Epigenomics of Common Diseases

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Epigenomics of Common Diseases 14 17 November 2017 Wellcome Genome Campus, Hinxton, Cambridge, UK Conference programme Tuesday, 14 November 12:30 13:50 Registration with buffet lunch 13:50 14:00

1 Epigenomics of Common Diseases November 2017 Wellcome Genome Campus, Hinxton, Cambridge, UK Conference programme Tuesday, 14 November 12:30 13:50 Registration with buffet lunch 13:50 14:00 Welcome and Introduction Doug Higgs, University of Oxford, UK 14:00 15:00 Keynote Lecture Chair: Doug Higgs, University of Oxford, UK Shaping chromatin in the nucleus, the bricks and the architects Genevieve Almouzni Institut Curie, France 15:00 16:30 Session 1: 4D genome Chair: Doug Higgs, University of Oxford, UK 15:00 The importance of higher order chromosome structure in the regulation of mammalian gene expression Doug Higgs University of Oxford, UK 15:30 Cohesin links inflammation and cancer Matthias Merkenschlager MRC Institute of Medical Sciences, UK 16:00 Mapping genomic regulatory architecture and interpreting non-coding variation with Promoter Capture Hi-C Mikhail Spivakov Babraham Institute, UK CTCF haploinsufficiency dysregulates cancer pathways by destabilising chromatin loops Sarah Aitken University of Cambridge, UK 16:30 Discussion 16:45 17:15 Afternoon Tea

2 17:00 17:30 Lightning talks 17:30 19:00 Drinks reception & poster session I (odd numbers) 19:00 21:00 Dinner 19:00 23:00 Bar open (Cash bar) Wednesday, 15 November 09:00 10:45 Session 2: Causal inference in epigenetics Chair: Edith Heard, Institut Curie, France 09:00 Applications of mendelian randomization in epigenomics George Davey-Smith University of Bristol, UK 09:30 Identification of directed networks in population genomics data Bas Heijmans Leiden University Medical Center, The Netherlands 10:00 DNA methylation and orofacial clefts Gemma Sharp University of Bristol, UK 10:15 Epigenetic mutations are features of aging Sara Hagg Karolinska Institutet, Sweden 10:30 Discussion 10:45 11:15 Morning Coffee 11:15 12:45 Session 3: Meiotic and mitotic inheritance in epigenetics Chair: Duncan Odom, Cancer Research UK Cambridge Institute, UK 11:15 Chromatin replication and epigenome maintenance Anja Groth University of Copenhagen, Denmark 11:45 Visualising epigenetic changes during development Mandy Fisher MRC Clinical Sciences Centre, UK 12:00 Single-cell Transcriptome and Methylome analysis in old oocytes Erika Herrera CES University, Columbia

3 12:45-14:15 Lunch 12:15 Overexpression of Histone deacetylase 1 in mouse forebrain leads to intergenerational behavioral phenotypes, potentially mediated by changes to the testis epigenome Mira Jakovcevski Max Planck Institute of Psychiatry, Germany 12:30 Discussion 13:30 14:15 Meet the speakers Conference Centre event space 14:15 16:00 Session 4: Epigenetic aspects of evolution Chair: Mandy Fisher, MRC Clinical Sciences Centre, UK 14:15 DNA methylation in great apes; an evolutionary perspective to human epigenetics Tomas Marques-Bonet Universitat Pompeu Fabra, Spain 14:45 Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression Duncan Odom Cancer Research UK Cambridge Institute, UK 15:15 Tissue-specific enhancer and promoter evolution in mammals Ericca Stamper CRUK Cambridge Institute, UK 15:30 Dissecting the impact of population variation in DNA methylation on transcriptional responses to immune activation Lucas Husquin Institut Pasteur, France 15:45 Discussion 16:00 16:45 Afternoon Tea 16:45 17:30 Lightning talks 17:30 19:00 Drinks reception & poster session II (even numbers) 19:00 21:00 Dinner 19:00 23:00 Bar open (Cash bar)

