GERD. gastroesophageal reflux disease : GERD. Laryngopharyngeal reflux disease : LPRD GERD GERD GERD LPRD GERD. gastroesophageal reflux ; GER GERD

Transcription

1 : GERD gastroesophageal reflux disease : GERD Laryngopharyngeal reflux disease : LPRD GERD GERD GERD GERD LPRD QOL GERD LPRD QOL LPRD : gastroesophageal reflux ; GER gastroesophageal reflux disesae ; GERD GERD GERD GERD GERD GERD GERD Grade IVb GERD

2 GERD GERD GERD PPI GERD OSAS GERD GERD : RCT : : 2 Laryngeal reflux Gastropharyngeal reflux Pharyngoesophageal reflux Supraesophageal reflux Gastroesophageal reflux otolaryngologic disease Extraesophageal reflux Laryngopharyngeal reflux GERD GERD Cherry GERD GER laryngopharyngeal refluxlpr laryngopharyngeal reflux diseaselprd GERD GERD GERD LPRD GERD Belafsky GERD LPR Oridate laryngeal pseudosulcus LPR proton pump inhibitor ; PPIPPI GERD PPI randomized placebocontrolled trial PPI PPI GERD GERD PPI LPR PPI ph LPR ph PPI

3 GERD 2011 globus sensation GERD PPI esophagopharyngeal reflux Ulualp ph Phipps Wong neuroinflammatory change GERD GERD GERD GERD Obstructive sleep apnea syndrome ; OSAS GER OSAS GERD OSAS GERD OSAS OSAS Orr GERD OSAS PPI PPI Suzuki ph GER LPR OSAS OSAS LPR GER LPR GERD OSAS GERD GERD OSAS Gibson GERD GERD GERD Velepic Tasker otitis media with effusion ; OME pepsinogen ; PG OME

4 GERD PG OME OME OME PG GERD PG PPI PG OME PPI OME PPI OME OME PG LPRD Quality of life, QOL GERD GERD QOL LPRD PPI GERD GERD

5 GERD PPI LPRD LPRD QOL, :GERD. ; :. Vakil N, van Zanten SV, Kahrilas P, et al : The Montreal definition and classification of gastroesophageal reflux disease : a global evidencebased consensus. Am J Gastroenterol 2006 ; 101 : GERD., ;. Cherry J, Margulies SI : Contact ulcer of the larynx. Laryngoscope 1968 ; 78 : Delahunty JE, Cherry J : Experimentally produce vocal cord granulomas. Laryngoscope 1968 ; 78 : Gaynor EB : Gastroesophageal reflux as an etiologic factor in laryngeal complications of intubation. Laryngoscope 1988 ; 98 : Koufman JA : The otolaryngologic manifestations of gastroesophageal reflux diseasegerd: a clinical investigation of 225 patients using ambulatory 24 hour ph monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991 ; 101 Suppl 53 : 178. Jaspersen D, Kulig M, Labenz J, et al : Prevalence of extra esophageal manifestations in gastro esophageal reflux disease : an analysis based on the progerd study. Aliment Pharmacol Ther 2003 ; 17 : Ford CN : Evaluation and management of laryngopharyngeal reflux. JAMA 2005 ; 294 : Belafsky PC, Postma GN, Koufman JA : Validity and reliability of the reflux symptom indexrsi. J Voice 2002 ; 16 : Groome M, Cotton JP, Borland M : Prevalence of laryngopharyngeal reflux in a population with gastroesophageal reflux. Laryngoscope 2007 ; 117 : Belafsky PC, Postma GN, Koufman JA : The validity and reliability of the reflux finding scorerfs. Laryngoscope 2001 ; 111 : Oridate N, Mesuda Y, Nishizawa N, et al : The prevalence of laryngeal pseudosulcus among Japanese patients with laryngeal reflux related symptoms. Auris Nasus Larynx 2005 ; 32 : Svensson G, Schalén L, Fex S, et al : Pathogenesis of idiopathic contact granuloma of the larynx : results of a prospective clinical study. Acta Otolaryngol 1988 ; 449 : Qadeer MA, Phillips CO, Lopez AR, et al : Proton pump inhibitor therapy for suspected GERDrelated chronic laryngitis : a meta analysis of randomized controlled trials. Am J Gastroenterol 2006 ; 101 : Ahmed TF, Khandwala F, Abelson TI, et al : Chronic

