Sepsis care and the new core measures
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1 Sepsis care and the new core measures Daniel S. Hagg, MD January 15, 2016 Outline What is sepsis? A brief history of sepsis care How should we take care of septic patients now? Core measures What strategies work? Advice for small hospitals 1
2 Sepsis IS Sepsis is NOT The inflammatory response to infection Bacteria in the Blood Sepsis is a major clinical problem DISEASE NUMBER OF DEATHS/YEAR Severe Sepsis (Angus, 2001) 215,000 AMI (Minino, 2002) 193,000 Lung Cancer (Minino, 2002) 156,000 Colon Cancer (Minino, 2002) 57,000 Breast Cancer (Minino, 2002) 42,000 Minino AM, Arias E, Kochanek KD, et al. Deaths: final data for National Vital Statistics Reports Web Site. 2
3 A patient presenting with severe sepsis has a mortality risk 6-10 times greater than AMI 4-5 times greater than stroke Diagnosis Terms to foster common dialogue 3
4 Diagnosis Sepsis = Systemic Inflammatory Response Syndrome (SIRS) plus suspected infection Sepsis hypotension First some definitions (you can t treat what you don t recognize) What is SIRS? Systemic inflammatory response syndrome What is sepsis? SIRS criteria (need 2 out of 4) Temp >38.3C or < 36C HR > 90 bpm RR >20/min or pco 2 <32 mmhg WBC < 4000, >12000, or >10% bands SIRS and a SUSPECTED infection Severity of sepsis? (and why it matters) Sepsis Severe sepsis 20-35% mortality Septic shock 30-70% mortality SEPSIS is a MEDICAL EMERGENCY 4
5 What is severe sepsis? More definitions Severe sepsis = sepsis + any end organ damage (mortality 20 35%) Evidence of sepsis-induced tissue hypoperfusion or organ dysfunction: Hypotension Elevated lactate > 4 Urine output <0.5ml/kg for >2hr Acute hypoxemia (P:F ratio < 300) Altered mental status Cr >2 mg/dl Bilirubin >2mg/dL Platelet <100, INR >1.5 Paralytic ileus What is septic shock? Septic shock = severe sepsis + need for vasopressors despite fluid resuscitation (mortality 30 70%) Progressive Mortality can be reversed SIRS 5
6 From: Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, JAMA. 2014;311(13): doi: /jama Figure Legend: Mean Annual Mortality in Patients With Severe SepsisError bars indicate 95% CI. Date of download: 7/22/2014 Copyright 2014 American Medical Association. All rights reserved. From: Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, JAMA. 2014;311(13): doi: /jama Figure Legend: Adjusted Annual Odds for the Change in Hospital Outcomes Reported as Odds Ratios Referenced Against the Year 2000When considered as a continuous variable, there was no difference between patients with severe sepsis or septic shock and other patients in the database for the decline in mortality over time (odds ratio [OR], 0.94 [95% CI, ] vs 0.94 [95% CI, ]; P =.37), whereas significant differences were observed in the change over time for discharge to home (OR, 1.03 [95% CI, ] vs 1.01 [95% CI, ]; P <.001) and discharge to rehabilitation facilities (OR, 1.08 [95% CI, ] vs 1.09 [95% CI, ]; P <.001). Discharge to rehabilitation included Copyright 2014 American Medical Association. All Date of discharge download: to 7/22/2014 rehabilitation facilities and chronic care facilities such as nursing homes. ICU indicates intensive care unit. rights reserved. 6
7 How did we do it? Randomized trial of usual care v. early goal directed therapy 263 patients 16% Absolute risk reduction in mortality Goal Directed therapy 1. Recognize sepsis (give fluid bolus) 2. Administer fluids to goal CVP 3. Give vasopressors to target MAP 4. Check ScVO2 and treat accordingly 1. low with normal Hgb, give dobutamine 2. low with low hgb, give blood 7
8 Early therapy reduces mortality ARR: = 16%. Therefore NNT: 1/ARR or 1/0.16 = 6.25 Comparisons in EGDT vs. Controls 8
9 Implementation and effectiveness analysis Hospital costs decrease 22.9% $2,749 - $7019 per QALY Survivorship has substantially increased 9
