October 25-26, 2018 Infinity Hotel & Conference Resort, Munich, Germany

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1 Programme 4 th CVOT Summit in cooperation with D&CVD EASD Study Group October 25-26, 2018 Infinity Hotel & Conference Resort, Munich, Germany Thursday, October 25, 2018 Room Ammersee I 18:00 18:30 Welcome, Introduction & Activities of the Study Group Schnell O (Munich, Germany), Ceriello A (Milan, Italy) 18:30 19:30 Keynote Lecture Chair: Ceriello A (Milan, Italy), Schnell O (Munich, Germany) 18:30 19:20 The Future of Diabetes Treatment in Europe: Decision-making and Patient Preferences Muehlbacher A (Neubrandenburg, Germany) 19:20 19:30 Discussion 19:45 Welcome reception

2 08:30 09:30 CVOTs 2018: Clinical Updates Chair: Itzhak B (Haifa, Israel), Valensi P (Bondy, France) 08:30 08:45 DPP-4 inhibitors Standl E (Munich, Germany) 08:45 09:00 SGLT-2 inhibitors Lalic N (Belgrade, Serbia) 09:00 09:15 GLP-1 receptor agonists Itzhak B (Haifa, Israel) 09:15 09:30 Discussion 09:30 10:30 Key therapeutic approaches (1) Chair: Standl E (Munich, Germany) 09:30 09:50 09:50 10:10 10:10 10:20 Cardiovascular effects of GLP-1 receptor agonists Cosentino F (Stockholm, Sweden) Supported by Novo Nordisk Treatment of Diabetes with SGLT-2 inhibitors: Potentials for optimization of heart failure outcomes Groop PH (Helsinki, Finland) Supported by Boehringer Ingelheim Oral Presentation: Linagliptin, cardiovascular safety and kidney outcomes in Typ-2- Diabetes: CARMELINA Trial Marx N (Aachen, Germany) 10:20 10:35 Discussion

3 10:35 11:00 Coffee Break 11:00 12:30 10 years after the FDA Guidance: Continue or change? Chair: Rydèn L (Stockholm, Sweden), Groop PH (Helsinki, Finland) 11:00 11:30 Unexpected knowledge gained Continue CVOTs Standl E (Munich, Germany) 11:30 12:00 Need for a change: Refocus and modify endpoints Home P (Newcastle, UK) 12:00 12:30 Panel Discussion 12:30 13:30 Lunch Break 13:30 14:30 Key therapeutic approaches (2) Chair: Catrinoiu D (Constanta, Romania) 13:30 14:00 Heart failure in Diabetes: Treatment Strategies with Valsartan / Sacubitril Marx N (Aachen, Germany) Supported by Novartis 14:00 14:30 CVOTs with PCSK9 inhibitors: Key learnings Mueller-Wieland D (Aachen, Germany)

4 14:30 15:00 Coffee Break 15:00 17:00 Adjunct Therapy in Type 1 Diabetes Chair: Schnell O (Munich, Germany) 15:00 15:10 Oral Presentation: Nationwide study of T1D vs. T2D: Characteristics and CV event rates Bodegard J (Oslo, Norway) 15:10 15:35 Type 1 Diabetes and CVD Rydèn L (Stockholm, Sweden) 15:35 16:00 Non-insulin Therapies in Type 1 Diabetes Battellino T (Ljubljana, Slovenia) 16:00 16:30 Panel Discussion 1 16:30 17:00 Industry s Perspective Bodegard J Carr R Muehlbacher A Pavo I Tadayon S and others

5 17:00 17:40 Oral Presentations Chair: Lalic N (Belgrade, Serbia), Battelino T (Ljubljana, Slovenia) 17:00 17:10 The relationship of insulin resistance and endothelial dysfunction with pro-inflammatory cytokines, adiponectin in patients with NAFLD Pivtorak, K (Vinnitsya, Ukraine) 17:10 17:20 Novel approaches to evaluate an early identification of diabetes La Sala L (Milan, Italy) 17:20 17:30 Type 2 diabetes increases the need for pacemaker and implantable cardioverter defibrillator treatment - A Swedish registry report Rautio E (Stockholm, Sweden) 17:30 17:40 Cardiac rehabilitation improves long-term survival of diabetic patients after coronary artery bypass graft surgery: a multicenter study with 13-y follow-up Dankner R (Ramat Gan, Israel)

6 17: Poster Presentations Poster Session 1: Treatment with GLP-1 receptor agonists, SGLT-2 inhibitors and other approaches Chair: Lalic N (Belgrade, Serbia) Poster Session 2: Diabetes and the Heart (1) Chair: Standl E (Munich, Germany) Poster Session 3: Diabetes and the Heart (2) Chair: Catrinoiu D (Constanta, Romania) Poster Session 4: Micro- and macrovascular complications beyond the heart Chair: Itzhak B (Haifa, Israel) Poster Session 5: Metabolic disturbances revisited Chair: Valensi P (Bondy, France) 18:20 18:30 Abstract Awards

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