4 Thursday, 16 November 09:00 10:45 Session 5: Population epigenomics Chair: Art Petronis, University of Toronto and CAMH, Canada 09:00 Genetics, environment and epigenetics. Cutting the Gordian knot Ewan Birney EMBL-EBI, UK 09:30 Capturing functional epigenomes for insight into complex disease susceptibility Tomi Pastinen Children's Mercy Kansas City, USA 10:00 A genome-wide meta-analysis of newborn DNA methylation and birth weight in 8809 newborns reveals widespread differential methylation Leanne Kupers MRC Integrative Epidemiology Unit, UK 10:15 Epigenome-wide association study in a cohort exposed to polybrominated biphenyl (PBB) Sarah Curtis Emory University, USA 10:30 Discussion 10:45 11:15 Morning Coffee 11:15 12:00 Session 6: Genetic-epigenetic interactions Chair: Stephan Beck, University College London, UK 11:15 Enrichment of local genetic impacts on DNA methylation at enhancers and insulators Juan Castillo Fernandez King's College London, UK 11:30 The components of the human epigenetic machinery are highly co-expressed and intolerant to variation Kasper Hansen Johns Hopkins University, USA 11:45 Genetic and Environmental Determination of Variation in the Human Methylome Yanni Zeng University of Edinburgh, UK 12:00-12:45 Session 7: New methods in epigenetics Chair: Bas Heijmans, Leiden University Medical Center, Netherlands 12:00 Profiling of 5-hydroxymethylcytosine in cell-free DNA: A novel biomarker approach for early diagnosis and monitoring of cancer Jason Mellad Cambridge Epigenetix, UK

5 12:45-14:15 Lunch 12:15 currbs: simple and robust evaluation of enzyme combinations for reduced representation approaches Daniel Elias Martin Herranz EMBL-EBI, UK 12:30 Imaging allele-specific gene expression in mouse tissues. Orsolya Symmons University of Pennsylvania, USA 14:15 16:00 Session 8: Regulatory networks Chair: Anja Groth, University of Copenhagen, Denmark 14:15 One variant, multiple mechanisms; dissecting the association of TCF7L2 with type 2 diabetes Marcelo Nobrega University of Chicago, USA 14:45 foxd3 acts as a pioneer factor to dynamically remodel the regulatory landscape of neural crest cells in vivo Tatiana Sauka Spengler University of Oxford, UK 15:15 Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Sarah Cooper Wellcome Trust Sanger Institute, UK 15:30 DNA Hypermethylation drives EMT-mediated resistance to various cancer therapies Eva Galle Kuleuven, Belgium 15:45 Discussion 16:00 16:30 Afternoon Tea 16:30 17:30 Keynote Lecture Chair: Caroline Relton, University of Bristol, UK 17:30 18:00 Free time 4D genome re-organisation - gene activation and repression Wendy Bickmore University of Edinburgh, UK 18:00 19:00 Cocktail reception with flair display! 19:00 Conference dinner 20:30 After dinner entertainment Conference Centre Bar

6 Friday, 17 November 09:00 10:45 Session 9: Brain epigenomics Chair: Caroline Relton, University of Bristol, UK 09:00 Epigenetic control of neuronal specification and survival Anne Schaefer Mount Sinai School of Medicine, USA 09:30 Oncohistones: professional hijackers of the epigenome? Nada Jabado Montreal Childrens Hospital, Canada 10:00 Coding and noncoding mutations in intellectual disability patients leads to altered enhancer function Pradeepa Madapura University of Essex, UK 10:15 A histone acetylome-wide association study of Alzheimer s disease: neuropathology-associated regulatory variation in the human entorhinal cortex Jonathan Mill University of Exeter, UK 10:30 Discussion 10:45 11:15 Morning Coffee 11:15 12:45 Session 10: Epigenomics of Ageing Chair: Janine Felix, Erasmus MC 11:15 Epigenetic clocks: from molecular pathways to anti-aging interventions Steven Horvath University of California, Los Angeles, USA 11:45 Epigenetics of cancer and aging from mechanisms to therapies and interventions Peter Adams University of Glasgow, UK 12:15 Gestational age acceleration in neonates predicts NICU course Anna Knight Emory University, USA 12:30 Analysis of a longitudinal cohort delineates the genetic control of age associated epigenetic changes Jonathan Higham University of Edinburgh, UK 12:45 13:00 Closing remarks & announcement of prizes 13:00 14:00 Lunch 14:00 Coaches depart for Cambridge, Stansted Airport & Heathrow Airport

Exploring Human Host-Microbiome Interactions in Health and Disease 5-7 December 2018

Exploring Human Host-Microbiome Interactions in Health and Disease 5-7 December 2018 Wellcome Genome Campus, Hinxton, Cambridge, UK Conference Programme Wednesday 5 December 2018 12:00-13:00 Registration