This group is comprised of copolymers, the monomers of which are partially comprised of acryloyldimethyltaurate monomers. Related recent report: Alkyl Taurate Amides and Taurate Salts (2015) 98. Hydroxylauric acid Hydroxystearic Acid (100) 1. Acrylamide/Sodium Acryloyldimethyltaurate/ Acrylic Acid Copolymer 2. Acrylamide/Sodium Acryloyldimethyltaurate Copolymer (238) 3. Ammonium Acryloyldimethyltaurate/ Beheneth-25 Methacrylate Crosspolymer (48) 4. Ammonium Acryloyldimethyltaurate/ Carboxyethyl Acrylate Crosspolymer (1) 5. Ammonium Acryloyldimethyltaurate/ Laureth-7 Methacrylate Copolymer 6. Ammonium Acryloyldimethyltaurate/ Steareth-8 Methacrylate Copolymer (1) 7. Ammonium Acryloyldimethyltaurate/ Steareth-25 Methacrylate Crosspolymer (6) 8. Ammonium Acryloyldimethyltaurate/ 5
6 Group/INGREDIENT NAME (Total # in Ingredient Group) Vinyl Formamide Copolymer 9. Ammonium Polyacryloyldimethyl Taurate (232) 10. Dimethylacrylamide/ Sodium Acryloyldimethyltaurate Crosspolymer (5) 11. Polyacryloyldimethyltaur ate Polyoxymethylene Melamine 12. Sodium Acrylate/ Acryloyldimethyltaurate/ Dimethylacrylamide Crosspolymer (1) 13. Sodium Acrylate/Sodium Acryloyldimethyl Taurate/Acrylamide Copolymer (6) 14. Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer (153) 15. Sodium Acryloyldimethyl Taurate/Acrylamide/VP Copolymer 16. Sodium Acryloyldimethyltaurate/ Methacrylamidolauric Acid Copolymer 17. Sodium Acryloyl Dimethyl Taurate/PEG-8 Diacrylate Crosspolymer 6
7 Group/INGREDIENT NAME HYDROFLUOROCARBON 152A 426 (422) In 1982, CIR reviewed the safety of the following alkane propellants: Isobutane, Isopentane, n-butane, and Propane. Hydrofluorocarbon 152A, however, is structurally differentiated from those ingredients with geminal difluoronation. 18. Sodium Acryloyldimethyltaurate/ VP Crosspolymer (7) 19. Sodium Polyacryloyldimethyl Taurate (23) (21) N/A 7 Alkoxyl Alkyl Silanes TRIETHOXYCAPRYLYLSILANE 409 Ethers of Ascorbate TETRAHEXYLDECYL ASCORBATE 382 (365) The ingredients in this report are structurally related as silanes bearing both alkyl and alkoxyl groups. The ingredients in this report are all ethers of ascorbic acid. Some of these ingredients were previously reviewed: Ascorbyl Dipalmitate, Ascorbyl Palmitate, and Ascorbyl Stearate (CIR: [S] IJT-18(SUPPL. 3)1999)). (1) 1. Bis- Stearoxydimethylsilane 2. Stearoxytrimethylsilane (10) 3. Trimethoxycaprylylsilane (6) (4) 1. Ascorbyl Isostearate 2. Ascorbyl Linoleate (3) 3. Ascorbyl Tetraisopalmitate (117) 4. Ascorbyl Dipalmitate (3) 5. Ascorbyl Palmitate (2241) 6. Ascorbyl Stearate (10) (7)
8 Group/INGREDIENT NAME Ether, esters, and salts of Panthenol and Pantothenic Acid PANTHENYL ETHYL ETHER 378 (375) These ingredients are closely related to the recently reviewed ingredients, Panthenol and Pantothenic Acid (CIR: [R] IJT-25(SUPPL. 2)2006), sharing the same structural core. Potentially, these ingredients may be incorporated into a re-review. 1. Panthenyl Ethyl Ether Acetate 2. Panthenyl Triacetate (94) 3. Calcium Pantothenate (198) 4. Sodium Pantothenate Etidronic acid and simple salts ETIDRONIC ACID 370 (345) The ingredients in this report share the same structural etidronic acid core. (5) 1. Disodium Etidronate (8) 2. Tetrapotassium Etidronate (2) 3. Tetrasodium Etidronate (322) 8 Dialkyl Carbonates DICAPRYLYL CARBONATE 366 The ingredients in this report are each structurally related as simple alkyl diesters of carbonic acid. (4) 1. Bis-Propylheptyl Carbonate 2. C14-15 Dialkyl Carbonate 3. Diethylhexyl Carbonate (15) 4. Dimethyl Carbonate 5. Dipropyl Carbonate (6)
