DR. MIHNEA IOAN NICOLESCU

Transcription

1 DATE AND PLACE OF BIRTH February, the 10 th, 1979, Bucharest, Romania DR. MIHNEA IOAN NICOLESCU Tel Fax CP 3-71, OP 3 Bucharest, sector 2, RO Romania UNIVERSITARY BACKGROUND Medical Doctor (Bachelor Degree in Medicine) Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest Medical Doctor (Bachelor Degree in Dentistry) Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, Bucharest CURRENT POSITIONS Teaching Assistant, Cellular and Molecular Medicine Department, Faculty of Medicine Carol Davila University of Medicine and Pharmacy, Bucharest Assistant, Immunology /Molecular Biology Department Victor Babeș National Institute of Pathology, Bucharest PhD student, Molecular Biology, under the coordination of Professor Ștefan Constantinescu Carol Davila University of Medicine and Pharmacy, Bucharest Oral and Maxillofacial Surgery Resident, OMF Surgery Department Carol Davila University of Medicine and Pharmacy, Bucharest Courses organizer/coordinator in the field of post-graduate medical teaching Continuous Communication, Bucharest SCIENTIFIC AND MANAGERIAL ACTIVITY 46 submitted papers at national/international scientific events (19 as first/single author) 3 lectures as invited speaker 16 received awards 30 organised scientific events 4 published articles 8 research grants (2 as project leader) MEMBER OF THE FOLLOWING PROFESSIONAL ASSOCIATIONS European Association for Cancer European Association for Cranio-Maxillo-Facial Surgery European Advanced Scientific Career Orientation Romanian Society of Biochemistry and Molecular Biology (FEBS member) Romanian Society of Oral and Maxillofacial Surgery FOREIGN LANGUAGES English, French, German OTHER COURSES Apple Platform in R&D Management. Keynote Presentation Technicques Macworld Conference, San Francisco, USA In Vivo Imaging: From Molecule to Organism Molecular Medicine Postgraduate School, Rotterdam, The Netherlands Project Manager, certified by the Ministery of Centre for the Improvement of Management Performance, Bucharest, Romania Basic Molecular Biology and Immunobiology Laboratory Techniques Ludwig Institute for Cancer, Brussels, Belgium Tumor Immunology Karolinska Institutet, Stockholm, Sweden Analyst / Programmer, certified by the Ministery of Highschool of Informatics, Bucharest (currently Tudor Vianu National College of Informatics)

2 I. List of submitted scientific papers 1. "A Study Concerning Odontogenesis in Human Fetus" M. Nicolescu, Andreea Ghita, Daniela Huidan / Dr. Andreea Didilescu Bucharest, May 1999, Student Scientific Essays Session S.Boata-Duta, M. Nicolescu / Dr. Andreea Didilescu, Dr. M.Rusu 2. "A Study Concerning the Forming and Evolution of the Alveolar Bone in Human Fetus" S.Boata-Duta, M. Nicolescu, Cornel Gherasim / Dr. M.Rusu Bucharest, May 1999, Student Scientific Essays Session 3. "Aspects Regarding the Histogenesis and Microvascularization of the Fetal Parotid Gland" M. Nicolescu, S.Boata-Duta, Ruxandra Neacsu / Dr. M.Rusu Bucharest, May 1999, Student Scientific Essays Session 4. "Morpho-clinical Links between the Lateral Petrygoid Muscle and the TMJ Disk" M. Nicolescu / Dr. M.Rusu Bucharest, May 1999, Student Scientific Essays Session 5. "Morphological and Microvascular Aspects on the Interface between the Lateral Petrygoid Muscle with the TMJ Disk - Mandibular Condyle Unit" M. Nicolescu, S.Boata-Duta, / Assoc.Prof. Dr. L.Podoleanu, Dr. M.Rusu 6. "Anencephaly - Case study" S.Boata-Duta, M. Nicolescu / Dr. M.Rusu, Dr. Andreea Didilescu 7. "A Study about the Microvascularization and Microinervation of the Masseter Muscle in Human Fetuses of Different Ages" Anca Popescu, M. Nicolescu / Dr. M.Rusu 8. "Histopathological Aspects in Mixed Tumours of the Salivary Glands" S.Boata-Duta, M. Nicolescu / Assoc.Prof.Dr. Florica Staniceanu, Dr. L. Mardari 9. "Fetal bone of Maxilla" M. Nicolescu / Dr. M.Rusu M. Nicolescu / Dr. M.Rusu M. Nicolescu, Alexandra Popescu / Dr. M.Rusu Timisoara, May 2000, International Congress of Dentistry for Students and Young Doctors MEDIS 2000 UMP Timisoara 10. "A Study on Formation and Evolution of the Fetal Palate. Anatomical - Clinical Relationships." S. Boata-Duta, M. Nicolescu / Dr. M.Rusu 11. "The universitary Hi-speed Communication - An Issue of nowadays" M. Nicolescu / Prof. T.Spircu Page 2

