aortic thromboembolism : ATE ATE ATE LOGIQ P ATE ECLOS ATE computed tomography fibrin/fibrinogen degradation products : FDP

Transcription

1 h h CT ATE.... Dh AST CK ALT Dh ATE Dh ATE Dh aortic thromboembolism : ATE ATE ATE ATE ATE computed tomography : CT ATE Dh fibrin/fibrinogen degradation products : FDP Dh FDP LOGIQ P GE CT ECLOS.... CT h h hh FAX hh kuniya@camic.jp 137

2 /l ASTCK ALT D h.. g/dl FDP CT CT.mg/kg/day KC kg kg kg kg 138 RBC l Hb gdl MCV fl MCHCgdl PCV TP gdl NE WBC l Band Seg Lym Mon Eos Bas Other Plat l TP gdl Alb gdl ALT Ul AST Ul ALP Ul ThBil Ul Glu gdl Thcho gdl BUN gdl Cre gdl Ca mmoldl NE P mmoldl NE Na mmoldl K mmoldl Cl mmoldl CK Ul NE Dhgdl FDPgdl NE NE not examined ATE ATE ATE. h h ATE ATE

3 CT CT mm CT mm h CT ATE X magnetic resonance imaging : MRIh ASTCKALTLDH BUNCre,, Dh ASTCKALT Dh ASTCKALT FDP Dh Dh FDP Dh disseminated intravascular coagulation : DIC FDP Dh, Dh pulmonary thromboembolism : PTEdeep vein thrombosis : DVT DIC PTE, h Dh ATE Dh ATE Dh ATE Dh ATE Dh Dh ATE ATE Dh 139

4 DIC ATE h,,, h ATE, ATE tissue-plasminogen activator : t-pa,,, h t-pa,,,,,, ATE ATE,, ATE QOL ATE ATE ATE ATE ATE Dh Lake-Bakaar GA, Johnson EG, Griffiths LG : Aortic thrombosis in dogs: cases (h), J Am Vet Med Assoc,, h () Ware WA : Thromboembolic Disease, Small Animal Internal Medicine, Nelson RW, ed, th ed, h, Mosby Elesevier () Goncalves R, Penderis J, Chang YP, Mosley J, Anderson TJ : Clinical and neurological characteristics of aortic thromboembolism in dogs, J Small Anim Pract,, h () Brofman PJ, Thrall DE : Magnetic resonance imaging findings in a dog with caudal aortic thromboembolism and icchemic myopathy, Vet Radiol Ultrasound,, h () Boswood A, Lamb CR, White RN : Aortic and iliac thrombosis in six dogs, J Small Anim Pract,, h () Dunn ME : Thrombectomy and thrombolysis: the interventional radiology approach, J Vet Emerg Crit Care,, h () DVT/PE h() DIC h 140

5 Nelson OL, Andreasen C : The utility of plasma D- dimer to identify thromboembolic disease in dogs, J Vet Intern Med,, h () Stokol T : Plasma D-dimer for the diagnosis of thromboembolic disorders in dogs, Vet Clin North Am Small Anim Pract,, h () Caldin M, Furlanello T, Lubas G : Validation of an immunoturbidimetric D-dimer assay in canine citrated plasma, Vet Clin Pathol,, h () Stokol T, Brooks MB, Erb HN, Mauldin GE : D-dimer concentrations in healthy dogs and dogs with disseminated intravascular coagulation, Am J Vet Res,, h () Ridyard AE, Shaw DJ, Milne EM : Evaluation of platelet activation in canine immune-mediated haemolytic anaemia, J Small Anim Pract,, h () Robert G : Pulmpnary thronboembolism, J Vet Emerg Crti Care,, h () Wells R, Guth A, Lappin M, Dow S : Anti-endothelial cell antibodies in dogs with immune-mediated hemolytic anemia and other diseases associated with high risk of thromboembolism, J Vet Intern Med,, h () Jacoby RC, Owings JT, Ortega T, Gosselin R, Feldman EC : Biochemical basis for the hypercoagulable state seen in Cushing syndrome, Arch Surg,, h () Johnson LR, Lappin MR, Baker DC : Pulmonary thromboembolism in dogs: h, J Vet Intern Med,, h () LaRue MJ, Murtaugh RJ : Pulmonary thromboembolism in dogs: cases (h), J Am Vet Med Assoc,, h () Schaub RG, Rawlings CA, Keith JC Jr : Platelet adhesion and myointimal proliferation in canine pulmonary arteries, Am J Pathol,, h () h h Scott KC, Hansen BD, DeFrancesco TC : Coagulation effects of low molecular weight heparin compared with heparin in dogs considered to be at risk for clinically significant venous thrombosis, J Vet Emerg Crit Care,, h () Bliss SP, Bliss SK, Harvey HJ : Use of recombinant tissue-plasminogen activator in a dog with chylothorax secondary to catheter-associated thrombosis of the cranial vena cava, J Am Anim Hosp Assoc,, h () Boudreaux MK, Dillon AR, Ravis WR, Sartin EA, Spano JS : Effects of treatment with aspirin or aspirin/dipyridamole combination in heartworm-negative, heartworm-infected, and embolized heartworm-infected dogs, Am J Vet Res,, h () Calvert CA, Thrall DE : Treatment of canine heartworm disease coexiting with right-side heart failure, J Am Med Assoc,, h () h h Clinical and Clinicopathological Findings in Four Dogs with Aortic Thromboembolism Takashi KUNIYA, Asuka SUBE, Michiya KANEMURA and Naoyuki WATANABE Watanabe Animal Hospital, 825h10 Oyanagi, Shimada, 427h0101, Japan To describe the characteristics of clinical signs and clinicopathological findings in dogs with aortic thromboembolism (ATE), the medical records of four dogs diagnosed with ATE were reviewed retrospectively. The diagnosis of ATE was based on computed tomography (CT) imaging. Four dogs ( years) presented with evaluation of progressive paresis. All the dogs had clinical signs of pelvic limb lameness prior to presentation. The onset of clinical signs was chronic ( days) in all the dogs. Laboratory findings revealed high D-dimer concentration (four dogs), aspartate aminotransferase activity (three dogs), creatine kinase activity (three dogs), alanine aminotransferase (three dogs) and mild thrombocytopenia (three dogs). This result suggests that high D-dimer concentration is correlated with ATE in aged dogs presenting clinical signs of pelvic limb lameness with chronic onset. D-dimer combined with other clinical examinations might be useful to support the diagnosis of ATE in dogs. Key words : aortic thromboembolism, D-dimer, dog. Correspondence to : Takashi KUNIYA (Watanabe Animal Hospital) 825h10 Oyanagi, Shimada, 427h0101, Japan TEL 0547h38h0144 FAX 0547h38h kuniya@camic.jp J. Jpn. Vet. Med. Assoc.,, () 141