9 Group/INGREDIENT NAME Monoalkylglycol Dialkyl Acid Esters TRIMETHYL PENTANYL DIISOBUTYRATE 351 The ingredients in this report are each structurally realted as simple alkyl esters of various monoalkyl diols. Related reports: Final Report on the Safety Assessment...Glycol Distearate (IJT 22(Suppl. 1):1-35, 2003 Not reopened; JACT 1(2):1-11, 1982) Neopentyl Glycol Diisononanoate - (IJT 30(Suppl. 3): , 2011) Final Report on the Safety Assessment of Propylene Glycol Esters [including diesters] as Used in Cosmetics (12/09/2014; IJT 18(S2):35-52, 1999) 1. 1,4-Butanediol Bisdecanoate 2. Butylene Glycol Dicaprylate/Dicaprate (82) 3. Butylene Glycol Diisononanoate 4. Butylethylpropanediol Dimer Dilinoleate 5. Diethylpentanediol Dineopentanoate 6. Dioctadecanyl Didecyltetradecanoate 7. Dioctadecanyl Ditetradecyloctadecanoate 8. Glycol Dibehenate 9. Glycol Diethylhexanoate 10. Glycol Dilaurate 11. Glycol Dioleate 12. Glycol Dipalmate/Palm Kernelate/Olivate/ Macadamiate 13. Glycol Dipalmate/Rapeseedate/ Soyate 14. Glycol Dipivalate 15. Glycol Distearate (1523) 16. Glycol Ditallowate 17. Hexanediol Distearate 18. 1,2-Hexanediyl Dicaprate 19. Neopentyl Glycol Dicaprate (55) 9
10 Group/INGREDIENT NAME (Total # in Ingredient Group) 20. Neopentyl Glycol Dicaprylate/Dicaprate (86) 21. Neopentyl Glycol Dicaprylate/ Dipelargonate/Dicaprate 22. Neopentyl Glycol Diethylhexanoate (67) 23. Neopentyl Glycol Diheptanoate (261) 24. Neopentyl Glycol Diisononanoate 25. Neopentyl Glycol Diisostearate (3) 26. Neopentyl Glycol Dilaurate 27. Propanediol Dicaprylate (5) 28. Propanediol Dicaprylate/Caprate (2) 29. Propanediol Diisostearate 30. Propanediol Dipelargonate (31) 10
11 Group/INGREDIENT NAME Hops HUMULUS LUPULUS (HOPS) EXTRACT Tea Tree MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL The ingredients in this report are related by source, as each is a derivative of Humulus lupulus (hops). While the identity and concentrations of ingredient components may vary from plant part to plant and from extract method to extract method, those component idenities and concentrations cannot be known for these exclusively industry specific ingredients until such information is provided as outlined in the industry s botanical framework. Differences in those components do not neccessitate the regrouping of such ingredients, but instead warrant a comparison/contrast effort as to how those differences effect safety. Those differences are likely to be informative. The ingredients in this report are related by source, as each is a derivative of Melaleuca alternifolia (tea tree). While the identity and concentrations of ingredient components may vary from plant part 1. Humulus Lupulus (Hops) Cone Extract (4) 2. Humulus Lupulus (Hops) Cone Oil 3. Humulus Lupulus (Hops) Flower Extract 4. Humulus Lupulus (Hops) Stem Extract 5. Humulus Lupulus (Hops) Strobile (9) (6) 1. Melaleuca Alternifolia (Tea Tree) Extract (36) 2. Melaleuca Alternifolia (Tea Tree) Flower/Leaf/Stem Extract (14) 3. Melaleuca Alternifolia (Tea Tree) Leaf (6) 4. Melaleuca Alternifolia (Tea Tree) Leaf Extract 11