6 GERD laryngitis associated with gastroesophageal reflux : prospective assessment of differences in practice patterns between gastroenterologists and ENT physicians. Am J Gastroenterol 2006 ; 101 : Sun G, Muddana S, Slaughter JC, et al : A new ph catheter for laryngopharyngeal reflux : Normal values. Laryngoscope 2009 ; 119 : ,,, :. ; :. Tokashiki R, Yamaguchi H, Nakamura K, et al : Globus sensation caused by gastroesophageal reflux disease. Auris Nasus Larynx 2002 ; 29 : Belafsky PC, Rees CJ, Rodriguez K, et al : Esophagopharyngeal reflux. Otolaryngol Head Neck Surg 2008 ; 138 : Ulualp SO, Toohill RJ, Hoffmann R, et al : Possible relationship of gastroesophagopharyngeal acid reflux with pathogenesis of chronic sinusitis. Am J Rhinol 1999 ; 13 : Phipps CD, Wood WE, Gibson WS, et al : Gastroesophageal reflux contributing to chronic sinus disease in children : a prospective analysis. Arch Otolaryngol Head Neck Surg 2000 ; 126 : Tolia V, Vandenplas Y : Systematic review : the extra oesophageal symptoms of gastro oesophageal reflux disease in children. Aliment Pharmacol Ther 2009 ; 29 : Wong IW, Omari TI, Myers JC, et al : Nasopharyngeal ph monitoring in chronic sinusitis patients using a novel four channel probe. Laryngoscope 2004 ; 114 : Delehaye E, Dore MP, Bozzo C, et al : Correlation between nasal mucociliary clearance time and gastroesophageal reflux disease : our experience on 50 patients. Auris Nasus Larynx 2009 ; 36 : Ozmen S, Yücel OT, Sinici I, et al : Nasal pepsin assay and ph monitoring in chronic rhinosinusitis. Laryngoscope 2008 ; 118 : kusano M, Kouzu T, Kawano T, et al : Nationwide epidemiological study on gastroesophageal reflux disease and sleep disorders in the Japanese population. J Gastroenterol 2008 ; 43 : Ing AJ, Ngu MC, Breslin AB : Obstructive sleep apnea and gastroesophageal reflux. Am J Med 2000 ; 108 Suppl 4a : 120S125S. Kim HN, Vorona RD, Winn MP, et al : Symptoms of gastrooesophageal reflux disease and the severity of obstructive sleep apnea syndrome are not related in sleep disorders center patients. Aliment Pharmacol Ther 2005 ; 21 : Noronha AC, de Bruin VM, Nobre e Souza MA, et al : Gastroesophageal reflux and obstructive sleep apnea in childhood. Int J Pediatr Otorhinolaryngol 2009 ; 73 : Orr WC, Robert JJ, Houck JR, et al : The effect of acid suppression on upper airway anatomy and obstruction in patients with sleep apnea and gastroesophageal reflux disease. J Clin Sleep Med 2009 ; 5 : Suzuki M, Saigusa H, Kurogi R, et al : Arousals in obstructive sleep apnea patients with laryngopharyngeal and gastroesophageal reflux. Sleep Med 2010 ; 11 : Gibson WS Jr, Cochran W : Otalgia in infants and childrena manifestation of gastroesophageal reflux. Int J Pediatr Otorhinolaryngo 1994 ; 28 : Velepic M, Velepic MS, Starcevic R, et al : Gastroesophageal reflux, allergy and chronic tubotympanal disorders in children. Int J Pediatr Otorhinolaryngol 2000 ; 55 : Tasker A, Dettmar PW, Panetti M, et al : Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 2002 ; 112 : Abd ElFattah AM, Abdul Maksoud GA, Ramadan AS, et al : Pepsin assay : a marker for reflux in pediatric glue ear. Otolaryngol Head Neck Surg 2007 ; 136 : O Reilly RC, He Z, Bloedon E, et al : The role of extraesophageal reflux in otitis media in infants and children. Laryngoscope 2008 ; 118suppl: 19. White DR, Heavner SB, Hardy SM, et al : Gastroesophageal reflux and eustachian tube dysfunction in an animal model. Laryngoscope 2002 ; 112 : Yazici ZM, Sari M, Uneri C, et al : Histologic changes in eustachian tube mucosa of rats after exposure to gastric reflux. Laryngoscope 2008 ; 118 : Sone M, Yamamuro E, Hayashi H, et al : Prediction of gastroesophageal reflux in otitis media with effusion in adults. Acta Otolaryngol 2007 ; 127 : Sone M, Yamamuro Y, Hayashi H, et al : Otitis media in adults as a symptom of gastroesophageal reflux. Otolaryngol Head Neck Surg 2007 ; 136 : Sone M, Kato T, Nakashima T : A woman with biliary reflux into her middle ear. Otolaryngol Head Neck Surg 2008 ; 139 : Sone M, Kato T, Suzuki Y, et al : Relevance and characteristics of gastroesophageal reflux in adult patients with

7 GERD 2011 otitis media with effusion. Auris Nasus Larynx ; in press. GERD OME