in Space Effects of Space Flight on the Musculo-Skeletal System Gilles Clément Doug Hamilton International Space University Strasbourg, France
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1 1 Muscle in Space Effects of Space Flight on the Musculo-Skeletal System Gilles Clément Doug Hamilton International Space University Strasbourg, France Wyle Laboratories & NASA Johnson Space Center Houston, USA
2 Lecture Outline 2 How the musculo-skeletal system works in Earth gravity to ensure upright posture, movements and storage of nutrients (calcium) Physiology of muscle and bone The effects of space flight on muscle and bone Implications of such changes for long-term missions, and potential countermeasures
3 Muscle Physiology 3 Humans have about 700 muscles in their bodies There are 3 types of muscles : Lujan and White (1995) Their sole function is contraction (they all work by shortening) Contractions of skeletal muscles are coordinated by the brain
4 Skeletal Muscles 4 Skeletal muscle is the largest tissue in the body, accounting for 40-45% of the total body weight Each end of a skeletal muscle is attached to a bone by tendons Skeletal muscles work in pairs: one muscle contracts to pull a bone forward, the other to pull it back The anti-gravity muscles, also known as postural muscles, owe their importance and strength to the presence of gravity Lujan and White (1995)
5 Muscle Contraction 5 Muscles are composed of fibers Each fiber is made up of myofibrils, consisting of many filaments (myosin and actin), the engines of the muscle Together, the actin and myosin provide all the muscleʼs movement and force as they slide together (contraction) and apart (during relaxation) In healthy muscles, there is a continual process of muscle protein production and breakdown When protein breakdown occurs more rapidly than protein production, there is a loss of muscle mass
6 Muscle Strength 6 Contraction refers to the active process of generating a force in a muscle The force exerted by a contracting muscle on an object is the muscle tension The force exerted on a muscle by the weight of an object is the load When a muscle shortens and lift a load, the muscle contraction is isotonic (constant tension) When shortening is prevented by a load that is greater than muscle tension, the muscle contraction is isometric (constant length)
7 Mechanisms of Muscle Contraction 7 Motor neuron from spinal cord innervates muscle Action potential opens channel in bilipid membrane Acetylcholine (AChe) is released and binds to channel Channel of ~0.65 nm allows positive ions in (primarily Na,K,Ca) Na+ influx reduces negative potential inside cell This depolarizes the membrane and allows a large Ca++ influx Ca++ causes change of actin filament sub-components, uncovers binding sight between actin and myosin ATP (produced by mitochondria) is "waiting" for binding sight As a result, ATP is cleaved into energy and ADP ATP energy causes myosin head to "snap" and moves actin Release of ADP causes myosin head to "snap back" to next site Series causes a ratcheting motion resulting in muscle contraction Pumps then activate to remove Ca++ and relax contraction AChe esterase breaks AChe down into acetate ions and choline Choline is recycled, acetate is a toxic byproduct (lactic acid which forms "crystals" that "cut" muscle tissue and generates soreness!)
8 Energy for Muscle Contraction 8 Basic source is Adenosine Tri-Phosphate or ATP ~ ~ ATP is the universal currency of biological energy ~ represent high energy phosphate bonds. Each one releases 7,500 calories when broken
9 Energy for Muscle Contraction 9 Basic source is Adenosine Tri-Phosphate or ATP The amount of ATP present in the muscle cells is only sufficient to sustain maximal muscle power for 5-6 seconds New ATP must be formed continuously: creatine phosphate: can sustain more sec of muscle activity anaerobic step of glucose breakdown: for another sec bursts of energy aerobic system: provides unlimited time muscle activity (as long as nutrients last) creatine phosphate creatine ADP+Pi ATP Myosin ATPase Contraction glycogen glucose oxygen GLYCOLISIS lactic acid protein OXIDATIVE PHOSPOHORYLATION fat
10 Muscle Activity 10 The filamentʼs force is all or nothing. When called upon, it always applies the same amount of force at the same speed There are 2 kinds of muscle fibers : Type I, or slow twitch, are slowmoving but high-endurance fibers. Use oxygen. Marathon runners typically develop those in the soleus muscle in the calf for prolonged lower leg muscle activity Type II, or fast twitch, are high-speed, high-output fibers. Sprinters and weight-lifters typically develop those in the gastocnemius muscle in the calf and in the biceps muscle for quick, powerful bursts of movement. They fatigue rapidly (use glycogen rather than oxygen) The average person has about 50%-50% of Type I and Type II fibers throughout the body