12 Group/INGREDIENT NAME 12 Alkoxylated Fatty Amides PPG-2 HYDROXYETHYL COCAMIDE 332 to plant and from extract method to extract method, those component idenities and concentrations cannot be known for these exclusively industry specific ingredients until such information is provided as outlined in the industry s botanical framework. Differences in those components do not neccessitate the regrouping of such ingredients, but instead warrant a comparison/contrast effort as to how those differences effect safety. Those differences are likely to be informative. The ingredients in this report are each structurally related as alkoxylated (PEG, PPG, etc.) simple amides. 5. Melaleuca Alternifolia (Tea Tree) Leaf Powder (5) 6. Melaleuca Alternifolia (Tea Tree) Leaf Water (7) 1. PEG-2 Cocamide (8) 2. PEG-3 Cocamide 3. PEG-4 Cocamide 4. PEG-5 Cocamide (25) 5. PEG-6 Cocamide (20) 6. PEG-7 Cocamide 7. PEG-11 Cocamide 8. PEG-20 Cocamide 9. PEG-3 Cocamide DEA 10. PEG-6 Hydrogenated Palmamide 11. PEG-50 Hydrogenated Palmamide (13) 12. PEG-13 Hydrogenated Tallow Amide 13. PEG-5 Lanolinamide 14. PEG-3 Lauramide 15. PEG-5 Lauramide 16. PEG-6 Lauramide 17. PEG-11 Lauramide 18. PEG-3 Oleamide 19. PEG-4 Oleamide
13 Group/INGREDIENT NAME (Total # in Ingredient Group) 20. PEG-5 Oleamide 21. PEG-6 Oleamide 22. PEG-7 Oleamide 23. PEG-9 Oleamide 24. PEG-5 Oleamide Dioleate 25. PEG-4 Rapeseedamide (257) 26. PEG-4 Stearamide 27. PEG-10 Stearamide 28. PEG-15 Stearamide 29. PEG-50 Stearamide 30. PEG-5 Tallow Amide 31. PEG-8 Tallow Amide 32. PEG-50 Tallow Amide (27) 33. PEG-2 Tallowamide DEA 34. Polyglyceryl-4-PEG-2 Cocamide 35. PPG-2 Cocamide (2) 36. PPG-1 Hydroxyethyl Caprylamide 37. PPG-2 Hydroxyethyl Coco/Isostearamide (44) 38. PPG-3 Hydroxyethyl Soyamide (39) 13
14 Group/INGREDIENT NAME Saccharide Esters SUCROSE ACETATE ISOBUTYRATE The ingredients in this report are related as carboxylic esters of of small saccharides. Ex., Maltitol Laurate, a saccharide ester Related reports: Final Report on Maltitol and Maltitol Laurate (2008) Final Report on Monosaccharides, Disaccharides, and Related Ingredients Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides (2013) 1. Glucose Pentaacetate 2. Maltitol Laurate 3. Raffinose Isostearate 4. Raffinose Myristate 5. Raffinose Oleate 6. Sucrose Acetate/Stearate 7. Sucrose Benzoate (49) 8. Sucrose Cocoate (128) 9. Sucrose Dilaurate (12) 10. Sucrose Disinapate 11. Sucrose Distearate (66) 12. Sucrose Hexaerucate 13. Sucrose Hexaoleate/ Hexapalmitate/ Hexastearate 14. Sucrose Hexapalmitate 15. Sucrose Laurate (35) 16. Sucrose Myristate (3) 17. Sucrose Octaacetate 18. Sucrose Oleate 19. Sucrose Palmitate (55) 20. Sucrose Palmitate/ Stearate (1)* 21. Sucrose Pentaerucate 22. Sucrose Pentahydroxystearate 23. Sucrose Polybehenate (2) 24. Sucrose Polycottonseedate (32) 25. Sucrose Polylaurate (1) 26. Sucrose Polylinoleate
15 Group/INGREDIENT NAME HYDROXYETHYL-3,4- METHYLENEDIOXYNAILINE HCl 58 Added upon request Hydroxyethyl-3,4-Methylenedioxyaniline HCl is the hair dye ingredient requested for addition to the 2016 Priorities List by the PCPC HCTC. 27. Sucrose Polyoleate (1) 28. Sucrose Polysoyate (19) 29. Sucrose Polystearate (14) 30. Sucrose Stearate (152) 31. Sucrose Tetrahydroxystearate 32. Sucrose Tetraisostearate (2) 33. Sucrose Tetrastearate Triacetate (56) 34. Sucrose Tribehenate 35. Sucrose Trilaurate 36. Sucrose Tristearate 37. Trehalose Isostearate Esters 38. Trehalose Undecylenoate 39. Xylityl Sesquicaprylate (40) N/A (1) 15
16 Group/INGREDIENT NAME TETRAFLUOROPROPENE 0 Added upon request In 1982, CIR reviewed the safety of the following alkane propellants: Isobutane, Isopentane, n-butane, and Propane. Hydrofluorocarbon 152A, however, is structurally differentiated from those ingredients with geminal difluoronation. N/A (Potential # of 283 Ingredients:) 17 proposed new reports (5 rescheduled from the 2015 Priorities List) to select from for 2016 *listed in the FDA VCRP data, but not in the INCI Dictionary (1) 16