3 12. "Arterial Microvascularisation of oro-maxillar structures" M. Sandulescu, Carmen Rotaru, M. Nicolescu / Dr. M.Rusu 13. "A Morphological Study of the Fetal Maxillary Bone" M. Nicolescu / Dr. M.Rusu Bucharest, April 2000, Student Scientific Essays Session Titu Maiorescu University Bucharest, Romanian Society of Stomatology 14. "Anencephaly - Clinical Embryology" S. Boata-Duta, M. Nicolescu, Carmen Rotaru / Dr. M.Rusu S. Boata-Duta, M. Nicolescu, Carmen Rotaru / Dr. M.Rusu Timisoara, May 2000, International Congress of Dentistry for Students and Young Doctors MEDIS 2000 UMP Timisoara 15. "Atrium-ventricular Blocks " M. Nicolescu, S. Boata-Duta, C. Vladan / Prof.Dr. A.Varlas, Dr. Alice Balaceanu 16. "Evaluation of the Metal-Ceramics Interface using the Electron-Microscope Apparatus in case of Non-noble Alloys" L.T. Ciocan, M. Nicolescu, B. Iordache / Assoc.Prof.Dr. I. Patrascu 17. "Biovitroceramics - Indispensable Biomaterial in Preprosthetical Preparation" L.T. Ciocan, M. Nicolescu, Cristina Ionita / Assoc.Prof.Dr. I. Patrascu 18. "Clinical Aspects in the Miofascial Pain Disfunction Syndrome" S. Boata-Duta, M. Nicolescu / Assoc.Prof.Dr. V. Bodnar Timisoara, May 2000, International Congress of Dentistry for Students and Young Doctors MEDIS 2000 UMP Timisoara 19. "The Microvascular Functional Structure of the TMJ Disc" M. Nicolescu, Dr. M.Rusu Sibiu, October 2000, 1st International Congress for Students and Young Doctors Lucian Blaga University of Sibiu, Victor Papilian Faculty of Medicine, European Medical Students Association 20. "Developing Temporomandibular Joint - Macroscopic and Microscopic Evidence" M. Rusu, M. Nicolescu Cluj-Napoca, March 2001, International Congress of Dentistry for Students and Young Dentists Dentis "Topographical Anatomy of the Maxillary Nerve and its Clinical Importance" M. Nicolescu, Dr. M. Rusu Cluj-Napoca, March 2001, International Congress of Dentistry for Students and Young Dentists Dentis "Gingival Pocket Atraumatic Opening for Taking Impressions in Fixed Dental Prosthodontics" M. Nicolescu, Dr. M.V. Constantinescu Cluj-Napoca, March 2001, International Congress of Dentistry for Students and Young Dentists Dentis "The Computer Assisted Learning in Dental Medicine Education - a Reality of the Third Millennium" M. Nicolescu, Alexandra Cristescu Bucharest, April 2001, International Congress of Dentistry for Students and Young Dentists student 2001, UNAS Student Department 24. "The Cervico-axillary Region -Topographical description" Viviana Gheorghe, M. Nicolescu, M. Sandulescu / Dr. M.Rusu Page 3

