Chang KH Chang KH Chang KH Chang KH Chang KH Chang KH Chang KH Chang KH Chang KH Chang KH Chang KH Chang KH

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1 * 張國軒醫師所有發表期刊論文 (1) Wu YR, Wang CK, Chen CM, Hsu Y, Lin SJ, Lin YY, Fung HC, Chang KH, Lee-Chen GJ(2004). Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease. Human Genetics 114(3): (SCI) (2) Ro LS, Chang KH. (2005). Neuropathic Pain: Mechanism and Treatment. Chang Gung Medical Journal 28(9): (3) Fung HC, Chen CM, Wu YR, Hsu WC, Ro LS, Lin JC, Chang KH, Wang HK, Lin SJ, Chan H, Lin YY, Wei SL, Hsu Y, Hwang JC, Tung LC, Lee-Chen GJ. Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia. (2005) Dementic and Geriatric Cognitive Disorders 20(1):1-7. (SCI) (4) Chang KH, Lyu RK, Chen CM, Hsu WC, Wu YR, Chen ST, Ro LS.(2006).Clinical characteristics of multiple sclerosis in Taiwan: a cross-sectional study. Multple Sclerosis12: (SCI) (5) Wang CK, Chen CM, Chang CY, Chang KH, Chen IC, Li ML, Lee-ChenGJ, Wu YR. (2006) α-synuclein promoter RsaI T-to-C substitution is associated with the risk of Parkinson's disease. J Neural Transm 113: (SCI) (6) Wang HK, Fung HC, Hsu WC, Wu YR, Lin JC, Ro LS, Chang KH, Hwu FJ, Hsu Y, Huang SY,Lee-Chen GJ, Chen CM (2006). Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer s disease and vascular dementia (2006). J Neural Transm 113: , (SCI) (7) Chang KH, Lyu RK, Ro LS, Wu YR (2006), Chen CM. Coexistence of Pernicious Anemia and Myasthenia Gravis A Rare Combination of Autoimmune Diseases in Taiwan. J Formos Med Assoc 105: (SCI) (8) Chang KH, Tan LM, Lyu RK (2006). Spontaneous Escherichia coli meningitis associated with hemophagocytic lymphohistiocytosis.j Formos Med Assoc 105: (SCI) (9) Chen CM, Chen IC, Chang KH, Chen YC, Lyu RK, Liu YT, Hu FJ, Chao CY, Lee-Chen GJ, Wu YR (2007). Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease. Am J Med Gen 144: (SCI) (10) Wu YR, Feng IH, Lyu RK, Chang KH, Lin YY, Chan H, Hu FJ, Lee-Chen GJ, Chen CM (2007). Tumor necrosis factor-α polymorphism is associated with the risk of Parkinson s disease. Am J Med Gen 144: (SCI) (11) Wu YR, Chen CM, Chao CY, Ro LS, Lyu RK, Chang KH, Lee-Chen GJ (2007). Glucocerebrosidase gene mutation is a risk factor for early onset of Parkinson disease among Taiwanese. J NeurolNeurosurg Psychiatry 78: (SCI) (12) Chang KH, Chuang CC, Lyu RK, Chen CM, Ro LS, Chen ST, Wu YR. Clinical

2 Characteristics of Corticobasal Syndrome amongst Chinese in Taiwan (2007). Parkinsonism Rel Disord 13: (SCI) (13) Chang KH, Lyu RK, Tseng MY, Ro LS, Wu YR, Chang HS, Hsu WC, Kuo HC, Huang CC, Chu CC, Hsieh SY, Chen CM (2007). Elevated haptoglobin level of cerebrospinal fluid in Guillain-Barre syndrome revealed by proteomics analysis. Proteomics- Clinical Applications 1: (SCI) (14) Hsieh MJ, Lyu RK, Chang WN, Chang KH, Chen CM, Chang HS, Wu YR, Chen ST, Ro LS (2008). Hypokalemic thyrotoxic periodic paralysis: clinical characteristics and predictors of