17 2016 CIR Re-Review Priority List (CIR will choose from these groupings to create a feasible number of reports.) Group/INGREDIENT NAME Ingredient Group with Potential Add-ons GLYOXAL The Expert Panel agreed to an abbreviated re-review per a strategies memo. 1. Glyoxal (1) Butyl Polyoxyalkylene Ethers 17 The Expert Panel agreed to combine two old reports and add these new ingredients per a strategies memo. IJT 19(S1):47-67, 2000 IJT 20(suppl 4):39-52, 2001 Year 2001: Final Report on the Safety Assessment of PPG-40 Butyl Ether & Amended Final Report on the Safety Assessment of PPG-40 Butyl Ether with an Addendum to Include PPG-2, -4, -5, -9, -12, -14, -15, -16, -17, -18, -20, -22, - 24, -26, -30, -33, -52, and -53 Butyl Ether (Amended conclusion for JACT 12(3): , 1993) 1. PPG-26-Buteth PPG-28-Buteth PPG-12-Buteth PPG-9-Buteth PPG-2 Butyl Ether 6. PPG-3 Butyl Ether 7. PPG-4 Butyl Ether 8. PPG-5 Butyl Ether 9. PPG-9 Butyl Ether 10. PPG-12 Butyl Ether 11. PPG-14 Butyl Ether 12. PPG-15 Butyl Ether 13. PPG-16 Butyl Ether 14. PPG-17 Butyl Ether 15. PPG-18 Butyl Ether 16. PPG-20 Butyl Ether 17. PPG-22 Butyl Ether 18. PPG-24 Butyl Ether 19. PPG-26 Butyl Ether 20. PPG-30 Butyl Ether 21. PPG-33 Butyl Ether 22. PPG-40 Butyl Ether 23. PPG-52 Butyl Ether 24. PPG-53 Butyl Ether
18 Group/INGREDIENT NAME Ingredient Group with Potential Add-ons 25. Buteth PPG-2-Buteth PPG-2-Buteth PPG-2-Buteth PPG-3-Buteth PPG-4-Buteth PPG-5-Buteth PPG-5-Buteth PPG-7-Buteth PPG-7-Buteth PPG-10-Buteth PPG-12-Buteth PPG-15-Buteth PPG-17-Buteth PPG-19-Buteth PPG-20-Buteth PPG-24-Buteth PPG-30-Buteth PPG-33-Buteth PPG-36-Buteth PPG-38-Buteth-37 (45) Fatty Amidopropyl N,N-Dimethyl -2- Hydroxyethylammonium Chlorides 18 The Expert Panel agreed to these two add-ons per a strategies memo. 1. Quaternium Hydroxyethyl Cetearamidopropyldimo nium Chloride 3. Hydroxyethyl Erucamidopropyl Dimonium Chloride (3)
19 Group/INGREDIENT NAME Ingredient Group with Potential Add-ons Triglycerides 19 The Expert Panel agreed to combine two old reports and add a new ingredient per a strategies memo. IJT 19(S1):89-94, 2000 IJT 20(suppl 4):61-94, Trihydroxystearin 2. Trilaurin 3. Triarachidin 4. Tribehenin 5. Tricaprin 6. Tricaprylin 7. Trierucin 8. Triheptanoin 9. Triheptylundecanoin 10. Triisononanoin 11. Triisopalmitin 12. Triisostearin 13. Trilinolein 14. Trilinolenin 15. Trimyristin 16. Trioctanoin (now Triethylhexanoin) 17. Triolein 18. Tripalmitin 19. Tripalmitolein 20. Triricinolein (is also a hydroxy substituted glyceride) 21. Tristearin 22. Triundecanoin 23. Glyceryl Triacetyl Hydroxystearate Glyceryl Triacetyl Ricinoleate 24. Glyceryl Stearate
20 Group/INGREDIENT NAME Ingredient Group with Potential Add-ons Diacetate 25. Isomerized Safflower Glycerides (25) Sarcosine and Sarcosinate Amides The ingredients in this report share in common a sarcosine core structure. Year 2001: Final Report on the Safety Assessment of Cocoyl Sarcosine, Lauroyl Sarcosine, Myristoyl Sarcosine, Oleoyl Sarcosine, Stearoyl Sarcosine, Sodium Cocoyl Sarcosinate, Sodium Lauroyl Sarcosinate, Sodium Myristoyl Sarcosinate, Ammonium Cocoyl Sarcosiate, and Ammonium Lauroyl Sarcosinate 4 proposed no-brainer add-ons: 1. Potassium Cocoyl Sarcosinate 2. Potassium Lauroyl Sarcosinate 3. Sodium Oleoyl Sarcosinate 4. Sodium Palmitoyl Sarcosinate -these only vary from those in the original report as other salts 1. Cocoyl Sarcosine 2. Lauroyl Sarcosine 3. Myristoyl Sarcosine 4. Oleoyl Sarcosine 5. Stearoyl Sarcosine 6. Sodium Cocoyl Sarcosinate 7. Sodium Lauroyl Sarcosinate 8. Sodium Myristoyl Sarcosinate 9. Ammonium Cocoyl Sarcosiate 10. Ammonium Lauroyl Sarcosinate 11. Potassium Cocoyl Sarcosinate 12. Potassium Lauroyl Sarcosinate 13. Sodium Oleoyl Sarcosinate 14. Sodium Palmitoyl Sarcosinate (14) 20