11 Muscular Exercise 11 Strength and endurance can be increased by exercise (training) Capacity of a muscle for activity can be altered: by transformation of one type of fiber to another: e.g. muscle required to perform endurance-type activity will develop more Type I fibers and number of blood capillaries will increase by the growth in size (hypertrophy) of the muscles fibers: e.g. weightlifting will induce hypertrophy in Type II fibers, with an increase in synthesis of actin and myosin filaments Endurance exercise also produces changes in the respiratory and circulatory systems, which improves the delivery of oxygen and nutrients to the muscle fibers
12 Muscle Atrophy 12 Denervation atrophy: If the nerve fibers to a muscle are severed or the motor neurons destroyed, the denervated muscle fibers become progressively smaller, their content of actin and myosin decreases, and connective tissue prolifers around the muscle fibers Disuse atrophy: A muscle can also atrophy with its nerve supply intact if it is not used for a long period of time Atrophy occurs when muscle can not breakdown ATP as fast
13 Effects of Spaceflight on Muscle 13 Decrease in body mass
14 Effects of Spaceflight on Muscle 14 Decrease in body mass Decrease in leg volume
15 Effects of Spaceflight on Muscle 15 Decrease in body mass Decrease in leg volume Atrophy of the antigravity muscles (thigh, calf) seen on muscle scans/biopsies decrease in leg muscle strength extensor muscles more affected than flexor muscles Data in flown rats showed an increase in number of Type II, fast twitch muscle fibers (those which are useful for quick body movements but more prone to fatigue) Ground control Flight
16 Muscle Atrophy Countermeasures 16 2 daily 1.5-hour sessions of exercise: Treadmill with axial loading Cycle ergometer Interim resistive exercise Traction on bungee cords 4-day cycle: Day 1, low load but high intensity Day 2, moderate load at moderate intensity Day 3, high load at low intensity Day 4, ad lib
17 "Penguin Suit" 17 The inside of the suit contains a system of elastic, straps, and buckles that can be used to adjust the fit and tension of the suit
18 Muscle Atrophy Challenges 18 Exercise alone has not prevented muscle atrophy during spaceflight The increase in fast-switch fibers could result in a higher susceptibility to contraction damage (sprain) Muscle atrophy caused by weightlessness participates in postural instability and locomotion difficulties after spaceflight Astronauts data are complicated by prior physical fitness and in-flight exercise countermeasures or work loads (e.g. EVA) Muscle development was disrupted when gravity-loading exercise was removed from immature rats flown on Neurolab The muscle weakness, fatigue, faulty coordination, and muscle soreness that astronauts experience after spaceflight mimics the changes seen in bed-rest patients and the elderly
19 Function of Bone 19 Structural organ Weight-bearing bones: support and make the body mobile (spine, skeleton) Protective bones: shield our delicate internal organs (skull, ribs) Mineral reservoir Life began in a primordial sea rich in potassium and magnesium and poor in sodium and calcium With time, geological changes altered the composition to one which is rich in sodium and calcium As organisms became multicellular they needed to also control their extracellular milieu An adult contains approximately 1000 grams of calcium: 99% in the skeleton 1% in the extracellular space and soft tissues
20 Weight Bearing Bone 20 Excessive mass versus fragility Could make fracture probability equal to zero if all bones were large Bear (heavy bone, reduced mobility) vs. Bird (light bone, flight) Natural selection gives minimum structure
21 Anti-Gravity Bones 21 The anti-gravity bones are responsible for bearing the weight of the body in a gravitational environment Lujan and White (1995)
22 The Major Parts of a Long Bone 2 extremities, cylindrical midshaft and hollow center (which contains the bone marrow) Bone can be layered around a blood vessel (lamellar bone) 22 Lujan and White (1995)
23 Bone Remodeling 23 Bone tissue is remodeled every 5 months by: (a) Activation (stress) (b) Resorption (osteoclasts) 3 weeks (c) Formation (osteoblasts) > 4 months Osteoblasts = builders Osteoclasts = crushers Lujan and White (1995)
24 Bone Growth 24 Bone contains a matrix of collagen fibers which provide a milieu for the deposition of calcium crystals (hydroxyapatite). These crystals give its strength to the bone A layer of cartilage called the growth plate is where the bone grow longer by increasing its thickness which is later calcified with hydroxyapatite Growth plate
25 Calcium Balance 25 Blood Absorption g Absorption g Diet g Bone Secretion g Filtration 5-7 g Secretion g Reabsorption g Intestine Urine g Kidney Feces g
