Functional Cosmetics Blends

Transcription

1 Functional Cosmetics Blends

2 Multi-Complex herb Ext. TM MCE-C Natural Preservatives for Cosmetics

3 Functional Cosmetics Blends Product Name Composition Uses MCE-C Cinnamon extract, Scutellaria baicalensis root extract, Lactobacillus ferment, Glycerin Natural preservative MCE-CS Cinnamon Extract, Citrus Peel Extract, Licorice extract, Lactobacillus Ferment, Glycerin Natural preservative MCE-CU MCE-PF MFP-KT Citrus fruit oil, Grape seed oil, Licorice Extract (hydrophobic phase) Cinnamon extract, Phenoxyethanol, 1,2- Hexanediol, Caprylyl Glycol Skullcap, Green tea, Mugwort, Houttuynia cordata, Citron, 1,2-Hexanediol, Caprylyl Glycol Natural Preservative Paraben-free preservative Hydrogel mask BCX-A Hinoki cypress, Lactobacillus ferment Anti-acne

4 Multi-Complex herb Ext. TM Natural Preservative for Cosmetics MCE-C & MCE-CS & MCE-CU

5 MCE-C : Cinnamomum Zeylanicum Bark Extract Scutellaria baicalensis Root Extract Lactobacillus ferment Glycerin MCE-CS : Cinnamomum Zeylanicum Bark Extract Citrus Unshius peel Ext, Licorice Root Ext. Garlic Ext. Lactobacillus ferment Glycerin MCE-CU : Citrus Unshius Fruit Oil Grape seed oil Licorice Root Ext. For Emulsions & Essential oil

6 Comparison of MCE-C With MCE-CS & CU MCE-C MCE-CS & CU Advantage Gram negative activity Formula Compatibility Pleasant odor Weakness Anti-Fugal activity Interactive with macromolecules Potent anti-fungal and Pseudomonas activity Improved discoloration MCE-CS & CU can be used alone (CS 2.0±0.2 % CU 1.5±0.2%) MCE-CU ; For oil & oily Emulsion Formula

7 sensory efficacy Recommend conc. Viscosity effect Process Solubility in water Bacteria Fungi MCE-C O O 2.5±0.5% Add at the final process MCE-CS O O 2.0±0.2% O Add at the final process O MCE-CU O O 1.5±0.2% 1.2- Hexane diol O Add at the -oil phase Or final process O O 2.0±0.2% O Add at the final process X O

8 MIC MHB, inoculum size : 8.0x10 4 cfu/ml, 35 48hrs incubation, ph7.0 (Microdilution method,) sample was treated with solubilizing agent) MCE-C MCE-CS MCE-CU A.niger S.aureus E.coli P.aeruginosa C.albicans

9 Heat stability MIC test was performed after every preservative was treated at 121 for 30 minutes (sterilization process). MIC value was same after heat treatment. MCE-C MCE-CS MCE-CU A.niger S.aureus E.coli P.aeruginosa C.albicans

10 Stability of ph MIC test was performed after ph of every preservative was adjusted to 4,6,8, respectively and incubated at 45 for 30 days. MIC value was same after ph adjustment. MIC(%) ph4/6/8 MCE-C MCE-CS MCE-CU A.niger 0.156/0.156/ /0.02/ /0.01/0.01 S.aureus 0.039/0.078/ /0.039/ /0/02/0/02 E.coli 0.156/0.156/ /0.156/ /0.078/0.078 P.aeruginosa 0.078/0.078/ /0.078/ /0.039/0.039 C.albicans 0.078/0.078/ /0.039/ /0.02/0.02

11 Challenge Test Each preservative was added to cream and total cell number was observed after 3, 7, 14, 21, and 28 days. Re-challenge test was performed if any microbe was not observed after 14 days. - Challenge test of microbes (inoculum cells : 2x10 6 cfu/g) Product Preservative Number of cells (CFU/g) 3day 7day 14day Control >10 5 >10 5 >10 5 MCE-C 2.5% ND AOIM (cream) MCE-CS 2% ND MCE-CU 1.5% ND ND ND E company 2% 100 ND ND Citros 2% 200 ND ND 1,2-Hxdiol 2% ND

12 Re-Challenge Test Each preservative was added to cream and total cell number was observed after 3, 7, 14, 21, and 28 days. Re-challenge test was performed if any microbe was not observed after 14 days. Re-challenge of microbes(inoculum cells : 1x10 6 cfu/g) Product Preservative Number of cells (CFU/g) 3day 7day 14day 21day 28day Control >10 5 >10 5 >10 5 >10 5 >10 5 MCE-C 2.5% ND AOIM (cream) MCE-CS 2% ND ND MCE-CU 1.5% ND ND ND ND ND E company 2% ND ND Citros 2% ND 1,2-Hxdiol 2% ND

13 Challenge Test Each preservative was added to cream and total cell number was observed after 3, 7, 14, 21, and 28 days. Re-challenge test was performed if any fungi was not observed after 14 days. - Challenge test of fungi (inoculum cells 1x10 6 cfu/g) Product Preservative Number of cells (CFU/g) 3day 7day 14day Control >10 5 >10 5 >10 5 MCE-C 2.5% ND AOIM (cream) MCE-CS 2% ND MCE-CU 1.5% ND ND ND E company 2% ND Citros 2% ,2-Hxdiol 2%

14 Re-Challenge Test Each preservative was added to cream and total cell number was observed after 3, 7, 14, 21, and 28 days. Re-challenge test was performed if any fungi was not observed after 14 days. - Re-challenge test of fungi (inoculum cells 1x106 cfu/g) Product Preservative Number of cells (CFU/g) 3day 7day 14day 21day 28day Control >10 5 >10 5 >10 5 >10 5 >10 5 MCE-C 2.5% AOIM (cream) MCE-CS 2% ND MCE-CU 1.5% 120 ND ND ND ND E 사 2% ND Citros 2% ,2-Hxdiol 2%

15 Vehicle solubility MCE-C(2.5% sol.) DW glycerin EtOH propanediol BG - Recommend concentration in transparent formula (etc. toner) - MCE-C: 2.5%±0.2% ->w/o Eumulgin HPS 0.1 ~ 0.2% (INCI: COCETH-7)

16 Vehicle solubility MCE-CS (2% sol.) DW Glycerin EtOH propandieol BG - Recommend concentration in transparent formula (etc. toner) - MCE-CS: 2.0%±0.2% ->w/o Eumulgin HPS 0.1 ~ 0.2% (INCI: COCETH-7)

17 Vehicle solubility MCE-CU (1.5% sol.) DW glycerin EtOH propanediol BG - Recommend concentration in transparent formula (etc. toner) - MCE-CU : 1.5%±0.2% ->w/o Eumulgin HPS 0.1 ~ 0.2% (INCI: COCETH-7)

18 Compatibility Test-natural polymer MCE-C (2.5% sol.) Collagen 3% 0.5%HA 3% 0.5% β-glucan 3% When MCE-C reacted with other natural macromolecules, precipitation was not detected, however, turbidity was observed.

19 Compatibility Test-natural polymer MCE-CS (2% sol.) Collagen 3% 0.5%HA 3% 0.5% β-glucan 3% When MCE-CS was react with other natural macromolecules, precipitation was not detected, however, turbidity was observed.

20 Compatibility Test-natural polymer MCE-CU (1.5% sol.) Collagen 3% 0.5%HA 3% 0.5% β-glucan 3% When MCE-CU was react with other natural macromolecules, precipitation was not detected, however, turbidity was observed.

21 점도영향 Viscosity analysis condition : 4, 6, 30 (spin, rpm, s) ph Viscosity (x1,000, R.T.) 1day 7day 14day 28day Carbopol 940 1% gel MCE-C 2.5% MCE-CS 2% MCE-CU 1.5% control Viscosity of carbomer was not affected by MCE-C, CS, and CU. However, if viscosity was affected by any, it is recommended to use carbomer that is stabilized at salinity, or by using gum or natural viscosity increasing agent (type of cellulose) or by adjusting ph.

22 For New Clients Recommended Usage 1. MCE- C, MCE-CS & MCE-CU can be used alone, and their recommended dosage is %. 2. Viscosity of carbomer was not affected. However, if the viscosity decreased by MCE-C, MCE-CS and MCE-CU, it can be improved by ph adjustment or/and gum type viscosity increasing agents 3. Aggregation or precipitation was not observed. However, if aggregation or precipitation from natural macromolecules appears, use MCE-C, MCE-CS and MCE-CU after mixing with polyol first 4. For clear liquid, use 0.1%~0.2% solubilizing agent together with MCE-C, MCE-CS and MCE-CU 5. Recommend to add at the final stage or oil phase of manufacturing process.