recurrent paralytic attacks. Eur J Neurol14: (SCI) (15) Weng WC, Huang WY, Ryu SJ, Chang KH, Lin SK, Peng TI (2008). Very early hemorrhagic transformation of a subcortical infarction. Acta Neurologica Taiwanica 17: (EI) (16) Vives J, Sasajala P, Chang KH, Zhao S, Li M (2008). A mouse model for tracking nigrostriatal dopamine neuron axon growth. Genesis 46: (SCI) (17) Chiang HL, Lyu RK, Tseng MY, Chang KH, Chang HS, Hsu WC, Kuo HC, Chu CC, Wu YR, Ro LS, Huang CC, Chen CM (2009). Analyses of transthyretin concentration in the cerebrospinal fluid of patients with Guillain-Barré syndrome and other neurological disorders. Clinica Chimica Acta 405: (SCI) (18) Ho HY, Chang KH, Nichols J, Li M (2009). Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells. MechDev126:18-29, (SCI) (19) Chang KH, Tsou JC, Chen ST, Ro LS, Lyu RK, Chang HS, Hsu WC, Chen CM, Wu YR, Chen CJ (2010). Temporal features of magnetic resonance imaging and spectroscopy in non-ketotic hyperglycemic chorea-ballism patients (2010).Eur J Neurol 17: (SCI) (20) Lee M, Saver JL, Chang KH, Liao HW, Chang SC, Ovbiagele B (2010).Impact of microalbuminuria on incident stroke: a meta-analysis.stroke 41: (SCI) (21) Lee M, Saver JL, Huang WH, Chow J, Chang KH, Ovbiagele B (2010).Impact of elevated cystatin C level on cardiovascular disease risk in predominantly high cardiovascular risk populations: a meta-analysis.circulation: Cardiovascular Quality and Outcomes 3: (22) Lee M, Saver JL, Chang KH, Ovbiagele B.Level of albuminuria and risk of stroke: systematic review and meta-analysis (2010).Cerebrovas Dis 30: (SCI) (23) Lee M, Saver JL, Chang KH, Liao HW, Chang SC, Ovbiagele B (2010).Low glomerular filtration rate and risk of stroke: meta-analysis.br Med J. 341:c4249. (SCI). (24) Lee M, Saver JL, Chang SC, Chang KH, Hao Q, Ovbiagele B (2011). Presence of baseline prehypertension and risk of incident stroke: ameta-analysis. Neurology77: (SCI)

3 (25) Weng WC, Huang WY, Peng TI, Chien YY, Chang KH, Ro LS, Lyu RK, Wu CL Clinical characteristics of adult tetanus in a Taiwan medical center. J Formos Med Assoc 110: (SCI) (26) Chang KH, Chuang TJ, Lyu RK, Ro LS, Wu YR, Chang HS, Huang CC, Kuo HC, Hsu WC, Chu CC, Chen CM (2012). Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome. PLoS ONE 7: e29506 (SCI) (27) Chang KH, Lyu RK, Chen CM, Wu YR, Chang HS, Huang CC,Kuo HC, Chu CC,Hsu WC,Ro LS (2013). Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-aquaporin 4 antibodies. Multiple Sclerosis 19: (SCI) (28) Chen IC, Wu YR, Yang SJ, Kao SH, Chen YC, Chang KH, Lee CM, Lee-Chen GJ, Chen CM (2012). ATXN8-62 G/A promoter polymorphism and risk of TaiwaneseParkinson s disease. Eur J Neurol 19: (SCI) (29) Hung CH, Chang KH, Kuo HC, Huang CC, Liao MF, Tsai YT, Ro LS (2012). Features of varicella zoster virus myelitis and dependence on immune status.j Neurol Sci 318: (SCI) (30) Lee M, Saver JL, Hong KS, Song S, Chang KH, Ovbiagele B (2012). Effect of pre-diabetes on future risk of stroke: meta-analysis.bmj 334: e3564. (SCI) (31) Chang KH, Chen YC, Wu YR, Lee WF, Chen CM (2012). Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients. PLoS One7(9):e (SCI) (32) Chang KH*, Li M (2013). Clonal Isolation of an Intermediate Pluripotent State. Stem Cells 31: (SCI)(Corresponding author) (33) Chang KH, Tseng MY, Ro LS, Lyu RK, Tai YH, Chang HS, Wu YR, Huang CC, Hsu WC, Kuo HC, Chu CC, Chen CM (2013). Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis. Clinica Chimica Acta 417:26-30 (SCI). (34) Chang KH, Chen CM, Chen YC, Hsiao YC, Huang CC, Kuo HC, Hsu HC, Lee-Chen GJ, Wu YR (2013). Association between GRN rs5848 polymorphism and Parkinson s disease in Taiwanese population. PLoS One 8(1):e54448 (SCI). (35) Chang KH,Chen WL, Lee LC, Lin CH,Kung PJ, Lin TH, Wu YC,Wu YR, Chen YC,Lee-Chen GJ, Chen CM (2013). Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3. Evidence-Based Complementary and Alternative Medicine2013: (SCI). (36) Hung CH, Chang KH, Wu YM, Chen YL, Lyu RK, Chang HS, Wu YR, Chen CM, Huang CC, Chu CC, Liao MF, Wai YY, Hsu SP, Ro LS (2013). A comparison of benign and inflammatory manifestations of Tolosa-Hunt syndrome. Cephalalgia

4 33: (SCI) (37) Chang KH, Chen CM, Chen YC, Lyu RK, Chang HS, Ro LS, Lee-Chen GJ, Wu YR (2013). Association between PARK16 and Parkinson s disease in the Han-Chinese population: a meta-analysis. Neurobiology of Aging 34(10):2442.e5-9(SCI) (38) Lyu RK, Chang KH, Chu CC, Kuo HC, Ro LS (2013). Sensory Conduction Study in FisherSyndrome: Patterns of Abnormalitiesand Their Clinical Correlation. European Neurology 70: (SCI) (39) Wei YC, Liu CH, Lin JJ, Lin KJ, Huang KL, Lee TH, Chang YJ, Peng TI, Lin KL, Chang TY, Chang CH, Kuo HC, Chang KH, Cheng MY, Huang CC (2013). Rapid progression and brain atrophy in anti-ampa receptor encephalitis.journal of Neuroimmunology 261(1-2):129-33(SCI) (40) Wu YR#, Chang KY#, Chang WT, Hsiao YC, Hsu HC, Chiang PR, Chen YC, Chao CY, Chang YC, Lee BH, Hu FJ, Chen WL, Lee-Chen GJ, Chen CM (2013). Genetic variants oflrrk2 in Taiwanese Parkinson s disease. PLoS One 8(12):e (SCI)(Co-first author) (41) Lyu RK, Chu CC, Kuo HC, Chang KH, Ro LS.Motor conduction findings in Fisher syndrome. (2013). European Neurology. 70(5-6): (SCI). (42) Hung CH#, Chang KH#, Chu CC, Liao MF, Chang HS, Lyu RK, Wu YM, Chen YL, Lai CL, Tseng HJ, Ro LS.Painful ophthalmoplegia with normal cranial imaging. (2014). BMC Neurology 14:7 (SCI)(Co-first author) (43) Chang KH, Chen WL, Wu YR, Lin TH, Wu YC, Chao CY, Lin JY, Lee LC, Chen YC, Lee-Chen GJ, Chen CM.Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyq aggregation in cell models of spinocerebellar ataxia 3.