10 But now I m told goaldirected therapy is dead 10
11 ProCESS Trial Objectives Study EGDT in multi-center format Compare 3 protocols Wild-type resuscitation Protocol guided standard care Protocol guided EGDT 11
12 Interventions Important Highlights 12
13 Outcomes Outcomes 13
14 Outcomes Outcomes 14
15 What is important All of these patients received fluids equivalent to Rivers et al EGDT 97%+ antibiotics within 6 hours >70% received antibiotics prior to enrollment All identified as sepsis Editorial 15
16 What should we do now? Our best recommendations are those of the core measures However, everything starts with EARLY recognition and a sense of medical emergency Identifying those at risk and making early diagnosis 16
17 The key trait for making early diagnosis is having a constantly elevated index of suspicion Physicians need to look for sepsis in the same way they look for stroke or AMI, in fact, it is probably more important Some thoughts on early diagnosis 17
18 A role for lactate? ED at Beth Israel Hospital in Boston 1287 patients with lactates drawn Lactate up = higher mortality 18
19 More on Lactate Blood pressure changes? 19
20 Isolated low BP? 4700 consecutive ED admissions screened for any episode of low BP 887 cases found Episodes of hypotension 20
21 Core Measures In development since before 2007 Extremely complicated measures specifications manual = 63 pages long! labelled as SEP-1 21
22 22
23 Strategies Create a culture of passion for the care of septic patients Become an evangelist! Take every moment to coach up the team Sepsis care is a TEAM effort Teach away medical mythology create pathways and order sets that leverage current practices in other areas into best sepsis care 23
24 Common Myths 1. Avoiding Fluids in certain patient populations 1. Renal failure 2. Heart failure 2. Giving Normal Saline because the potassium is high 3. There is a maximum vasopressor dose 4. We give fluids to raise the blood pressure Myth #1 I am commonly told that people didn t want to give too much fluid due to either heart failure or renal failure The 30cc/kg bolus septic patients need is well tolerated by almost everyone. Avoiding sufficient fluids is practicing as per the control group in Dr. Rivers goal-directed trial sepsis associated renal failure is much harder to reverse if we fail to restore perfusion 24
25 Myth #2 It is common to avoid Lactated Ringer s if there is acute kidney injury or elevated potassium due to potassium content There is only 4mEq/L of potassium LR is a neutral ph buffered solution vs. NS that has a ph of 4.5 and causes a hyperchloremic acidosis Most hyperkalemia is due to acidosis related cellular shifts. correcting the acidosis fixes the hyperkalemia. Myth #3 The patient is on max norepi There is simply no such thing. They need what they need. I have used doses as high as 4mkg/kg/min (>400mkg/min) in patients who survive. 25
26 Myth # 4 Fluids are given to raise the blood pressure Fact: fluids fill the ventricles and improve stroke volume/cardiac output. If cardiac output doesn t increase with fluid, the patient will NOT benefit from more fluid. use vasopressors. Straight leg raise 26
27 27
28 Antibiotics 28
29 Retrospective data collection at 22 centers All patients with sepsis Evaluated appropriate abx by whether it fit guidelines or covered eventual cultures Outcomes 29
30 Summary Sepsis is a MEDICAL EMERGENCY Sepsis care has evolved substantially over 15 years with significantly reduced mortality The core of sepsis care is: Early diagnosis Early fluids Early antibiotics The new core measures reflect these data Advice Find committed and motivated people Give them the time, tools and authority to work on this system Support the message every day Be prepared for this to take a long time 30
Sepsis Care and the New Core Measures. Daniel S. Hagg, MD January 15, 2016
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