Annual Meeting and Reception Agenda: 6:00 to 6:10: Greeting and gathering 6:10 to 6:45: Business meeting Welcome and opening remarks

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2 Annual Meeting and Reception Agenda: 6:00 to 6:10: Greeting and gathering 6:10 to 6:45: Business meeting Welcome and opening remarks President s report Finance report Membership report Election report Award presentation Appreciation for outgoing board members New President Speech Hanna Ng Hanna Ng Robert Li Alex Xu Gene Hsu Zemin Wang Hanna Ng Alex Xu 6:45 to 7:00: Sponsor Presentation (5 min each) 1. Pharmaron 2. WuXi AppTec 3. Regeneron 7:00 to 8:00: Reception

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4 AACT President Report o Continue its mission and objectives: Recognize outstanding Chinese toxicologists for their contributions to toxicology by AACT awards Provide networking opportunities for career development through AACT career workshop, annual meeting and reception Fundraising to promote collaborations among academia, industry and government Facilitate exchange of knowledge and information among toxicologists through emerging new communication platform i.e. WeChat) Provide communication to AACT members through semiannual Newsletter (two issues in Fall 2016 and Spring 2017)

5 Financial Report Robert Li

6 AACT Financial Status o Financially, AACT is doing well during the years o As of end Dec 2016, AACT had a balance of $32,801 in our General Fund and a balance of $36,224 in the Jean Lu Endowment Fund. o Fundraising ended up a great success with a total of $14,500 from 7 companies (3 at Gold Sponsorship Level: Pharmaron, WuXi and Regeneron) for 2017 Annual meeting and reception to date.

7 Pharmaron WuXi AppTec Regeneron L Oreal Charles River Laboratories Genentech Boehringer Ingelheim

8 Membership Report Alex Xu

9 Membership: 238 as of March 2rd, 2017 o AACT is the second largest SOT special interest group (SIG) AACT members do not have to be members of SOT (restricted membership, i.e., can not be AACT Board Member). o o o Obtain an AACT Membership Application from AACT website at Click Join AACT SOT Members Full and Associate Members: Add AACT to your existing membership via SOT Website Student/Postdocs Members: First Specialty Section/Special Interest group membership free Non-SOT members Print, fill the application form, and send to Ashley Pomper Thanks to everyone for supporting AACT

10 Election Report Gene Hsu

11 Election Committee o Chair: Gene Hsu Members: Alex Xu, Zemin Wang, Wei Xu, Nan Mei, Chia- Wen Hsu, and Matt Liu Open positions o President-Elect o Councilors (2) o Student representative Results for new elected officers are

12 President-Elect: X. Sherwin Yan Newell Brands Inc. Councilor Xi Yang US FDA/CDER Councilor Qihong Huang Boehringer Ingelheim Pharmaceuticals Student Representativ e Jun Zhou University of Georgia

13 Award Presentation Zemin Wang/Hanna Ng

14 Acknowledgements to Committee Members o Wang, Zemin, MD, Ph.D (Chairperson) o Mei, Nan, Ph.D o Zhang, Qinli, MD, Ph.D o Cheng, Qiuqiong (Joan), Ph.D o Jia, Zhengquan, Ph.D o Hsu, Ching-Hung (Gene), Ph.D o Xu, Alex, Ph.D o Lin, Haixia, Ph.D o Yang, June, MD, Ph.D o Liu, Matt, Ph.D

15 Awards Distinguished Chinese Toxicologist Lectureship (two nominations) Best Abstracts Award (11 abstracts) Jean Lu Student Scholarship (4 applicants)

16 Presented to Dr. Wei Xu Marian A. Messerschmidt Professor Department of Oncology University of Wisconsin-Madison In recognition of outstanding achievements as a researcher, mentor and leader in toxicology Baltimore, Maryland 2017

17 Shuo Xiao Northwestern University Title: Establishing an Integrated ex-vivo Female Reproductive Tract in a Microphysiologic, Dynamic, and Microfluidic Platform: Screening of Reproductive Toxic Chemicals Session: Poster Session: Reproductive Toxicology; March 13, 9:30 AM to 12:45 PM; # 1181, P302 Mentor: Teresa K. Woodruff, Ph.D.

18 Xilin Li Indiana University, Bloomington Title: Role of micrornas in Non-Alcoholic Fatty Liver Disease Session: Poster Session: Carcinogenesis I; March 13, 9:30 AM to 12:45 PM; #1082, P117 Mentor: James E Klaunig, PhD, ATS, IATP

19 Rosa Chan University of California at San Francisco Title: The Role of Mrp3, Mrp4 And Bsep Inhibition Individually And Synergistically And Their Relationship With DILI. Session: Poster Session: Liver 1: Mechanisms and Translational Biomarkers; March 15, 9:30 AM to 12:45 PM; #2507, P314 Mentor: Leslie Z. Benet, PhD

20 Jean Lu Frank C. Lu Established in 2008 Initial generous gift from Dr. Frank C. Lu, a charter member of the SOT, in memory of his wife, Jean Lu.

21 Presented to Kathy Xue University of Georgia Mentor: Jia-Sheng Wang, MD, PhD In recognition of outstanding academic achievement in the field of toxicology and who has provided leadership and service Baltimore, Maryland 2017

22 Appreciation Hanna Ng

23 Appreciation for the outstanding service of the outgoing board members Zemin Wang (Secretary) Robert Li (Treasurer) Jinpeng Li (Student Rep) Gene Hsu (Immediate Past President)

24 Jun Liu Victoria Tu Yi Jin Xing Cheng Millie Chen Lei Guo Matt Liu Robert Jiang Anna Zhang Bob Zhang Allison Perkins Dave Burns Jufeng Wang Bin He Nick Kerwin Qihong Hunag Robert Li

25 Looking Ahead Alex Xu

26 Continue the streak of success Further strengthen communication o WeChat is a good tool to connect us Possibility of Scientific Seminars Look forward input from our members o What you may want to get from AACT Expect a large body of membership Participate Chinese SOT annual meeting

27 Prepare for Success in China Chairperson: Alex Xu, PHD, DABT, USFDA Speakers John Gong, PhD, MD, CEO, 3D Medicines Inc. Joe Zhang, PhD, DABT, Head of Preclinical R&D, Simcere Pharaceuticals Leshuai Zhang, PhD, DABT, Professor, Medical College of Soochow University Discussion Panelists Victoria Tu, PhD, MBA, DABT, Vice President, Asia Pacific Product Safety, Regulation Affairs and Claims, L'Oreal Charles Wang, PhD, DABT, Director and Head of TPPS, GSK R&D China Date: Tuesday, March 14, 12:15 PM 1:30 PM Location: Baltimore Convention Center Room Boxed lunch will be provided.

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29 Enjoy the reception! Wishing you all a happy, healthy and prosperous year of the Rooster