21 Group/INGREDIENT NAME Ingredient Group with Potential Add-ons Alkyl Morpholinium Ethosulfates The ingredients in this report share in common a morpholinium ethosulfate core structure. Year 2001: Final Report on the Safety Assessment of Cetethyl Morpholinium Ethosulfate 1. Cetethyl Morpholinium Ethosulfate 2. Soyethyl Morpholinium Ethosulfate (2) Persulfates PEG Propylene Glycol Esters 21 1 proposed no-brainer add-on: Soyethyl Morpholinium Ethosulfate only varies from above structure by replacement of the cetyl chain with the fatty alky chains derived from soy. These ingredients are all simple persulfate salts. Year 2001: Final Report on the Safety Assessment of Ammonium, Potassium, and Sodium Persulfate No proposed add-ons The ingredients in this report are structurally related as PEGylated propylene glycyl fatty acid esters. Year 2001: Final Report on the Safety Assessment of PEG-25 Propylene Glycol Stearate, PEG-75 Propylene Glycol, PEG-120 Propylene Glycol Stearate, PEG-10 Propylene Glycol, PEG-8 Propylene Glycol Cocoate, and PEG-55 Propylene Glycol Oleate 1 proposed no-brainer add-on: PEG-6 Propylene Glycol Caprylate/Caprate 1. Ammonium Persulfate 2. Potassium Persulfate 3. Sodium Persulfate (3) 1. PEG-25 Propylene Glycol Stearate 2. PEG-75 Propylene Glycol Stearate 3. PEG-120 Propylene Glycol Stearate, PEG-10 Propylene Glycol 4. PEG-8 Propylene Glycol Cocoate 5. PEG-55 Propylene Glycol
22 Group/INGREDIENT NAME Ingredient Group with Potential Add-ons Oleate 6. PEG-6 Propylene Glycol Caprylate/Caprate (6) Peppermint ACID VIOLET 43 The ingredients in this report are related by source, as each is a derivative of Mentha piperita (peppermint). Year 2001: Final Report on the Safety Assessment of Mentha Piperita (Peppermint) Oil, Mentha Piperita (Peppermint) Leaf Extract, Mentha Piperita (Peppermint) Leaf, and Mentha Piperita (Peppermint) Leaf Water No proposed add-ons Year 2001: Final Report on the Safety Assessment of Acid Violet Mentha Piperita (Peppermint) Oil 2. Mentha Piperita (Peppermint) Leaf Extract 3. Mentha Piperita (Peppermint) Leaf 4. Mentha Piperita (Peppermint) Leaf Water (5) 1. Acid Violet 43 (1) BIOTIN No proposed add-ons Year 2001: Final Report on the Safety Assessment of Biotin 1. Biotin (1) 22 No proposed add-ons
23 Group/INGREDIENT NAME Ingredient Group with Potential Add-ons Lard Ingredients The ingredients in this report are related by source, as each is a derivative of purified fat obtained from the abdomen of the hog. Year 2001: Final Report on the Safety Assessment of Lard Glyceride, Hydrogenated Lard Glyceride, Lard Glycerides, Hydrogenated Lard Glycerides, Lard and Hydrogenated Lard 1. Lard Glyceride 2. Hydrogenated Lard Glyceride 3. Lard Glycerides 4. Hydrogenated Lard Glycerides 5. Lard 6. Hydrogenated Lard (6) Malic Acid & Sodium Malate No proposed add-ons Year 2001: Final Report on the Safety Assessment of Malic Acid and Sodium Malate 1. Malic Acid 2. Sodium Malate (2) SODIUM SULFATE No proposed add-ons Year 2000: Final Report on the Safety Assessment of Sodium Sulfate 1. Sodium Sulfate (1) No proposed add-ons (Potential# of Ingredients: 115) 14 proposed re-review reports 23
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