(2014). Neuropharmacology 81: (SCI) (44) Chen CM, Weng YT, Chen WL, Lin TH, Chao CY, Lin CH, Chen IC, Lee LC, Lin HY, Wu YR, Chen YC, Chang KH, Tang HY, Cheng ML, Lee-Chen GJ, Lin JY.Aqueous extract of Glycyrrhiza inflata inhibits aggregation through upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3. (2014). Free Radical Biology and Medicine 71: (SCI). (45) Kung PJ, Tao YC, Hsu HC, Chen WL, Lin TH, Janreddy D, Yao CF, Chang KH, Lin JY, Su MT,Wu CH, Lee-Chen GJ, Hsieh-Li HM. Indole and synthetic derivative activate chaperone expression to reduce polyq aggregation in SCA17neuronal cell and slice culture models. (2014). Drug Des Devel Ther 8: (SCI) (46) Tsao WC, Lyu RK, Ro LS, Liao MF, Chen CM, Wu YR, Huang CC, Chang HS, Kuo HC, Chu CC, Chang KH*. Clinical correlations of motor and somatosensory evoked potentials in neuromyelitis optica. (2014). PLoS One 9(11):e (SCI) (Corresponding author) (47) Lin CH, Wu YR, Kung PJ, Chen WL, Lee LC, Lin TH, Chao CY, Chen CM, Chang KH,

5 Janreddy D, Lee-Chen GJ, Yao CF.The Potential of Indole and a Synthetic Derivative for PolyQ Aggregation Reduction by Enhancement of the Chaperone and Autophagy Systems. (2014). ACS Chem Neurosci 5: (SCI) (48) Chang KH, Ro LS, Lyu RK, Chen CM. Biomarkers for neuromyelitis optica (2015). Clinica Chimica Acta 440: (SCI) (49) Liao MF, Chang KH*, Lyu RK, Huang CC, Chang HS, Wu YR, Chen CM, Chu CC, Kuo HC, Ro LS*. Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients(2015). BMC Neurol 14: 218 (SCI) (co-corresponding author) (50) Lyu RK, Liao MF, Kuo HC, Chu CC, Chang KH.Effect of coexistent carpal tunnel abnormality on sensory conduction findings in polyneuropathy (2014). J Clin Neuromuscul Dis16:51-8. (EI) (51) Chang KH, Wu YR, Chen YC, Chen CM. Plasma Inflammatory biomarkers for Huntington s disease patients and mouse model. (2015). Brain Behavior and Immunity 44: (SCI). (52) Chang NJ, Weng WH, Chang KH, Liu EK, Chuang CK, Luo CC, Lin CH, Wei FC, Pang ST. Genome-wide gene expression profiling of ischemia-reperfusion injury in rat kidney, intestine and skeletal muscle implicate a common involvement of MAPK signaling pathway (2015).Mol Med Rep 11(5): (SCI). (53) Hung CH, Chang KH, Chen YL, Wu YM, Lai CL, Chang HS, Lyu RK, Wu YR, Chen CM, Huang CC, Chu CC, Chen CH, Ro LS.Clinical and radiological findings suggesting disorders other than tolosa-hunt syndrome among ophthalmoplegic patients: a retrospective analysis (2015). Headache 55: (54) Huang YH, Ro LS, Lyu RK, Chang HS, Wu YR, Chang KH, Kuo HC.Wegener's granulomatosis with nervous system involvement: ahospital-based study (2015). Eur Neurol 73: (55) Ho WM, Chen CM, Lee YS, Chang KH, Chen HW, Chen ST, Chen YC (2015). Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population. PLoS One 10:e (56) Soong YK, Huang SY, Yeh CH, Wang TH,Chang KH, Cheng PJ, Shaw SW (2015). The use of human amniotic fluid mesenchymal stem cells as the feeder layer to establish human embryonic stem cell lines. Journal of Tissue Engineering and Regenerative Medicine 9(12): e302-e307 (SCI). (57) Chang KH, Chiu YJ, Chen SL, Huang CH, Lin CH, Lin TH, Lee CM, Ramesh C, Wu CH, Huang CC, Fung HC, Chen YC, Lin JY, Yao CF, Huang HJ, Lee-Chen GJ, Lee MC, Hsieh-Li HM(2016). The potential of synthetic indolylquinoline derivatives for Aβ aggregation reduction by chemical chaperone activity.neuropharmacology 101:

6 (58) Chang KH, Wu YR, Chen YC, Fung HC, Lee-Chen GJ, Chen CM (2015). STK39, but not BST1, HLA-DQB1, and SPPL2B polymorphism, is associated withhan-chinese Parkinson s disease in Taiwan. Medicine (Baltimore). 94(41):e1690. (59) Chang KH, Wang SH, Chi CC (2015). Efficacy and safety of topiramate for essential tremor: a meta-analysis of randomized controlled trials. Medicine (Baltimore) 94(43):e1809. (60) Weng YC, Chen CM, Chen YC, Fung HC, Chang CW, Chang KH, Wu YR (2016). Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese.J Formos Med Assoc. (in press). (61) Cheng ML, Chang KH, Wu YR, Chen CM (2016). Metabolic disturbances in plasma as biomarkers for Huntington s disease. J Nutr Biochem 31: (co-first author). (62) Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM (2016). The aqueous extract of Glycyrrhiza inflata can up-regulate UPR-mediated chaperones to reduce tau misfolding in cell models of Alzheimer s disease. Drug Des Devel Ther 10: (63) Chen CM, Chen YC, Chiang MC, Fung HC, Chang KH, Lee-Chen GJ, Wu YR (2016). Association of GCH1 and MIR4697, but not SIPA1L2 and VPS13C polymorphisms, with Parkinson's disease in Taiwan. Neurobiol Aging 211: e1-5. (64) Chang KH, Lee-Chen GJ, Wu YR, Chen YJ, Lin JL, Li M, Chen IC, Lo YS, Wu HC, Chen CM (2016). Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson s disease. Parkinsonism Rel Disord 24: (Corresponding author). (65) Lin CH, Hsieh YS, Wu YR, Hsu CJ, Chen HC, Huang WH, Chang KH, Hsieh-Li HM, Su MT, Sun YC, Lee GC, Lee-Chen GJ (2016). Identifying GSK-3β kinase inhibitors ofalzheimer s disease: Virtual screening, enzyme,and cell assays. Eur J Pharm Sci 89:11-9. (66) Chang, KH, Chen CM,Lin CH, Chang WT, Jiang PR, Hsiao YC, Yih-Ru Wu YR, Guey-Jen Lee-Chen GJ (2016). Functional properties of LRRK2 mutations in Taiwanese Parkinson s disease. J Formos Med Assoc (in press). (67) Chang KH, Lin CH, Chen HC, Huang HY, Chen SL, Lin TH, Ramesh Chintakunta, Huang CC, Fung HC, Wu YR, Huang HJ, Lee-Chen GJ, Hsieh-Li HM, Yao CF (2016). The Potential of Indole/Indolylquinoline Compounds for Tau Misfolding Reduction by Enhancement of HSPB1. CNS Neurosci Ther (in press). (68) Liao MF, Chang HS, Chang KH, Ro LS, Chu CC, Kuo HC, Lyu RK (2016). Correlations of clinical, neuroimaging, and electrophysiological features in Hirayama disease. Medicine 95:e4210. (69) Chang KH, Lyu RK, Ro YS, Chen YC, Ro LS, Chang HS, Huang CC, Liao MF, Wu YR,

7 Kuo HC, Chu CC, Chen CM (2016). Increased serum concentrations of transforming growth factor-β1(tgf-β1) in patients with Guillain-Barré syndrome. Clin Chim Acta 463: (70) Li HT, Chu CC, Chang KH, Liao MF, Chang HS, Kuo HC, Lyu RK (2016).Clinical and electrodiagnostic characteristics of nitrous oxide-induced neuropathy in Taiwan. Clin Neurophysiol 127: