Primary Meeting Venue: The University Club July 27 th Evening Venue: Host Hotel / Wyndham Pittsburgh University Center.

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1 1 PancreasFest 2016: Risk Factors which Alter the Injury Response and New Targets for Therapy and 9th International Symposium on Inherited Diseases of the Pancreas Primary Meeting Venue: The University Club July 27 th Evening Venue: Host Hotel / Wyndham Pittsburgh University Center July 27-29, 2016 Wednesday July 27, The University Club Pittsburgh, PA USA morning/afternoon sessions NIDDK Workshop Chronic Pancreatitis in the 21 st Century: Research Challenges and Opportunities This NIDDK workshop will precede PancreasFest 2016 but will occur separately from PancreasFest 2016 symposia. NIDDK workshop registration information may be found at NIDDK.NIH.gov. Follow links for News/Calendar of Events. PancreasFest 2016 Schedule Wednesday, July 27, 2016 Evening Wyndham Pittsburgh University Center - 1 st Floor Ballroom Session 1: 9 th International Symposium on Inherited Diseases of the Pancreas 20 th Anniversary of the Hereditary Pancreatitis Gene 5:30 pm Registration & Reception 6:00 Welcome Mark E. Lowe, MD, PhD 6:05 Introduction to the Henry Lynch Award: The Pancreas and 1996: Before and Beyond Markus M. Lerch, MD 6:20 Henry Lynch Award Lecture: Pancreatic Disorders and Precision Medicine David C. Whitcomb, MD, PhD 7:00 Reception & Light Dinner Buffet 8:30 Adjourn Day I

2 2 Thursday July 28, 2016 PF16 Day The University Club 7:30 am Registration, Exhibits, and Continental Breakfast 8:00 Welcome Day II David C. Whitcomb, MD, PhD Session 2: 9 th International Symposium on Inherited Diseases of the Pancreas Genetics of the Pancreas: Acute Pancreatitis Etiology Moderators: Miklos Sahin-Toth, MD, PhD and Markus M. Lerch, MD 8:10 Genetic Susceptibility to Pancreatitis Claude Ferec, MD, PhD 8:25 New Genetic Insights into Alcohol-Related Pancreatitis Jonas Rosendahl, MD 8:40 Advances in Pancreatic Disease Genetics in Japan Atsushi Masamune, MD, PhD 8:55 Panel Discussion 9:10 Break and Exhibits Session 3: Pancreatic Pain Moderator: P. Jay Pasricha, MD and G. Nicholas Verne, MD 9:20 Pathogenesis and Cell Biology of Pancreatic Neuropathic Pain Güralp O. Ceyhan, MD 9:35 Medical Therapies for Pancreatic Pain Asbjørn Mohr Drewes, MD 9:50 Cognitive Behavioral Therapy and Related Treatments for Pancreatic Pain Eva M. Szigethy, MD, PhD 10:05 Do We Need Another Trial Comparing Surgical and Endoscopic Treatment of Pancreatic Pain? John A. Windsor, MD 10:20 Sensory Nerves and Pancreatic Cancer Brian Davis, PhD 10:50 Break & Exhibits - Pediatric group moves to a separate room 11:00 Pediatric Session: Acute Pancreatitis in Childhood Moderator: Veronique Morinville, MD 11:00 Treatment of Pseudocysts and Other Complications in Children Bradley Barth, MD 11:20 Treatment of Acute Pancreatitis in Childhood Maisam Abu-El-Haija, MD 11:40 What Tests to do After the First Episode of Acute Pancreatitis Steven L. Werlin, MD

3 3 12:00 Panel Discussion 12:15 Lunch break for lunch buffet 12:30 1:15 Pediatric Pancreatitis Case Discussions Moderator and Case Presenter: John Eisses, MD, PhD Panel: Matthew J. Geifer, MD, Tom Lin, MD, Quin Liu, MD 1:15 2:45 Meeting of INSPPIRE (International Study Group of Pediatric Pancreatitis In Search of a Cure) Moderator: Aliye Uc, MD Session 4: Genetics of Pancreatic Cancer Moderator: Randall E. Brand, MD and William E. Fisher, MD 11:00 Novel Developments in the Genetics of Pancreatic Cancer Nicholas Roberts, MD 11:20 Advances in Population Genetics and Hereditary Prediction Models for Pancreatic Cancer Gloria Peterson, PhD 11:40 Genetics of Cystic Neoplasms Aatur Singhi, MD, PhD 12:00 Panel Discussion 12:15 pm Lunch Buffet and Exhibits Session 5: The Ruth C. Brufsky Award for Excellence in Research in Pancreatic Cancer Moderator: Randall E. Brand, MD 12:45 Ruth C. Brufsky Award Lecture: Earlier Detection of Pancreatic Cancer Teri Brentnall, MD 1:15 Discussion 1:25 Break and Exhibits Session 6: Pancreas Working Group Meetings 1:30 2:30 1. Acute Pancreatitis Biomarkers & Measures and APPRENTICE (Acute Pancreatitis Patient Registry to Enhance Novel Therapies in Clinical Experience) Facilitators: Georgios I. Papachristou, MD, PhD and Vikesh K. Singh, MD, MSc 2. Chronic Pancreatitis: Biomarkers of Inflammation, Cell Function, Fibrosis & Pain Facilitators: John A. Windsor, MD and Christopher Forsmark, MD 3. Pancreatic Cancer, Pancreatic Cysts & IPMNs Facilitators: Walter G. Park, MD, MS and Gregory B. Lesinski, PhD, MPH 4. Diabetes, Surgery & TP-IAT Facilitators: Suresh Chari, MD and Martin Freeman, MD 2:30 Break & Exhibits