4 Bucharest, April 2001, International Congress of Dentistry for Students and Young Dentists student 2001, UNAS Student Department 25. "The Advantages of Preoperatory Embolisation in Mandibular Bone Angiomas" M. Nicolescu / Assoc.Prof.Dr. Alex. Bucur Cluj-Napoca, April 2002, International Congress of Dentistry for Students and Young Dentists Dentis 2002 M. Nicolescu / Assoc.Prof.Dr. Alex. Bucur Bucharest, April 2002, The IX-th edition of the Student Scientific Essays Session Titu Maiorescu University, Romanian Society of Stomatology, "N. Malaxa" Hospital M. Nicolescu / Assoc.Prof.Dr. Alex. Bucur Bucharest, May 2002, Student Scientific Essays Session student 2002, SSS Bucharest 26. "The Prophylactic Neck Dissection in N0 following Lower Lip Cancer - An Option or a Therapy?" M. Nicolescu / Assoc.Prof.Dr. Alex. Bucur Cluj-Napoca, April 2002, International Congress of Dentistry for Students and Young Dentists Dentis 2002 M. Nicolescu, A. Stan / Assoc.Prof.Dr. Alex. Bucur Bucharest, May 2002, Student Scientific Essays Session student 2002, SSS Bucharest 27. " (The Student Point of View Regarding the Lectures in the Romanian Medical Education System)" M. Nicolescu Cluj-Napoca, April 2002, International Congress of Dentistry for Students and Young Dentists Dentis 2002 M. Nicolescu Bucharest, April 2002, The IX-th edition of the Student Scientific Essays Session Titu Maiorescu University, Romanian Society of Stomatology, "N. Malaxa" Hospital M. Nicolescu Bucharest, May 2002, Student Scientific Essays Session student 2002, SSS Bucharest 28. "Silver Impregnation of the Superior Cervical Ganglion of the Laterovertebral Sympathetic Chain" M. Nicolescu, O. Rus, Dr. M. Rusu Bucharest, November 2002, Carol Davila International Scientific Congress for Students and Young Doctors 29. "The Submandibular Ganglion" C. Vasiliu, M. Nicolescu, A.E. David, Dr. M. Rusu Bucharest, November 2002, Carol Davila International Scientific Congress for Students and Young Doctors 30. "The Stellate Ganglion: Topography and Structure" Alexandra Popescu, M. Nicolescu, O. Rus, Dr. M. Rusu Bucharest, November 2002, Carol Davila International Scientific Congress for Students and Young Doctors 31. "Links between the Primary Tumour Depth and the Cervical Micromethastases Incidence in Malignant Tumours of the Tongue (T1,T2)" Alex. Bucur, H. Ionescu, B.Florian, D. Slavescu, L. Preda, T. Nita, O. Dinca, M. Nicolescu, S. Florian, Ruxandra Cioaca 32. "Perineural Invasion, Prognostic Factor in Malignant Oral Tumours" Alex. Bucur, H. Ionescu, B.Florian, D. Slavescu, L. Preda, T. Nita, O. Dinca, M. Nicolescu, S. Florian, Ruxandra Cioaca Page 4

5 33. "The Value of the Sentinel Node Concept in the Cervical Therapeutically Attitude in N0" Alex. Bucur, T. Nita, O. Dinca, Lidia Stefanescu, M. Nicolescu, L. Preda 34. "Clinical and Statistical study on the Metastases Tumours in Oral and Maxillo-Facial Area" Alex. Bucur, B.Florian, L. Preda, T. Nita, O. Dinca, D. Slavescu, H. Ionescu, M. Nicolescu 35. "Phenotyping of Cervical Lymph Nodes Immune Cells in Malignant Tumours in Oral and Maxillo-facial Area" M. Nicolescu, Fl. Pop, D.L. Radu, Alex. Bucur 36. "Diagnostic and procedural coding in craniomandibular disorders. Example: ICD-9-CM" M.I. Nicolescu Bucharest, November 2006, EUROTMJ Workshop, The promotion of Romanian medical research integration in the European Space by participating in the health degree of TMJ evaluation in the context of the efforts of improving the quality of life in the younger population, according to FP-7 priorities 37. "Caveolin-1 expression and proliferation markers in human pancreatic cancer" C. Tanase, M. Mihai, E. Codorean, E. Raducan, M.I. Nicolescu, M.L. Cruceru, A.C. Popa, T. Dumitrascu, S.O. Dima, L.M. Popescu, M.E. Hinescu, I. Popescu Bucharest, 2007, National Surgery Conference - News in hepatic, cholecyst and pancreatic surgery and hepatic transplant, The IX-th Symposium and Postuniversitary Course of IASGO Romanian Division C. Tanase, M. Mihai, E. Codorean, E. Raducan, M.I. Nicolescu, L. Albulescu, M.L. Cruceru, A.C. Popa, T. Dumitrascu, S.O. Dima, L.M. Popescu, M.E. Hinescu, I. Popescu Bucharest, May 2007, 1 st Conference in New Perspectives in Cancer Pathology C. Tanase, M.I. Nicolescu, M. Mihai, M.L. Cruceru, A.C. Popa, T. Dumitrascu, S.O. Dima, L.M. Popescu, M.E. Hinescu, I. Popescu Vienna, Austria, 2007, 32 nd FEBS Congress, Molecular Machines FEBS Journal, Vol. 274, Supp. 1, pg.173, 2007, ISSN X DOI /j x 38. "Immunohistochemical analysis of APAF1 and cathepsinb, regulators of mitochondrial apoptotic pathway in pituitary tumor progression" Tanase C., Codorean E., Arsene D., Ardeleanu C., Raducan. E., Spineanu G., Tanase M., Nicolescu M., Albulescu L., Ogrezeanu I., Ciubotaru V., Cruceru M.L., and Hinescu M. Rio de Janeiro, Brasil, 2007, 13 th International Congress of Immunology 39. "Correlation between caveolin-1 and angiogenic markers VEGF, bfgf in human brain tumors" Tanase C., Codorean E., Arsene D., Ardeleanu C., Raducan E., Spineanu G., Ogrezeanu I., Cruceru M.L, Nicolescu M., Georgescu M., Hinescu M. Florence, Italy, 2007, First International Symposium on Combinatorial Sciences in Biology, Chemistry, Catalysts and Materials 40. "Correlation of Caveolin-1 expression and proliferation markers in human pancreatic cancer" C. Tanase, M. Mihai, C. Ardeleanu, E. Raducan, E. Codorean, M.I. Nicolescu, T. Dumitrascu, S.O. Dima, L.M. Popescu, M.E. Hinescu, I. Popescu Istanbul, Turkey, 2007, 21 st European Congress of Pathology Virchows Archiv, 2007, Vol. 451, pg. 379, ISSN Caveolin-1 expression as a possible biomarker in pancreatic cancer diagnosis C. Tanase, E. Raducan, I.D. Popescu, L. Albulescu, E. Codorean, M.I. Nicolescu, M.L. Cruceru, A.C. Popa, I. Popescu, M. Leabu, S.O. Dima, M.E. Hinescu, L.M. Popescu Bucharest, 2007, 4th National Symposium of Pathology. V. Babes Institute Anniversary Symposium 4th National Symposium of Pathology, Abstracts Volume, 2007, pg. 26, ISBN "Caveolin-1, a potential biomarker for tumor progression and invasiveness" C.Tanase,M.I. Nicolescu, E. Raducan, E. Codorean, I.D. Popescu, M.L. Cruceru, S.O. Dima, M. Leabu, M.E. Hinescu, I. Popescu, L.M. Popescu Warwick, UK, December 2007, Genes and Cancer 2007, 24 th UK Molecular Biology and Cancer Network Meeting 43. "Retrospectie study of oral-maxillo-facial malignant tumoral pathology between 2005 and 2007" C.M.Cîrcu, Adriana şerban, Dr. Lucia Cionca, Dr. M.I. Nicolescu Page 5

6 Bucharest, 2008, The International Dental Medicine Congress for Students and Young Medics student "Signaling proteins profile in pancreatic cancer" C. Tanase, L. Albulescu, M.I. Nicolescu, O.S. Dima, L.M. Cruceru, A. Popa, S. Mihai, M. Neagu, R. Albulescu, M.E. Hinescu Athens, 2008, Biochemistry of Cell Regulation, 33rd FEBS Congress and 11th IUBMB Conference FEBS Journal, 2008, Vol. 275, Supp. 1, pg. 346, ISSN X, doi: /j x 45. "Signaling profile pathways involved in pancreatic cancer progression" C. Tanase, M.I. Nicolescu, L. Albulescu, L.M. Cruceru, A. Popa, S. Mihai, M. Neagu, S.O. Dima, R. Albulescu, M.E. Hinescu Lyon, 2008, 20th Meeting of the European Association for Cancer European Journal of Cancer Supplements, 2008, Vol. 6, Issue 9, pg. 151, ISSN , doi: /S (08) "Salivary cytokines profile and smoking in patients with oral cancer" M.I. Nicolescu, L. Albulescu, I.F. Drăgan, C.M. Cîrcu, C. Tanase, Al. Bucur Lyon, 2008, 20th Meeting of the European Association for Cancer European Journal of Cancer Supplements, 2008, Vol. 6, Issue 9, pg. 169, ISSN , doi: /S (08) II. List of sustained lectures 1. Postgraduate options and opportunities the biomedical research pathway" M.I. Nicolescu Predeal, 2007, Dental Project Meeting 2. Increasing the efficiency in biomedical science research M.I. Nicolescu Bucharest, 2008, Cantacuzino Institute, Biotechnology Ethics Workshop 3. Rapid Acquisition of Management Skills (RAMS) testing software M.I. Nicolescu Bologna, 2008, EASCO and University of Bologna, Bologna European School of Management - New Tools for Training ers in Management, Career Development and Communication III. List of received awards Page 6 1. First Prize, Preclinical Section Bucharest, 14 May 1999, Student Scientific Essays Session 2. First Prize, Preclinical Section 3. Third Prize, Oral Presentations Section 4. Third Prize, Preclinical Section 5. Special Prize of the Jury 6. Special Prize of the Jury, for presenting an outstanding scientific paper Timisoara, May 2000, International Congress of Dentistry for Students and Young Doctors "MEDIS UMP Timisoara 7. Third Prize, Poster Presentations Cluj-Napoca, March 2001, International Congress of Dentistry for Students and Young Dentists "Dentis

