Pathway Map Reference Guide
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1 Pathway Map Reference Guide Focus Attention-grabber Your Pathway The most popular cell signaling pathways Sample & Assay Technologies
2 Table of contents AKT Signaling 4 camp Signaling 5 Cellular Apoptosis 6 Chemokine Signaling 7 Cyclins and Cell Cycle Regulation 8 Cytokine Network 9 DNA Repair Mechanisms 10 EGF 11 Epithelial Tight Junctions 12 ErbB Family 13 ERK Signaling 14 Estrogen 15 Glucocorticoid Receptor Signaling 16 GPCR 17 HIF1a 18 IL-6 19 Insulin Receptor 20 JAK/STAT 21 LDL Oxidation in Atherogenesis 22 MAP Kinase Signaling 23 Molecular Mechanisms of Cancer 24 NFkB Family 25 Notch Signaling 26 p38 Signaling 27 p53 Signaling 28 PI3K Signaling 29 PPAR 30 Ras 31 Rho Family GTPases 32 SMAD Signaling Network 33 TCR Signaling 34 TGFb 35 TNF Superfamily 36 Toll-like Receptors 37 Transcriptional Network in Embryonic Stem Cells 38 Ubiquitin-Proteasome dependent Proteolysis 39 VEGF 40 Wnt Signaling 41 Product listing 42 For up-to-date licensing information and product-specific disclaimers, see the respective QIAGEN kit handbook or user manual. QIAGEN kit handbooks and user manuals are available at or can be requested from QIAGEN Technical Services or your local distributor. Trademarks: QIAGEN, EpiTect (QIAGEN Group); PowerPoint (Microsoft Corporation). Registered names, trademarks, etc. used in this document, even when not specifically marked as such, are not be considered unprotected by law. The products featured in the guide are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease QIAGEN, all rights reserved 2 Pathway Map Reference Guide 07/2011
3 The Pathway Map Reference Guide This guide illustrates important signaling pathways with their related RT 2 Profiler PCR Arrays and. To view the entire list of 500 pathway maps, editable PowerPoint slides, and related QIAGEN products, visit: Disclaimer: We acknowledge Protein Lounge, Inc. as the source of the Pathway Maps. Any questions or comments regarding the validity or accuracy of the pathway maps should be directed to Protein Lounge, Inc. directly. Product information enable the analysis of key genes for a biological pathway or disease state using real-time PCR in 2 hours. are available for all real-time PCR instruments. Associated pathway PCR arrays related to the top 50 pathways are provided in this guide. An example of a complete PCR array identifier catalog number is shown below: PAXX-###Y-# XX = species ### = unique pathway identifier Y = plate format # = pack size To view the entire list of available, visit: provide a rapid, sensitive, and quantitative assessment of over 45 signal transduction pathways by measuring the activities of downstream transcription factors. GFP and luciferase reporter systems are available. For a complete list of, visit: Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 3
4 Akt Signaling PI3K-Akt Signaling Pathway PAHS-058 PI3K/Akt CCS-1022L mtor Signaling PAHS-098 MAPK/ERK CCS-010L Oncogenes & Tumor Suppressor Genes PAHS-502 MAPK/JNK CCS-011L MAP Kinase Signaling Pathway PAHS-61 NFkB CCS-013L 4 Pathway Map Reference Guide 07/2011
5 camp Signaling camp/ca 2+ Signaling PathwayFinder PAHS-066 camp/pka CCS-002L p53 Signaling Pathway PAHS-071 Amino Acid Deprivation CCS-8034L Synaptic Plasticity PAHS-126 PKC/Ca 2+ CCS-015L MAP Kinase Signaling Pathway PAHS-061 MAPK/ERK CCS-010L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 5
