ect of Long-term Ingestion of Porcine Elastin Peptide on Human Skin Elasticity

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1 23 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /2, No.., +/3 +0- (,*++) 159 * * E# ect of Long-term Ingestion of Porcine Elastin Peptide on Human Skin Elasticity Mikako Sato, Kohji Iwai, Eiichiro Onitsuka, Yoshihisa Takahata, R and D Center, Nippon Meat Packers, Inc., -- Midorigahara, Tsukuba, Ibaraki -**,0.0 * Department of Health Sciences, School of Health and Social Services, Saitama Prefectural University, 2,* Sannomiya, Koshigaya, Saitama -.-2/.* Keywords : elastin, clinical study, skin elasticity : Fumiki Morimatsu and Yuji Sato* The e# ect of oral administration of elastin peptide (hydrolysate of elastin from porcine aorta) on human skin elasticity was studied. First, five healthy volunteers were administered elastin peptide after fasting for +, h. A significant increase in total amino acid concentration in blood was observed. The composition of increased amino acids in blood was similar to the amino acid composition of the elastin peptide. In addition, the concentrations of peptide forms of hydroxyproline and arginine significantly increased in blood. These results suggest that a portion of the administered elastin peptide migrates into blood in peptide form. Second, thirty-nine middle-aged volunteers were divided into three groups and administered *, +**, or,** mg/day of elastin peptide for 2 weeks. Significant increases in skin elasticity were observed in the +** - and,**-mg groups after 2 weeks. Increase in skin elasticity of the,**-mg group was significantly higher than that in the *-mg group. These results suggest that ingestion of elastin peptide increases skin elasticity. (Received Oct.,3,,*+* ; Accepted Jan. /,,*++) +, 2 -. / 0 1 0* kg,/ g -**, * -.-2/.* 2,* Corresponding authorm.satou@nipponham.co.jp + /,1-, P,* wv +, 3 -*

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4 162 /2.,* / +2 MMP-+, - n/ * *: p*.*/ **: p*.**/. n +- * / *: p*.*/ **: p*.*+ ***: p*.**+ n +- * *: p**/. 2 Pro-Hyp, Pro-Hyp in vitro Lysyl Oxidase +. mrna +0

5 27 : 163 LD 0 gkg / +, * +**,** mg 2 +** mg,** mg 2 * mg,** mg + Gibson, M.A., Kumaratilake, J.S. and Cleary, E.G., The protein components of the +, -nanometer microfibrils of elastic and nonelastic tissues. J. Biol. Chem.,,0.,./3*./32 ( +323)., Rosenbloom, J., Abrams, W.R. and Mecham, R., Extracellular matrix. : the elastic fiber. FASEB J., 1, +,*2 +,+2 ( +33-). - Reiser, K., McCormick, R. J. and Rucker, R.B., Enzymatic and nonenzymatic cross-linking of collagen and elastin. FASEB J., 0,,.-3,..3 ( +33, ).. Debelle, L. and Tamburro, A.M., Elastin : molecular de- /* scription and function. Int. J. Biochem. Cell Biol., -+,,0+,1, ( +333). / Sandberg, L.B., Elastin structure in health and disease. Int. Rev. Connect. Tissue Res., 1, +/3,+* ( +310). 0 Braverman, I.M. and Fonferko, E., Studies in cutaneous aging :.The elastic fiber network. J. Invest. Dermatol., 12, ( +32, ). 1 :,1,2/,23,**- 2 2*,+/,,,,**3 3 Cua, A.B., Wilhelm, K.P. and Maibach, H.I., Elastic properties of human skin : relation to age, sex, and anatomical region. Arch. Dermatol. Res.,,2,,,2-,22 ( +33* ). +* 1./ /,,** ,**3 +, / /,**3 +- Iwai, K., Hasegawa, T., Taguchi, Y., Morimatsu, F., Sato, K., Nakamura, Y., Higashi, A., Kido, Y. and Ohtsuki, K., Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hyrdolysates. J. Agric. Food Chem., /-, 0/-+ 0/-0 (,**/). +. Shigemura, Y., Iwai, K., Morimatsu, F., Iwamoto, T., Mori, T., Oda, C., Taira, T., Park, E.Y., Nakamura, Y. and Sato, K., E# ect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J. Agric. Food Chem., /1, (,**3). +/ Ohara, H., Ichikawa, S., Matsumoto, H., Akiyama, M., Fujimoto, N., Kobayashi, T. and Tajima, S., Collagenderived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J. Dermatol., -1, --* --2 (,*+*). +0 Nakatani, S., Mano, H., Sampei, C., Shimizu, J. and Wada, M., Chondroprotective e# ect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo. Osteoarthritis Cartilage, +1, +0,* +0,1 (,**3). +1 / ,**1 +2 Mizobe, Y., Oikawa, D., Akimoto, Y., Tsuyama, S., Onitsuka, E., Sato, M., Takahata, Y., Morimatsu, F. and Furuse, M., Ingestion of elastin peptides alters messenger RNA expression in mice skin. Curr. Top. Nutraceutical Res., 1, +,1 +-* (,**3).,, +*,3,- + /

Effects of Collagen Peptide Ingestion on Blood Lipids in Rats Fed a High-Lipid and

Food Sci. Technol. Res., 19 (6), 1149 1153, 2013 Note Effects of Collagen Peptide Ingestion on Blood Lipids in Rats Fed a High-Lipid and High-Sucrose Diet Yoh-ichi Koyama * and Masashi Kusubata Research