7 2001" 8. First Prize, Oral Presentations Section Bucharest, April 2001, International Congress of Dentistry for Students and Young Dentists "student 2001", UNAS Student Department 9. Special Prize of the Jury Cluj-Napoca, April 2002, International Congress of Dentistry for Students and Young Dentists"Dentis 2002" 10. The Diploma of Honour Bucharest, April 2002, The IX-th edition of the Student Scientific Essays Session Titu Maiorescu University, Romanian Society of Stomatology, "N. Malaxa" Hospital 11. First Prize, Varia Section Bucharest, May 2002, Student Scientific Essays Session "student 2002", SSS Bucharest 12. First Prize, Anatomy, Oral and Maxillo-Facial Surgery Section Bucharest, May 2002, Student Scientific Essays Session "student 2002", SSS Bucharest 13. First Prize, Poster Section Bucharest, May 2002, Student Scientific Essays Session "student 2002", SSS Bucharest 14. Prize of the Jury Bucharest, 2007, National Surgery Conference - News in hepatic, cholecyst and pancreatic surgery and hepatic transplant, The IX-th Symposium and Postuniversitary Course of IASGO Romanian Division 15. First Prize, Health Section Bucharest, November 2007, National Authority for Scientific 16. Third Prize - Clinical Section Bucharest, 2008, The International Dental Medicine Congress for Students and Young Medics stu- DENT 2008, UMP Carol Davila Bucureşti, LSMDB IV. List of published articles 1. "The Formation and Evolution of the Alveolar Processes" (romanian) Dr. M. Rusu, S. Boata-Duta, M. Nicolescu National Revue of Stomatology, vol. II, nr. 5-6, pag , ed. National, 1999 ISSN "The Student Point of View Regarding the Courses in the Romanian Medical Education System. The Virtual Course Concept." (romanian) M. Nicolescu Stomatological Medicine, vol. VI, nr. 6 (nov-dec 2002), pag , UNAS, 2002 ISSN "Notes on the Jugulo-Digastric Lymph Nodes" (romanian) M. Nicolescu, Assoc.Prof. Al. Bucur, F. Pop, M. Rusu National Revue of Stomatology, Oral and Maxillo-Facial Surgery, vol. I, nr. 4, pag , ed. Medicala Nationala, "Caveolin-1 overexpression correlates with tumour progression markers in pancreatic ductal adenocarcinoma" Tanase CP, Dima S, Mihai M, Raducan E, Nicolescu MI, Albulescu L, Voiculescu B, Dumitrascu T, Cruceru LM, Leabu M, Popescu I, Hinescu ME J Mol Histol, 2009, vol. 40, nr.1, pag , DOI /s , ISSN Page 7

8 V. List of research projects/grants Project Position Time frame CEEX 56/2005 Gene expression profile and biomarkers study corelated with clinicopathological parameters in pancreatic cancer, GENOPACT CNCSIS BD 457/2006 Genetic and mollecular aspects in pancreatic cancer CEEX 62/2006 Genic profiles induced by transcriptional supression of ets-1 in pancreatic cancer Assistant Project leader Assistant CEEX 91/2006 Fetal hepatic stem cells: characterisation and conditioning for celullar transplant CEEX 85/2006 New cell therapy strategies by using hematopoetic progenitors from umbilical cord blood Assistant Assistant CEEX 64/2006 Caveolins 1,2 and 3 expression in pancreatic cancers, molecular targets in diagnosis and therapy CEEX 111/2006 The promotion of integration of the romanian researches concerning the new molecular targets in cancer therapies in european scientific domain PN II 30/2007 Increasing the efficiency and efficacy in the preparation, approach and management of research and development projects in the field pf pathology and biomedical sciences Assistant IT Manager Assistant IT Manager Project leader IT Manager Page 8