6 Cellular Apoptosis Apoptosis PAHS-012 p53/dna Damage CCS-004L p53 Signaling Pathway PAHS-027 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 ATF6 CCS-9031L Autophagy PAHS-084 PI3K/Akt CCS-1022L 6 Pathway Map Reference Guide 07/2011
7 Chemokine Signaling Chemokines & Receptors PAHS-022 NFkB CCS-013L NFkB Signaling Pathway PAHS-025 MAPK/JNK CCS-011L Toll-like Receptor Signaling Pathway PAHS-018 MAPK/ERK CCS-010L MAP Kinase Signaling Pathway PAHS-061 Type I Interferon CCS-008L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 7
8 Cyclins and Cell Cycle Regulation Cell Cycle PAHS-020 Cell Cycle CCS-003L p53 Signaling Pathway PAHS-027 p53/dna Damage CCS-004L DNA Damage Signaling Pathway PAHS-029 PI3K/Akt CCS-1022L Cellular Senescence PAHS-050 Wnt CCS-018L 8 Pathway Map Reference Guide 07/2011
9 Cytokine Network Common Cytokines PAHS-021 Interferon g CCS-009L Chemokines & Receptors PAHS-022 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon Regulation CCS-7040L Interferon a, b Response PAHS-016 Type I Interferon CCS-008L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 9
10 DNA Repair Mechanisms DNA Repair PAHS-042 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 p53/dna Damage CCS-004L Telomeres and Telomerase PAHS-010 Hedgehog CCS-6030L qbiomarker Somatic Mutation SMH-### Amino Acid Deprivation CCS-8034L 10 Pathway Map Reference Guide 07/2011
11 EGF EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L Growth Factors PAHS-041 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGFR qbiomarker Somatic Mutation SMH-001 Estrogen Receptor CCS-005L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 11
12 Epithelial Tight Junctions Epithelial to Mesenchymal Transition PAHS-090 PKC/Ca 2+ CCS-015L Endothelial Cell Biology PAHS-015 MAPK/ERK CCS-010L Primary Cilia PAHS-127 SP1 CCS-6027L Amino Acid Metabolism II PAHS-130 MAPK/JNK CCS-004L 12 Pathway Map Reference Guide 07/2011
13 ErbB Family EGF/PDGF Signaling Pathway PAHS-040 Estrogen Receptor CCS-005L PI3K-Akt Signaling Pathway PAHS-058 Progesterone CCS-6043L Breast Cancer PAHS-131 PI3K/Akt CCS-1022L ErbB2 qbiomarker Somatic Mutation SMH-002 MAPK/ERK CCS-010L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 13
14 ERK Signaling MAP Kinase Signaling Pathway PAHS-061 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L NFkB Signaling Pathway PAHS-025 NFkB CCS-013L 14 Pathway Map Reference Guide 07/2011
15 Estrogen Breast Cancer and ER Signaling PAHS-005 Estrogen Receptor CCS-005L Breast Cancer PAHS-131 Progesterone CCS-6043L Nuclear Receptors and Coregulators PAHS-056 Androgen CCS-1019L EGF/PDGF Signaling Pathway PAHS-040 C/EBP CCS-001L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 15
16 Glucocorticoid Receptor Signaling Inflammatory Cytokines and Receptors PAHS-011 Glucocorticoid Receptor CCS-006L Nuclear Receptors and Coregulators PAHS-056 C/EBP CCS-001L Neutrophins & Receptors PAHS-031 VDRE CCS-2029L Stress Response to Cellular Damage PAHS-019 Androgen CCS-1019L 16 Pathway Map Reference Guide 07/2011
17 GPCR GPCR Signaling PathwayFinder PAHS-071 camp/pka CCS-002L Hedgehog Signaling Pathway PAHS-078 Hedgehog CCS-6030L Primary Cilia PAHS-127 PKC/Ca 2+ CCS-015L Neurotransmitter Receptors & Regulators PAHS-060 Wnt CCS-018L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 17