26 Osteoporosis on Earth 26 On Earth, osteoporosis is a bone disease in which the bone mass is reduced by % per year Approximately hip fractures secondary to osteoporosis occur annually in the U.S. By age 80, 25% of women and 15% of men will suffer a hip fracture. 10% of these patients will die as a result of this fracture The hospital care costs for these patients will reach 5 billion dollars annually. The cost from non-hospital care facilities is an order of magnitude greater
27 Bone Loss during Spaceflight 27 Vostok: Gemini: Apollo: Soyuz: Skylab: Mir: Increased fecal and urinary calcium first noticed Loss of approximately 2-4% of bone mass in heel after 4-11 days of spaceflight 3-5% decrease in bone mass after 10 days 8-10% decrease in bone density 1-3% per month loss in bone mineral 10% loss of trabecular bone from lumbar spine in one cosmonaut after a 1-year mission Shuttle-Mir: With countermeasures: 5.4% decrease in bone density in tibia. Did not return to preflight level in some individuals Without countermeasures: % per month decrease in bone density (worst case: 15-22% total in some bones) ISS: Preliminary data similar to Shuttle-Mir
28 Bone Loss during Spaceflight 28 Postflight changes in bone density compared to preflight
29 Calcium Loss during Spaceflight 29 Compiled data from Gemini 7, Skylab 2-4, and Shuttle missions (each data point represents the mean ± SD of n= 2 to14 subjects)
30 Bone Loss during a Mars Mission 30 National Geographic, January 2001 During a mission to Mars, a 45-year-old astronaut could see bone deterioration reach the weakened state of severe osteoporosis
31 Definition of Stress and Strain Compression 31 Tension = Strain = (l-lo)/lo lo l Mechanical loads (stress) causes slight deformation called strain Bone length changes of 0.1% correspond to 1,000 microstrain (µs) The amount of microstrain is dependent on loading, elasticity and geometry of the bone Physiological window: µs
32 Stress versus Strain 32 An upper limit strain must be exceeded to provoke remodeling to increase bone mass Mechanical strain below a lower limit will provoke adaptive remodeling to reduce mass Normal remodeling activity is associated with compressive strains between µs Tension has an upper limit of µs Dimensional changes in excess of 25,000 µs will result in fractures
33 Bone Loss Countermeasures 33 A turkey standing on a vibrating platform which stimulates muscle and bone interaction, thus promoting bone growth After a year of daily 20-minute sessions, sheep showed the robust striations of increased density (lower right) Control sheep showed normal bone (lower left) National Geographic, Jan. 2001
34 Bone Density Measurements 34 Description : Pre- and postflight whole body bone density scan Pre- and postflight bone density local scans: Proximal femur (hip) Lumbar spine (back) Calcaneous (heel) Objectives : To assess effectiveness of countermeasures To assess postflight recovery To predict long-term bone fracture risk To determine return-toflight status
35 Bone Loss Challenges 35 Bone loss during spaceflight is about 1-3% per month. What will be the new state for bone after very long missions? What is the fracture risk for such changes in bone density and structure? Risk of renal (kidney) stone formation Will reduced Mars gravity be enough for preventing further bone loss? How should bones be loaded in reduced gravity? Which countermeasure (mechanical loading, exercise,diet, drugs, artificial gravity) work best?
36 Muscle Summary 36 Muscle Decrease in body mass, and in leg muscle size and strength Increase in number of fast twitch muscle fibers Bone Continuous decrease in bone mass and density Risk of bone fracture and renal stones probably increases during long-duration spaceflight Countermeasures and Issues Experience of long-duration missions indicates that current in-flight countermeasures are not optimal; Using the current methods, humans would not be operational after landing on Mars Is Mars gravity sufficient for regaining normal muscle and bone function?
37 Additional Reading 37 Clément G (2005) Fundamentals of Space Medicine. Dordrecht: Springer Johnston RS, Dietlein LF (1977) Biomedical Results from Skylab. Chapter 21. Muscular deconditioning and its prevention in space flight. NASA SP-377, Washington DC: NASA Long ME (2001) Surviving space. National Geographic, January Rittweger J, Gunga HC, Felsenberg D, Kirsch KA (1999) Muscle and bone Aging and space. J Gravitat Physiol 6: Integrative Physiology in Space. European J Physiol 441, Number 2-3, (Supplement), 2000 International Workshop on Bone Research in Space. Bone, Official Journal of the International Bone and Mineral Society, Volume 22, Number 5 (Supplement), 1999 Muscle Research in Space: International Workshop. International Journal of Sports Medicine, Vol 18 (Supplement 4): , 1997 NASA Critical Path Roadmap at
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