4 4 Acute Pancreatitis & PCOE Track: Session 7A: Acute Pancreatitis Severity Index Meeting / Discussion Moderators: Stephen Pandol, MD and Bechien Wu, MD 2:45 3:45 APSI Discussion & Voting Session 8A: Pancreas Center of Excellence (PCOE) Meeting/Discussion Moderators: Darwin Conwell, MD, MPH and David C. Whitcomb, MD, PhD 3:45 4:30 PCOE Discussion Pancreas Pain Track: Session 7B: Taxonomy of Pain: Reports Moderators: G. Nicholas Verne, MD and Ajay Wasan, MD, PhD 2:45 2:50 Dimension 1: Core Diagnostic Criteria 2:50 2:55 Dimension 2: Common Features 2:55 3:00 Dimension 3: Common Medical Comorbidities 3:00 3:15 Dimension 4: Neurobiological, Psychological and Functional Consequences 3:15 3:30 Dimension 5: Putative Neurobiological and Psychosocial Mechanisms, Risk Factors and Protective Factors Session 8B: Developing Consensus on Pancreatic Pain Moderators: Asbjørn Mohr Drewes, MD and John Windsor, MD 3:30 4:30 Pancreatic Pain Discussion 4:30 Adjourn Day II Session 9: Poster Rounds and Reception (not accredited symposia) 4:30 5:45 Poster Rounds and Reception July 28 evening activities will be on your own. Suggestions for restaurants and activities will be provided. 6:30 am Registration, Exhibits, Continental Breakfast Friday July 29, 2016 PF16 Day The University Club 6:45 8:00 Reports and Open Discussion from Day II Sessions: Pancreas Working Group & PCOE Moderators: Darwin Conwell, MD, MPH and David C. Whitcomb, MD, PhD This session is open to all and is accredited symposia. Speakers will be asked to summarize group activities and goals within five minutes, leaving 30+ minutes for discussion. Discussion

5 5 8:15 Welcome Day III Georgios I. Papachristou, MD, PhD Clinical Pancreatology & Endoscopy Track: Session 10A: Mechanisms of Acute Pancreatitis Moderator: Adam Slivka, MD, PhD 8:15 Therapeutic Targets for Pancreatitis Robert Sutton, MB, BS, DPhil, FRCS 8:35 Diabetes after Acute Pancreatitis Melena Bellin, MD 8:55 Deciphering Mechanisms for Post-ERCP Pancreatitis Sohail Husain, MD 9:15 Late-Breaking Abstract TBA 9:35 Panel Discussion Basic Science Track: Session 10B: Pain Scientific Mini Symposium Moderators: Kathryn Albers, PhD, Brian M. Davis, PhD and Michael Gold, PhD 8:15 9:50 Basic Science Approaches to Mechanisms of Pain This mini symposium will provide an opportunity for international pain specialists to describe their own research and today s cutting edge advancements in greater detail. This session is designed for attendees interested in pain research. 9:50 Break and Exhibits Session 11: Professors Perspectives <<< Moderator: David C. Whitcomb, MD, PhD 10:10 Strategies to Translate the Gut-Lymph Concept into Clinical Practice John Windsor, MD 10:40 Emerging Concepts in the Management of Chronic Pancreatitis D. Nagashwar Reddy, MD, DM DSc Questions will be addressed as part of each separate lecture in Session 10. Session 12: CAPER Young Investigator Research Moderator: Walter G. Park, MD, MS 11:10 Quality Improvement in the Training of Advanced Endoscopy Fellows Sachin Wani, MD 11:30 Updates in Autoimmune Pancreatitis Philip A. Hart, MD 11:50 Break, Exhibits and Lunch (sponsored by CAPER)

6 6 12:30 Heading Funded Endoscopic RCTs B. Joseph El Munzer, MD 12:50 Infected Pancreatic Necrosis Robert Moran, MD 1:10 Panel Discussion Session 13: CAPER Award Ceremony Moderator: Georgios I. Papachristou, MD, PhD 1:30 CAPER Research Award Presentations Moderator: Vikesh K. Singh, MD, MSc 1:45 CAPER Lifetime Achievement Award to Dr. Suresh Chari Introduced by: Wahid Wassef, MD, MPH 1:50 Lifetime Achievement Award Lecture Suresh Chari, MD 2:20 CAPER Business Meeting and Elections Wahid Wassef, MD, MPH 2:30 Adjourn PancreasFest 2016 Afternoon On your own