18 HIF1a Hypoxia Signaling Pathway PAHS-032 Hypoxia CCS-007L VEGF Signaling PAHS-091 ATF6 CCS-9031L Angiogenic Growth Factors and Inhibitors PAHS-072 Amino Acid Deprivation CCS-8034L Angiogenesis PAHS-024 PKC/Akt CCS-1022L 18 Pathway Map Reference Guide 07/2011
19 IL-6 TNF Ligands and Receptors PAHS-063 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 NFkB CCS-013L Chemokines and Receptors PAHS-022 Interferon g CCS-009L Common Cytokines PAHS-021 Interferon Regulation CCS-7040L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 19
20 Insulin Receptor Insulin Signaling Pathway PAHS-030 PI3K/Akt CCS-1022L Adipogenesis PAHS-049 PPAR CCS-3026L Notch Signaling Pathway PAHS-058 MAPK/ERK CCS-010L Alzheimer s Disease PAHS-056 MAPK/JNK CCS-011L 20 Pathway Map Reference Guide 07/2011
21 JAK/STAT JAK/STAT Signaling Pathway PAHS-039 Type I Interferon CCS-008L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon g CCS-009L Interferon a, b Response PAHS-016 STAT3 CCS-9028L Stem Cell Transcription Factors PAHS-501 Interferon Regulation CCS-7040L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 21
22 LDL Oxidation in Atherogenesis Atherosclerosis PAHS-038 Liver X Receptor CCS-004L Lipoprotein and Cholesterol Signaling PAHS-080 PPAR CCS-3026L Endothelial Cell Biology PAHS-015 Hepatocyte NF CCS-3039L Diabetes PAHS-023 NFkB CCS-013L 22 Pathway Map Reference Guide 07/2011
23 MAP Kinase Signaling MAP Kinase Signaling Pathway PAHS-061 MAPK/JNK CCS-011L PI3K-Akt Signaling Pathway PAHS-058 MAPK/ERK CCS-010L NFkB Signaling Pathway PAHS-025 PI3K/Akt CCS-1022L Signal Transduction PathwayFinder PAHS-014 NFkB CCS-013L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 23
24 Molecular Mechanisms of Cancer Cancer PathwayFinder PAHS-025 p53 CCS-004L Epithelial to Mesenchymal Transition PAHS-061 Cell Cycle CCS-003L EpiTect Methyl qpcr Arrays MeAH-### Wnt CCS-018L qbiomarker Somatic Mutation SMH-### Notch CCS-014L 24 Pathway Map Reference Guide 07/2011
25 NFkB Family NFkB Signaling Pathway PAHS-025 NFkB CCS-013L Toll-like Receptor Signaling Pathway PAHS-018 MAPK/JNK CCS-011L TNF Ligands and Receptors PAHS-063 MAPK/ERK CCS-010L MAP Kinase Signaling Pathway PAHS-061 SP1 CCS-6027L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 25
26 Notch Signaling Notch Signaling Pathway PAHS-059 Notch CCS-014L Stem Cell Signaling PAHS-047 Wnt CCS-018L Hedgehog Signaling Pathway PAHS-078 Hedgehog CCS-6030L WNT Signaling Pathway PAHS-043 EGR1 CCS-8021L 26 Pathway Map Reference Guide 07/2011
27 p38 Signaling MAP Kinase Signaling Pathway PAHS-061 MAPK/JNK CCS-011L NFkB Signaling Pathway PAHS-025 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 Amino Acid Deprivation CCS-8034L Toll-like Receptor Signaling Pathway PAHS-018 NFkB CCS-013L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 27
28 p53 Signaling p53 Signaling Pathway PAHS-027 p53/dna Damage CCS-004L Cell Cycle PAHS-020 Cell Cycle CCS-003L DNA Damage Signaling Pathway PAHS-029 SP1 CCS-6027L qbiomarker Somatic Mutation SMH-### Amino Acid Deprivation CCS-8034L 28 Pathway Map Reference Guide 07/2011
29 PI3K Signaling in B-Lymphocyte PI3K-Akt Signaling Pathway PAHS-058 PI3K/Akt CCS-1022L T-Cell and B-Cell Activation PAHS-053 MAPK/ERK CCS-010L mtor Signaling PAHS-098 MAPK/JNK CCS-011L Dendritic and Antigen Presenting Cell PAHS-406 NFkB CCS-013L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 29
30 PPAR Adipogenesis PAHS-049 PPAR CCS-3026L Nuclear Receptors and Coregulators PAHS-056 C/EBP CCS-001L Fatty Acid Metabolism PAHS-007 Liver X Receptor CCS-041L Insulin Signaling Pathway PAHS-030 Antioxidant Response CCS-5020L 30 Pathway Map Reference Guide 07/2011
31 Ras Oncogenes & Tumor Suppressor Genes PAHS-502 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L RTK Panel II qbiomarker Somatic Mutation SMH-009 p53/dna Damage CCS-004L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 31
32 Rho Family GTPases Cell Motility PAHS-128 PKC/Ca 2+ CCS-015L Cytoskeleton Regulators PAHS-088 PI3K/Akt CCS-1022L Epithelial to Mesenchymal Transition PAHS-090 MAPK/ERK CCS-010L PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L 32 Pathway Map Reference Guide 07/2011
33 SMAD Signaling Network TGFb/BMP Signaling Pathway PAHS-035 TGFb CCS-017L Epithelial to Mesenchymal Transition PAHS-090 Wnt CCS-018L Stem Cell Signaling PAHS-047 Interferon g CCS-009L Growth Factors PAHS-041 EGR1 CCS-8021L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 33
34 TCR Signaling T-Cell Anergy and Immune Tolerance PAHS-074 Interferon g CCS-009L T-Cell and B-Cell Activation PAHS-053 STAT3 CCS-9028L Th17 for Autoimmunity and Inflammation PAHS-073 Interferon Regulation CCS-7040L Dendritic and Antigen Presenting Cell PAHS-406 Notch CCS-014L 34 Pathway Map Reference Guide 07/2011
35 TGFb TGFb/BMP Signaling Pathway PAHS-035 TGFb CCS-017L Epithelial to Mesenchymal Transition PAHS-090 Wnt CCS-018L Growth Factors PAHS-041 Interferon g CCS-009L Th17 for Autoimmunity and Inflammation PAHS-073 EGR1 CCS-8021L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 35
36 TNF Superfamily TNF Ligands and Receptors PAHS-063 STAT3 CCS-9028L NFkB Signaling Pathway PAHS-025 NFkB CCS-013L Common Cytokines PAHS-021 Interferon g CCS-009L Toll-like Receptor Signaling PAHS-018 Interferon Regulation CCS-7040L 36 Pathway Map Reference Guide 07/2011
37 Toll-like Receptors Toll-like Receptor Signaling PAHS-018 NFkB CCS-013L Inflammasomes PAHS-097 Type I Interferon CCS-008L Innate and Adaptive Immune Response PAHS-052 Interferon Regulation CCS-7040L Dendritic and Antigen Presenting Cell PAHS-406 STAT3 CCS-9028L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 37
38 Transcriptional Network in Embryonic Stem Cells Embryonic Stem Cells PAHS-081 Nanog CCS-7037L Stem Cell PAHS-405 Oct4 CCS-025L Terminal Differentiation Markers PAHS-048 Sox2 CCS-038L qbiomarker Screening and Validation IPHS-### KLF4 CCS-4036L 38 Pathway Map Reference Guide 07/2011
39 Ubiquitin-Proteasome dependent Proteolysis Ubiquitination (Ubiquitinylation) PAHS-079 ATF6 CCS-9031L Autophagy PAHS-084 Cell Cycle CCS-003L Unfolded Protein Response PAHS-089 ER Stress CCS-2032L Chromatin Modification Enzymes PAHS-085 Antioxidant Response CCS-5020L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 39
40 VEGF Angiogenic Growth Factors & Inhibitors PAHS-072 Hypoxia CCS-007L VEGF Signaling PAHS-091 PI3K/Akt CCS-1022L Angiogenesis PAHS-024 TGFb CCS-017L Growth Factors PAHS-041 SP1 CCS-6027L 40 Pathway Map Reference Guide 07/2011
41 Wnt Wnt Signaling Pathway PAHS-043 Wnt CCS-018L Hedgehog Signaling Pathway PAHS-078 Notch CCS-014L Stem Cell Signaling PAHS-047 Hedgehog CCS-6030L Notch Signaling Pathway PAHS-059 TGFb CCS-017L Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 41
42 Top 60 Cat. no. Cat. no. Angiogenesis PAXX-024 Lipoprotein and Cholesterol Signaling PAXX-080 Apoptosis PAXX-012 MAP Kinase (MAPK) Signaling Pathway PAXX-061 Atherosclerosis PAXX-038 Mesenchymal Stem Cell PAXX-082 Autophagy PAXX-084 Mitochondria PAXX-087 Breast Cancer and ER Signaling PAXX-005 Mitochondrial Energy Metabolism PAXX-008 Cancer Drug Resistance & Metabolism PAXX-004 Neurogenesis and Neural Stem Cell PAXX-404 Cancer PathwayFinder PAXX-033 Neurotransmitter Receptors & Regulators PAXX-060 Cell Cycle PAXX-020 Neurotrophins and Receptors PAXX-031 Common Cytokines PAXX-022 NFκB Signaling Pathway PAXX-025 Cytoskeleton Regulators PAXX-021 Notch Signaling Pathway PAXX-059 Dendritic and Antigen Presenting Cell PAXX-088 Obesity PAXX-017 Diabetes PAXX-406 Oncogenes & Tumor Suppressor Genes PAXX-502 DNA Damage Signaling Pathway PAXX-023 Osteogenesis PAXX-026 DNA Repair PAXX-029 Oxidative Stress & Antioxidant Defense PAXX-065 Embryonic Stem Cell PAXX-042 p53 Signaling Pathway PAXX-027 Endothelial Cell Biology PAXX-081 PI3K-AKT Signaling Pathway PAXX-058 Epigenetic Chromatin Mod Enzymes PAXX-015 Signal Transduction PathwayFinder PAXX-014 Epithelial to Mesenchymal Transition PAXX-085 Stem Cell PAXX-405 ECM and Adhesion Molecules PAXX-090 Stress and Toxicity PathwayFinder PAXX-003 Fibrosis PAXX-013 T-Cell and B-Cell Activation PAXX-053 Glucose Metabolism PAXX-120 T-Cell Anergy and Immune Tolerance PAXX-074 Growth Factors PAXX-006 TGFβ BMP Signaling Pathway PAXX-035 Hedgehog Signaling Pathway PAXX-041 Th17 for Autoimmunity & Inflammation PAXX-073 Hypoxia Signaling Pathway PAXX-078 Th1-Th2-Th3 PAXX-034 Inflammatory Cytokines and Receptors PAXX-032 Toll-like Receptor Signaling Pathway PAXX-018 Inflammatory Response & Autoimmunity PAXX-011 Transcription Factors PAXX-075 Innate & Adaptive Immune Responses PAXX-077 Tumor Metastasis PAXX-028 Insulin Signaling Pathway PAXX-052 Unfolded Protein Response PAXX-089 Interferon α, β Response PAXX-030 VEGF Signaling PAXX-091 JAK/STAT Signaling Pathway PAXX-016 Wnt Signaling Pathway PAXX Pathway Map Reference Guide 07/2011
43 Pathway Trxn. Factor Pathway Trxn. Factor Amino Acid Deprivation ATF4/3/2 MAPK/ERK Elk-1/SRF Androgen Androgen MAPK/JNKA P -1 Antioxidant Response Nrf2/1 MEF2 MEF2 ATF6 ATF6 c-myc Myc/Max C/EBP C/EBP Nanog Nanog camp/pka CREB NFkB NFkB Cell Cycle E2F/DP1 Notch RBP-Jk p53/dna Damage p53 Oct4 Oct4 EGR1 EGR1 Pax6 Pax6 ER Stress CBF/NF-Y/YY1 PI3K/AKT FOXO Estrogen Receptor ER PKC/Ca 2+ NFAT GATA GATA PPAR PPAR Glucocorticoid Receptor GR Progesterone Receptor PR Heat Shock Response HSF Retinoic Acid Receptor RAR Heavy Metal Stress MTF1 Retinoid X Receptor RXR Hedgehog GLI Sox2 Sox2 Hepatocyte Nuclear Factor 4 HNF4 SP1 SP1 Hypoxia HIF-1 STAT3 STAT3 Interferon Regulatory Factor IRF1 TGFb SMAD2/3/4 Type I Interferon a, b STAT1/2 Vitamin D Receptor VDR Interferon g STAT1/1 Wnt TCF/LEF KLF4 KLF4 Xenobiotic AhR Liver X Receptor LXRa Multi-Pathway Arrays Signal Transduction 45-Pathway Cancer 10-Pathway Immune Signaling 10-Pathway Multi-Pathway Arrays Nuclear Receptors 10-Pathway Stress & Toxicity 10-Pathway Stem Cell & Differentiation 10-Pathway Development 10-Pathway * (#XXXXXX) = SAP Number. (Note: The catalog numbers shown are incomplete. See page 3 for instruction.) Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 43
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