Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers

Size: px

Start display at page:

Download "Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers"

Basil Gregory
6 years ago
Views:

1 Table S7B- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 expressers ListHits ListTotal PopulationHits PopulationTotal Terms Glycolysis Pathway Regulation of PGC-1a Apoptotic Signaling in Response to DNA Damage Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling Signal Dependent Regulation of Myogenesis by Corepressor MITR Regulation of p27 Phosphorylation during Cell Cycle Progression g-secretase mediated ErbB4 Signaling Pathway IFN gamma signaling pathway Proteolysis and Signaling Pathway of Notch Vitamin C in the Brain Hypoxia-Inducible Factor in the Cardiovascular System Reelin Signaling Pathway Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase Regulation of BAD phosphorylation Cyclin E Destruction Pathway IFN alpha signaling pathway Role of Mitochondria in Apoptotic Signaling E2F1 Destruction Pathway p38 MAPK Signaling Pathway Cyclins and Cell Cycle Regulation HIV-I Nef: negative effector of Fas and TNF Regulation of ck1/cdk5 by type 1 glutamate receptors ER associated degradation (ERAD) Pathway Presenilin action in Notch and Wnt signaling Spliceosomal Assembly Stathmin and breast cancer resistance to antimicrotubule agents Induction of apoptosis through DR3 and DR4/5 Death Receptors Opposing roles of AIF in Apoptosis and Cell Survival Polyadenylation of mrna Generation of amyloid b-peptide by PS Cardiac Protection Against ROS Hop Pathway in Cardiac Development Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine

2 FAS signaling pathway ( CD95 ) p53 Signaling Pathway Reversal of Insulin Resistance by Leptin Ca++/ Calmodulin-dependent Protein Kinase Activation Activation of PKC through G protein coupled receptor Cycling of Ran in nucleocytoplasmic transport Basic Mechanisms of SUMOylation IL 6 signaling pathway TPO Signaling Pathway Catabolic Pathways for Arginine, Histidine, Glutamate, Glutamine, and Proline Phospholipase C Signaling Pathway Overview of telomerase RNA component gene hterc Transcriptional Regulation Eicosanoid Metabolism cdc25 and chk1 Regulatory Pathway in response to DNA damage TSP-1 Induced Apoptosis in Microvascular Endothelial Cell G-Protein Signaling Through Tubby Proteins CCR3 signaling in Eosinophils Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia Caspase Cascade in Apoptosis Rho cell motility signaling pathway Antigen Processing and Presentation Phospholipase C-epsilon pathway Regulation of cell cycle progression by Plk Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrene RNA polymerase III transcription Influence of Ras and Rho proteins on G1 to S Transition PDGF Signaling Pathway Free Radical Induced Apoptosis Ion Channels and Their Functional Role in Vascular Endothelium Apoptotic DNA fragmentation and tissue homeostasis Cell Cycle: G1/S Check Point EGF Signaling Pathway fmlp induced chemokine gene expression in HMC-1 cells BTG family proteins and cell cycle regulation Eph Kinases and ephrins support platelet aggregation Cell to Cell Adhesion Signaling Signal transduction through IL1R

3 TNFR1 Signaling Pathway IL22 Soluble Receptor Signaling Pathway ß-arrestins in GPCR Desensitization Mechanism of Protein Import into the Nucleus Regulation of eif Role of Ran in mitotic spindle regulation RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage AKAP95 role in mitosis and chromosome dynamics Hemoglobin's Chaperone Tumor Suppressor Arf Inhibits Ribosomal Biogenesis Bioactive Peptide Induced Signaling Pathway D4-GDI Signaling Pathway PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphata The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Hist Bone Remodelling Role of Erk5 in Neuronal Survival B Cell Survival Pathway Cadmium induces DNA synthesis and proliferation in macrophages Human Cytomegalovirus and Map Kinase Pathways IL-7 Signal Transduction Role of ß-arrestins in the activation and targeting of MAP kinases IL-2 Receptor Beta Chain in T cell Activation Role of nicotinic acetylcholine receptors in the regulation of apoptosis ucalpain and friends in Cell spread VEGF, Hypoxia, and Angiogenesis Multi-step Regulation of Transcription by Pitx Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy METS affect on Macrophage Differentiation Chaperones modulate interferon Signaling Pathway Synaptic Proteins at the Synaptic Junction ADP-Ribosylation Factor Lck and Fyn tyrosine kinases in initiation of TCR Activation Thrombin signaling and protease-activated receptors MAPKinase Signaling Pathway NFAT and Hypertrophy of the heart (Transcription in the broken heart) Roles of ß-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling ATM Signaling Pathway

4 Actions of Nitric Oxide in the Heart Transcription factor CREB and its extracellular signals Role of MAL in Rho-Mediated Activation of SRF IGF-1 Signaling Pathway Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylati Ras Signaling Pathway Insulin Signaling Pathway Oxidative Stress Induced Gene Expression Via Nrf Aspirin Blocks Signaling Pathway Involved in Platelet Activation Th1/Th2 Differentiation Inhibition of Cellular Proliferation by Gleevec AKT Signaling Pathway Rac 1 cell motility signaling pathway mtor Signaling Pathway Ceramide Signaling Pathway Cytokine Network Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility Growth Hormone Signaling Pathway Phospholipids as signalling intermediaries Hypoxia and p53 in the Cardiovascular system Cell Cycle: G2/M Checkpoint TNF/Stress Related Signaling NFkB activation by Nontypeable Hemophilus influenzae IL12 and Stat4 Dependent Signaling Pathway in Th1 Development Cytokines and Inflammatory Response Selective expression of chemokine receptors during T-cell polarization Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling ALK in cardiac myocytes Integrin Signaling Pathway Toll-Like Receptor Pathway Keratinocyte Differentiation T Cell Receptor Signaling Pathway

5 Fisher Exact P-Values TermID 1.14E-02 h_glycolysispathway 1.51E-02 h_pgc1apathway 1.85E-02 h_chemicalpathway 2.27E-02 h_erbb3pathway 2.27E-02 h_mitrpathway h_p27pathway 3.29E-02 h_erbb4pathway 3.29E-02 h_ifngpathway 3.29E-02 h_notchpathway 3.29E-02 h_vitcbpathway 4.28E-02 h_hifpathway 4.46E-02 h_reelinpathway 5.81E-02 h_hdacpathway 6.65E-02 h_badpathway 7.16E-02 h_fbw7pathway 7.16E-02 h_ifnapathway 8.50E-02 h_mitochondriapathway 8.67E-02 h_skp2e2fpathway 8.77E-02 h_p38mapkpathway h_cellcyclepathway h_hivnefpathway h_ck1pathway h_eradpathway h_ps1pathway h_smpathway h_stathminpathway h_deathpathway h_aifpathway h_cpsfpathway h_apppathway h_flumazenilpathway h_hoppathway h_methioninepathway h_faspathway

6 h_p53pathway h_leptinpathway h_cacampathway h_pkcpathway h_ranpathway h_sumopathway h_il6pathway h_tpopathway h_argininecpathway h_plcpathway h_tercpathway h_eicosanoidpathway h_cdc25pathway h_tsp1pathway h_tubbypathway h_ccr3pathway h_ecmpathway h_caspasepathway h_rhopathway h_mhcpathway h_plcepathway h_plk3pathway h_cftrpathway h_rnapol3pathway h_raccycdpathway h_pdgfpathway h_freepathway h_raccpathway h_dnafragmentpathway h_g1pathway h_egfpathway h_fmlppathway h_btg2pathway h_epha4pathway h_cell2cellpathway h_il1rpathway h_tnfr1pathway

7 h_il22bppathway h_barrestinpathway h_npcpathway h_eif2pathway h_ranmspathway h_rbpathway h_akap95pathway h_ahsppathway h_arfpathway h_biopeptidespathway h_d4gdipathway h_myosinpathway h_prc2pathway h_ranklpathway h_erk5pathway h_bcellsurvivalpathway h_cdmacpathway h_hcmvpathway h_il7pathway h_barr-mapkpathway h_il2rbpathway h_achpathway h_ucalpainpathway h_vegfpathway h_pitx2pathway h_cardiacegfpathway h_etspathway h_tidpathway h_pdzspathway h_arappathway h_tcrapathway h_par1pathway h_mapkpathway h_nfatpathway h_barrestin-srcpathway h_atmpathway h_no1pathway

8 h_crebpathway h_malpathway h_igf1pathway h_igf1rpathway h_raspathway h_insulinpathway h_arenrf2pathway h_sppapathway h_th1th2pathway h_gleevecpathway h_aktpathway h_rac1pathway h_mtorpathway h_ceramidepathway h_cytokinepathway h_atrbrcapathway h_ghpathway h_edg1pathway h_p53hypoxiapathway h_g2pathway h_stresspathway h_nthipathway h_il12pathway h_inflampathway h_nktpathway h_at1rpathway h_alkpathway h_integrinpathway h_tollpathway h_keratinocytepathway h_tcrpathway

Table S7C- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 non-expressers

Table S7C- Biocarta functional annotation of celecoxib-modulated genes unique to COX-2 non-expressers Terms ListHits ListTotal PopulationHits PopulationTotal Hypoxia and p53 in the Cardiovascular system